{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Orthodontic+Treatment&page=2",
    "query": {
      "condition": "Orthodontic Treatment",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Orthodontic+Treatment&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-06-11T04:55:17.551Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT04512482",
      "title": "Evaluation of Oral Plaque Removal Utilizing an Adjunct Enzyme Pre-rinse",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Dental Plaque",
        "Dental Caries"
      ],
      "interventions": [
        {
          "name": "Bromelain",
          "type": "DRUG"
        },
        {
          "name": "Powdered sugar",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "Indiana University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "10 Years",
        "maximum_age": "25 Years",
        "sex": "ALL",
        "summary": "10 Years to 25 Years"
      },
      "enrollment_count": 46,
      "start_date": "2018-06-14",
      "completion_date": "2019-03-04",
      "has_results": true,
      "last_update_posted_date": "2020-12-03",
      "last_synced_at": "2026-06-11T04:55:17.551Z",
      "location_count": 1,
      "location_summary": "Indianapolis, Indiana",
      "locations": [
        {
          "city": "Indianapolis",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04512482"
    },
    {
      "nct_id": "NCT07506993",
      "title": "Inflammation in Clear Aligners With and Without Attachments",
      "overall_status": "NOT_YET_RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Periodontal Inflammation"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "University of Nebraska",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "14 Years",
        "maximum_age": "25 Years",
        "sex": "ALL",
        "summary": "14 Years to 25 Years"
      },
      "enrollment_count": 30,
      "start_date": "2026-05-01",
      "completion_date": "2027-05-01",
      "has_results": false,
      "last_update_posted_date": "2026-04-02",
      "last_synced_at": "2026-06-11T04:55:17.551Z",
      "location_count": 1,
      "location_summary": "Lincoln, Nebraska",
      "locations": [
        {
          "city": "Lincoln",
          "state": "Nebraska"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07506993"
    },
    {
      "nct_id": "NCT06426238",
      "title": "Self-reported and Experimental Pain in Patients Undergoing Orthodontic Treatment",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Pain"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Midwestern University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": null,
      "eligibility": {
        "minimum_age": "14 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "14 Years and older"
      },
      "enrollment_count": 38,
      "start_date": "2024-01-03",
      "completion_date": "2025-06-01",
      "has_results": false,
      "last_update_posted_date": "2025-06-08",
      "last_synced_at": "2026-06-11T04:55:17.551Z",
      "location_count": 1,
      "location_summary": "Downers Grove, Illinois",
      "locations": [
        {
          "city": "Downers Grove",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06426238"
    },
    {
      "nct_id": "NCT03202355",
      "title": "The Effect of OrthoPulse Photobiomodulation on the Rate of Tooth Movement During Alignment With Fixed Appliances",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Malocclusion"
      ],
      "interventions": [
        {
          "name": "Fixed Appliance Orthodontic Treatment",
          "type": "DEVICE"
        },
        {
          "name": "OrthoPulse™",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Biolux Research Holdings, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "11 Years",
        "maximum_age": "60 Years",
        "sex": "ALL",
        "summary": "11 Years to 60 Years"
      },
      "enrollment_count": 10,
      "start_date": "2017-04-20",
      "completion_date": "2019-03-11",
      "has_results": false,
      "last_update_posted_date": "2019-04-08",
      "last_synced_at": "2026-06-11T04:55:17.551Z",
      "location_count": 3,
      "location_summary": "Chandler, Arizona • Peoria, Arizona • Phoenix, Arizona",
      "locations": [
        {
          "city": "Chandler",
          "state": "Arizona"
        },
        {
          "city": "Peoria",
          "state": "Arizona"
        },
        {
          "city": "Phoenix",
          "state": "Arizona"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03202355"
    },
    {
      "nct_id": "NCT02211547",
      "title": "Effect of Low Level Laser Therapy on Pain Induced by Placement of Orthodontic Separators in Pediatric Patients",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Levels of Pain"
      ],
      "interventions": [
        {
          "name": "Epic 10 Diode Laser by Biolase Inc.",
          "type": "DEVICE"
        },
        {
          "name": "Placebo",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "OTHER"
      ],
      "sponsor": "University of Colorado, Denver",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "6 Years",
        "maximum_age": "17 Years",
        "sex": "ALL",
        "summary": "6 Years to 17 Years"
      },
      "enrollment_count": 0,
      "start_date": "2014-08",
      "completion_date": "2015-10",
      "has_results": false,
      "last_update_posted_date": "2017-01-31",
      "last_synced_at": "2026-06-11T04:55:17.551Z",
      "location_count": 1,
      "location_summary": "Aurora, Colorado",
      "locations": [
        {
          "city": "Aurora",
          "state": "Colorado"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02211547"
    },
    {
      "nct_id": "NCT03683017",
      "title": "OrthoPulse 2.0 and 2.1 Feasibility Evaluation",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Malocclusion"
      ],
      "interventions": [
        {
          "name": "OrthoPulse 2.0",
          "type": "DEVICE"
        },
        {
          "name": "OrthoPulse 2.1",
          "type": "DEVICE"
        },
        {
          "name": "Invisalign 3.5 Day Wear",
          "type": "DEVICE"
        },
        {
          "name": "Fixed Orthodontic Appliances (Braces)",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Biolux Research Holdings, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "11 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "11 Years and older"
      },
      "enrollment_count": 35,
      "start_date": "2017-12-22",
      "completion_date": "2020-06",
      "has_results": false,
      "last_update_posted_date": "2019-10-22",
      "last_synced_at": "2026-06-11T04:55:17.551Z",
      "location_count": 6,
      "location_summary": "Chandler, Arizona • Peoria, Arizona • Phoenix, Arizona + 3 more",
      "locations": [
        {
          "city": "Chandler",
          "state": "Arizona"
        },
        {
          "city": "Peoria",
          "state": "Arizona"
        },
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Scottsdale",
          "state": "Arizona"
        },
        {
          "city": "San Francisco",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03683017"
    },
    {
      "nct_id": "NCT06627829",
      "title": "Effect of Different Grafting Material Following Surgically Facilitated Orthodontics Therapy",
      "overall_status": "NOT_YET_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Malocclusion, Angle Class I"
      ],
      "interventions": [
        {
          "name": "Surgically facilitated orthodontics therapy (SFOT) using allograft",
          "type": "DEVICE"
        },
        {
          "name": "Surgically facilitated orthodontics therapy (SFOT) using xenograft",
          "type": "DEVICE"
        },
        {
          "name": "Usual care",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "The University of Texas Health Science Center, Houston",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 24,
      "start_date": "2025-01-06",
      "completion_date": "2027-01-06",
      "has_results": false,
      "last_update_posted_date": "2024-10-04",
      "last_synced_at": "2026-06-11T04:55:17.551Z",
      "location_count": 1,
      "location_summary": "Houston, Texas",
      "locations": [
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06627829"
    },
    {
      "nct_id": "NCT02438280",
      "title": "Accelerated Tooth Movement With AcceleDent® and Aligners - a Pilot Project",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Tooth Movement",
        "Malocclusion"
      ],
      "interventions": [
        {
          "name": "AcceleDent, Vibrational Device",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of Washington",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 27,
      "start_date": "2015-05",
      "completion_date": "2017-03",
      "has_results": true,
      "last_update_posted_date": "2018-10-30",
      "last_synced_at": "2026-06-11T04:55:17.551Z",
      "location_count": 1,
      "location_summary": "Seattle, Washington",
      "locations": [
        {
          "city": "Seattle",
          "state": "Washington"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02438280"
    },
    {
      "nct_id": "NCT03440996",
      "title": "Comparison of Three Toothpastes for the Prevention and Reduction of White Spot Lesions",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "White Spot Lesion",
        "Orthodontic Treatment",
        "Decalcification; Teeth"
      ],
      "interventions": [
        {
          "name": "Clinpro™ 5000",
          "type": "OTHER"
        },
        {
          "name": "Clinpro™ Tooth Crème",
          "type": "OTHER"
        },
        {
          "name": "MI-Paste Plus",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Alabama at Birmingham",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "12 Years",
        "maximum_age": "60 Years",
        "sex": "ALL",
        "summary": "12 Years to 60 Years"
      },
      "enrollment_count": 90,
      "start_date": "2011-01-14",
      "completion_date": "2011-12-30",
      "has_results": false,
      "last_update_posted_date": "2018-02-22",
      "last_synced_at": "2026-06-11T04:55:17.551Z",
      "location_count": 1,
      "location_summary": "Birmingham, Alabama",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03440996"
    },
    {
      "nct_id": "NCT02868554",
      "title": "Accelerated Invisalign Therapy in Conjunction With Acceledent Aura",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Malocclusion"
      ],
      "interventions": [
        {
          "name": "AcceleDent Aura",
          "type": "DEVICE"
        },
        {
          "name": "Accelerated Invisalign therapy",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of North Carolina, Chapel Hill",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "99 Years",
        "sex": "ALL",
        "summary": "18 Years to 99 Years"
      },
      "enrollment_count": 34,
      "start_date": "2016-08",
      "completion_date": "2019-04-26",
      "has_results": true,
      "last_update_posted_date": "2020-01-27",
      "last_synced_at": "2026-06-11T04:55:17.551Z",
      "location_count": 1,
      "location_summary": "Chapel Hill, North Carolina",
      "locations": [
        {
          "city": "Chapel Hill",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02868554"
    }
  ]
}