{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Orthostatic%3B+Hypotension%2C+Parkinsonism",
    "query": {
      "condition": "Orthostatic; Hypotension, Parkinsonism"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 21,
    "total_pages": 3,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Orthostatic%3B+Hypotension%2C+Parkinsonism&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-07-21T23:48:03.711Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT02705755",
      "title": "TD-9855 Phase 2 in Neurogenic Orthostatic Hypotension (nOH)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Neurogenic Orthostatic Hypotension",
        "Multiple System Atrophy (MSA) With Orthostatic Hypotension",
        "Pure Autonomic Failure",
        "Parkinson Disease",
        "Hypotension, Orthostatic",
        "Orthostatic Hypotension",
        "Pure Autonomic Failure With Orthostatic Hypotension",
        "Parkinson Disease With Orthostatic Hypotension"
      ],
      "interventions": [
        {
          "name": "TD-9855",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Theravance Biopharma",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "40 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "40 Years and older"
      },
      "enrollment_count": 34,
      "start_date": "2017-09-09",
      "completion_date": "2018-11-28",
      "has_results": true,
      "last_update_posted_date": "2022-09-26",
      "last_synced_at": "2026-07-21T23:48:03.711Z",
      "location_count": 6,
      "location_summary": "Long Beach, California • Farmington Hills, Michigan • Berlin, New Jersey + 3 more",
      "locations": [
        {
          "city": "Long Beach",
          "state": "California"
        },
        {
          "city": "Farmington Hills",
          "state": "Michigan"
        },
        {
          "city": "Berlin",
          "state": "New Jersey"
        },
        {
          "city": "New York",
          "state": "New York"
        },
        {
          "city": "Nashville",
          "state": "Tennessee"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02705755"
    },
    {
      "nct_id": "NCT04346394",
      "title": "The Role of the Noradrenergic System in the Nonmotor Symptoms of Parkinson's Disease",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "EARLY_PHASE1"
      ],
      "conditions": [
        "Parkinson Disease"
      ],
      "interventions": [
        {
          "name": "Yohimbine HCl",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Nathaniel M. Robbins",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 0,
      "start_date": "2021-05-11",
      "completion_date": "2023-08-01",
      "has_results": false,
      "last_update_posted_date": "2023-08-23",
      "last_synced_at": "2026-07-21T23:48:03.711Z",
      "location_count": 1,
      "location_summary": "Lebanon, New Hampshire",
      "locations": [
        {
          "city": "Lebanon",
          "state": "New Hampshire"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04346394"
    },
    {
      "nct_id": "NCT04510922",
      "title": "Lundbeck TOMs Orthostatic Hypotension",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Orthostatic Hypotension",
        "Idiopathic Parkinson Disease"
      ],
      "interventions": [
        {
          "name": "Droxidopa 100 MG [Northera]",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Alberto Espay, MD, MSc",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "30 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "30 Years to 80 Years"
      },
      "enrollment_count": 9,
      "start_date": "2019-02-11",
      "completion_date": "2020-12-31",
      "has_results": true,
      "last_update_posted_date": "2022-09-26",
      "last_synced_at": "2026-07-21T23:48:03.711Z",
      "location_count": 1,
      "location_summary": "Cincinnati, Ohio",
      "locations": [
        {
          "city": "Cincinnati",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04510922"
    },
    {
      "nct_id": "NCT05489575",
      "title": "CPAP for the Treatment of Supine Hypertension",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Autonomic Failure",
        "Pure Autonomic Failure",
        "Multiple System Atrophy",
        "Parkinson Disease",
        "Supine Hypertension",
        "Neurogenic Orthostatic Hypotension"
      ],
      "interventions": [
        {
          "name": "Active CPAP",
          "type": "DEVICE"
        },
        {
          "name": "Sham CPAP",
          "type": "DEVICE"
        },
        {
          "name": "Sleeping in a head-up tilt (HUT) position",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "OTHER"
      ],
      "sponsor": "Vanderbilt University Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "40 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "40 Years to 80 Years"
      },
      "enrollment_count": 59,
      "start_date": "2022-06-23",
      "completion_date": "2027-08-31",
      "has_results": false,
      "last_update_posted_date": "2026-04-07",
      "last_synced_at": "2026-07-21T23:48:03.711Z",
      "location_count": 1,
      "location_summary": "Nashville, Tennessee",
      "locations": [
        {
          "city": "Nashville",
          "state": "Tennessee"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05489575"
    },
    {
      "nct_id": "NCT04095793",
      "title": "Phase 3 Open-Label Extension Study of TD-9855 for Treating Symptomatic nOH in Subjects With Primary Autonomic Failure",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Symptomatic Neurogenic Orthostatic Hypotension"
      ],
      "interventions": [
        {
          "name": "ampreloxetine",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Theravance Biopharma",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "30 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "30 Years and older"
      },
      "enrollment_count": 110,
      "start_date": "2019-09-19",
      "completion_date": "2021-11-12",
      "has_results": true,
      "last_update_posted_date": "2022-11-30",
      "last_synced_at": "2026-07-21T23:48:03.711Z",
      "location_count": 13,
      "location_summary": "Colorado Springs, Colorado • Boca Raton, Florida • Port Charlotte, Florida + 10 more",
      "locations": [
        {
          "city": "Colorado Springs",
          "state": "Colorado"
        },
        {
          "city": "Boca Raton",
          "state": "Florida"
        },
        {
          "city": "Port Charlotte",
          "state": "Florida"
        },
        {
          "city": "Chicago",
          "state": "Illinois"
        },
        {
          "city": "Glenview",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04095793"
    },
    {
      "nct_id": "NCT02897063",
      "title": "Effects of Midodrine and Droxidopa on Splanchnic Capacitance in Autonomic Failure",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Autonomic Failure",
        "Pure Autonomic Failure",
        "Multiple System Atrophy",
        "Parkinson Disease",
        "Orthostatic Hypotension"
      ],
      "interventions": [
        {
          "name": "Droxidopa",
          "type": "DRUG"
        },
        {
          "name": "Midodrine",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Vanderbilt University Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "40 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "40 Years to 80 Years"
      },
      "enrollment_count": 34,
      "start_date": "2016-09",
      "completion_date": "2026-12",
      "has_results": false,
      "last_update_posted_date": "2025-10-14",
      "last_synced_at": "2026-07-21T23:48:03.711Z",
      "location_count": 1,
      "location_summary": "Nashville, Tennessee",
      "locations": [
        {
          "city": "Nashville",
          "state": "Tennessee"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02897063"
    },
    {
      "nct_id": "NCT05400174",
      "title": "Blood Pressure Effects on Cognition and Brain Blood Flow in PD",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Parkinson Disease",
        "Orthostatic Hypotension",
        "Dysautonomia"
      ],
      "interventions": [
        {
          "name": "Tilt table (upright position)",
          "type": "DIAGNOSTIC_TEST"
        }
      ],
      "intervention_types": [
        "DIAGNOSTIC_TEST"
      ],
      "sponsor": "University of California, San Diego",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "50 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "50 Years and older"
      },
      "enrollment_count": 60,
      "start_date": "2021-12-14",
      "completion_date": "2026-08-15",
      "has_results": false,
      "last_update_posted_date": "2026-04-27",
      "last_synced_at": "2026-07-21T23:48:03.711Z",
      "location_count": 1,
      "location_summary": "San Diego, California",
      "locations": [
        {
          "city": "San Diego",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05400174"
    },
    {
      "nct_id": "NCT05487300",
      "title": "Effect of Levodopa on Cardiovascular Autonomic Function in Parkinson's Disease",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2",
        "PHASE3"
      ],
      "conditions": [
        "Parkinson Disease",
        "Orthostatic Hypotension"
      ],
      "interventions": [
        {
          "name": "Autonomic testing on and off levodopa",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Utah",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 40,
      "start_date": "2022-05-11",
      "completion_date": "2023-05-01",
      "has_results": true,
      "last_update_posted_date": "2024-12-05",
      "last_synced_at": "2026-07-21T23:48:03.711Z",
      "location_count": 1,
      "location_summary": "Salt Lake City, Utah",
      "locations": [
        {
          "city": "Salt Lake City",
          "state": "Utah"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05487300"
    },
    {
      "nct_id": "NCT01927055",
      "title": "A Clinical Study of Patients With Symptomatic NOH to Assess Sustained Effects of Droxidopa Therapy",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Symptomatic Neurogenic Orthostatic Hypotension",
        "Parkinson's Disease",
        "Multiple Systems Atrophy",
        "Pure Autonomic Failure",
        "Dopamine Beta Hydroxylase Deficiency"
      ],
      "interventions": [
        {
          "name": "Droxidopa",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Chelsea Therapeutics",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 61,
      "start_date": "2013-11",
      "completion_date": "2015-02",
      "has_results": true,
      "last_update_posted_date": "2016-01-08",
      "last_synced_at": "2026-07-21T23:48:03.711Z",
      "location_count": 3,
      "location_summary": "New York, New York • Charlotte, North Carolina • Milwaukee, Wisconsin",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        },
        {
          "city": "Charlotte",
          "state": "North Carolina"
        },
        {
          "city": "Milwaukee",
          "state": "Wisconsin"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01927055"
    },
    {
      "nct_id": "NCT03229174",
      "title": "Brain Perfusion & Oxygenation in Parkinson's Disease With NOH",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Parkinson Disease",
        "Neurogenic Orthostatic Hypotension"
      ],
      "interventions": [
        {
          "name": "Droxidopa",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "William Ondo, MD",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "85 Years",
        "sex": "ALL",
        "summary": "18 Years to 85 Years"
      },
      "enrollment_count": 17,
      "start_date": "2018-08-23",
      "completion_date": "2022-02-02",
      "has_results": false,
      "last_update_posted_date": "2022-09-06",
      "last_synced_at": "2026-07-21T23:48:03.711Z",
      "location_count": 1,
      "location_summary": "Houston, Texas",
      "locations": [
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03229174"
    }
  ]
}