{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Ototoxicity%2C+Drug-Induced",
    "query": {
      "condition": "Ototoxicity, Drug-Induced"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 19,
    "total_pages": 2,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Ototoxicity%2C+Drug-Induced&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-06-11T01:34:55.446Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT01451853",
      "title": "SPI-1005 for Prevention and Treatment of Chemotherapy Induced Hearing Loss",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Lung Cancer",
        "Head and Neck Cancer",
        "Hearing Loss",
        "Ototoxicity",
        "Tinnitus",
        "Neuropathy"
      ],
      "interventions": [
        {
          "name": "SPI-1005 Low Dose",
          "type": "DRUG"
        },
        {
          "name": "SPI-1005 Middle Dose",
          "type": "DRUG"
        },
        {
          "name": "SPI-1005 High Dose",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Sound Pharmaceuticals, Incorporated",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "19 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "19 Years to 80 Years"
      },
      "enrollment_count": 0,
      "start_date": "2026-06",
      "completion_date": "2026-06",
      "has_results": false,
      "last_update_posted_date": "2026-06-03",
      "last_synced_at": "2026-06-11T01:34:55.446Z",
      "location_count": 1,
      "location_summary": "Seattle, Washington",
      "locations": [
        {
          "city": "Seattle",
          "state": "Washington"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01451853"
    },
    {
      "nct_id": "NCT00458887",
      "title": "Assessing Ear Damage in Young Cancer Patients Treated With Cisplatin",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Ototoxicity",
        "Unspecified Childhood Solid Tumor, Protocol Specific"
      ],
      "interventions": [
        {
          "name": "management of therapy complications",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Children's Oncology Group",
      "sponsor_class": "NETWORK",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "1 Year",
        "maximum_age": "18 Years",
        "sex": "ALL",
        "summary": "1 Year to 18 Years"
      },
      "enrollment_count": 301,
      "start_date": "2007-05",
      "completion_date": "2017-02-28",
      "has_results": false,
      "last_update_posted_date": "2017-03-13",
      "last_synced_at": "2026-06-11T01:34:55.446Z",
      "location_count": 73,
      "location_summary": "Birmingham, Alabama • Little Rock, Arkansas • Los Angeles, California + 65 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Little Rock",
          "state": "Arkansas"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Madera",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00458887"
    },
    {
      "nct_id": "NCT00477607",
      "title": "Alpha-Lipoic Acid in Preventing Hearing Loss in Cancer Patients Undergoing Treatment With Cisplatin",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2",
        "PHASE3"
      ],
      "conditions": [
        "Ototoxicity",
        "Unspecified Adult Solid Tumor"
      ],
      "interventions": [
        {
          "name": "alpha-lipoic acid",
          "type": "DRUG"
        },
        {
          "name": "Audiology",
          "type": "BEHAVIORAL"
        },
        {
          "name": "laboratory biomarker analysis",
          "type": "BIOLOGICAL"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG",
        "BEHAVIORAL",
        "BIOLOGICAL"
      ],
      "sponsor": "US Department of Veterans Affairs",
      "sponsor_class": "FED",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 39,
      "start_date": "2007-10",
      "completion_date": "2011-06",
      "has_results": true,
      "last_update_posted_date": "2014-03-07",
      "last_synced_at": "2026-06-11T01:34:55.446Z",
      "location_count": 2,
      "location_summary": "Portland, Oregon",
      "locations": [
        {
          "city": "Portland",
          "state": "Oregon"
        },
        {
          "city": "Portland",
          "state": "Oregon"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00477607"
    },
    {
      "nct_id": "NCT05730283",
      "title": "Prevention of Ototoxicity in NTM Patients Treated With IV Amikacin",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Ototoxicity, Drug-Induced"
      ],
      "interventions": [
        {
          "name": "ORC-13661",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Kevin Winthrop",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 105,
      "start_date": "2025-06-02",
      "completion_date": "2028-02-29",
      "has_results": false,
      "last_update_posted_date": "2026-05-07",
      "last_synced_at": "2026-06-11T01:34:55.446Z",
      "location_count": 7,
      "location_summary": "San Francisco, California • Denver, Colorado • Baltimore, Maryland + 4 more",
      "locations": [
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "Denver",
          "state": "Colorado"
        },
        {
          "city": "Baltimore",
          "state": "Maryland"
        },
        {
          "city": "Rochester",
          "state": "Minnesota"
        },
        {
          "city": "Portland",
          "state": "Oregon"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05730283"
    },
    {
      "nct_id": "NCT00716976",
      "title": "Sodium Thiosulfate in Preventing Hearing Loss in Young Patients Receiving Cisplatin for Newly Diagnosed Germ Cell Tumor, Hepatoblastoma, Medulloblastoma, Neuroblastoma, Osteosarcoma, or Other Malignancy",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Brain Tumor",
        "Central Nervous System Tumor",
        "Childhood Germ Cell Tumor",
        "Extragonadal Germ Cell Tumor",
        "Liver Cancer",
        "Neuroblastoma",
        "Ototoxicity",
        "Ovarian Cancer",
        "Sarcoma"
      ],
      "interventions": [
        {
          "name": "sodium thiosulfate",
          "type": "DRUG"
        },
        {
          "name": "examination",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "DRUG",
        "PROCEDURE"
      ],
      "sponsor": "Children's Oncology Group",
      "sponsor_class": "NETWORK",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "1 Year",
        "maximum_age": "18 Years",
        "sex": "ALL",
        "summary": "1 Year to 18 Years"
      },
      "enrollment_count": 131,
      "start_date": "2008-06-23",
      "completion_date": "2021-06-30",
      "has_results": true,
      "last_update_posted_date": "2023-11-09",
      "last_synced_at": "2026-06-11T01:34:55.446Z",
      "location_count": 68,
      "location_summary": "Birmingham, Alabama • Little Rock, Arkansas • Los Angeles, California + 61 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Little Rock",
          "state": "Arkansas"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Madera",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00716976"
    },
    {
      "nct_id": "NCT02819856",
      "title": "SPI-1005 for Prevention and Treatment of Tobramycin Induced Ototoxicity",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Ototoxicity"
      ],
      "interventions": [
        {
          "name": "Placebo",
          "type": "DRUG"
        },
        {
          "name": "SPI-1005 Ebselen 200mg Capsule x1",
          "type": "DRUG"
        },
        {
          "name": "SPI-1005 Ebselen 200mg Capsule x2",
          "type": "DRUG"
        },
        {
          "name": "SPI-1005 Ebselen 200mg Capsule x3",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Sound Pharmaceuticals, Incorporated",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 40,
      "start_date": "2017-07-21",
      "completion_date": "2023-04-07",
      "has_results": false,
      "last_update_posted_date": "2024-08-02",
      "last_synced_at": "2026-06-11T01:34:55.446Z",
      "location_count": 1,
      "location_summary": "Charleston, South Carolina",
      "locations": [
        {
          "city": "Charleston",
          "state": "South Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02819856"
    },
    {
      "nct_id": "NCT05789316",
      "title": "Head and Neck Cancer Survivorship Ototoxicity Screening (SOS)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Head and Neck Cancer Survivors",
        "Cancer of the Head and Neck Surviors"
      ],
      "interventions": [
        {
          "name": "Ototoxicity Screening Protocol",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Washington University School of Medicine",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 55,
      "start_date": "2023-06-06",
      "completion_date": "2025-11-21",
      "has_results": false,
      "last_update_posted_date": "2026-01-12",
      "last_synced_at": "2026-06-11T01:34:55.446Z",
      "location_count": 1,
      "location_summary": "St Louis, Missouri",
      "locations": [
        {
          "city": "St Louis",
          "state": "Missouri"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05789316"
    },
    {
      "nct_id": "NCT05676944",
      "title": "Vestibular Implantation in Older Adults",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Other Disorders of Vestibular Function, Bilateral",
        "Bilateral Vestibular Deficiency (BVD)",
        "Gentamicin Ototoxicity",
        "Labyrinth Diseases",
        "Vestibular Diseases",
        "Sensation Disorders",
        "Bilateral Vestibular Hypofunction",
        "Bilateral Vestibulopathy",
        "Presbyvestibulopathy",
        "Aminoglycoside Ototoxicity"
      ],
      "interventions": [
        {
          "name": "Labyrinth Devices MVI™ Multichannel Vestibular Implant System",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Johns Hopkins University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "65 Years",
        "maximum_age": "90 Years",
        "sex": "ALL",
        "summary": "65 Years to 90 Years"
      },
      "enrollment_count": 15,
      "start_date": "2023-04-11",
      "completion_date": "2028-01-31",
      "has_results": false,
      "last_update_posted_date": "2026-01-12",
      "last_synced_at": "2026-06-11T01:34:55.446Z",
      "location_count": 1,
      "location_summary": "Baltimore, Maryland",
      "locations": [
        {
          "city": "Baltimore",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05676944"
    },
    {
      "nct_id": "NCT07622407",
      "title": "Maximizing Quality of Life After Cancer Through Rehabilitation",
      "overall_status": "NOT_YET_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Head and Neck Cancer",
        "Hearing Loss",
        "Tinnitus",
        "Dysphagia"
      ],
      "interventions": [
        {
          "name": "TIMELY REHAB",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "VA Office of Research and Development",
      "sponsor_class": "FED",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "89 Years",
        "sex": "ALL",
        "summary": "18 Years to 89 Years"
      },
      "enrollment_count": 74,
      "start_date": "2027-03-01",
      "completion_date": "2030-06-30",
      "has_results": false,
      "last_update_posted_date": "2026-06-03",
      "last_synced_at": "2026-06-11T01:34:55.446Z",
      "location_count": 3,
      "location_summary": "Durham, North Carolina • Portland, Oregon • Madison, Wisconsin",
      "locations": [
        {
          "city": "Durham",
          "state": "North Carolina"
        },
        {
          "city": "Portland",
          "state": "Oregon"
        },
        {
          "city": "Madison",
          "state": "Wisconsin"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07622407"
    },
    {
      "nct_id": "NCT05674786",
      "title": "Vestibular Implantation to Treat Adult-Onset Bilateral Vestibular Hypofunction",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Other Disorders of Vestibular Function, Bilateral",
        "Bilateral Vestibular Deficiency (BVD)",
        "Gentamicin Ototoxicity",
        "Labyrinth Diseases",
        "Vestibular Diseases",
        "Sensation Disorders",
        "Bilateral Vestibular Hypofunction",
        "Bilateral Vestibulopathy",
        "Aminoglycoside Ototoxicity"
      ],
      "interventions": [
        {
          "name": "Labyrinth Devices MVI™ Multichannel Vestibular Implant System",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Johns Hopkins University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "22 Years",
        "maximum_age": "90 Years",
        "sex": "ALL",
        "summary": "22 Years to 90 Years"
      },
      "enrollment_count": 8,
      "start_date": "2023-02-28",
      "completion_date": "2027-03-31",
      "has_results": false,
      "last_update_posted_date": "2026-01-12",
      "last_synced_at": "2026-06-11T01:34:55.446Z",
      "location_count": 1,
      "location_summary": "Baltimore, Maryland",
      "locations": [
        {
          "city": "Baltimore",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05674786"
    }
  ]
}