{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=PMDD&page=2",
    "query": {
      "condition": "PMDD",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=PMDD&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-07-22T07:27:55.832Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT04123483",
      "title": "EnBrace HR for PMS With Prominent Mood Symptoms or Menstrual Related Mood Disorders",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Premenstrual Syndrome",
        "Premenstrual Dysphoric Disorder",
        "Premenstrual Tension",
        "Menstrual Related Mood Disorder"
      ],
      "interventions": [
        {
          "name": "EnBrace HR Softgel",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Massachusetts General Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "52 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 52 Years · Female only"
      },
      "enrollment_count": 0,
      "start_date": "2019-11",
      "completion_date": "2022-11",
      "has_results": false,
      "last_update_posted_date": "2020-01-02",
      "last_synced_at": "2026-07-22T07:27:55.832Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04123483"
    },
    {
      "nct_id": "NCT06227676",
      "title": "Effect of 'Cramp Bites' on Period Cramps in Women Aged 18-25",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2",
        "PHASE3"
      ],
      "conditions": [
        "Dysmenorrhea Primary",
        "Dysmenorrhea",
        "Menstrual Discomfort",
        "Menstrual Problem",
        "Menstrual Cycle Abnormal",
        "Menstrual Pain",
        "Period Pain",
        "Period Problem",
        "PMS",
        "Premenstrual Syndrome",
        "PCOS",
        "PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries",
        "PCOS (Polycystic Ovary Syndrome) of Left Ovary",
        "PCOS (Polycystic Ovary Syndrome) of Right Ovary",
        "Polycystic Ovary Syndrome",
        "Premenstrual Dysphoric Disorder",
        "Cramps",
        "Ovarian Cysts"
      ],
      "interventions": [
        {
          "name": "Cramp Bites by Aunt Flo's Kitchen",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "Cornell University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "25 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 25 Years · Female only"
      },
      "enrollment_count": 12,
      "start_date": "2022-07-21",
      "completion_date": "2022-10-31",
      "has_results": false,
      "last_update_posted_date": "2024-04-12",
      "last_synced_at": "2026-07-22T07:27:55.832Z",
      "location_count": 1,
      "location_summary": "Ithaca, New York",
      "locations": [
        {
          "city": "Ithaca",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06227676"
    },
    {
      "nct_id": "NCT01799733",
      "title": "Alternative Treatments for Premenstrual Dysphoric Disorder",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Premenstrual Dysphoric Disorder"
      ],
      "interventions": [
        {
          "name": "LWT+AM BWL",
          "type": "OTHER"
        },
        {
          "name": "EWT+PM BWL",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of California, San Diego",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "45 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 45 Years · Female only"
      },
      "enrollment_count": 43,
      "start_date": "2013-06-18",
      "completion_date": "2018-07-03",
      "has_results": false,
      "last_update_posted_date": "2022-02-04",
      "last_synced_at": "2026-07-22T07:27:55.832Z",
      "location_count": 1,
      "location_summary": "San Diego, California",
      "locations": [
        {
          "city": "San Diego",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01799733"
    },
    {
      "nct_id": "NCT00005119",
      "title": "Altered Calcium and Vitamin D in PMDD or Severe PMS",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Premenstrual Syndrome"
      ],
      "interventions": [
        {
          "name": "Measures of calcium and bone turnover",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)",
      "sponsor_class": "NIH",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "45 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 45 Years · Female only"
      },
      "enrollment_count": null,
      "start_date": "2000-05",
      "completion_date": "2003-10",
      "has_results": false,
      "last_update_posted_date": "2010-03-02",
      "last_synced_at": "2026-07-22T07:27:55.832Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00005119"
    },
    {
      "nct_id": "NCT00318773",
      "title": "Short-Term Versus Long-Term Treatment for Severe Premenstrual Syndrome (PMS)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Premenstrual Syndrome"
      ],
      "interventions": [
        {
          "name": "sertraline",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)",
      "sponsor_class": "NIH",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "45 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 45 Years · Female only"
      },
      "enrollment_count": 174,
      "start_date": "2002-02",
      "completion_date": "2008-02",
      "has_results": false,
      "last_update_posted_date": "2009-02-27",
      "last_synced_at": "2026-07-22T07:27:55.832Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00318773"
    },
    {
      "nct_id": "NCT00678574",
      "title": "The Role of GABA and Neurosteroids in Premenstrual Dysphoric Disorder",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Premenstrual Dysphoric Disorder",
        "Premenstrual Syndrome"
      ],
      "interventions": [
        {
          "name": "fluoxetine",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Pennsylvania",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "45 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 45 Years · Female only"
      },
      "enrollment_count": 45,
      "start_date": "1998-03",
      "completion_date": "2008-12",
      "has_results": true,
      "last_update_posted_date": "2018-07-27",
      "last_synced_at": "2026-07-22T07:27:55.832Z",
      "location_count": 1,
      "location_summary": "New Haven, Connecticut",
      "locations": [
        {
          "city": "New Haven",
          "state": "Connecticut"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00678574"
    },
    {
      "nct_id": "NCT06771583",
      "title": "Identification and Validation of Epigenetic Biomarkers of PMDD",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "PMDD",
        "Premenstrual Dysphoric Disorder (PMDD)",
        "Premenstrual Syndrome-PMS",
        "Premenstrual Syndrome",
        "Menstrual Cycle"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Johns Hopkins University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "50 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 50 Years · Female only"
      },
      "enrollment_count": 500,
      "start_date": "2025-09-12",
      "completion_date": "2031-02-15",
      "has_results": false,
      "last_update_posted_date": "2026-05-07",
      "last_synced_at": "2026-07-22T07:27:55.832Z",
      "location_count": 1,
      "location_summary": "Baltimore, Maryland",
      "locations": [
        {
          "city": "Baltimore",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06771583"
    },
    {
      "nct_id": "NCT01385709",
      "title": "The Influence of the Menstrual Cycle on Lithium and Sertraline Blood Levels",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Bipolar Affective Disorders",
        "Cyclothymic Disorder",
        "Schizoaffective Disorder",
        "Major Depressive Disorder",
        "Dysthymic Disorder",
        "Obsessive-Compulsive Disorder",
        "Panic Disorder",
        "Posttraumatic Stress Disorder",
        "Premenstrual Dysphoric Disorder",
        "Social Anxiety Disorder"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Weill Medical College of Cornell University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "40 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 40 Years · Female only"
      },
      "enrollment_count": 29,
      "start_date": "2008-08",
      "completion_date": "2013-08",
      "has_results": false,
      "last_update_posted_date": "2017-02-20",
      "last_synced_at": "2026-07-22T07:27:55.832Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01385709"
    },
    {
      "nct_id": "NCT06136104",
      "title": "The Effects of Mixhers HERTIME Supplements on Menstrual Symptoms",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Healthy",
        "Premenstrual Dysphoric Disorder",
        "Premenstrual Syndrome"
      ],
      "interventions": [
        {
          "name": "Mixhers HERTIME",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Placebo",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "Midwestern University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "45 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 45 Years · Female only"
      },
      "enrollment_count": 100,
      "start_date": "2023-08-30",
      "completion_date": "2023-12-20",
      "has_results": false,
      "last_update_posted_date": "2024-05-08",
      "last_synced_at": "2026-07-22T07:27:55.832Z",
      "location_count": 1,
      "location_summary": "Glendale, Arizona",
      "locations": [
        {
          "city": "Glendale",
          "state": "Arizona"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06136104"
    },
    {
      "nct_id": "NCT03862469",
      "title": "Premenstrual Hormonal and Affective State Evaluation (PHASE) Project",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Premenstrual Dysphoric Disorder"
      ],
      "interventions": [
        {
          "name": "Individualized laboratory test",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "University of Illinois at Chicago",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "35 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 35 Years · Female only"
      },
      "enrollment_count": 129,
      "start_date": "2019-09-26",
      "completion_date": "2023-09-01",
      "has_results": true,
      "last_update_posted_date": "2025-04-24",
      "last_synced_at": "2026-07-22T07:27:55.832Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03862469"
    }
  ]
}