{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=POLD", "query": { "condition": "POLD" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 7, "total_pages": 1, "next_page_url": null, "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-07-22T02:25:56.392Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT05020743", "title": "Natural History Study in Adult-Onset Leukoencephalopathy With Axonal Spheroids and Pigmented Glia", "overall_status": "TERMINATED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "ALSP" ], "interventions": [ { "name": "No intervention", "type": "OTHER" } ], "intervention_types": [ "OTHER" ], "sponsor": "Vigil Neuroscience, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 56, "start_date": "2021-09-13", "completion_date": "2025-05-30", "has_results": true, "last_update_posted_date": "2025-08-13", "last_synced_at": "2026-07-22T02:25:56.392Z", "location_count": 6, "location_summary": "San Francisco, California • Englewood, Colorado • Boca Raton, Florida + 3 more", "locations": [ { "city": "San Francisco", "state": "California" }, { "city": "Englewood", "state": "Colorado" }, { "city": "Boca Raton", "state": "Florida" }, { "city": "Jacksonville", "state": "Florida" }, { "city": "Boston", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT05020743" }, { "nct_id": "NCT02171104", "title": "MT2013-31: Allo HCT for Metabolic Disorders and Severe Osteopetrosis", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Mucopolysaccharidosis Disorders", "Hurler Syndrome", "Hunter Syndrome", "Maroteaux Lamy Syndrome", "Sly Syndrome", "Alpha-Mannosidosis", "Fucosidosis", "Aspartylglucosaminuria", "Glycoprotein Metabolic Disorders", "Sphingolipidoses", "Recessive Leukodystrophies", "Globoid Cell Leukodystrophy", "Metachromatic Leukodystrophy", "Niemann-Pick B", "Niemann-Pick C Subtype 2", "Sphingomyelin Deficiency", "Peroxisomal Disorders", "Adrenoleukodystrophy With Cerebral Involvement", "Zellweger Syndrome", "Neonatal Adrenoleukodystrophy", "Infantile Refsum Disease", "Acyl-CoA Oxidase Deficiency", "D-Bifunctional Enzyme Deficiency", "Multifunctional Enzyme Deficiency", "Alpha-methylacyl-CoA Racmase Deficiency", "Mitochondrial Neurogastrointestingal Encephalopathy", "Severe Osteopetrosis", "Hereditary Leukoencephalopathy With Axonal Spheroids (HDLS; CSF1R Mutation)", "Inherited Metabolic Disorders" ], "interventions": [ { "name": "Stem Cell Transplantation", "type": "BIOLOGICAL" }, { "name": "IMD Preparative Regimen", "type": "DRUG" }, { "name": "Osteopetrosis Only Preparative Regimen", "type": "DRUG" }, { "name": "Osteopetrosis Haploidentical Only Preparative Regimen", "type": "DRUG" }, { "name": "cALD SR-A (Standard-Risk, Regimen A)", "type": "DRUG" }, { "name": "cALD SR-B (Standard-Risk, Regimen B)", "type": "DRUG" }, { "name": "cALD HR-D (High-Risk, Regimen C)", "type": "DRUG" }, { "name": "cALD HR-D (High-Risk, Regimen D)", "type": "DRUG" } ], "intervention_types": [ "BIOLOGICAL", "DRUG" ], "sponsor": "Masonic Cancer Center, University of Minnesota", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": null, "maximum_age": "55 Years", "sex": "ALL", "summary": "Up to 55 Years" }, "enrollment_count": 149, "start_date": "2014-07-10", "completion_date": "2029-07-14", "has_results": false, "last_update_posted_date": "2026-01-07", "last_synced_at": "2026-07-22T02:25:56.392Z", "location_count": 1, "location_summary": "Minneapolis, Minnesota", "locations": [ { "city": "Minneapolis", "state": "Minnesota" } ], "official_url": "https://clinicaltrials.gov/study/NCT02171104" }, { "nct_id": "NCT05677659", "title": "A Study of VGL101 in Patients With Adult-Onset Leukoencephalopathy With Axonal Spheroids and Pigmented Glia", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "ALSP" ], "interventions": [ { "name": "VGL101", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Vigil Neuroscience, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 20, "start_date": "2022-12-14", "completion_date": "2025-06-04", "has_results": false, "last_update_posted_date": "2025-06-11", "last_synced_at": "2026-07-22T02:25:56.392Z", "location_count": 5, "location_summary": "San Francisco, California • Englewood, Colorado • Jacksonville, Florida + 2 more", "locations": [ { "city": "San Francisco", "state": "California" }, { "city": "Englewood", "state": "Colorado" }, { "city": "Jacksonville", "state": "Florida" }, { "city": "Boston", "state": "Massachusetts" }, { "city": "Philadelphia", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT05677659" }, { "nct_id": "NCT01962415", "title": "Reduced Intensity Conditioning for Non-Malignant Disorders Undergoing UCBT, BMT or PBSCT", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Primary Immunodeficiency (PID)", "Congenital Bone Marrow Failure Syndromes", "Inherited Metabolic Disorders (IMD)", "Hereditary Anemias", "Inflammatory Conditions", "Systemic Juvenile Idiopathic Arthritis (sJIA)", "Juvenile Rheumatoid Arthritis (JRA)" ], "interventions": [ { "name": "Hydroxyurea", "type": "DRUG" }, { "name": "Alemtuzumab", "type": "DRUG" }, { "name": "Fludarabine", "type": "DRUG" }, { "name": "Melphalan", "type": "DRUG" }, { "name": "Thiotepa", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Paul Szabolcs", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "2 Months", "maximum_age": "55 Years", "sex": "ALL", "summary": "2 Months to 55 Years" }, "enrollment_count": 100, "start_date": "2014-02-04", "completion_date": "2027-11", "has_results": false, "last_update_posted_date": "2025-12-15", "last_synced_at": "2026-07-22T02:25:56.392Z", "location_count": 1, "location_summary": "Pittsburgh, Pennsylvania", "locations": [ { "city": "Pittsburgh", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT01962415" }, { "nct_id": "NCT04503213", "title": "A Study to Assess CSF1R-related Leukoencephalopathy After Stem Cell Transplantation", "overall_status": "ENROLLING_BY_INVITATION", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "CSF1R-related Leukoencephalopathy", "ALSP", "POLD", "Hematopoietic Stem Cell Transplantation" ], "interventions": [], "intervention_types": [], "sponsor": "Mayo Clinic", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 20, "start_date": "2020-07-21", "completion_date": "2027-12", "has_results": false, "last_update_posted_date": "2026-01-08", "last_synced_at": "2026-07-22T02:25:56.392Z", "location_count": 1, "location_summary": "Jacksonville, Florida", "locations": [ { "city": "Jacksonville", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT04503213" }, { "nct_id": "NCT03428802", "title": "Pembrolizumab in Treating Participants With Metastatic, Recurrent or Locally Advanced Cancer and Genomic Instability", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "BRCA1 Gene Mutation", "BRCA2 Gene Mutation", "Locally Advanced Solid Neoplasm", "Metastatic Malignant Solid Neoplasm", "POLD1 Gene Mutation", "POLE Gene Mutation", "Recurrent Malignant Solid Neoplasm", "Recurrent Ovarian Carcinoma", "Stage III Breast Cancer AJCC v7", "Stage III Ovarian Cancer AJCC v8", "Stage IIIA Breast Cancer AJCC v7", "Stage IIIA Ovarian Cancer AJCC v8", "Stage IIIB Breast Cancer AJCC v7", "Stage IIIB Ovarian Cancer AJCC v8", "Stage IIIC Breast Cancer AJCC v7", "Stage IIIC Ovarian Cancer AJCC v8", "Stage IV Breast Cancer AJCC v6 and v7", "Stage IV Ovarian Cancer AJCC v8", "Stage IVA Ovarian Cancer AJCC v8", "Stage IVB Ovarian Cancer AJCC v8" ], "interventions": [ { "name": "Laboratory Biomarker Analysis", "type": "OTHER" }, { "name": "Pembrolizumab", "type": "BIOLOGICAL" } ], "intervention_types": [ "OTHER", "BIOLOGICAL" ], "sponsor": "Rutgers, The State University of New Jersey", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 21, "start_date": "2018-03-08", "completion_date": "2027-09-21", "has_results": true, "last_update_posted_date": "2026-04-03", "last_synced_at": "2026-07-22T02:25:56.392Z", "location_count": 2, "location_summary": "New Brunswick, New Jersey • New York, New York", "locations": [ { "city": "New Brunswick", "state": "New Jersey" }, { "city": "New York", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT03428802" }, { "nct_id": "NCT05420064", "title": "An Intervention to Increase Genetic Testing in Families Who May Share a Gene Mutation Related to Cancer Risk and An Intervention to Help Patients and Their Primary Care Providers Stay Up-to-date About Uncertain Genetic Test Results", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "BRCA1 Mutation", "POLD1 Gene Mutation", "CDKN2A Mutation", "BRCA2 Mutation", "POLE Gene Mutation", "APC Gene Mutation", "ATM Gene Mutation", "MLH1 Gene Mutation", "BARD1 Gene Mutation", "MSH2 Gene Mutation", "BRIP1 Gene Mutation", "MSH6 Gene Mutation", "CHEK2 Gene Mutation", "PMS2 Gene Mutation", "PALB2 Gene Mutation", "EPCAM Gene Mutation", "RAD51C Gene Mutation", "BMPR1A Gene Mutation", "RAD51D Gene Mutation", "SMAD4", "PTEN Gene Mutation", "GREM1" ], "interventions": [ { "name": "Intervention Arm At-risk Relative/ARR Contacts", "type": "BEHAVIORAL" }, { "name": "MyGene Portal", "type": "BEHAVIORAL" }, { "name": "Standard of Care", "type": "BEHAVIORAL" } ], "intervention_types": [ "BEHAVIORAL" ], "sponsor": "Memorial Sloan Kettering Cancer Center", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "25 Years", "maximum_age": null, "sex": "ALL", "summary": "25 Years and older" }, "enrollment_count": 1000, "start_date": "2022-12-01", "completion_date": "2026-11-30", "has_results": false, "last_update_posted_date": "2025-11-12", "last_synced_at": "2026-07-22T02:25:56.392Z", "location_count": 8, "location_summary": "Basking Ridge, New Jersey • Middletown, New Jersey • Montvale, New Jersey + 4 more", "locations": [ { "city": "Basking Ridge", "state": "New Jersey" }, { "city": "Middletown", "state": "New Jersey" }, { "city": "Montvale", "state": "New Jersey" }, { "city": "Commack", "state": "New York" }, { "city": "Harrison", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT05420064" } ] }