{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=POSTOPERATIVE+COGNITIVE+DECLINE&page=2",
    "query": {
      "condition": "POSTOPERATIVE COGNITIVE DECLINE",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=POSTOPERATIVE+COGNITIVE+DECLINE&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-05-22T07:47:35.965Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT05777187",
      "title": "Mitigation of Postoperative Delirium in High-Risk Patients",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Post-operative Delirium",
        "Decision Support Systems, Clinical",
        "Cognitive Impairment"
      ],
      "interventions": [
        {
          "name": "Clinical Decision Support",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Icahn School of Medicine at Mount Sinai",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "120 Years",
        "sex": "ALL",
        "summary": "18 Years to 120 Years"
      },
      "enrollment_count": 7412,
      "start_date": "2023-06-20",
      "completion_date": "2024-08-31",
      "has_results": true,
      "last_update_posted_date": "2026-02-19",
      "last_synced_at": "2026-05-22T07:47:35.965Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05777187"
    },
    {
      "nct_id": "NCT03068442",
      "title": "The Role of Large Artery Plaque Imaging Features in Predicting Inflammation and Cognition",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Cognitive Impairment",
        "Carotid Artery Plaque",
        "Inflammation"
      ],
      "interventions": [
        {
          "name": "Imaging with flutemetamol F 18 PET/CT",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Scott Mcnally",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 45,
      "start_date": "2017-02-17",
      "completion_date": "2030-09-10",
      "has_results": false,
      "last_update_posted_date": "2026-05-13",
      "last_synced_at": "2026-05-22T07:47:35.965Z",
      "location_count": 2,
      "location_summary": "Salt Lake City, Utah",
      "locations": [
        {
          "city": "Salt Lake City",
          "state": "Utah"
        },
        {
          "city": "Salt Lake City",
          "state": "Utah"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03068442"
    },
    {
      "nct_id": "NCT03802396",
      "title": "Modulating ApoE Signalling to Reduce Brain Inflammation, deLirium and postopErative Cognitive Dysfunction",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Postoperative Delirium",
        "Postoperative Cognitive Dysfunction"
      ],
      "interventions": [
        {
          "name": "CN-105",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Miles Berger, MD PhD",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "60 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "60 Years and older"
      },
      "enrollment_count": 203,
      "start_date": "2018-07-15",
      "completion_date": "2022-12-28",
      "has_results": true,
      "last_update_posted_date": "2024-10-16",
      "last_synced_at": "2026-05-22T07:47:35.965Z",
      "location_count": 1,
      "location_summary": "Durham, North Carolina",
      "locations": [
        {
          "city": "Durham",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03802396"
    },
    {
      "nct_id": "NCT01079468",
      "title": "Cognition in Postoperative Total Hip Arthroplasty and Total Hip Resurfacing Patients",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Cognition"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Rothman Institute Orthopaedics",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 100,
      "start_date": "2010-01",
      "completion_date": "2011-11",
      "has_results": false,
      "last_update_posted_date": "2011-11-08",
      "last_synced_at": "2026-05-22T07:47:35.965Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01079468"
    },
    {
      "nct_id": "NCT04246320",
      "title": "Taking Brain Monitoring to the Next Level",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Postoperative Cognitive Dysfunction",
        "Postoperative Delirium",
        "Obstructive Sleep Apnea"
      ],
      "interventions": [
        {
          "name": "Goal directed therapy (GDT)",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of California, Los Angeles",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "45 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "45 Years to 75 Years"
      },
      "enrollment_count": 7,
      "start_date": "2020-01-30",
      "completion_date": "2022-08-13",
      "has_results": false,
      "last_update_posted_date": "2023-01-19",
      "last_synced_at": "2026-05-22T07:47:35.965Z",
      "location_count": 1,
      "location_summary": "Los Angeles, California",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04246320"
    },
    {
      "nct_id": "NCT00561678",
      "title": "Perioperative Cognitive Function - Dexmedetomidine and Cognitive Reserve",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Postoperative Delirium",
        "PD",
        "Postoperative Cognitive Dysfunction",
        "POCD"
      ],
      "interventions": [
        {
          "name": "Precedex (Dexmedetomidine)",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Icahn School of Medicine at Mount Sinai",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "68 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "68 Years and older"
      },
      "enrollment_count": 404,
      "start_date": "2008-02",
      "completion_date": "2014-05",
      "has_results": true,
      "last_update_posted_date": "2018-04-23",
      "last_synced_at": "2026-05-22T07:47:35.965Z",
      "location_count": 10,
      "location_summary": "Miami, Florida • Baltimore, Maryland • College Park, Maryland + 7 more",
      "locations": [
        {
          "city": "Miami",
          "state": "Florida"
        },
        {
          "city": "Baltimore",
          "state": "Maryland"
        },
        {
          "city": "College Park",
          "state": "Maryland"
        },
        {
          "city": "Rochester",
          "state": "Minnesota"
        },
        {
          "city": "St Louis",
          "state": "Missouri"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00561678"
    },
    {
      "nct_id": "NCT00182884",
      "title": "Donepezil in Preventing Delirium in Hospitalized Elderly",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Postoperative Complications",
        "Delirium"
      ],
      "interventions": [
        {
          "name": "Donepezil",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Indiana University Health",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "65 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "65 Years and older"
      },
      "enrollment_count": 30,
      "start_date": "2004-07",
      "completion_date": "2007-04",
      "has_results": false,
      "last_update_posted_date": "2008-03-03",
      "last_synced_at": "2026-05-22T07:47:35.965Z",
      "location_count": 1,
      "location_summary": "Indianapolis, Indiana",
      "locations": [
        {
          "city": "Indianapolis",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00182884"
    },
    {
      "nct_id": "NCT02109081",
      "title": "Dexamethasone and Postoperative Delirium",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Delirium",
        "Postoperative Cognitive Dysfunction"
      ],
      "interventions": [
        {
          "name": "Dexamethasone",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Endeavor Health",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "70 Years",
        "maximum_age": "100 Years",
        "sex": "ALL",
        "summary": "70 Years to 100 Years"
      },
      "enrollment_count": 200,
      "start_date": "2014-04",
      "completion_date": "2021-02",
      "has_results": false,
      "last_update_posted_date": "2021-12-21",
      "last_synced_at": "2026-05-22T07:47:35.965Z",
      "location_count": 1,
      "location_summary": "Evanston, Illinois",
      "locations": [
        {
          "city": "Evanston",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02109081"
    },
    {
      "nct_id": "NCT02051452",
      "title": "Reversal of General Anesthesia With Methylphenidate",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Post Operative Cognitive Dysfunction",
        "Emergence From Anesthesia"
      ],
      "interventions": [
        {
          "name": "Methylphenidate",
          "type": "DRUG"
        },
        {
          "name": "Saline",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "Massachusetts General Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "18 Years to 75 Years"
      },
      "enrollment_count": 32,
      "start_date": "2014-11",
      "completion_date": "2018-05",
      "has_results": true,
      "last_update_posted_date": "2019-08-22",
      "last_synced_at": "2026-05-22T07:47:35.965Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02051452"
    },
    {
      "nct_id": "NCT02922634",
      "title": "Preoperative Cognitive Screening in Older Spinal Surgical Patients",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Cognitive Impairment",
        "Frail Elderly Syndrome"
      ],
      "interventions": [
        {
          "name": "Mini Cog",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Brigham and Women's Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "70 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "70 Years and older"
      },
      "enrollment_count": 229,
      "start_date": "2017-04-17",
      "completion_date": "2019-06-09",
      "has_results": true,
      "last_update_posted_date": "2021-07-21",
      "last_synced_at": "2026-05-22T07:47:35.965Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02922634"
    }
  ]
}