{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Parkinson+Disease%2C+Off+Episodes", "query": { "condition": "Parkinson Disease, Off Episodes" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 11, "total_pages": 2, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Parkinson+Disease%2C+Off+Episodes&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-07-24T09:31:39.390Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT00142545", "title": "Long Term Safety and Efficacy of SC Apomorphine in Treatment of \"Off\" Episodes in Late-Stage Parkinson's Disease", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Parkinson Disease" ], "interventions": [ { "name": "apomorphine HCl injection", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Mylan Bertek Pharmaceuticals", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 800, "start_date": "1999-07", "completion_date": "2005-07", "has_results": false, "last_update_posted_date": "2005-09-02", "last_synced_at": "2026-07-24T09:31:39.390Z", "location_count": 1, "location_summary": "Morgantown, West Virginia", "locations": [ { "city": "Morgantown", "state": "West Virginia" } ], "official_url": "https://clinicaltrials.gov/study/NCT00142545" }, { "nct_id": "NCT01777555", "title": "Efficacy and Safety Study of Inhaled CVT 301 in Parkinson's Disease Patients for Treatment of OFF Episodes", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Idiopathic Parkinson's Disease" ], "interventions": [ { "name": "CVT-301", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Acorda Therapeutics", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "30 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "30 Years to 80 Years" }, "enrollment_count": 89, "start_date": "2013-04", "completion_date": "2014-01", "has_results": false, "last_update_posted_date": "2018-08-08", "last_synced_at": "2026-07-24T09:31:39.390Z", "location_count": 13, "location_summary": "Little Rock, Arkansas • Boca Raton, Florida • Port Charlotte, Florida + 10 more", "locations": [ { "city": "Little Rock", "state": "Arkansas" }, { "city": "Boca Raton", "state": "Florida" }, { "city": "Port Charlotte", "state": "Florida" }, { "city": "Tampa", "state": "Florida" }, { "city": "Kansas City", "state": "Kansas" } ], "official_url": "https://clinicaltrials.gov/study/NCT01777555" }, { "nct_id": "NCT02242487", "title": "Twelve Month Safety and Efficacy Study of CVT-301 In Parkinson's Disease Patients With OFF Episodes", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Idiopathic Parkinson's Disease" ], "interventions": [ { "name": "CVT-301", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Acorda Therapeutics", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "30 Years", "maximum_age": "86 Years", "sex": "ALL", "summary": "30 Years to 86 Years" }, "enrollment_count": 325, "start_date": "2015-03", "completion_date": "2018-05", "has_results": true, "last_update_posted_date": "2019-08-14", "last_synced_at": "2026-07-24T09:31:39.390Z", "location_count": 55, "location_summary": "Scottsdale, Arizona • Fresno, California • Fullerton, California + 47 more", "locations": [ { "city": "Scottsdale", "state": "Arizona" }, { "city": "Fresno", "state": "California" }, { "city": "Fullerton", "state": "California" }, { "city": "Loma Linda", "state": "California" }, { "city": "Long Beach", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT02242487" }, { "nct_id": "NCT02469090", "title": "Efficacy, Safety and Tolerability Study of APL-130277 for the Acute Treatment of OFF Episodes in Patients With Parkinson's Disease", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Parkinson Disease, Off Episodes" ], "interventions": [ { "name": "APL-130277", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Sumitomo Pharma America, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 141, "start_date": "2015-06-18", "completion_date": "2017-12-11", "has_results": true, "last_update_posted_date": "2020-07-30", "last_synced_at": "2026-07-24T09:31:39.390Z", "location_count": 32, "location_summary": "Birmingham, Alabama • Phoenix, Arizona • Scottsdale, Arizona + 27 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Phoenix", "state": "Arizona" }, { "city": "Scottsdale", "state": "Arizona" }, { "city": "Scottsdale", "state": "Arizona" }, { "city": "Fountain Valley", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT02469090" }, { "nct_id": "NCT02352363", "title": "Randomized Safety Study of CVT-301 Compared to an Observational Control Group", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Idiopathic Parkinson's Disease" ], "interventions": [ { "name": "CVT-301", "type": "DRUG" }, { "name": "Observational cohort", "type": "OTHER" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "Acorda Therapeutics", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "30 Years", "maximum_age": "85 Years", "sex": "ALL", "summary": "30 Years to 85 Years" }, "enrollment_count": 408, "start_date": "2015-03", "completion_date": "2017-05", "has_results": true, "last_update_posted_date": "2019-05-28", "last_synced_at": "2026-07-24T09:31:39.390Z", "location_count": 14, "location_summary": "Scottsdale, Arizona • Fountain Valley, California • Panorama City, California + 10 more", "locations": [ { "city": "Scottsdale", "state": "Arizona" }, { "city": "Fountain Valley", "state": "California" }, { "city": "Panorama City", "state": "California" }, { "city": "Sunnyvale", "state": "California" }, { "city": "Ormond Beach", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT02352363" }, { "nct_id": "NCT05979415", "title": "Study to Evaluate the Efficacy and Safety of Staccato Apomorphine (AZ-009) in Patients With Parkinson's Disease Experiencing OFF Episodes", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Parkinson Disease" ], "interventions": [ { "name": "Apomorphine Cartridge", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Alexza Pharmaceuticals, Inc.", "sponsor_class": "UNKNOWN", "healthy_volunteers": false, "eligibility": { "minimum_age": "30 Years", "maximum_age": "85 Years", "sex": "ALL", "summary": "30 Years to 85 Years" }, "enrollment_count": 8, "start_date": "2023-09-27", "completion_date": "2024-02-28", "has_results": false, "last_update_posted_date": "2025-10-21", "last_synced_at": "2026-07-24T09:31:39.390Z", "location_count": 13, "location_summary": "Scottsdale, Arizona • Tucson, Arizona • Fountain Valley, California + 10 more", "locations": [ { "city": "Scottsdale", "state": "Arizona" }, { "city": "Tucson", "state": "Arizona" }, { "city": "Fountain Valley", "state": "California" }, { "city": "Englewood", "state": "Colorado" }, { "city": "Bradenton", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT05979415" }, { "nct_id": "NCT03187301", "title": "A Cardiac Safety Study of an Investigational Drug to See How if Affects the Heart in People With Parkinson's Disease Complicated by Motor Fluctuations \"OFF\" Episodes", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Parkinson's Disease", "Off Episodes of Parkinson Disease" ], "interventions": [ { "name": "APL-130277", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" }, { "name": "Moxifloxacin", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Sumitomo Pharma America, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 48, "start_date": "2017-08-03", "completion_date": "2017-12-21", "has_results": true, "last_update_posted_date": "2020-08-10", "last_synced_at": "2026-07-24T09:31:39.390Z", "location_count": 10, "location_summary": "Scottsdale, Arizona • Little Rock, Arkansas • Fountain Valley, California + 7 more", "locations": [ { "city": "Scottsdale", "state": "Arizona" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "Fountain Valley", "state": "California" }, { "city": "Boca Raton", "state": "Florida" }, { "city": "Hallandale", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT03187301" }, { "nct_id": "NCT02240030", "title": "Efficacy and Safety Study of CVT-301 In Parkinson's Disease Patients With OFF Episodes", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Idiopathic Parkinson's Disease" ], "interventions": [ { "name": "CVT-301 Low Dose", "type": "DRUG" }, { "name": "CVT-301 High Dose", "type": "DRUG" }, { "name": "Placebo", "type": "OTHER" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "Acorda Therapeutics", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "30 Years", "maximum_age": "85 Years", "sex": "ALL", "summary": "30 Years to 85 Years" }, "enrollment_count": 351, "start_date": "2014-11", "completion_date": "2016-12", "has_results": true, "last_update_posted_date": "2019-05-28", "last_synced_at": "2026-07-24T09:31:39.390Z", "location_count": 55, "location_summary": "Scottsdale, Arizona • Fresno, California • Fullerton, California + 47 more", "locations": [ { "city": "Scottsdale", "state": "Arizona" }, { "city": "Fresno", "state": "California" }, { "city": "Fullerton", "state": "California" }, { "city": "Loma Linda", "state": "California" }, { "city": "Long Beach", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT02240030" }, { "nct_id": "NCT03292016", "title": "A Study That Compares the Extent to Which Apomorphine Becomes Available in the Body After Taking Either an Investigational Drug Containing Apomorphine or Apomorphine That is Injected Under the Skin in People With PD Complicated by \"OFF\" Episodes", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Parkinson Disease" ], "interventions": [ { "name": "APL-130277", "type": "DRUG" }, { "name": "APO-go", "type": "DRUG" }, { "name": "Apokyn", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Sumitomo Pharma America, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 8, "start_date": "2017-08-22", "completion_date": "2019-03-05", "has_results": true, "last_update_posted_date": "2020-08-13", "last_synced_at": "2026-07-24T09:31:39.390Z", "location_count": 3, "location_summary": "Boca Raton, Florida • Port Charlotte, Florida • Farmington Hills, Michigan", "locations": [ { "city": "Boca Raton", "state": "Florida" }, { "city": "Port Charlotte", "state": "Florida" }, { "city": "Farmington Hills", "state": "Michigan" } ], "official_url": "https://clinicaltrials.gov/study/NCT03292016" }, { "nct_id": "NCT02542696", "title": "Open-Label Phase 3 Study to Examine the Long-Term Safety, Tolerability and Efficacy of APL-130277 for the Acute Treatment of \"OFF\" Episodes in Patients With Parkinson's Disease", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Parkinson Disease" ], "interventions": [ { "name": "APL-130277", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Sumitomo Pharma America, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 496, "start_date": "2015-08-31", "completion_date": "2022-11-08", "has_results": true, "last_update_posted_date": "2023-11-22", "last_synced_at": "2026-07-24T09:31:39.390Z", "location_count": 48, "location_summary": "Birmingham, Alabama • Phoenix, Arizona • Scottsdale, Arizona + 42 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Phoenix", "state": "Arizona" }, { "city": "Scottsdale", "state": "Arizona" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "Fountain Valley", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT02542696" } ] }