{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Pathophysiology&page=35",
    "query": {
      "condition": "Pathophysiology",
      "page": 35
    },
    "page_size": 10
  },
  "pagination": {
    "page": 35,
    "page_size": 10,
    "total_count": 3978,
    "total_pages": 398,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Pathophysiology&page=36&page_size=10",
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Pathophysiology&page=34&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-11-08T17:41:41.688Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT05366023",
      "title": "Elucidating the Necessary Active Components of Training",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Alzheimer Disease",
        "Cognitive Change",
        "Cognitive Impairment"
      ],
      "interventions": [
        {
          "name": "BUD1",
          "type": "BEHAVIORAL"
        },
        {
          "name": "BUD2",
          "type": "BEHAVIORAL"
        },
        {
          "name": "TDD1",
          "type": "BEHAVIORAL"
        },
        {
          "name": "TDD2",
          "type": "BEHAVIORAL"
        },
        {
          "name": "CSA10",
          "type": "BEHAVIORAL"
        },
        {
          "name": "CSA20",
          "type": "BEHAVIORAL"
        },
        {
          "name": "CSA30",
          "type": "BEHAVIORAL"
        },
        {
          "name": "CSA40",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Clemson University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "55 Years",
        "maximum_age": "85 Years",
        "sex": "ALL",
        "summary": "55 Years to 85 Years"
      },
      "enrollment_count": 280,
      "start_date": "2022-02-21",
      "completion_date": "2024-02",
      "has_results": false,
      "last_update_posted_date": "2022-05-09",
      "last_synced_at": "2026-11-08T17:41:41.688Z",
      "location_count": 1,
      "location_summary": "Seneca, South Carolina",
      "locations": [
        {
          "city": "Seneca",
          "state": "South Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05366023"
    },
    {
      "nct_id": "NCT05690503",
      "title": "Glutamatergic Modulation as a Treatment for Depressive Symptoms Among Patients With Post-acute Sequelae of COVID (PASC): A Pilot Trial",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Post-acute Sequelae of COVID-19",
        "Depressive Symptoms",
        "Cognitive Dysfunction"
      ],
      "interventions": [
        {
          "name": "CI-581a",
          "type": "DRUG"
        },
        {
          "name": "CI-581b",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "New York State Psychiatric Institute",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 12,
      "start_date": "2023-03-20",
      "completion_date": "2025-12-31",
      "has_results": false,
      "last_update_posted_date": "2024-07-16",
      "last_synced_at": "2026-11-08T17:41:41.688Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05690503"
    },
    {
      "nct_id": "NCT02957227",
      "title": "Diagnosis of Alzheimer's Disease Using Event Related Potentials",
      "overall_status": "UNKNOWN",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Mild Cognitive Impairment"
      ],
      "interventions": [
        {
          "name": "No intervention is part of this study but patients use an EEG device during observational data collection.",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "VA Boston Healthcare System",
      "sponsor_class": "FED",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "50 Years",
        "maximum_age": "100 Years",
        "sex": "ALL",
        "summary": "50 Years to 100 Years"
      },
      "enrollment_count": 170,
      "start_date": "2016-07",
      "completion_date": "2023-07",
      "has_results": false,
      "last_update_posted_date": "2022-09-10",
      "last_synced_at": "2026-11-08T17:41:41.688Z",
      "location_count": 1,
      "location_summary": "Jamaica Plain, Massachusetts",
      "locations": [
        {
          "city": "Jamaica Plain",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02957227"
    },
    {
      "nct_id": "NCT01843283",
      "title": "Meaningful Activity Intervention for Persons With Mild Cognitive Impairment",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Mild Cognitive Impairment"
      ],
      "interventions": [
        {
          "name": "Daily Enhancement Meaningful Activity (DEMA)",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Information Support (IS)",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Indiana University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "95 Years",
        "sex": "ALL",
        "summary": "21 Years to 95 Years"
      },
      "enrollment_count": 80,
      "start_date": "2012-07",
      "completion_date": "2016-05",
      "has_results": false,
      "last_update_posted_date": "2016-10-25",
      "last_synced_at": "2026-11-08T17:41:41.688Z",
      "location_count": 1,
      "location_summary": "Indianapolis, Indiana",
      "locations": [
        {
          "city": "Indianapolis",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01843283"
    },
    {
      "nct_id": "NCT05150990",
      "title": "Technology and Family Thriving Study",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Alzheimer Disease",
        "Dementia",
        "Caregiver Burnout",
        "Quality of Life",
        "Mental Health Wellness 1",
        "Loneliness",
        "Family Relationship"
      ],
      "interventions": [
        {
          "name": "Virtual Reality",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Video Chat",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "University of California, Santa Barbara",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 186,
      "start_date": "2021-10-02",
      "completion_date": "2024-03-16",
      "has_results": true,
      "last_update_posted_date": "2026-07-29",
      "last_synced_at": "2026-11-08T17:41:41.688Z",
      "location_count": 27,
      "location_summary": "Calabasas, California • Camarillo, California • Goleta, California + 16 more",
      "locations": [
        {
          "city": "Calabasas",
          "state": "California"
        },
        {
          "city": "Camarillo",
          "state": "California"
        },
        {
          "city": "Goleta",
          "state": "California"
        },
        {
          "city": "Montecito",
          "state": "California"
        },
        {
          "city": "Ojai",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05150990"
    },
    {
      "nct_id": "NCT03748082",
      "title": "Effects of Nitric Oxide on the Endothelium During Hemolysis.",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Endothelial Dysfunction",
        "Hemolysis Intravascular",
        "Cardiovascular Diseases",
        "Cardiovascular Risk Factor"
      ],
      "interventions": [
        {
          "name": "Nitric Oxide",
          "type": "DRUG"
        },
        {
          "name": "Reactive Hyperemia Index",
          "type": "DIAGNOSTIC_TEST"
        },
        {
          "name": "Endothelial Cells Collection",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "DRUG",
        "DIAGNOSTIC_TEST",
        "PROCEDURE"
      ],
      "sponsor": "Massachusetts General Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 0,
      "start_date": "2018-12-05",
      "completion_date": "2023-11",
      "has_results": false,
      "last_update_posted_date": "2025-12-02",
      "last_synced_at": "2026-11-08T17:41:41.688Z",
      "location_count": 2,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03748082"
    },
    {
      "nct_id": "NCT01636596",
      "title": "Efficacy of Pulsatile IV Insulin on Cognition and Amyloid Burden in Patients With Alzheimer's Disease",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Alzheimer's Disease",
        "Mild Cognitive Impairment"
      ],
      "interventions": [
        {
          "name": "Insulin LISPRO",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Louisiana State University Health Sciences Center Shreveport",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "50 Years",
        "maximum_age": "95 Years",
        "sex": "ALL",
        "summary": "50 Years to 95 Years"
      },
      "enrollment_count": 0,
      "start_date": "2013-09",
      "completion_date": "2015-01",
      "has_results": false,
      "last_update_posted_date": "2014-03-13",
      "last_synced_at": "2026-11-08T17:41:41.688Z",
      "location_count": 1,
      "location_summary": "Shreveport, Louisiana",
      "locations": [
        {
          "city": "Shreveport",
          "state": "Louisiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01636596"
    },
    {
      "nct_id": "NCT06020703",
      "title": "A Study of Healthy Microbiome, Healthy Mind",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Critical Illness",
        "COVID-19",
        "PICS",
        "Cognitive Impairment",
        "Mental Health Impairment",
        "Weakness, Muscle",
        "Dysbiosis"
      ],
      "interventions": [
        {
          "name": "Fermented Food Diet",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Mayo Clinic",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 40,
      "start_date": "2024-02-26",
      "completion_date": "2026-12",
      "has_results": false,
      "last_update_posted_date": "2026-06-03",
      "last_synced_at": "2026-11-08T17:41:41.688Z",
      "location_count": 1,
      "location_summary": "Rochester, Minnesota",
      "locations": [
        {
          "city": "Rochester",
          "state": "Minnesota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06020703"
    },
    {
      "nct_id": "NCT02256969",
      "title": "Intraductal Meibomian Gland Probing Trial",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Meibomian Gland Dysfunction"
      ],
      "interventions": [
        {
          "name": "Blephamide",
          "type": "DRUG"
        },
        {
          "name": "GenTeal PM Night-Time",
          "type": "DRUG"
        },
        {
          "name": "Meibomian Gland Probing",
          "type": "PROCEDURE"
        },
        {
          "name": "Sham Meibomian Gland Probing",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "DRUG",
        "PROCEDURE"
      ],
      "sponsor": "Joseph B. Ciolino, MD",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "89 Years",
        "sex": "ALL",
        "summary": "18 Years to 89 Years"
      },
      "enrollment_count": 45,
      "start_date": "2014-10",
      "completion_date": "2015-08",
      "has_results": true,
      "last_update_posted_date": "2017-06-19",
      "last_synced_at": "2026-11-08T17:41:41.688Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02256969"
    },
    {
      "nct_id": "NCT05531591",
      "title": "RCT of Brain Longitudinal Biomarker Study (OPT-Neuro RCT)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Depression",
        "Dementia",
        "Mild Cognitive Impairment",
        "Treatment Resistant Depression",
        "Major Depressive Disorder",
        "Treatment-Refractory Depression",
        "Late Life Depression",
        "Geriatric Depression"
      ],
      "interventions": [
        {
          "name": "Aripiprazole Augmentation",
          "type": "DRUG"
        },
        {
          "name": "Bupropion Augmentation",
          "type": "DRUG"
        },
        {
          "name": "Switch to bupropion",
          "type": "DRUG"
        },
        {
          "name": "Lithium Augmentation",
          "type": "DRUG"
        },
        {
          "name": "Switch to nortriptyline",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Centre for Addiction and Mental Health",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "60 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "60 Years and older"
      },
      "enrollment_count": 87,
      "start_date": "2019-08-01",
      "completion_date": "2024-07-31",
      "has_results": false,
      "last_update_posted_date": "2024-11-25",
      "last_synced_at": "2026-11-08T17:41:41.688Z",
      "location_count": 3,
      "location_summary": "Los Angeles, California • St Louis, Missouri • New York, New York",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "St Louis",
          "state": "Missouri"
        },
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05531591"
    }
  ]
}