{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Periodontal+Diseases&page=2",
    "query": {
      "condition": "Periodontal Diseases",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Periodontal+Diseases&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-06-11T04:08:52.278Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT04681885",
      "title": "Evaluation of Toothbrush Bristles in Plaque Reduction",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Plaque, Dental",
        "Gingivitis"
      ],
      "interventions": [
        {
          "name": "Tapered bristles A",
          "type": "DEVICE"
        },
        {
          "name": "Tapered bristles B",
          "type": "DEVICE"
        },
        {
          "name": "End rounded bristles",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Sunstar Americas",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "18 Years to 70 Years"
      },
      "enrollment_count": 10,
      "start_date": "2021-06-30",
      "completion_date": "2021-09-17",
      "has_results": true,
      "last_update_posted_date": "2024-10-15",
      "last_synced_at": "2026-06-11T04:08:52.278Z",
      "location_count": 1,
      "location_summary": "Memphis, Tennessee",
      "locations": [
        {
          "city": "Memphis",
          "state": "Tennessee"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04681885"
    },
    {
      "nct_id": "NCT03003689",
      "title": "Effects of Scaling and Root Planing With and Without Er:YAG Laser in Chronic Periodontitis Patients",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Chronic Periodontitis"
      ],
      "interventions": [
        {
          "name": "Scaling and Root Planing",
          "type": "PROCEDURE"
        },
        {
          "name": "Er:YAG Laser",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "PROCEDURE",
        "DEVICE"
      ],
      "sponsor": "Tufts University School of Dental Medicine",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 56,
      "start_date": "2017-04-20",
      "completion_date": "2018-03",
      "has_results": false,
      "last_update_posted_date": "2018-01-11",
      "last_synced_at": "2026-06-11T04:08:52.278Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03003689"
    },
    {
      "nct_id": "NCT00881959",
      "title": "Study of Root Coverage With Acellular Dermal Matrix: Puros® Dermis Versus Alloderm®",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Gingival Recession"
      ],
      "interventions": [
        {
          "name": "Puros® Dermis versus Alloderm®",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Zimmer Biomet",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 80,
      "start_date": "2009-08",
      "completion_date": "2012-06",
      "has_results": true,
      "last_update_posted_date": "2015-05-27",
      "last_synced_at": "2026-06-11T04:08:52.278Z",
      "location_count": 4,
      "location_summary": "Birmingham, Alabama • Ann Arbor, Michigan • Newark, New Jersey + 1 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Ann Arbor",
          "state": "Michigan"
        },
        {
          "city": "Newark",
          "state": "New Jersey"
        },
        {
          "city": "Rochester",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00881959"
    },
    {
      "nct_id": "NCT02710903",
      "title": "IL29 and IL28B Variants Associated With Periodontal Disease Pathogenesis",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Periodontitis"
      ],
      "interventions": [
        {
          "name": "Stent-induced biofilm overgrowth",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "University of North Carolina, Chapel Hill",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "25 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "25 Years and older"
      },
      "enrollment_count": 79,
      "start_date": "2016-05",
      "completion_date": "2018-03-28",
      "has_results": false,
      "last_update_posted_date": "2019-09-26",
      "last_synced_at": "2026-06-11T04:08:52.278Z",
      "location_count": 1,
      "location_summary": "Chapel Hill, North Carolina",
      "locations": [
        {
          "city": "Chapel Hill",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02710903"
    },
    {
      "nct_id": "NCT00066131",
      "title": "Obstetrics and Periodontal Therapy (OPT) Study",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Periodontitis",
        "Infant, Premature"
      ],
      "interventions": [
        {
          "name": "Periodontal scaling and root planing",
          "type": "PROCEDURE"
        },
        {
          "name": "Scaling and root planing",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "University of Minnesota",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "16 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "16 Years and older · Female only"
      },
      "enrollment_count": 823,
      "start_date": "2003-03",
      "completion_date": "2006-02",
      "has_results": false,
      "last_update_posted_date": "2015-07-27",
      "last_synced_at": "2026-06-11T04:08:52.278Z",
      "location_count": 1,
      "location_summary": "Minneapolis, Minnesota",
      "locations": [
        {
          "city": "Minneapolis",
          "state": "Minnesota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00066131"
    },
    {
      "nct_id": "NCT03700788",
      "title": "2% Chlorhexidine (CHX) vs CaOH2 (CH) Calcium Hydroxide Paste as an Intracanal Medicament",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Apical Periodontitis"
      ],
      "interventions": [
        {
          "name": "Chlorhexidine",
          "type": "DRUG"
        },
        {
          "name": "Calcium Hydroxide",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Southern California",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 40,
      "start_date": "2023-05-30",
      "completion_date": "2025-08-31",
      "has_results": false,
      "last_update_posted_date": "2023-03-08",
      "last_synced_at": "2026-06-11T04:08:52.278Z",
      "location_count": 1,
      "location_summary": "Los Angeles, California",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03700788"
    },
    {
      "nct_id": "NCT03641989",
      "title": "Correlation Between Oral Health and Systemic Inflammation (COHESION)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Inflammation",
        "Periodontal Disease",
        "Gingivitis"
      ],
      "interventions": [
        {
          "name": "Plaque disclosing toothpaste",
          "type": "OTHER"
        },
        {
          "name": "Non-plaque disclosing toothpaste",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Marshfield Clinic Research Foundation",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "84 Years",
        "sex": "ALL",
        "summary": "21 Years to 84 Years"
      },
      "enrollment_count": 112,
      "start_date": "2018-09-17",
      "completion_date": "2019-12-30",
      "has_results": false,
      "last_update_posted_date": "2020-02-20",
      "last_synced_at": "2026-06-11T04:08:52.278Z",
      "location_count": 1,
      "location_summary": "Marshfield, Wisconsin",
      "locations": [
        {
          "city": "Marshfield",
          "state": "Wisconsin"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03641989"
    },
    {
      "nct_id": "NCT05721781",
      "title": "Reducing Risk for Infective Endocarditis",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Bacteremia",
        "Infective Endocarditis"
      ],
      "interventions": [
        {
          "name": "Oral Hygiene instruction",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Dental Cleaning",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL",
        "PROCEDURE"
      ],
      "sponsor": "Wake Forest University Health Sciences",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 320,
      "start_date": "2023-08-31",
      "completion_date": "2027-09",
      "has_results": false,
      "last_update_posted_date": "2025-08-22",
      "last_synced_at": "2026-06-11T04:08:52.278Z",
      "location_count": 6,
      "location_summary": "Boston, Massachusetts • Ann Arbor, Michigan • Newark, New Jersey + 3 more",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "Ann Arbor",
          "state": "Michigan"
        },
        {
          "city": "Newark",
          "state": "New Jersey"
        },
        {
          "city": "New York",
          "state": "New York"
        },
        {
          "city": "Rochester",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05721781"
    },
    {
      "nct_id": "NCT05419102",
      "title": "Retrospective Study of Implants With Peri-implantitis Surgically Treated Using Enamel Matrix Derivative (EMD)",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Determination of Beneficial Effect of Using Enamel Matrix Derivative During Implant Treatment"
      ],
      "interventions": [
        {
          "name": "peri-implantitis surgery with enamel matrix derivative",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "North Dallas Dental Health",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "90 Years",
        "sex": "ALL",
        "summary": "18 Years to 90 Years"
      },
      "enrollment_count": 34,
      "start_date": "2022-04-01",
      "completion_date": "2022-06-06",
      "has_results": false,
      "last_update_posted_date": "2022-06-15",
      "last_synced_at": "2026-06-11T04:08:52.278Z",
      "location_count": 1,
      "location_summary": "Dallas, Texas",
      "locations": [
        {
          "city": "Dallas",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05419102"
    },
    {
      "nct_id": "NCT03161301",
      "title": "Role of IL-37 Genetic Variants in Modulating Innate Immune Response to Periodontal Pathogens",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Periodontal Diseases"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "University of North Carolina, Chapel Hill",
      "sponsor_class": "OTHER",
      "healthy_volunteers": null,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 86,
      "start_date": "2015-05-07",
      "completion_date": "2019-05-24",
      "has_results": false,
      "last_update_posted_date": "2019-09-25",
      "last_synced_at": "2026-06-11T04:08:52.278Z",
      "location_count": 1,
      "location_summary": "Chapel Hill, North Carolina",
      "locations": [
        {
          "city": "Chapel Hill",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03161301"
    }
  ]
}