{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Periorbital+Wrinkles",
    "query": {
      "condition": "Periorbital Wrinkles"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 13,
    "total_pages": 2,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Periorbital+Wrinkles&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-07-23T11:22:36.118Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT07028203",
      "title": "Non-invasive Rejuvenation of the Periorbital Area and Lower Eyelid",
      "overall_status": "ENROLLING_BY_INVITATION",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Periorbital Wrinkles",
        "Periorbital Area",
        "Under-eyes Dark Circles",
        "Crows Feet"
      ],
      "interventions": [
        {
          "name": "Treatment with BTL-785 with the applicator BTL-785-7-11",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "BTL Industries Ltd.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 30,
      "start_date": "2024-11-05",
      "completion_date": "2025-12-31",
      "has_results": false,
      "last_update_posted_date": "2025-06-19",
      "last_synced_at": "2026-07-23T11:22:36.118Z",
      "location_count": 3,
      "location_summary": "Sacramento, California • Solana Beach, California • Youngstown, Ohio",
      "locations": [
        {
          "city": "Sacramento",
          "state": "California"
        },
        {
          "city": "Solana Beach",
          "state": "California"
        },
        {
          "city": "Youngstown",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07028203"
    },
    {
      "nct_id": "NCT00747422",
      "title": "Evaluation of the Effectiveness and Safety of the Ulthera™ System for the Treatment of Wrinkles Around the Eyes",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Periorbital Wrinkles"
      ],
      "interventions": [
        {
          "name": "Ulthera™ System",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Ulthera, Inc",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "40 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "40 Years to 70 Years"
      },
      "enrollment_count": 100,
      "start_date": "2008-07",
      "completion_date": "2009-05",
      "has_results": false,
      "last_update_posted_date": "2017-11-24",
      "last_synced_at": "2026-07-23T11:22:36.118Z",
      "location_count": 4,
      "location_summary": "San Diego, California • Chicago, Illinois • Chestnut Hill, Massachusetts + 1 more",
      "locations": [
        {
          "city": "San Diego",
          "state": "California"
        },
        {
          "city": "Chicago",
          "state": "Illinois"
        },
        {
          "city": "Chestnut Hill",
          "state": "Massachusetts"
        },
        {
          "city": "Edina",
          "state": "Minnesota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00747422"
    },
    {
      "nct_id": "NCT01354743",
      "title": "Upper Facial Remodeling With Perlane-L and Dysport",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Mild to Moderate Temporal Atrophy",
        "Moderate to Severe Glabellar Rhytids",
        "Moderate to Severe Periorbital Rhytids"
      ],
      "interventions": [
        {
          "name": "Dysport",
          "type": "DRUG"
        },
        {
          "name": "Perlane L",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DRUG",
        "DEVICE"
      ],
      "sponsor": "Beer, Kenneth R., M.D., PA",
      "sponsor_class": "INDIV",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "40 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "40 Years to 75 Years"
      },
      "enrollment_count": 20,
      "start_date": "2010-12",
      "completion_date": "2012-05",
      "has_results": false,
      "last_update_posted_date": "2013-09-26",
      "last_synced_at": "2026-07-23T11:22:36.118Z",
      "location_count": 1,
      "location_summary": "West Palm Beach, Florida",
      "locations": [
        {
          "city": "West Palm Beach",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01354743"
    },
    {
      "nct_id": "NCT01368900",
      "title": "Reducing Wrinkles Around the Eyes Using the Ulthera® System",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Periorbital Wrinkles"
      ],
      "interventions": [
        {
          "name": "Ulthera® System treatment",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Ulthera, Inc",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "30 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "30 Years to 65 Years"
      },
      "enrollment_count": 68,
      "start_date": "2011-03",
      "completion_date": "2012-01",
      "has_results": true,
      "last_update_posted_date": "2017-12-13",
      "last_synced_at": "2026-07-23T11:22:36.118Z",
      "location_count": 2,
      "location_summary": "Hunt Valley, Maryland • Nashville, Tennessee",
      "locations": [
        {
          "city": "Hunt Valley",
          "state": "Maryland"
        },
        {
          "city": "Nashville",
          "state": "Tennessee"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01368900"
    },
    {
      "nct_id": "NCT01529983",
      "title": "Fractional Laser vs. Ultrasound for Periorbital Wrinkles",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "EARLY_PHASE1"
      ],
      "conditions": [
        "Wrinkles"
      ],
      "interventions": [
        {
          "name": "Laser treatment",
          "type": "PROCEDURE"
        },
        {
          "name": "High-intensity focused ultrasound",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "PROCEDURE",
        "DEVICE"
      ],
      "sponsor": "Northwestern University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "35 Years",
        "maximum_age": "60 Years",
        "sex": "ALL",
        "summary": "35 Years to 60 Years"
      },
      "enrollment_count": 20,
      "start_date": "2012-02",
      "completion_date": "2024-05-30",
      "has_results": false,
      "last_update_posted_date": "2026-07-01",
      "last_synced_at": "2026-07-23T11:22:36.118Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01529983"
    },
    {
      "nct_id": "NCT04639713",
      "title": "Clinical Study Evaluating the Safety and Effectiveness of The Tixel Fractional System in The Treatment of Periorbital Wrinkles",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Wrinkle",
        "Periorbital",
        "Tixel 2",
        "Fractional",
        "Resurfacing"
      ],
      "interventions": [
        {
          "name": "Tixel 2",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Novoxel Ltd.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "35 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "35 Years to 70 Years"
      },
      "enrollment_count": 51,
      "start_date": "2021-03-02",
      "completion_date": "2022-04-04",
      "has_results": true,
      "last_update_posted_date": "2024-03-19",
      "last_synced_at": "2026-07-23T11:22:36.118Z",
      "location_count": 2,
      "location_summary": "Chicago, Illinois • New York, New York",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        },
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04639713"
    },
    {
      "nct_id": "NCT01813760",
      "title": "Treatment of Periorbital and Perioral Wrinkles With the Applications of the Iluminage Diode Laser",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Peri-orbital Wrinkles",
        "Peri-oral Wrinkles"
      ],
      "interventions": [
        {
          "name": "Illuiminage ® Diode Laser",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Cynosure, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "35 Years",
        "maximum_age": "60 Years",
        "sex": "FEMALE",
        "summary": "35 Years to 60 Years · Female only"
      },
      "enrollment_count": 60,
      "start_date": "2012-11",
      "completion_date": "2013-08",
      "has_results": false,
      "last_update_posted_date": "2014-03-26",
      "last_synced_at": "2026-07-23T11:22:36.118Z",
      "location_count": 1,
      "location_summary": "Westford, Massachusetts",
      "locations": [
        {
          "city": "Westford",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01813760"
    },
    {
      "nct_id": "NCT05089851",
      "title": "Investigation of the Efficacy and Tolerability of a Cosmetic Product With Onabotulinumtoxin A in the Treatment of Facial Lines",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Wrinkles",
        "Photoaging",
        "Fine Lines"
      ],
      "interventions": [
        {
          "name": "Onabotulinumtoxin A",
          "type": "PROCEDURE"
        },
        {
          "name": "Facial Cleanser",
          "type": "COMBINATION_PRODUCT"
        },
        {
          "name": "Facial Moisturizer",
          "type": "COMBINATION_PRODUCT"
        },
        {
          "name": "Sunscreen",
          "type": "COMBINATION_PRODUCT"
        }
      ],
      "intervention_types": [
        "PROCEDURE",
        "COMBINATION_PRODUCT"
      ],
      "sponsor": "Revision Skincare",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "35 Years",
        "maximum_age": "60 Years",
        "sex": "FEMALE",
        "summary": "35 Years to 60 Years · Female only"
      },
      "enrollment_count": 29,
      "start_date": "2020-08-23",
      "completion_date": "2021-06-03",
      "has_results": false,
      "last_update_posted_date": "2021-10-28",
      "last_synced_at": "2026-07-23T11:22:36.118Z",
      "location_count": 3,
      "location_summary": "Fort Lauderdale, Florida • Coralville, Iowa • Columbus, Ohio",
      "locations": [
        {
          "city": "Fort Lauderdale",
          "state": "Florida"
        },
        {
          "city": "Coralville",
          "state": "Iowa"
        },
        {
          "city": "Columbus",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05089851"
    },
    {
      "nct_id": "NCT05282979",
      "title": "A Prospective, Single Center, Single-Arm Clinical Study of 20 Participants to Reduce the Appearance of the Peri-orbital Wrinkles. Participants Will Receive up to Four Treatments With Tixel Every 4 Weeks. Follow-up Will Occur 1 Month and 3 Months Following Last Treatment.",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Wrinkle"
      ],
      "interventions": [
        {
          "name": "Tixel 2",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Physicians Laser and Dermatology Institute",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "35 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "35 Years to 75 Years"
      },
      "enrollment_count": 20,
      "start_date": "2021-08-20",
      "completion_date": "2022-08-20",
      "has_results": false,
      "last_update_posted_date": "2022-03-16",
      "last_synced_at": "2026-07-23T11:22:36.118Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05282979"
    },
    {
      "nct_id": "NCT05082766",
      "title": "Improvement in the Appearance of Periorbital Wrinkles",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Periorbital Wrinkles"
      ],
      "interventions": [
        {
          "name": "enhanced DefenAge 8-in-1 BioSerum",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Goldman, Butterwick, Fitzpatrick and Groff",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "31 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "31 Years and older"
      },
      "enrollment_count": 20,
      "start_date": "2021-10-11",
      "completion_date": "2022-12-01",
      "has_results": false,
      "last_update_posted_date": "2021-10-28",
      "last_synced_at": "2026-07-23T11:22:36.118Z",
      "location_count": 1,
      "location_summary": "San Diego, California",
      "locations": [
        {
          "city": "San Diego",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05082766"
    }
  ]
}