{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Periventricular+Leukomalacia", "query": { "condition": "Periventricular Leukomalacia" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 20, "total_pages": 2, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Periventricular+Leukomalacia&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-05-22T03:39:11.244Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT00515281", "title": "Inhaled Nitric Oxide and Neuroprotection in Premature Infants", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2", "PHASE3" ], "conditions": [ "Prematurity", "Bronchopulmonary Dysplasia", "Intraventricular Hemorrhage", "Periventricular Leukomalacia" ], "interventions": [ { "name": "inhaled nitric oxide", "type": "DRUG" }, { "name": "oxygen", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of Chicago", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "2 Hours", "maximum_age": "72 Hours", "sex": "ALL", "summary": "2 Hours to 72 Hours" }, "enrollment_count": 273, "start_date": "2008-05", "completion_date": "2023-11-28", "has_results": true, "last_update_posted_date": "2024-10-17", "last_synced_at": "2026-05-22T03:39:11.244Z", "location_count": 1, "location_summary": "Chicago, Illinois", "locations": [ { "city": "Chicago", "state": "Illinois" } ], "official_url": "https://clinicaltrials.gov/study/NCT00515281" }, { "nct_id": "NCT02133573", "title": "Randomized Trial of Maternal Progesterone Therapy", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Congenital Heart Disease", "Periventricular Leucomalacia", "Brain Development", "Cardiac Surgery", "Neurodevelopmental Disability", "Fetal Neuroprotection" ], "interventions": [ { "name": "Progesterone", "type": "DRUG" }, { "name": "Vaginal lubricant", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Children's Hospital of Philadelphia", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": null, "maximum_age": null, "sex": "ALL", "summary": "Not listed" }, "enrollment_count": 102, "start_date": "2014-07", "completion_date": "2021-11", "has_results": true, "last_update_posted_date": "2023-08-09", "last_synced_at": "2026-05-22T03:39:11.244Z", "location_count": 1, "location_summary": "Philadelphia, Pennsylvania", "locations": [ { "city": "Philadelphia", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT02133573" }, { "nct_id": "NCT00065949", "title": "Magnesium Sulfate to Prevent Brain Injury in Premature Infants", "overall_status": "UNKNOWN", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Brain Injuries", "Cerebral Palsy" ], "interventions": [ { "name": "magnesium sulfate", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)", "sponsor_class": "NIH", "healthy_volunteers": false, "eligibility": { "minimum_age": "0 Years", "maximum_age": "12 Hours", "sex": "ALL", "summary": "0 Years to 12 Hours" }, "enrollment_count": null, "start_date": "1987-08", "completion_date": "2003-02", "has_results": false, "last_update_posted_date": "2005-06-24", "last_synced_at": "2026-05-22T03:39:11.244Z", "location_count": 1, "location_summary": "Philadelphia, Pennsylvania", "locations": [ { "city": "Philadelphia", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT00065949" }, { "nct_id": "NCT06938542", "title": "Palliative Care Needs of Children With Rare Diseases and Their Families", "overall_status": "ENROLLING_BY_INVITATION", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Trisomy 13 Syndrome", "Arthrogryposis Congenita Multiplex With Intestinal Atresia", "Asparagine Synthetase Deficiency", "CHARGE Syndrome", "Early Infantile Epileptic Encephalopathy", "FOXG1 Syndrome", "KBG Syndrome", "Noonan Syndrome", "Severe Hemophilia A", "Short Bowel Syndrome", "Beta-Propeller Protein-Associated Neurodegeneration", "Brain Injury of Prematurity With Periventricular Leukomalacia", "Chromosome 17p13.3 Microdeletion Syndrome", "Chromosome 1q43-1q44 Deletion", "Cockayne Syndrome", "Congenital Diaphragmatic Hernia", "End-Stage Renal Disease With Cloacal Anomaly", "Mitochondrial Depletion Disorder", "Severe Factor VII Deficiency" ], "interventions": [ { "name": "Family Centered pediatric palliative care for family caregivers of children with rare diseases.", "type": "BEHAVIORAL" } ], "intervention_types": [ "BEHAVIORAL" ], "sponsor": "Children's National Research Institute", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "12 Months", "maximum_age": "99 Years", "sex": "ALL", "summary": "12 Months to 99 Years" }, "enrollment_count": 480, "start_date": "2025-10-02", "completion_date": "2029-08-02", "has_results": false, "last_update_posted_date": "2026-01-28", "last_synced_at": "2026-05-22T03:39:11.244Z", "location_count": 1, "location_summary": "Washington D.C., District of Columbia", "locations": [ { "city": "Washington D.C.", "state": "District of Columbia" } ], "official_url": "https://clinicaltrials.gov/study/NCT06938542" }, { "nct_id": "NCT02784821", "title": "Antibiotic \"Dysbiosis\" in Preterm Infants", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Enterocolitis, Necrotizing", "Bacteremia", "Bronchopulmonary Dysplasia", "Intraventricular Hemorrhage", "Periventricular Leukomalacia", "Chronic Lung Disease", "Ileal Perforation" ], "interventions": [ { "name": "Antibiotic", "type": "DRUG" }, { "name": "Gastric fluid", "type": "OTHER" }, { "name": "Breast milk", "type": "OTHER" }, { "name": "Stool samples", "type": "OTHER" }, { "name": "Antibiotics", "type": "DRUG" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "University of Florida", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "23 Weeks", "maximum_age": "33 Weeks", "sex": "ALL", "summary": "23 Weeks to 33 Weeks" }, "enrollment_count": 98, "start_date": "2017-01-16", "completion_date": "2019-09-11", "has_results": true, "last_update_posted_date": "2024-06-05", "last_synced_at": "2026-05-22T03:39:11.244Z", "location_count": 1, "location_summary": "Gainesville, Florida", "locations": [ { "city": "Gainesville", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT02784821" }, { "nct_id": "NCT00375908", "title": "Umbilical Cord Blood Proteomic Analysis and Neonatal Brain Injury", "overall_status": "COMPLETED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Hypoxia-Ischemia, Brain", "Periventricular Leukomalacia" ], "interventions": [], "intervention_types": [], "sponsor": "Johns Hopkins University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": null, "maximum_age": null, "sex": "ALL", "summary": "Not listed" }, "enrollment_count": 4, "start_date": "2005-10", "completion_date": "2008-12", "has_results": false, "last_update_posted_date": "2015-09-01", "last_synced_at": "2026-05-22T03:39:11.244Z", "location_count": 1, "location_summary": "Baltimore, Maryland", "locations": [ { "city": "Baltimore", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT00375908" }, { "nct_id": "NCT00589953", "title": "High-Dose Erythropoietin in Extremely Premature Infants to Prevent/Attenuate Brain Injury: A Phase II Study", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Infant, Premature", "Erythropoietin", "Brain Injury", "Intraventricular Hemorrhage", "Periventricular Leukomalacia", "Neurodevelopmental Outcomes", "Randomized Clinical Trial" ], "interventions": [ { "name": "Erythropoietin", "type": "DRUG" }, { "name": "Saline placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Atlantic Health System", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": null, "maximum_age": "24 Hours", "sex": "ALL", "summary": "Up to 24 Hours" }, "enrollment_count": 22, "start_date": "2007-07", "completion_date": "2010-09", "has_results": false, "last_update_posted_date": "2013-07-30", "last_synced_at": "2026-05-22T03:39:11.244Z", "location_count": 1, "location_summary": "Morristown, New Jersey", "locations": [ { "city": "Morristown", "state": "New Jersey" } ], "official_url": "https://clinicaltrials.gov/study/NCT00589953" }, { "nct_id": "NCT05520359", "title": "Spinal Stimulation and Mobility Devices", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Cerebral Palsy", "Stroke", "Premature Birth", "Hypoxic-Ischemic Encephalopathy", "Periventricular Leukomalacia" ], "interventions": [ { "name": "Mobility Device", "type": "DEVICE" }, { "name": "Spinal Stimulation", "type": "DEVICE" } ], "intervention_types": [ "DEVICE" ], "sponsor": "University of Washington", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "4 Years", "maximum_age": "70 Years", "sex": "ALL", "summary": "4 Years to 70 Years" }, "enrollment_count": 20, "start_date": "2022-08-04", "completion_date": "2026-12-31", "has_results": false, "last_update_posted_date": "2025-08-13", "last_synced_at": "2026-05-22T03:39:11.244Z", "location_count": 1, "location_summary": "Seattle, Washington", "locations": [ { "city": "Seattle", "state": "Washington" } ], "official_url": "https://clinicaltrials.gov/study/NCT05520359" }, { "nct_id": "NCT07275021", "title": "Cerebral/ Cortical Visual Impairment: Screening, Identification and Outcome Prediction in Neonates", "overall_status": "RECRUITING", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Preterm Less Than 32wks With IVH, WMI/PVL", "Late Preterm or Term (37-42wks) With Neonatal Encephalopathy Treated With Hypothermia for HIE" ], "interventions": [ { "name": "Prospective Clinical and Neurodevelopmental Data Collection", "type": "OTHER" } ], "intervention_types": [ "OTHER" ], "sponsor": "Brigham and Women's Hospital", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "31 Weeks", "maximum_age": "42 Weeks", "sex": "ALL", "summary": "31 Weeks to 42 Weeks" }, "enrollment_count": 60, "start_date": "2025-07-07", "completion_date": "2028-12-31", "has_results": false, "last_update_posted_date": "2025-12-10", "last_synced_at": "2026-05-22T03:39:11.244Z", "location_count": 1, "location_summary": "Boston, Massachusetts", "locations": [ { "city": "Boston", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT07275021" }, { "nct_id": "NCT05013736", "title": "Baby Brain Recovery Study", "overall_status": "RECRUITING", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Perinatal Stroke" ], "interventions": [ { "name": "Magnetic Resonance Imaging", "type": "DEVICE" }, { "name": "Behavioral Assessments", "type": "BEHAVIORAL" }, { "name": "Non invasive Transcranial Magnetic Stimulation", "type": "DEVICE" } ], "intervention_types": [ "DEVICE", "BEHAVIORAL" ], "sponsor": "University of Wisconsin, Madison", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "0 Years", "maximum_age": "24 Months", "sex": "ALL", "summary": "0 Years to 24 Months" }, "enrollment_count": 65, "start_date": "2022-07-26", "completion_date": "2026-09", "has_results": false, "last_update_posted_date": "2026-01-08", "last_synced_at": "2026-05-22T03:39:11.244Z", "location_count": 1, "location_summary": "Madison, Wisconsin", "locations": [ { "city": "Madison", "state": "Wisconsin" } ], "official_url": "https://clinicaltrials.gov/study/NCT05013736" } ] }