{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Persistent+Post+Concussion+Syndrome",
    "query": {
      "condition": "Persistent Post Concussion Syndrome"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 20,
    "total_pages": 2,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Persistent+Post+Concussion+Syndrome&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-06-10T06:01:03.273Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT05780658",
      "title": "Feasibility of a Purpose in Life Renewal Intervention for Adults With Persistent Symptoms After Concussion",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Concussion; Syndrome"
      ],
      "interventions": [
        {
          "name": "Compass Course",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Mary Radomski",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 22,
      "start_date": "2023-03-08",
      "completion_date": "2023-12-31",
      "has_results": false,
      "last_update_posted_date": "2024-07-17",
      "last_synced_at": "2026-06-10T06:01:03.273Z",
      "location_count": 1,
      "location_summary": "Minneapolis, Minnesota",
      "locations": [
        {
          "city": "Minneapolis",
          "state": "Minnesota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05780658"
    },
    {
      "nct_id": "NCT01611194",
      "title": "mTBI Mechanisms of Action of HBO2 for Persistent Post-Concussive Symptoms",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Traumatic Brain Injury With Brief Loss of Consciousness",
        "Post-Concussion Syndrome"
      ],
      "interventions": [
        {
          "name": "Hyperbaric oxygen (HBO2) at 1.5 atms",
          "type": "DRUG"
        },
        {
          "name": "Sham control 1.2 atms",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "U.S. Army Medical Research and Development Command",
      "sponsor_class": "FED",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 71,
      "start_date": "2012-09-11",
      "completion_date": "2016-01-29",
      "has_results": true,
      "last_update_posted_date": "2018-11-21",
      "last_synced_at": "2026-06-10T06:01:03.273Z",
      "location_count": 5,
      "location_summary": "Colorado Springs, Colorado • Fort Carson, Colorado • Jacksonville, North Carolina + 2 more",
      "locations": [
        {
          "city": "Colorado Springs",
          "state": "Colorado"
        },
        {
          "city": "Fort Carson",
          "state": "Colorado"
        },
        {
          "city": "Jacksonville",
          "state": "North Carolina"
        },
        {
          "city": "Fort Lewis",
          "state": "Washington"
        },
        {
          "city": "Tacoma",
          "state": "Washington"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01611194"
    },
    {
      "nct_id": "NCT07071350",
      "title": "Randomized Controlled Trial of Treatment to Optimize Heart Rate Variability for Persistent Post-Concussion Symptoms",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2",
        "PHASE3"
      ],
      "conditions": [
        "Autonomic Nervous System Disease",
        "Concussive Injury",
        "Mild Traumatic Brain Injury",
        "Post Traumatic Stress Disorder",
        "Persistent Post Concussion Syndrome"
      ],
      "interventions": [
        {
          "name": "HRV Coherence Ratio",
          "type": "OTHER"
        },
        {
          "name": "NSI",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Pittsburgh Sleep Quality Index (PSQI)",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Quantitative Sleep Measures",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Patient Global Impression of Change (PGIC)",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Cognitive Performance/NIH Toolbox Cognitive Battery",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Pain Interference/TBI-QoL Pain Interference Short-Form",
          "type": "OTHER"
        },
        {
          "name": "Patient Health Questionnaire-9 (PHQ-9)",
          "type": "BEHAVIORAL"
        },
        {
          "name": "PTSD Checklist for DSM-5 (PCL-5)",
          "type": "BEHAVIORAL"
        },
        {
          "name": "HRV Biofeedback (HRV-B)",
          "type": "OTHER"
        },
        {
          "name": "Psychoeducational (Edu) Comparator Intervention",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER",
        "BEHAVIORAL"
      ],
      "sponsor": "Virginia Commonwealth University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 148,
      "start_date": "2025-09-02",
      "completion_date": "2028-09",
      "has_results": false,
      "last_update_posted_date": "2025-09-17",
      "last_synced_at": "2026-06-10T06:01:03.273Z",
      "location_count": 1,
      "location_summary": "Richmond, Virginia",
      "locations": [
        {
          "city": "Richmond",
          "state": "Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07071350"
    },
    {
      "nct_id": "NCT05173818",
      "title": "Hyperbaric Oxygen Effects on Persistent Post-concussive Symptoms",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Persistent Post-concussive Syndrome",
        "Concussion Post Syndrome"
      ],
      "interventions": [
        {
          "name": "Hyperbaric oxygen at 1.5 ATA",
          "type": "DRUG"
        },
        {
          "name": "Sham treatment",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Essentia Health",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 20,
      "start_date": "2022-06-28",
      "completion_date": "2025-08-01",
      "has_results": false,
      "last_update_posted_date": "2025-12-24",
      "last_synced_at": "2026-06-10T06:01:03.273Z",
      "location_count": 1,
      "location_summary": "Fargo, North Dakota",
      "locations": [
        {
          "city": "Fargo",
          "state": "North Dakota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05173818"
    },
    {
      "nct_id": "NCT05302479",
      "title": "Validating a Modified COMPASS 31questionnaire for Treatment Outcomes",
      "overall_status": "UNKNOWN",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Headache, Migraine",
        "Persistent Post Traumatic Headache",
        "Cervicogenic Headache"
      ],
      "interventions": [
        {
          "name": "COMPASS 31 questionnaire",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Brooke Army Medical Center",
      "sponsor_class": "FED",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "64 Years",
        "sex": "ALL",
        "summary": "18 Years to 64 Years"
      },
      "enrollment_count": 35,
      "start_date": "2022-04-15",
      "completion_date": "2023-09-20",
      "has_results": false,
      "last_update_posted_date": "2022-07-21",
      "last_synced_at": "2026-06-10T06:01:03.273Z",
      "location_count": 1,
      "location_summary": "Houston, Texas",
      "locations": [
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05302479"
    },
    {
      "nct_id": "NCT06036147",
      "title": "Concussion Health Improvement Program",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Concussion, Brain",
        "Brain Injury Traumatic Mild"
      ],
      "interventions": [
        {
          "name": "Concussion-focused cognitive behavioral therapy",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Parent skills training",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Care management",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Seattle Children's Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "11 Years",
        "maximum_age": "18 Years",
        "sex": "ALL",
        "summary": "11 Years to 18 Years"
      },
      "enrollment_count": 304,
      "start_date": "2023-11-10",
      "completion_date": "2028-01-31",
      "has_results": false,
      "last_update_posted_date": "2025-03-13",
      "last_synced_at": "2026-06-10T06:01:03.273Z",
      "location_count": 1,
      "location_summary": "Dallas, Texas",
      "locations": [
        {
          "city": "Dallas",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06036147"
    },
    {
      "nct_id": "NCT05741411",
      "title": "Facilitating Access to Specialty Treatment",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Mild Traumatic Brain Injury",
        "Concussion, Mild",
        "Concussion, Severe",
        "Concussion, Intermediate"
      ],
      "interventions": [
        {
          "name": "RPM-assisted specialist access",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Children's Hospital of Philadelphia",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "13 Years",
        "maximum_age": "18 Years",
        "sex": "ALL",
        "summary": "13 Years to 18 Years"
      },
      "enrollment_count": 210,
      "start_date": "2024-03-11",
      "completion_date": "2027-08-01",
      "has_results": false,
      "last_update_posted_date": "2026-05-22",
      "last_synced_at": "2026-06-10T06:01:03.273Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05741411"
    },
    {
      "nct_id": "NCT03034720",
      "title": "Collaborative Care Model for the Treatment of Persistent Symptoms After Concussion Among Youth",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Concussion, Brain",
        "TBI",
        "Depression",
        "Anxiety"
      ],
      "interventions": [
        {
          "name": "Collaborative Care",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Seattle Children's Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "11 Years",
        "maximum_age": "18 Years",
        "sex": "ALL",
        "summary": "11 Years to 18 Years"
      },
      "enrollment_count": 200,
      "start_date": "2017-03-09",
      "completion_date": "2020-05-29",
      "has_results": false,
      "last_update_posted_date": "2021-04-08",
      "last_synced_at": "2026-06-10T06:01:03.273Z",
      "location_count": 1,
      "location_summary": "Seattle, Washington",
      "locations": [
        {
          "city": "Seattle",
          "state": "Washington"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03034720"
    },
    {
      "nct_id": "NCT02089594",
      "title": "Hyperbaric Oxygen Treatment to Treat Mild Traumatic Brain Injury (mTBI)/Persistent Post-Concussion Syndrome (PPCS)",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Post-Concussion Syndrome",
        "Traumatic Brain Injury"
      ],
      "interventions": [
        {
          "name": "Hyperbaric Oxygen",
          "type": "DRUG"
        },
        {
          "name": "No Hyperbaric Oxygen",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Louisiana State University Health Sciences Center in New Orleans",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 59,
      "start_date": "2014-05",
      "completion_date": "2019-03",
      "has_results": false,
      "last_update_posted_date": "2017-04-18",
      "last_synced_at": "2026-06-10T06:01:03.273Z",
      "location_count": 1,
      "location_summary": "New Orleans, Louisiana",
      "locations": [
        {
          "city": "New Orleans",
          "state": "Louisiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02089594"
    },
    {
      "nct_id": "NCT01986205",
      "title": "Hyperbaric Oxygen for Traumatic and Non-traumatic Brain Injury",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Brain Injury, Chronic"
      ],
      "interventions": [
        {
          "name": "Hyperbaric Oxygen",
          "type": "COMBINATION_PRODUCT"
        },
        {
          "name": "Minimal pressure air",
          "type": "COMBINATION_PRODUCT"
        }
      ],
      "intervention_types": [
        "COMBINATION_PRODUCT"
      ],
      "sponsor": "Lindell Weaver",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "18 Years to 70 Years"
      },
      "enrollment_count": 49,
      "start_date": "2017-09-06",
      "completion_date": "2022-05-31",
      "has_results": false,
      "last_update_posted_date": "2022-08-04",
      "last_synced_at": "2026-06-10T06:01:03.273Z",
      "location_count": 2,
      "location_summary": "Murray, Utah • Salt Lake City, Utah",
      "locations": [
        {
          "city": "Murray",
          "state": "Utah"
        },
        {
          "city": "Salt Lake City",
          "state": "Utah"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01986205"
    }
  ]
}