{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Polygenic+Score",
    "query": {
      "condition": "Polygenic Score"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 20,
    "total_pages": 2,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Polygenic+Score&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-06-25T13:00:42.481Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT06398639",
      "title": "Polygenic Risk Stratification Combined With mpMRI to Identify Clinically Relevant Prostate Cancer",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Prostate Cancer",
        "Polygenic Risk Score"
      ],
      "interventions": [
        {
          "name": "Polygenic Risk Score (PRS)",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Adam S. Kibel, MD",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "40 Years",
        "maximum_age": "69 Years",
        "sex": "MALE",
        "summary": "40 Years to 69 Years · Male only"
      },
      "enrollment_count": 1500,
      "start_date": "2024-05-07",
      "completion_date": "2030-04-30",
      "has_results": false,
      "last_update_posted_date": "2025-11-10",
      "last_synced_at": "2026-06-25T13:00:42.481Z",
      "location_count": 5,
      "location_summary": "Washington D.C., District of Columbia • Bethesda, Maryland • Boston, Massachusetts",
      "locations": [
        {
          "city": "Washington D.C.",
          "state": "District of Columbia"
        },
        {
          "city": "Bethesda",
          "state": "Maryland"
        },
        {
          "city": "Bethesda",
          "state": "Maryland"
        },
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06398639"
    },
    {
      "nct_id": "NCT07118592",
      "title": "Genetic Architecture of Natriuretic Peptides and Blood Pressure Response",
      "overall_status": "NOT_YET_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Hypertension (HTN)",
        "Cardiometabolic Diseases"
      ],
      "interventions": [
        {
          "name": "Low Salt Diet",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "High Salt Diet",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Saline Infusion",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "University of Alabama at Birmingham",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 200,
      "start_date": "2026-09-01",
      "completion_date": "2030-12-01",
      "has_results": false,
      "last_update_posted_date": "2026-03-10",
      "last_synced_at": "2026-06-25T13:00:42.481Z",
      "location_count": 1,
      "location_summary": "Birmingham, Alabama",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07118592"
    },
    {
      "nct_id": "NCT02517593",
      "title": "Genetic Risk Estimation of Breast Cancer Prior to Preventive Medication Uptake",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Breast Cancer"
      ],
      "interventions": [
        {
          "name": "Polygenic Risk Score",
          "type": "GENETIC"
        }
      ],
      "intervention_types": [
        "GENETIC"
      ],
      "sponsor": "Mayo Clinic",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "35 Years",
        "maximum_age": "75 Years",
        "sex": "FEMALE",
        "summary": "35 Years to 75 Years · Female only"
      },
      "enrollment_count": 151,
      "start_date": "2016-03",
      "completion_date": "2019-12-01",
      "has_results": false,
      "last_update_posted_date": "2020-12-30",
      "last_synced_at": "2026-06-25T13:00:42.481Z",
      "location_count": 1,
      "location_summary": "Rochester, Minnesota",
      "locations": [
        {
          "city": "Rochester",
          "state": "Minnesota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02517593"
    },
    {
      "nct_id": "NCT07087431",
      "title": "Impact of Disclosing Coronary Artery Disease Polygenic Risk Score on Cardiovascular Health",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Coronary Artery Disease"
      ],
      "interventions": [
        {
          "name": "Immediate disclosure of CAD PRS results",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Deferred Disclosure of CAD PRS results",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Massachusetts General Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "30 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "30 Years to 75 Years"
      },
      "enrollment_count": 500,
      "start_date": "2025-10-15",
      "completion_date": "2027-08-15",
      "has_results": false,
      "last_update_posted_date": "2026-03-23",
      "last_synced_at": "2026-06-25T13:00:42.481Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07087431"
    },
    {
      "nct_id": "NCT04789473",
      "title": "OneinSeven Gestational Diabetes Genetic and Socioeconomic Risk Study",
      "overall_status": "UNKNOWN",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Gestational Diabetes",
        "Pregnancy Complications",
        "Pregnancy Related",
        "Genetic Predisposition",
        "Risk Reduction"
      ],
      "interventions": [
        {
          "name": "Polygenic Risk Score Generation",
          "type": "GENETIC"
        }
      ],
      "intervention_types": [
        "GENETIC"
      ],
      "sponsor": "Prenome",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": null,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 10000,
      "start_date": "2021-06-24",
      "completion_date": "2022-08-01",
      "has_results": false,
      "last_update_posted_date": "2021-06-30",
      "last_synced_at": "2026-06-25T13:00:42.481Z",
      "location_count": 1,
      "location_summary": "Foster City, California",
      "locations": [
        {
          "city": "Foster City",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04789473"
    },
    {
      "nct_id": "NCT03688204",
      "title": "Clinical Implementation of a Polygenic Risk Score (PRS) for Breast Cancer",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Breast Cancer Risk"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Ambry Genetics",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 118,
      "start_date": "2018-09-21",
      "completion_date": "2020-11-11",
      "has_results": false,
      "last_update_posted_date": "2022-03-07",
      "last_synced_at": "2026-06-25T13:00:42.481Z",
      "location_count": 3,
      "location_summary": "Burbank, California • Orange, California • Huntington, West Virginia",
      "locations": [
        {
          "city": "Burbank",
          "state": "California"
        },
        {
          "city": "Orange",
          "state": "California"
        },
        {
          "city": "Huntington",
          "state": "West Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03688204"
    },
    {
      "nct_id": "NCT06542432",
      "title": "Utility and Effectiveness of Polygenic Risk Scoring (PRS) for Coronary Artery Disease (CAD)",
      "overall_status": "ENROLLING_BY_INVITATION",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Coronary Artery Disease",
        "Polygenic Risk Score",
        "Heart Diseases",
        "Coronary Disease",
        "Myocardial Infarction",
        "Cardiovascular Diseases"
      ],
      "interventions": [
        {
          "name": "Disclosure of integrate risk score for coronary artery disease",
          "type": "GENETIC"
        }
      ],
      "intervention_types": [
        "GENETIC"
      ],
      "sponsor": "MyOme",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "40 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "40 Years to 70 Years"
      },
      "enrollment_count": 1000,
      "start_date": "2025-01-01",
      "completion_date": "2029-07-01",
      "has_results": false,
      "last_update_posted_date": "2025-09-16",
      "last_synced_at": "2026-06-25T13:00:42.481Z",
      "location_count": 2,
      "location_summary": "Rochester, Minnesota • Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Rochester",
          "state": "Minnesota"
        },
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06542432"
    },
    {
      "nct_id": "NCT07516119",
      "title": "Predicting Pre-dementia",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Mild Cognitive Impairment (MCI)",
        "Alzheimer Dementia (AD)",
        "Alzheimer Disease (AD)",
        "APOE-4 Positive"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Prevention Research Consortium Corp.",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "55 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "55 Years and older"
      },
      "enrollment_count": 100,
      "start_date": "2026-04-15",
      "completion_date": "2029-04-15",
      "has_results": false,
      "last_update_posted_date": "2026-04-07",
      "last_synced_at": "2026-06-25T13:00:42.481Z",
      "location_count": 1,
      "location_summary": "San Diego, California",
      "locations": [
        {
          "city": "San Diego",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07516119"
    },
    {
      "nct_id": "NCT06436248",
      "title": "Polygenic Risk Scores and Multi-cancer Early Detection for Ovarian Cancer",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Ovarian Cancer",
        "BRCA Mutation"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Abramson Cancer Center at Penn Medicine",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "25 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "25 Years and older · Female only"
      },
      "enrollment_count": 24,
      "start_date": "2024-07-01",
      "completion_date": "2027-10",
      "has_results": false,
      "last_update_posted_date": "2025-10-22",
      "last_synced_at": "2026-06-25T13:00:42.481Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06436248"
    },
    {
      "nct_id": "NCT05143073",
      "title": "Understanding Genetic Risk for Alcohol Use Disorder",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Alcohol Use Disorder"
      ],
      "interventions": [
        {
          "name": "Alcohol use disorder and strategies to reduce risk educational material",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Complex polygenic risk scores, alcohol use disorder, and strategies to reduce risk educational material",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Virginia Commonwealth University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 338,
      "start_date": "2021-11-15",
      "completion_date": "2021-12-13",
      "has_results": false,
      "last_update_posted_date": "2022-01-19",
      "last_synced_at": "2026-06-25T13:00:42.481Z",
      "location_count": 1,
      "location_summary": "Richmond, Virginia",
      "locations": [
        {
          "city": "Richmond",
          "state": "Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05143073"
    }
  ]
}