{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Post-Operative+Cognitive+Decline+in+Older+Adults",
    "query": {
      "condition": "Post-Operative Cognitive Decline in Older Adults"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 14,
    "total_pages": 2,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Post-Operative+Cognitive+Decline+in+Older+Adults&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-07-23T11:07:15.621Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT03802396",
      "title": "Modulating ApoE Signalling to Reduce Brain Inflammation, deLirium and postopErative Cognitive Dysfunction",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Postoperative Delirium",
        "Postoperative Cognitive Dysfunction"
      ],
      "interventions": [
        {
          "name": "CN-105",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Miles Berger, MD PhD",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "60 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "60 Years and older"
      },
      "enrollment_count": 203,
      "start_date": "2018-07-15",
      "completion_date": "2022-12-28",
      "has_results": true,
      "last_update_posted_date": "2024-10-16",
      "last_synced_at": "2026-07-23T11:07:15.621Z",
      "location_count": 1,
      "location_summary": "Durham, North Carolina",
      "locations": [
        {
          "city": "Durham",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03802396"
    },
    {
      "nct_id": "NCT01786577",
      "title": "Study To Analyze Memory/Thinking Problems In Older Adults After Surgery",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Post-Operative Cognitive Decline in Older Adults"
      ],
      "interventions": [
        {
          "name": "Magnetic Resonance Imaging",
          "type": "OTHER"
        },
        {
          "name": "Cognitive assessment testing",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "OTHER",
        "BEHAVIORAL"
      ],
      "sponsor": "University of Florida",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "60 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "60 Years and older"
      },
      "enrollment_count": 147,
      "start_date": "2013-03-19",
      "completion_date": "2018-07-21",
      "has_results": false,
      "last_update_posted_date": "2019-07-08",
      "last_synced_at": "2026-07-23T11:07:15.621Z",
      "location_count": 1,
      "location_summary": "Gainesville, Florida",
      "locations": [
        {
          "city": "Gainesville",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01786577"
    },
    {
      "nct_id": "NCT00788008",
      "title": "Cognitive Effects of Inhalational Versus Intravenous General Anesthesia in the Elderly",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Lumbar Spondylosis",
        "Cervical Spondylosis",
        "Hip Osteoarthritis",
        "Knee Osteoarthritis"
      ],
      "interventions": [
        {
          "name": "inhalation anesthesia with isoflurane vs. TIVA with propofol",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Duke University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "65 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "65 Years and older"
      },
      "enrollment_count": 200,
      "start_date": "2008-11",
      "completion_date": "2013-12",
      "has_results": true,
      "last_update_posted_date": "2015-03-26",
      "last_synced_at": "2026-07-23T11:07:15.621Z",
      "location_count": 2,
      "location_summary": "Durham, North Carolina",
      "locations": [
        {
          "city": "Durham",
          "state": "North Carolina"
        },
        {
          "city": "Durham",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00788008"
    },
    {
      "nct_id": "NCT03089866",
      "title": "Effect of Sedation on Cognitive Performance in the Elderly",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Postoperative Cognitive Dysfunction"
      ],
      "interventions": [
        {
          "name": "Midazolam (0.02mg/kg)",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Alabama at Birmingham",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "55 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "55 Years and older"
      },
      "enrollment_count": 20,
      "start_date": "2015-03",
      "completion_date": "2020-09-04",
      "has_results": false,
      "last_update_posted_date": "2025-07-11",
      "last_synced_at": "2026-07-23T11:07:15.621Z",
      "location_count": 1,
      "location_summary": "Birmingham, Alabama",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03089866"
    },
    {
      "nct_id": "NCT02275026",
      "title": "Trajectory of Recovery in the Elderly",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Delayed Emergence From Anesthesia",
        "Postoperative Delirium",
        "Postoperative Cognitive Dysfunction"
      ],
      "interventions": [
        {
          "name": "Functional magnetic resonance imaging",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Icahn School of Medicine at Mount Sinai",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "40 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "40 Years to 80 Years"
      },
      "enrollment_count": 104,
      "start_date": "2015-07",
      "completion_date": "2020-04-22",
      "has_results": true,
      "last_update_posted_date": "2021-06-15",
      "last_synced_at": "2026-07-23T11:07:15.621Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02275026"
    },
    {
      "nct_id": "NCT04566562",
      "title": "Blood Brain Barrier Dysfunction and Postoperative Neurocognitive Disorders",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Neurocognitive Disorders",
        "Postoperative Cognitive Dysfunction"
      ],
      "interventions": [
        {
          "name": "Brain Imaging",
          "type": "DIAGNOSTIC_TEST"
        },
        {
          "name": "Cognitive Testing",
          "type": "DIAGNOSTIC_TEST"
        },
        {
          "name": "Blood Biomarkers",
          "type": "DIAGNOSTIC_TEST"
        }
      ],
      "intervention_types": [
        "DIAGNOSTIC_TEST"
      ],
      "sponsor": "University of California, Los Angeles",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "65 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "65 Years to 75 Years"
      },
      "enrollment_count": 32,
      "start_date": "2020-08-03",
      "completion_date": "2024-02-29",
      "has_results": false,
      "last_update_posted_date": "2024-12-10",
      "last_synced_at": "2026-07-23T11:07:15.621Z",
      "location_count": 1,
      "location_summary": "Los Angeles, California",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04566562"
    },
    {
      "nct_id": "NCT01561378",
      "title": "Cardiac Surgery Neuroprotection Study in Elders",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Post-operative Cognitive Decline",
        "Post-operative Delirium"
      ],
      "interventions": [
        {
          "name": "Aspart insulin",
          "type": "DRUG"
        },
        {
          "name": "Normal saline",
          "type": "DRUG"
        },
        {
          "name": "Intranasal mucosal atomizer device",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DRUG",
        "DEVICE"
      ],
      "sponsor": "Albert Einstein College of Medicine",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "65 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "65 Years and older"
      },
      "enrollment_count": 22,
      "start_date": "2012-08",
      "completion_date": "2014-10",
      "has_results": true,
      "last_update_posted_date": "2021-11-10",
      "last_synced_at": "2026-07-23T11:07:15.621Z",
      "location_count": 1,
      "location_summary": "The Bronx, New York",
      "locations": [
        {
          "city": "The Bronx",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01561378"
    },
    {
      "nct_id": "NCT02997930",
      "title": "fMRI Connectivity in Fracture Hip Patients",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Postoperative Delirium",
        "Postoperative Cognitive Dysfunction"
      ],
      "interventions": [
        {
          "name": "fMRI",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Montreal Cognitive Assessment (MoCA)",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Digital Clock Drawing Test Command and Copy",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Wide Range Achievement Test reading subtest",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Hopkins Verbal Learning Test (HVLT)",
          "type": "BEHAVIORAL"
        },
        {
          "name": "General Depression Scale (GDS)",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "University of Florida",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "65 Years",
        "maximum_age": "99 Years",
        "sex": "ALL",
        "summary": "65 Years to 99 Years"
      },
      "enrollment_count": 2,
      "start_date": "2017-01-29",
      "completion_date": "2019-05-06",
      "has_results": false,
      "last_update_posted_date": "2019-08-12",
      "last_synced_at": "2026-07-23T11:07:15.621Z",
      "location_count": 1,
      "location_summary": "Gainesville, Florida",
      "locations": [
        {
          "city": "Gainesville",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02997930"
    },
    {
      "nct_id": "NCT00991328",
      "title": "Role of Absolute Cerebral Oximetry to Prevent Neurocognitive Injury in Elderly Patients Undergoing Cardiac Surgery",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Post-Operative Delirium",
        "Postoperative Cognitive Dysfunction"
      ],
      "interventions": [
        {
          "name": "SctO2 < 60 %.",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Icahn School of Medicine at Mount Sinai",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "65 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "65 Years and older"
      },
      "enrollment_count": 15,
      "start_date": "2009-09",
      "completion_date": "2010-12",
      "has_results": false,
      "last_update_posted_date": "2016-09-16",
      "last_synced_at": "2026-07-23T11:07:15.621Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00991328"
    },
    {
      "nct_id": "NCT06567574",
      "title": "Stanford PIPRA Validation Study in an Elderly Orthopedic Population",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Delirium",
        "Postoperative Delirium",
        "Cognitive Impairment"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Stanford University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "65 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "65 Years and older"
      },
      "enrollment_count": 250,
      "start_date": "2024-04-30",
      "completion_date": "2024-06-30",
      "has_results": false,
      "last_update_posted_date": "2024-08-22",
      "last_synced_at": "2026-07-23T11:07:15.621Z",
      "location_count": 1,
      "location_summary": "Palo Alto, California",
      "locations": [
        {
          "city": "Palo Alto",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06567574"
    }
  ]
}