{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Post-operative+Cognitive+Decline&page=2",
    "query": {
      "condition": "Post-operative Cognitive Decline",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Post-operative+Cognitive+Decline&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-06-10T09:29:21.868Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT06042699",
      "title": "Kids With Iron Deficiency and Scoliosis",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Adolescent Idiopathic Scoliosis",
        "Neuromuscular Scoliosis",
        "Perioperative/Postoperative Complications",
        "Iron Deficiencies",
        "Anemia",
        "Spinal Fusion",
        "Postoperative Cognitive Dysfunction"
      ],
      "interventions": [
        {
          "name": "Oral ferrous sulfate",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Oral placebo tablet",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "Columbia University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "10 Years",
        "maximum_age": "26 Years",
        "sex": "ALL",
        "summary": "10 Years to 26 Years"
      },
      "enrollment_count": 275,
      "start_date": "2024-01-11",
      "completion_date": "2028-02-01",
      "has_results": false,
      "last_update_posted_date": "2025-07-28",
      "last_synced_at": "2026-06-10T09:29:21.868Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06042699"
    },
    {
      "nct_id": "NCT02834065",
      "title": "Cognitive Effects of Body Temperature During Hypothermic Circulatory Arrest",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Cognition Disorders"
      ],
      "interventions": [
        {
          "name": "Cardiopulmonary bypass machine",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Duke University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 273,
      "start_date": "2016-07-28",
      "completion_date": "2023-02",
      "has_results": false,
      "last_update_posted_date": "2023-02-24",
      "last_synced_at": "2026-06-10T09:29:21.868Z",
      "location_count": 4,
      "location_summary": "Atlanta, Georgia • Durham, North Carolina • Philadelphia, Pennsylvania + 1 more",
      "locations": [
        {
          "city": "Atlanta",
          "state": "Georgia"
        },
        {
          "city": "Durham",
          "state": "North Carolina"
        },
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        },
        {
          "city": "Plano",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02834065"
    },
    {
      "nct_id": "NCT06042413",
      "title": "Prediction and Prevention of Postoperative Mortality and Morbidity",
      "overall_status": "NOT_YET_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Dementia",
        "Postoperative Delirium (POD)",
        "Postoperative Neurocognitive Disorder",
        "Major Adverse Cardiac and Cerebrovascular Events",
        "Perioperative Complications",
        "Postoperative Cognitive Decline"
      ],
      "interventions": [
        {
          "name": "Personalized CPC Prehabilitation",
          "type": "OTHER"
        },
        {
          "name": "Cognitive Training",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Meditation",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Daily Exercise",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Enhanced Social Support",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Proactive Bundle Interventions",
          "type": "OTHER"
        },
        {
          "name": "Pre-operative Standard of Care",
          "type": "PROCEDURE"
        },
        {
          "name": "Intra-operative Standard of Care",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "OTHER",
        "BEHAVIORAL",
        "PROCEDURE"
      ],
      "sponsor": "University of Pittsburgh",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "65 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "65 Years and older"
      },
      "enrollment_count": 1200,
      "start_date": "2026-06",
      "completion_date": "2027-06",
      "has_results": false,
      "last_update_posted_date": "2026-06-04",
      "last_synced_at": "2026-06-10T09:29:21.868Z",
      "location_count": 5,
      "location_summary": "Pittsburgh, Pennsylvania",
      "locations": [
        {
          "city": "Pittsburgh",
          "state": "Pennsylvania"
        },
        {
          "city": "Pittsburgh",
          "state": "Pennsylvania"
        },
        {
          "city": "Pittsburgh",
          "state": "Pennsylvania"
        },
        {
          "city": "Pittsburgh",
          "state": "Pennsylvania"
        },
        {
          "city": "Pittsburgh",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06042413"
    },
    {
      "nct_id": "NCT02570438",
      "title": "Improving Surgical Safety of Seniors Through Preoperative Cognitive Screening",
      "overall_status": "TERMINATED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Cognitive Impairment"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Brigham and Women's Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "65 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "65 Years and older"
      },
      "enrollment_count": 500,
      "start_date": "2015-07-31",
      "completion_date": "2017-12-31",
      "has_results": false,
      "last_update_posted_date": "2021-04-15",
      "last_synced_at": "2026-06-10T09:29:21.868Z",
      "location_count": 2,
      "location_summary": "Boston, Massachusetts • Newton, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "Newton",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02570438"
    },
    {
      "nct_id": "NCT05574400",
      "title": "The Caffeine, Postoperative Delirium, and Change in Outcomes After Surgery (CAPACHINOS-2) Study",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Postoperative Delirium",
        "Postoperative Cognitive Dysfunction",
        "Mild Cognitive Impairment"
      ],
      "interventions": [
        {
          "name": "Dextrose Water",
          "type": "DRUG"
        },
        {
          "name": "Caffeine citrate",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Michigan",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "70 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "70 Years and older"
      },
      "enrollment_count": 250,
      "start_date": "2023-02-20",
      "completion_date": "2026-05-31",
      "has_results": false,
      "last_update_posted_date": "2026-04-21",
      "last_synced_at": "2026-06-10T09:29:21.868Z",
      "location_count": 1,
      "location_summary": "Ann Arbor, Michigan",
      "locations": [
        {
          "city": "Ann Arbor",
          "state": "Michigan"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05574400"
    },
    {
      "nct_id": "NCT00561678",
      "title": "Perioperative Cognitive Function - Dexmedetomidine and Cognitive Reserve",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Postoperative Delirium",
        "PD",
        "Postoperative Cognitive Dysfunction",
        "POCD"
      ],
      "interventions": [
        {
          "name": "Precedex (Dexmedetomidine)",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Icahn School of Medicine at Mount Sinai",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "68 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "68 Years and older"
      },
      "enrollment_count": 404,
      "start_date": "2008-02",
      "completion_date": "2014-05",
      "has_results": true,
      "last_update_posted_date": "2018-04-23",
      "last_synced_at": "2026-06-10T09:29:21.868Z",
      "location_count": 10,
      "location_summary": "Miami, Florida • Baltimore, Maryland • College Park, Maryland + 7 more",
      "locations": [
        {
          "city": "Miami",
          "state": "Florida"
        },
        {
          "city": "Baltimore",
          "state": "Maryland"
        },
        {
          "city": "College Park",
          "state": "Maryland"
        },
        {
          "city": "Rochester",
          "state": "Minnesota"
        },
        {
          "city": "St Louis",
          "state": "Missouri"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00561678"
    },
    {
      "nct_id": "NCT01983384",
      "title": "Anesthetic Depth and Postoperative Delirium Trial - 2",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Delirium",
        "Cognitive Disorders"
      ],
      "interventions": [
        {
          "name": "Processed EEG-guided anesthetic depth",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of California, San Francisco",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "65 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "65 Years and older"
      },
      "enrollment_count": 205,
      "start_date": "2015-07",
      "completion_date": "2017-10",
      "has_results": false,
      "last_update_posted_date": "2019-12-18",
      "last_synced_at": "2026-06-10T09:29:21.868Z",
      "location_count": 1,
      "location_summary": "San Francisco, California",
      "locations": [
        {
          "city": "San Francisco",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01983384"
    },
    {
      "nct_id": "NCT00182884",
      "title": "Donepezil in Preventing Delirium in Hospitalized Elderly",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Postoperative Complications",
        "Delirium"
      ],
      "interventions": [
        {
          "name": "Donepezil",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Indiana University Health",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "65 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "65 Years and older"
      },
      "enrollment_count": 30,
      "start_date": "2004-07",
      "completion_date": "2007-04",
      "has_results": false,
      "last_update_posted_date": "2008-03-03",
      "last_synced_at": "2026-06-10T09:29:21.868Z",
      "location_count": 1,
      "location_summary": "Indianapolis, Indiana",
      "locations": [
        {
          "city": "Indianapolis",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00182884"
    },
    {
      "nct_id": "NCT04189861",
      "title": "Use of Brain Wave Monitoring During Surgery to Reduce Postoperative Cognitive Dysfunction",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Postoperative Cognitive Dysfunction"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Dartmouth-Hitchcock Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "60 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "60 Years to 80 Years"
      },
      "enrollment_count": 31,
      "start_date": "2020-01-24",
      "completion_date": "2025-11-11",
      "has_results": false,
      "last_update_posted_date": "2026-01-14",
      "last_synced_at": "2026-06-10T09:29:21.868Z",
      "location_count": 1,
      "location_summary": "Lebanon, New Hampshire",
      "locations": [
        {
          "city": "Lebanon",
          "state": "New Hampshire"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04189861"
    },
    {
      "nct_id": "NCT02230605",
      "title": "Perioperative Cognitive Protection - Cognitive Exercise and Cognitive Reserve (The Neurobics Trial)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Delirium"
      ],
      "interventions": [
        {
          "name": "Mini-Mental State Examination",
          "type": "OTHER"
        },
        {
          "name": "Self-Administered Gerocognitive Examination",
          "type": "OTHER"
        },
        {
          "name": "Geriatric Depression Scale",
          "type": "OTHER"
        },
        {
          "name": "Charlson Comorbidity Index",
          "type": "OTHER"
        },
        {
          "name": "Short Form 36 Health Survey",
          "type": "OTHER"
        },
        {
          "name": "Confusion Assessment Method",
          "type": "OTHER"
        },
        {
          "name": "Memorial Delirium Assessment Scale",
          "type": "OTHER"
        },
        {
          "name": "Postoperative Quality of Recovery Scale",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Ohio State University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "60 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "60 Years and older"
      },
      "enrollment_count": 322,
      "start_date": "2015-07",
      "completion_date": "2019-08-20",
      "has_results": false,
      "last_update_posted_date": "2019-09-11",
      "last_synced_at": "2026-06-10T09:29:21.868Z",
      "location_count": 1,
      "location_summary": "Columbus, Ohio",
      "locations": [
        {
          "city": "Columbus",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02230605"
    }
  ]
}