{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Postural+Tachycardia+Syndrome+%28POTS%29",
    "query": {
      "condition": "Postural Tachycardia Syndrome (POTS)"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 66,
    "total_pages": 7,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Postural+Tachycardia+Syndrome+%28POTS%29&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-06-26T02:22:18.095Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT03261570",
      "title": "Cardiovagal Baroreflex Deficits Impair Neurovascular Coupling and Cognition in POTS",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "EARLY_PHASE1"
      ],
      "conditions": [
        "Postural Orthostatic Tachycardia Syndrome (POTS)",
        "POTS",
        "Orthostatic Intolerance"
      ],
      "interventions": [
        {
          "name": "Pyridostigmine",
          "type": "DRUG"
        },
        {
          "name": "Digoxin",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "New York Medical College",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "15 Years",
        "maximum_age": "30 Years",
        "sex": "FEMALE",
        "summary": "15 Years to 30 Years · Female only"
      },
      "enrollment_count": 51,
      "start_date": "2017-07-01",
      "completion_date": "2022-06-01",
      "has_results": false,
      "last_update_posted_date": "2022-09-28",
      "last_synced_at": "2026-06-26T02:22:18.095Z",
      "location_count": 1,
      "location_summary": "Hawthorne, New York",
      "locations": [
        {
          "city": "Hawthorne",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03261570"
    },
    {
      "nct_id": "NCT02854683",
      "title": "Reducing Orthostatic Intolerance With Oral Rehydration in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Chronic Fatigue Syndrome",
        "Myalgic Encephalomyelitis",
        "Systemic Exertion Intolerance Disease (SEID)",
        "Postural Tachycardia Syndrome (POTS)",
        "Neurally Mediated Syncope (NMS)"
      ],
      "interventions": [
        {
          "name": "Normal Saline",
          "type": "DRUG"
        },
        {
          "name": "Oral Rehydration Solution",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DRUG",
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "New York Medical College",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "15 Years",
        "maximum_age": "29 Years",
        "sex": "ALL",
        "summary": "15 Years to 29 Years"
      },
      "enrollment_count": 45,
      "start_date": "2016-02",
      "completion_date": "2021-12",
      "has_results": false,
      "last_update_posted_date": "2021-06-10",
      "last_synced_at": "2026-06-26T02:22:18.095Z",
      "location_count": 1,
      "location_summary": "Hawthorne, New York",
      "locations": [
        {
          "city": "Hawthorne",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02854683"
    },
    {
      "nct_id": "NCT07478172",
      "title": "Effects of Whole-body Electrical Muscle Stimulation Exercise on Adults With Neuromuscular Disease",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Neuromuscular Diseases (NMD)",
        "Amyotrophic Lateral Sclerosis",
        "Myasthenia Gravis",
        "Lambert-eaton Myasthenic Syndrome",
        "Primary Lateral Sclerosis",
        "Spinal Muscular Atrophy",
        "Charcot Marie Tooth Disease (CMT)",
        "Fascioscapulohumeral Muscular Dystrophy",
        "Inclusion Body Myositis",
        "Mitochondrial Myopathy",
        "Nemaline Myopathy",
        "Centronuclear Myopathy",
        "Postpolio Syndrome",
        "Pompe Disease (Late-onset)",
        "Chronic Inflammatory Demyelinating Polyneuropathy",
        "Hereditary Spastic Paraplegia",
        "Postural Orthostatic Tachycardia Syndrome (POTS)",
        "Progressive Muscular Atrophy"
      ],
      "interventions": [
        {
          "name": "Whole-body Electrical Muscle Stimulation Exercise",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of Missouri-Columbia",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 50,
      "start_date": "2026-03-10",
      "completion_date": "2031-01-07",
      "has_results": false,
      "last_update_posted_date": "2026-03-17",
      "last_synced_at": "2026-06-26T02:22:18.095Z",
      "location_count": 1,
      "location_summary": "Columbia, Missouri",
      "locations": [
        {
          "city": "Columbia",
          "state": "Missouri"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07478172"
    },
    {
      "nct_id": "NCT01366963",
      "title": "Cognitive Dysfunction in Postural Tachycardia Syndrome",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Postural Tachycardia Syndrome"
      ],
      "interventions": [
        {
          "name": "Seated Measurements",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Standing Measurements",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Self-Administered Surveys",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Vanderbilt University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "60 Years",
        "sex": "ALL",
        "summary": "18 Years to 60 Years"
      },
      "enrollment_count": 60,
      "start_date": "2011-03",
      "completion_date": "2015-06",
      "has_results": false,
      "last_update_posted_date": "2016-08-17",
      "last_synced_at": "2026-06-26T02:22:18.095Z",
      "location_count": 1,
      "location_summary": "Nashville, Tennessee",
      "locations": [
        {
          "city": "Nashville",
          "state": "Tennessee"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01366963"
    },
    {
      "nct_id": "NCT03124355",
      "title": "Vagal Stimulation in POTS",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Postural Tachycardia Syndrome"
      ],
      "interventions": [
        {
          "name": "placebo sugar pill",
          "type": "DRUG"
        },
        {
          "name": "Pyridostigmine Pill",
          "type": "DRUG"
        },
        {
          "name": "Galantamine Pill",
          "type": "DRUG"
        },
        {
          "name": "Vagal stimulation",
          "type": "DEVICE"
        },
        {
          "name": "Sham vagal stimulation",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DRUG",
        "DEVICE"
      ],
      "sponsor": "Vanderbilt University Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "45 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 45 Years · Female only"
      },
      "enrollment_count": 11,
      "start_date": "2017-09-30",
      "completion_date": "2026-12",
      "has_results": false,
      "last_update_posted_date": "2025-08-05",
      "last_synced_at": "2026-06-26T02:22:18.095Z",
      "location_count": 1,
      "location_summary": "Nashville, Tennessee",
      "locations": [
        {
          "city": "Nashville",
          "state": "Tennessee"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03124355"
    },
    {
      "nct_id": "NCT01550315",
      "title": "Effect of Dietary Sodium Intake on Vascular Endothelium",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Postural Tachycardia Syndrome (POTS)"
      ],
      "interventions": [
        {
          "name": "Pulsitile Arterial Tonometry (PAT) Protocol",
          "type": "PROCEDURE"
        },
        {
          "name": "Calf Blood Flow in Reactive Hyperemia (CBF-RH)",
          "type": "DEVICE"
        },
        {
          "name": "Evaluation of Forearm-Mediated Dilation",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "PROCEDURE",
        "DEVICE"
      ],
      "sponsor": "Vanderbilt University Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "60 Years",
        "sex": "ALL",
        "summary": "18 Years to 60 Years"
      },
      "enrollment_count": 27,
      "start_date": "2012-04",
      "completion_date": "2021-09",
      "has_results": true,
      "last_update_posted_date": "2022-01-05",
      "last_synced_at": "2026-06-26T02:22:18.095Z",
      "location_count": 1,
      "location_summary": "Nashville, Tennessee",
      "locations": [
        {
          "city": "Nashville",
          "state": "Tennessee"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01550315"
    },
    {
      "nct_id": "NCT04050410",
      "title": "Autonomic Determinants of POTS - Pilot1",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "EARLY_PHASE1"
      ],
      "conditions": [
        "Postural Tachycardia Syndrome"
      ],
      "interventions": [
        {
          "name": "Moxonidine",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Vanderbilt University Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "55 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 55 Years · Female only"
      },
      "enrollment_count": 48,
      "start_date": "2019-08-27",
      "completion_date": "2026-12-31",
      "has_results": false,
      "last_update_posted_date": "2026-03-27",
      "last_synced_at": "2026-06-26T02:22:18.095Z",
      "location_count": 1,
      "location_summary": "Nashville, Tennessee",
      "locations": [
        {
          "city": "Nashville",
          "state": "Tennessee"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04050410"
    },
    {
      "nct_id": "NCT00608725",
      "title": "Pathophysiology of Orthostatic Intolerance",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Tachycardia",
        "Postural Orthostatic Tachycardia Syndrome"
      ],
      "interventions": [
        {
          "name": "DAXOR",
          "type": "RADIATION"
        },
        {
          "name": "QSweat",
          "type": "PROCEDURE"
        },
        {
          "name": "Intrinsic Heart Rate",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "RADIATION",
        "PROCEDURE",
        "DRUG"
      ],
      "sponsor": "Satish R. Raj",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 260,
      "start_date": "1996-12",
      "completion_date": "2029-12",
      "has_results": false,
      "last_update_posted_date": "2025-10-08",
      "last_synced_at": "2026-06-26T02:22:18.095Z",
      "location_count": 1,
      "location_summary": "Nashville, Tennessee",
      "locations": [
        {
          "city": "Nashville",
          "state": "Tennessee"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00608725"
    },
    {
      "nct_id": "NCT07197905",
      "title": "Restoring Iron Deficiency in POTS",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "POTS - Postural Orthostatic Tachycardia Syndrome"
      ],
      "interventions": [
        {
          "name": "Intravenous iron",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Vanderbilt University Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "45 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 45 Years · Female only"
      },
      "enrollment_count": 12,
      "start_date": "2025-11-24",
      "completion_date": "2026-12",
      "has_results": false,
      "last_update_posted_date": "2025-12-11",
      "last_synced_at": "2026-06-26T02:22:18.095Z",
      "location_count": 1,
      "location_summary": "Nashville, Tennessee",
      "locations": [
        {
          "city": "Nashville",
          "state": "Tennessee"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07197905"
    },
    {
      "nct_id": "NCT07189936",
      "title": "Effect of 2-HOBA in Persistent Immune Activation in Long COVID POTS",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Post-Acute COVID-19 Syndrome",
        "Postural Tachycardia Syndrome (POTS)",
        "SARS CoV 2 Infection",
        "Long COVID19"
      ],
      "interventions": [
        {
          "name": "To Measure levels of circulating monocyte/ T cell doublets at Baseline",
          "type": "DRUG"
        },
        {
          "name": "To measure levels of circulating monocyte/ T cell doublets after 28 days of 2 HOBA treatment",
          "type": "DRUG"
        },
        {
          "name": "To measure levels of circulating monocyte/ T cell doublets after 28 days of Placebo treatment",
          "type": "DRUG"
        },
        {
          "name": "To Measure Splanchnic venous capacitance after 28 days of Treatment with 2HOBA",
          "type": "DIAGNOSTIC_TEST"
        },
        {
          "name": "To Measure Splanchnic venous capacitance after 28 days of Treatment with Placebo",
          "type": "DIAGNOSTIC_TEST"
        },
        {
          "name": "To Measure Orthostatic Tachycardia after 28 days of Treatment with 2HOBA",
          "type": "DIAGNOSTIC_TEST"
        },
        {
          "name": "To Measure Orthostatic Tachycardia after 28 days of Treatment with Placebo",
          "type": "DIAGNOSTIC_TEST"
        }
      ],
      "intervention_types": [
        "DRUG",
        "DIAGNOSTIC_TEST"
      ],
      "sponsor": "Vanderbilt University Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 50,
      "start_date": "2025-12-18",
      "completion_date": "2029-06-30",
      "has_results": false,
      "last_update_posted_date": "2026-01-22",
      "last_synced_at": "2026-06-26T02:22:18.095Z",
      "location_count": 1,
      "location_summary": "Nashville, Tennessee",
      "locations": [
        {
          "city": "Nashville",
          "state": "Tennessee"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07189936"
    }
  ]
}