{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Premature+Rupture+of+Membrane&page=2",
    "query": {
      "condition": "Premature Rupture of Membrane",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Premature+Rupture+of+Membrane&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-05-22T08:16:15.165Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT00342277",
      "title": "Microarray Expression Profiling to Identify Stereotypic mRNA Profiles in Human Parturition",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Preterm Birth",
        "Premature Rupture of Membranes"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)",
      "sponsor_class": "NIH",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 6838,
      "start_date": "1999-12-21",
      "completion_date": "2016-05-05",
      "has_results": false,
      "last_update_posted_date": "2023-02-24",
      "last_synced_at": "2026-05-22T08:16:15.165Z",
      "location_count": 1,
      "location_summary": "Detroit, Michigan",
      "locations": [
        {
          "city": "Detroit",
          "state": "Michigan"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00342277"
    },
    {
      "nct_id": "NCT04318470",
      "title": "Identification of Microbial DNA in Maternal Plasma After PPROM",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Preterm Rupture of Membranes"
      ],
      "interventions": [
        {
          "name": "mNGS",
          "type": "DIAGNOSTIC_TEST"
        }
      ],
      "intervention_types": [
        "DIAGNOSTIC_TEST"
      ],
      "sponsor": "University of California, San Francisco",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "55 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 55 Years · Female only"
      },
      "enrollment_count": 70,
      "start_date": "2020-02-12",
      "completion_date": "2022-12-31",
      "has_results": false,
      "last_update_posted_date": "2023-04-07",
      "last_synced_at": "2026-05-22T08:16:15.165Z",
      "location_count": 1,
      "location_summary": "San Francisco, California",
      "locations": [
        {
          "city": "San Francisco",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04318470"
    },
    {
      "nct_id": "NCT04478942",
      "title": "PROMMO Trial: Oral Misoprostol vs IV Oxytocin",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "EARLY_PHASE1"
      ],
      "conditions": [
        "Premature Rupture of Membrane",
        "Induction of Labor Affected Fetus / Newborn"
      ],
      "interventions": [
        {
          "name": "Misoprostol Oral Product",
          "type": "DRUG"
        },
        {
          "name": "Intravenous Oxytocin",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Wisconsin, Madison",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 138,
      "start_date": "2020-10-26",
      "completion_date": "2025-01-14",
      "has_results": false,
      "last_update_posted_date": "2025-08-28",
      "last_synced_at": "2026-05-22T08:16:15.165Z",
      "location_count": 1,
      "location_summary": "Madison, Wisconsin",
      "locations": [
        {
          "city": "Madison",
          "state": "Wisconsin"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04478942"
    },
    {
      "nct_id": "NCT06396078",
      "title": "Improvement of PPROM Management With Prophylactic Antimicrobial Therapy (iPROMPT)",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Preterm Premature Rupture of Membrane",
        "Pregnancy, High Risk",
        "Preterm Birth"
      ],
      "interventions": [
        {
          "name": "Ceftriaxone 1000 MG",
          "type": "DRUG"
        },
        {
          "name": "Clarithromycin 500mg",
          "type": "DRUG"
        },
        {
          "name": "Metronidazole 500 mg",
          "type": "DRUG"
        },
        {
          "name": "Ampicillin 2 GM Injection",
          "type": "DRUG"
        },
        {
          "name": "Amoxicillin 250 MG",
          "type": "DRUG"
        },
        {
          "name": "Azithromycin",
          "type": "DRUG"
        },
        {
          "name": "Erythromycin",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Ohio State University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 56,
      "start_date": "2024-07-18",
      "completion_date": "2026-12",
      "has_results": false,
      "last_update_posted_date": "2026-01-27",
      "last_synced_at": "2026-05-22T08:16:15.165Z",
      "location_count": 2,
      "location_summary": "Columbus, Ohio • Galveston, Texas",
      "locations": [
        {
          "city": "Columbus",
          "state": "Ohio"
        },
        {
          "city": "Galveston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06396078"
    },
    {
      "nct_id": "NCT04516226",
      "title": "Vaginal Cleansing With Chlorhexidine Gluconate in Women With Preterm Pre-labor Rupture of Membranes",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Preterm Premature Rupture of Membrane"
      ],
      "interventions": [
        {
          "name": "Vaginal cleansing with chlorhexidine gluconate solution",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Albany Medical College",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "50 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 50 Years · Female only"
      },
      "enrollment_count": 40,
      "start_date": "2020-08-01",
      "completion_date": "2024-12-31",
      "has_results": false,
      "last_update_posted_date": "2023-04-18",
      "last_synced_at": "2026-05-22T08:16:15.165Z",
      "location_count": 1,
      "location_summary": "Albany, New York",
      "locations": [
        {
          "city": "Albany",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04516226"
    },
    {
      "nct_id": "NCT01852188",
      "title": "Intrapartum Study of Sterile and Clean Gloves",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Chorioamnionitis"
      ],
      "interventions": [
        {
          "name": "Type of glove used for intrapartum vaginal exams",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Medical University of South Carolina",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 507,
      "start_date": "2011-05",
      "completion_date": "2014-11-02",
      "has_results": false,
      "last_update_posted_date": "2018-05-18",
      "last_synced_at": "2026-05-22T08:16:15.165Z",
      "location_count": 1,
      "location_summary": "Charleston, South Carolina",
      "locations": [
        {
          "city": "Charleston",
          "state": "South Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01852188"
    },
    {
      "nct_id": "NCT01050647",
      "title": "Progesterone for the Management of Preterm, Premature Rupture of the Membranes: A Randomized Controlled Trial.",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Pregnancy Complications"
      ],
      "interventions": [
        {
          "name": "17-Hydroxyprogesterone Caproate",
          "type": "DRUG"
        },
        {
          "name": "Caster Oil injections",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "Stanford University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "Female only"
      },
      "enrollment_count": 21,
      "start_date": "2010-02",
      "completion_date": "2015-12",
      "has_results": true,
      "last_update_posted_date": "2019-04-09",
      "last_synced_at": "2026-05-22T08:16:15.165Z",
      "location_count": 2,
      "location_summary": "San Jose, California • Stanford, California",
      "locations": [
        {
          "city": "San Jose",
          "state": "California"
        },
        {
          "city": "Stanford",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01050647"
    },
    {
      "nct_id": "NCT02469519",
      "title": "Impact of a Booster Course of Antenatal Steroids on Neonatal Outcome in Patients With Premature Rupture of the Membranes",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2",
        "PHASE3"
      ],
      "conditions": [
        "Premature Birth"
      ],
      "interventions": [
        {
          "name": "Betamethasone - ACTIVE",
          "type": "DRUG"
        },
        {
          "name": "Normal Saline - PLACEBO",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "Pediatrix",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 65 Years · Female only"
      },
      "enrollment_count": 194,
      "start_date": "2016-03-03",
      "completion_date": "2022-10-31",
      "has_results": false,
      "last_update_posted_date": "2022-12-15",
      "last_synced_at": "2026-05-22T08:16:15.165Z",
      "location_count": 9,
      "location_summary": "Mobile, Alabama • Phoenix, Arizona • Long Beach, California + 6 more",
      "locations": [
        {
          "city": "Mobile",
          "state": "Alabama"
        },
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Long Beach",
          "state": "California"
        },
        {
          "city": "San Jose",
          "state": "California"
        },
        {
          "city": "Denver",
          "state": "Colorado"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02469519"
    },
    {
      "nct_id": "NCT00021671",
      "title": "Antibiotics to Reduce Chorioamnionitis-Related Perinatal HIV Transmission",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "HIV Infections"
      ],
      "interventions": [
        {
          "name": "Erythromycin",
          "type": "DRUG"
        },
        {
          "name": "Nevirapine",
          "type": "DRUG"
        },
        {
          "name": "Ampicillin sodium",
          "type": "DRUG"
        },
        {
          "name": "Metronidazole",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "National Institute of Allergy and Infectious Diseases (NIAID)",
      "sponsor_class": "NIH",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "Female only"
      },
      "enrollment_count": 3720,
      "start_date": null,
      "completion_date": "2004-11",
      "has_results": false,
      "last_update_posted_date": "2021-11-01",
      "last_synced_at": "2026-05-22T08:16:15.165Z",
      "location_count": 1,
      "location_summary": "Research Triangle Park, North Carolina",
      "locations": [
        {
          "city": "Research Triangle Park",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00021671"
    },
    {
      "nct_id": "NCT03060473",
      "title": "Treatment of ppROM With Erythromycin vs. Azithromycin Trial",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Preterm Premature Rupture of Membranes (PPROM)"
      ],
      "interventions": [
        {
          "name": "Azithromycin",
          "type": "DRUG"
        },
        {
          "name": "Erythromycin",
          "type": "DRUG"
        },
        {
          "name": "Ampicillin",
          "type": "DRUG"
        },
        {
          "name": "Amoxicillin",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "The University of Texas Medical Branch, Galveston",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 21,
      "start_date": "2017-02-23",
      "completion_date": "2023-12-08",
      "has_results": true,
      "last_update_posted_date": "2024-06-25",
      "last_synced_at": "2026-05-22T08:16:15.165Z",
      "location_count": 3,
      "location_summary": "Austin, Texas • Galveston, Texas • Salt Lake City, Utah",
      "locations": [
        {
          "city": "Austin",
          "state": "Texas"
        },
        {
          "city": "Galveston",
          "state": "Texas"
        },
        {
          "city": "Salt Lake City",
          "state": "Utah"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03060473"
    }
  ]
}