{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Prescribing%2C+Off-Label",
    "query": {
      "condition": "Prescribing, Off-Label"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 27,
    "total_pages": 3,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Prescribing%2C+Off-Label&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-03T03:22:58.968Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT05172687",
      "title": "The Effect of De-Prescribing Antipsychotics on Health and Quality of Life for People With Dementia",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Alzheimer Disease",
        "Dementia",
        "Prescribing, Off-Label"
      ],
      "interventions": [
        {
          "name": "Overprescribing letter to attributed physician",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Placebo letter to attributed physician",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Columbia University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 336460,
      "start_date": "2015-04",
      "completion_date": "2018-12-31",
      "has_results": false,
      "last_update_posted_date": "2024-02-13",
      "last_synced_at": "2026-09-03T03:22:58.968Z",
      "location_count": 3,
      "location_summary": "Boston, Massachusetts • Cambridge, Massachusetts • New York, New York",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "Cambridge",
          "state": "Massachusetts"
        },
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05172687"
    },
    {
      "nct_id": "NCT06006143",
      "title": "Off-Label Medications for Alcohol Use Disorder Among Patients With HIV: Pilot Study 2",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Alcohol Use Disorder",
        "Hiv",
        "Tobacco Use Disorder"
      ],
      "interventions": [
        {
          "name": "Varenicline",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Yale University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 30,
      "start_date": "2025-06-16",
      "completion_date": "2026-08-31",
      "has_results": false,
      "last_update_posted_date": "2026-04-16",
      "last_synced_at": "2026-09-03T03:22:58.968Z",
      "location_count": 1,
      "location_summary": "Decatur, Georgia",
      "locations": [
        {
          "city": "Decatur",
          "state": "Georgia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06006143"
    },
    {
      "nct_id": "NCT04565977",
      "title": "Evaluating Off-label Use of Direct Oral Anticoagulants (DOACs) in Hypercoagulable States",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Hypercoagulable States"
      ],
      "interventions": [
        {
          "name": "Observational",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Methodist Health System",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 42,
      "start_date": "2020-07-01",
      "completion_date": "2021-06-10",
      "has_results": false,
      "last_update_posted_date": "2024-11-20",
      "last_synced_at": "2026-09-03T03:22:58.968Z",
      "location_count": 1,
      "location_summary": "Dallas, Texas",
      "locations": [
        {
          "city": "Dallas",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04565977"
    },
    {
      "nct_id": "NCT04884763",
      "title": "Safety and Efficacy of Erenumab-aooe in Patients With Temporomandibular Disorder",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Temporomandibular Disorder"
      ],
      "interventions": [
        {
          "name": "Erenumab-aooe (EREN) 140 mg s.c. administered every four weeks for a total of five treatments",
          "type": "DRUG"
        },
        {
          "name": "Placebo (EREN-P) s.c. administered every four weeks for a total of five treatments",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Indiana University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "59 Years",
        "sex": "ALL",
        "summary": "18 Years to 59 Years"
      },
      "enrollment_count": 30,
      "start_date": "2021-11-15",
      "completion_date": "2024-01-04",
      "has_results": true,
      "last_update_posted_date": "2025-08-19",
      "last_synced_at": "2026-09-03T03:22:58.968Z",
      "location_count": 1,
      "location_summary": "Indianapolis, Indiana",
      "locations": [
        {
          "city": "Indianapolis",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04884763"
    },
    {
      "nct_id": "NCT01286519",
      "title": "Pharmacokinetics of Off Label Pediatric Medications",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Off Label Use of Medications in Pediatric Patients"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "University of North Carolina, Chapel Hill",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "1 Day",
        "maximum_age": "8 Years",
        "sex": "ALL",
        "summary": "1 Day to 8 Years"
      },
      "enrollment_count": 400,
      "start_date": "2010-07",
      "completion_date": "2035-12",
      "has_results": false,
      "last_update_posted_date": "2026-07-01",
      "last_synced_at": "2026-09-03T03:22:58.968Z",
      "location_count": 1,
      "location_summary": "Chapel Hill, North Carolina",
      "locations": [
        {
          "city": "Chapel Hill",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01286519"
    },
    {
      "nct_id": "NCT04918914",
      "title": "Critical Care Results of SARS-CoV-2 ARDS by Dapsone and Standard COVID-19 Treatment",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "EARLY_PHASE1"
      ],
      "conditions": [
        "SARS-CoV-2",
        "Hypoxia",
        "ARDS"
      ],
      "interventions": [
        {
          "name": "Dapsone 100 MG",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Hunt Regional Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "100 Years",
        "sex": "ALL",
        "summary": "18 Years to 100 Years"
      },
      "enrollment_count": 100,
      "start_date": "2020-10-18",
      "completion_date": "2021-12-31",
      "has_results": false,
      "last_update_posted_date": "2021-06-09",
      "last_synced_at": "2026-09-03T03:22:58.968Z",
      "location_count": 1,
      "location_summary": "Greenville, Texas",
      "locations": [
        {
          "city": "Greenville",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04918914"
    },
    {
      "nct_id": "NCT04090684",
      "title": "Ciprofloxacin/Celecoxib Combination in Patients With ALS",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "ALS (Amyotrophic Lateral Sclerosis)"
      ],
      "interventions": [
        {
          "name": "Fixed dose combination Ciprofloxacin/Celecoxib",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "NeuroSense Therapeutics Ltd.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "18 Years to 75 Years"
      },
      "enrollment_count": 10,
      "start_date": "2019-12-09",
      "completion_date": "2022-01-20",
      "has_results": false,
      "last_update_posted_date": "2022-02-01",
      "last_synced_at": "2026-09-03T03:22:58.968Z",
      "location_count": 1,
      "location_summary": "Phoenix, Arizona",
      "locations": [
        {
          "city": "Phoenix",
          "state": "Arizona"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04090684"
    },
    {
      "nct_id": "NCT01347619",
      "title": "iADAPT: Off Label Use of Antipsychotics in the Nursing Home",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Off-label Use of Atypical Antipsychotic Drugs"
      ],
      "interventions": [
        {
          "name": "Toolkit only with Web Access to Online Version",
          "type": "OTHER"
        },
        {
          "name": "Toolkit, Periodic Audit/Feedback, Educational Messages",
          "type": "OTHER"
        },
        {
          "name": "Items in Arm 2 plus Academic Detailing Program",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Massachusetts, Worcester",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 42,
      "start_date": "2010-11",
      "completion_date": "2013-09",
      "has_results": false,
      "last_update_posted_date": "2014-04-01",
      "last_synced_at": "2026-09-03T03:22:58.968Z",
      "location_count": 1,
      "location_summary": "Rocky Hill, Connecticut",
      "locations": [
        {
          "city": "Rocky Hill",
          "state": "Connecticut"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01347619"
    },
    {
      "nct_id": "NCT04435808",
      "title": "Efficacy of Hydroxychloroquine Prophylaxis for Health Care Workers at High Risk for COVID-19",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "COVID-19"
      ],
      "interventions": [
        {
          "name": "Hydroxychloroquine",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of New Mexico",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 1,
      "start_date": "2020-04-14",
      "completion_date": "2020-07-15",
      "has_results": true,
      "last_update_posted_date": "2022-02-14",
      "last_synced_at": "2026-09-03T03:22:58.968Z",
      "location_count": 1,
      "location_summary": "Albuquerque, New Mexico",
      "locations": [
        {
          "city": "Albuquerque",
          "state": "New Mexico"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04435808"
    },
    {
      "nct_id": "NCT00419380",
      "title": "Treatment of Clogged Tympanostomy Tubes: An Off-Label Use of Dornase Alfa (Pulmozyme®)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Otitis Media"
      ],
      "interventions": [
        {
          "name": "dornase alfa (Pulmozyme®)",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Colorado, Denver",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "1 Year",
        "maximum_age": "18 Years",
        "sex": "ALL",
        "summary": "1 Year to 18 Years"
      },
      "enrollment_count": 41,
      "start_date": "2007-01",
      "completion_date": "2011-05",
      "has_results": true,
      "last_update_posted_date": "2026-06-08",
      "last_synced_at": "2026-09-03T03:22:58.968Z",
      "location_count": 1,
      "location_summary": "Denver, Colorado",
      "locations": [
        {
          "city": "Denver",
          "state": "Colorado"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00419380"
    }
  ]
}