{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Prescription+Drug+Misuse",
    "query": {
      "condition": "Prescription Drug Misuse"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 134,
    "total_pages": 14,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Prescription+Drug+Misuse&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-07-24T06:06:01.749Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT06005402",
      "title": "Safety, Tolerability, and Pharmacokinetics of CSX-1004",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Opioid Overdose",
        "Opioid Use Disorder"
      ],
      "interventions": [
        {
          "name": "CSX-1004",
          "type": "BIOLOGICAL"
        },
        {
          "name": "Placebo",
          "type": "BIOLOGICAL"
        }
      ],
      "intervention_types": [
        "BIOLOGICAL"
      ],
      "sponsor": "Cessation Therapeutics, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "50 Years",
        "sex": "ALL",
        "summary": "18 Years to 50 Years"
      },
      "enrollment_count": 32,
      "start_date": "2023-08-01",
      "completion_date": "2024-05-28",
      "has_results": false,
      "last_update_posted_date": "2024-08-21",
      "last_synced_at": "2026-07-24T06:06:01.749Z",
      "location_count": 1,
      "location_summary": "Overland Park, Kansas",
      "locations": [
        {
          "city": "Overland Park",
          "state": "Kansas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06005402"
    },
    {
      "nct_id": "NCT05377255",
      "title": "Pharmacokinetics (PK) and Safety of Multiple Doses of Intranasal Naloxone in Healthy Adults",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Opioid Overdose"
      ],
      "interventions": [
        {
          "name": "16 mg naloxone AP003",
          "type": "COMBINATION_PRODUCT"
        },
        {
          "name": "8 mg naloxone NARCAN Nasal Spray",
          "type": "COMBINATION_PRODUCT"
        }
      ],
      "intervention_types": [
        "COMBINATION_PRODUCT"
      ],
      "sponsor": "Emergent BioSolutions",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "55 Years",
        "sex": "ALL",
        "summary": "18 Years to 55 Years"
      },
      "enrollment_count": 24,
      "start_date": "2022-03-28",
      "completion_date": "2022-05-10",
      "has_results": false,
      "last_update_posted_date": "2026-04-15",
      "last_synced_at": "2026-07-24T06:06:01.749Z",
      "location_count": 1,
      "location_summary": "Miami, Florida",
      "locations": [
        {
          "city": "Miami",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05377255"
    },
    {
      "nct_id": "NCT05362357",
      "title": "iSTART: A Campus & Community Initiative for Services in Tec-health",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Substance Use",
        "Binge Drinking",
        "Marijuana Use",
        "Alcohol Drinking",
        "Prescription Opioid Misuse",
        "Illicit Drug Use"
      ],
      "interventions": [
        {
          "name": "iSTART Web-app",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "California State University, Northridge",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "30 Years",
        "sex": "ALL",
        "summary": "18 Years to 30 Years"
      },
      "enrollment_count": 1100,
      "start_date": "2021-02-20",
      "completion_date": "2023-12-04",
      "has_results": false,
      "last_update_posted_date": "2024-02-07",
      "last_synced_at": "2026-07-24T06:06:01.749Z",
      "location_count": 1,
      "location_summary": "Northridge, California",
      "locations": [
        {
          "city": "Northridge",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05362357"
    },
    {
      "nct_id": "NCT05657106",
      "title": "Kentucky Outreach Service Kiosk (KyOSK): Reducing HIV, HCV, and Overdose Risk",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Opioid-Related Disorders",
        "Hepatitis C (HCV)",
        "Human Immunodeficiency Virus (HIV)",
        "Drug Overdose",
        "Substance Abuse",
        "Intravenous Drug Usage",
        "Opiate Substitution Treatment",
        "Sexually Transmitted Diseases"
      ],
      "interventions": [
        {
          "name": "Harm reduction kiosk",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "April M Young",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 752,
      "start_date": "2023-03-06",
      "completion_date": "2027-07-31",
      "has_results": false,
      "last_update_posted_date": "2026-05-06",
      "last_synced_at": "2026-07-24T06:06:01.749Z",
      "location_count": 1,
      "location_summary": "Lexington, Kentucky",
      "locations": [
        {
          "city": "Lexington",
          "state": "Kentucky"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05657106"
    },
    {
      "nct_id": "NCT06238128",
      "title": "Opioid Rapid Response System: Naloxone Training in Communities",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Opioid Overdose"
      ],
      "interventions": [
        {
          "name": "Opioid Rapid Resonse System (ORRS) training",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Non-active opioid overdose response training",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "University of Missouri-Columbia",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "100 Years",
        "sex": "ALL",
        "summary": "18 Years to 100 Years"
      },
      "enrollment_count": 773,
      "start_date": "2024-05-24",
      "completion_date": "2025-12-29",
      "has_results": true,
      "last_update_posted_date": "2026-07-07",
      "last_synced_at": "2026-07-24T06:06:01.749Z",
      "location_count": 1,
      "location_summary": "San Francisco, California",
      "locations": [
        {
          "city": "San Francisco",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06238128"
    },
    {
      "nct_id": "NCT04134767",
      "title": "Kentucky Communities and Researchers Engaging to Halt the Opioid Epidemic (CARE2HOPE)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Substance Use",
        "HIV Infections",
        "HCV Infection",
        "Sexually Transmitted Infections (Not HIV or Hepatitis)",
        "Overdose, Drug",
        "Opioid Use"
      ],
      "interventions": [
        {
          "name": "Health Linkage",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Overdose Education",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "April M Young",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 234,
      "start_date": "2019-11-15",
      "completion_date": "2022-10-27",
      "has_results": true,
      "last_update_posted_date": "2023-12-21",
      "last_synced_at": "2026-07-24T06:06:01.749Z",
      "location_count": 1,
      "location_summary": "Lexington, Kentucky",
      "locations": [
        {
          "city": "Lexington",
          "state": "Kentucky"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04134767"
    },
    {
      "nct_id": "NCT02464410",
      "title": "Primary Care Intervention to Reduce Prescription Opioid Overdoses",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Pain",
        "Drug Overdose",
        "Opioid Use Disorders"
      ],
      "interventions": [
        {
          "name": "Motivational intervention",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Psycho-educational control",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Long-term opioid therapy informed consent",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL",
        "OTHER"
      ],
      "sponsor": "VA Office of Research and Development",
      "sponsor_class": "FED",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 299,
      "start_date": "2016-08-04",
      "completion_date": "2021-03-31",
      "has_results": true,
      "last_update_posted_date": "2023-07-27",
      "last_synced_at": "2026-07-24T06:06:01.749Z",
      "location_count": 1,
      "location_summary": "Ann Arbor, Michigan",
      "locations": [
        {
          "city": "Ann Arbor",
          "state": "Michigan"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02464410"
    },
    {
      "nct_id": "NCT04317053",
      "title": "Multi-Center Randomized Controlled Trial of Relay- NYC's Nonfatal Overdose Response Program",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Opioid Overdose"
      ],
      "interventions": [
        {
          "name": "RELAY",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "NYU Langone Health",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "99 Years",
        "sex": "ALL",
        "summary": "18 Years to 99 Years"
      },
      "enrollment_count": 253,
      "start_date": "2020-10-08",
      "completion_date": "2023-07-01",
      "has_results": true,
      "last_update_posted_date": "2024-11-25",
      "last_synced_at": "2026-07-24T06:06:01.749Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04317053"
    },
    {
      "nct_id": "NCT04301895",
      "title": "Pupillary Unrest in Ambient Light, and Relationship to Opioid-Induced Respiratory Depression",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Opioid; Intoxication, Perception Disturbance (Acute)",
        "Acute Pain",
        "Overdose of Opiate",
        "Respiratory Depression",
        "Safety Issues"
      ],
      "interventions": [
        {
          "name": "Continuous conversational interaction",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Remifentanil infusion",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL",
        "DRUG"
      ],
      "sponsor": "University of California, San Francisco",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "20 Years",
        "maximum_age": "55 Years",
        "sex": "ALL",
        "summary": "20 Years to 55 Years"
      },
      "enrollment_count": 20,
      "start_date": "2019-04-30",
      "completion_date": "2019-09-03",
      "has_results": false,
      "last_update_posted_date": "2020-03-10",
      "last_synced_at": "2026-07-24T06:06:01.749Z",
      "location_count": 1,
      "location_summary": "San Francisco, California",
      "locations": [
        {
          "city": "San Francisco",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04301895"
    },
    {
      "nct_id": "NCT06429436",
      "title": "Vending Machine Naloxone Distribution for Your Community (VENDY)",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Harm Reduction",
        "Naloxone",
        "Opioid Overdose"
      ],
      "interventions": [
        {
          "name": "VENDY",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "University of Colorado, Denver",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 4000,
      "start_date": "2024-06-01",
      "completion_date": "2026-06-30",
      "has_results": false,
      "last_update_posted_date": "2026-06-02",
      "last_synced_at": "2026-07-24T06:06:01.749Z",
      "location_count": 3,
      "location_summary": "Denver, Colorado • Frisco, Colorado • Pueblo, Colorado",
      "locations": [
        {
          "city": "Denver",
          "state": "Colorado"
        },
        {
          "city": "Frisco",
          "state": "Colorado"
        },
        {
          "city": "Pueblo",
          "state": "Colorado"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06429436"
    }
  ]
}