{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Preterm+Prelabor+Rupture+of+Membranes",
    "query": {
      "condition": "Preterm Prelabor Rupture of Membranes"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 55,
    "total_pages": 6,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Preterm+Prelabor+Rupture+of+Membranes&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-06-26T15:04:08.780Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT00326521",
      "title": "Evaluation of Fever Occurring in Labor in Patients Receiving Epidural Anesthesia",
      "overall_status": "UNKNOWN",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Fever"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "MemorialCare",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 50,
      "start_date": "2006-10",
      "completion_date": "2009-05",
      "has_results": false,
      "last_update_posted_date": "2008-06-06",
      "last_synced_at": "2026-06-26T15:04:08.780Z",
      "location_count": 2,
      "location_summary": "Long Beach, California • Orange, California",
      "locations": [
        {
          "city": "Long Beach",
          "state": "California"
        },
        {
          "city": "Orange",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00326521"
    },
    {
      "nct_id": "NCT02469519",
      "title": "Impact of a Booster Course of Antenatal Steroids on Neonatal Outcome in Patients With Premature Rupture of the Membranes",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2",
        "PHASE3"
      ],
      "conditions": [
        "Premature Birth"
      ],
      "interventions": [
        {
          "name": "Betamethasone - ACTIVE",
          "type": "DRUG"
        },
        {
          "name": "Normal Saline - PLACEBO",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "Pediatrix",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 65 Years · Female only"
      },
      "enrollment_count": 194,
      "start_date": "2016-03-03",
      "completion_date": "2022-10-31",
      "has_results": false,
      "last_update_posted_date": "2022-12-15",
      "last_synced_at": "2026-06-26T15:04:08.780Z",
      "location_count": 9,
      "location_summary": "Mobile, Alabama • Phoenix, Arizona • Long Beach, California + 6 more",
      "locations": [
        {
          "city": "Mobile",
          "state": "Alabama"
        },
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Long Beach",
          "state": "California"
        },
        {
          "city": "San Jose",
          "state": "California"
        },
        {
          "city": "Denver",
          "state": "Colorado"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02469519"
    },
    {
      "nct_id": "NCT06074601",
      "title": "MIRACLE of LIFE Study",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Preterm Labor",
        "Preterm Birth",
        "Preterm Birth Complication",
        "Preterm Premature Rupture of Membrane",
        "Preeclampsia",
        "HELLP",
        "Gestational Hypertension",
        "Gestational Diabetes Mellitus in Pregnancy",
        "Small for Gestational Age at Delivery",
        "Intrauterine Growth Restriction"
      ],
      "interventions": [
        {
          "name": "Mirvie Predictive Test for Adverse Pregnancy Outcomes",
          "type": "DIAGNOSTIC_TEST"
        }
      ],
      "intervention_types": [
        "DIAGNOSTIC_TEST"
      ],
      "sponsor": "Mirvie",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": null,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 10000,
      "start_date": "2021-08-01",
      "completion_date": "2025-12-31",
      "has_results": false,
      "last_update_posted_date": "2024-11-27",
      "last_synced_at": "2026-06-26T15:04:08.780Z",
      "location_count": 10,
      "location_summary": "San Diego, California • Orlando, Florida • New Orleans, Louisiana + 7 more",
      "locations": [
        {
          "city": "San Diego",
          "state": "California"
        },
        {
          "city": "Orlando",
          "state": "Florida"
        },
        {
          "city": "New Orleans",
          "state": "Louisiana"
        },
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "St Louis",
          "state": "Missouri"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06074601"
    },
    {
      "nct_id": "NCT04451109",
      "title": "Dilapan-S®: A Multicenter US E-registry",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Post Term Pregnancy",
        "Premature Rupture of Membrane",
        "Fetal Growth Retardation",
        "Oligohydramnios",
        "Gestational Diabetes",
        "High Blood Pressure in Pregnancy"
      ],
      "interventions": [
        {
          "name": "Dilapan-S",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Medicem Technology s.r.o.",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 1200,
      "start_date": "2020-12-01",
      "completion_date": "2025-06-30",
      "has_results": false,
      "last_update_posted_date": "2024-11-22",
      "last_synced_at": "2026-06-26T15:04:08.780Z",
      "location_count": 1,
      "location_summary": "Galveston, Texas",
      "locations": [
        {
          "city": "Galveston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04451109"
    },
    {
      "nct_id": "NCT00397735",
      "title": "N-acetylcysteine in Intra-amniotic Infection/Inflammation",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Labor, Premature",
        "Preterm Premature Rupture of the Membranes",
        "Infection",
        "Inflammation",
        "Chorioamnionitis"
      ],
      "interventions": [
        {
          "name": "amniocentesis",
          "type": "PROCEDURE"
        },
        {
          "name": "N-acetylcysteine or placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "PROCEDURE",
        "DRUG"
      ],
      "sponsor": "Ohio State University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 68,
      "start_date": "2006-10-01",
      "completion_date": "2018-08-01",
      "has_results": false,
      "last_update_posted_date": "2018-10-10",
      "last_synced_at": "2026-06-26T15:04:08.780Z",
      "location_count": 2,
      "location_summary": "New Haven, Connecticut • Columbus, Ohio",
      "locations": [
        {
          "city": "New Haven",
          "state": "Connecticut"
        },
        {
          "city": "Columbus",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00397735"
    },
    {
      "nct_id": "NCT05893485",
      "title": "Physiological and Psychological Effects of Music Therapy in the Pregnant Woman and Fetus",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Music Therapy",
        "Preterm Premature Rupture of Membrane (PPROM)"
      ],
      "interventions": [
        {
          "name": "Music Therapy Intervention",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Christina Chianis Reed",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "64 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 64 Years · Female only"
      },
      "enrollment_count": 60,
      "start_date": "2023-05-15",
      "completion_date": "2026-03-01",
      "has_results": false,
      "last_update_posted_date": "2024-09-19",
      "last_synced_at": "2026-06-26T15:04:08.780Z",
      "location_count": 1,
      "location_summary": "Houston, Texas",
      "locations": [
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05893485"
    },
    {
      "nct_id": "NCT00294242",
      "title": "Safety Study of Membrane Sweeping in Pregnancy",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Pregnancy",
        "Prelabor Rupture of Membranes"
      ],
      "interventions": [
        {
          "name": "Membrane Sweep",
          "type": "PROCEDURE"
        },
        {
          "name": "No Membrane Sweep",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Tripler Army Medical Center",
      "sponsor_class": "FED",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "50 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 50 Years · Female only"
      },
      "enrollment_count": 300,
      "start_date": "2006-02",
      "completion_date": "2007-05",
      "has_results": false,
      "last_update_posted_date": "2025-02-11",
      "last_synced_at": "2026-06-26T15:04:08.780Z",
      "location_count": 1,
      "location_summary": "Tripler AMC, Hawaii",
      "locations": [
        {
          "city": "Tripler AMC",
          "state": "Hawaii"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00294242"
    },
    {
      "nct_id": "NCT03133104",
      "title": "Repeat Antenatal Corticosteroids",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Antenatal Corticosteroids"
      ],
      "interventions": [
        {
          "name": "Antenatal corticosteroids",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "St. Louis University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "13 Years",
        "maximum_age": "55 Years",
        "sex": "FEMALE",
        "summary": "13 Years to 55 Years · Female only"
      },
      "enrollment_count": 182,
      "start_date": "2017-01-05",
      "completion_date": "2017-08",
      "has_results": false,
      "last_update_posted_date": "2017-11-29",
      "last_synced_at": "2026-06-26T15:04:08.780Z",
      "location_count": 1,
      "location_summary": "St Louis, Missouri",
      "locations": [
        {
          "city": "St Louis",
          "state": "Missouri"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03133104"
    },
    {
      "nct_id": "NCT00201656",
      "title": "Removal Versus Retention of Cerclage in Preterm Premature Rupture of Membranes (PPROM)",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Fetal Membranes, Premature Rupture"
      ],
      "interventions": [
        {
          "name": "Retention of Cerclage",
          "type": "PROCEDURE"
        },
        {
          "name": "Removal of Cerclage",
          "type": "PROCEDURE"
        },
        {
          "name": "Removal vs. Retention of Cervical Cerclage",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Obstetrix Medical Group",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "60 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 60 Years · Female only"
      },
      "enrollment_count": 58,
      "start_date": "2004-11",
      "completion_date": "2014-04",
      "has_results": false,
      "last_update_posted_date": "2014-12-19",
      "last_synced_at": "2026-06-26T15:04:08.780Z",
      "location_count": 23,
      "location_summary": "Mesa, Arizona • Phoenix, Arizona • Tucson, Arizona + 18 more",
      "locations": [
        {
          "city": "Mesa",
          "state": "Arizona"
        },
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Tucson",
          "state": "Arizona"
        },
        {
          "city": "Laguna Hills",
          "state": "California"
        },
        {
          "city": "Long Beach",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00201656"
    },
    {
      "nct_id": "NCT07610642",
      "title": "Amnioinfusion for Chorioamnionitis: Targeting Neonatal Brain Injury Biomarkers",
      "overall_status": "NOT_YET_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Chorioamnionitis Affecting Fetus or Newborn",
        "Amnioinfusion",
        "Neonatal Brain Injury"
      ],
      "interventions": [
        {
          "name": "Intrauterine Pressure Catheter",
          "type": "DEVICE"
        },
        {
          "name": "Standard obstetric care at discretion of delivery provider",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "OTHER"
      ],
      "sponsor": "Medical College of Wisconsin",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 80,
      "start_date": "2026-07-01",
      "completion_date": "2027-12",
      "has_results": false,
      "last_update_posted_date": "2026-05-29",
      "last_synced_at": "2026-06-26T15:04:08.780Z",
      "location_count": 1,
      "location_summary": "Milwaukee, Wisconsin",
      "locations": [
        {
          "city": "Milwaukee",
          "state": "Wisconsin"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07610642"
    }
  ]
}