{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Preterm+Premature+Rupture+of+Fetal+Membranes",
    "query": {
      "condition": "Preterm Premature Rupture of Fetal Membranes"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 55,
    "total_pages": 6,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Preterm+Premature+Rupture+of+Fetal+Membranes&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-07-23T10:15:28.377Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT03060473",
      "title": "Treatment of ppROM With Erythromycin vs. Azithromycin Trial",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Preterm Premature Rupture of Membranes (PPROM)"
      ],
      "interventions": [
        {
          "name": "Azithromycin",
          "type": "DRUG"
        },
        {
          "name": "Erythromycin",
          "type": "DRUG"
        },
        {
          "name": "Ampicillin",
          "type": "DRUG"
        },
        {
          "name": "Amoxicillin",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "The University of Texas Medical Branch, Galveston",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 21,
      "start_date": "2017-02-23",
      "completion_date": "2023-12-08",
      "has_results": true,
      "last_update_posted_date": "2024-06-25",
      "last_synced_at": "2026-07-23T10:15:28.377Z",
      "location_count": 3,
      "location_summary": "Austin, Texas • Galveston, Texas • Salt Lake City, Utah",
      "locations": [
        {
          "city": "Austin",
          "state": "Texas"
        },
        {
          "city": "Galveston",
          "state": "Texas"
        },
        {
          "city": "Salt Lake City",
          "state": "Utah"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03060473"
    },
    {
      "nct_id": "NCT01852188",
      "title": "Intrapartum Study of Sterile and Clean Gloves",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Chorioamnionitis"
      ],
      "interventions": [
        {
          "name": "Type of glove used for intrapartum vaginal exams",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Medical University of South Carolina",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 507,
      "start_date": "2011-05",
      "completion_date": "2014-11-02",
      "has_results": false,
      "last_update_posted_date": "2018-05-18",
      "last_synced_at": "2026-07-23T10:15:28.377Z",
      "location_count": 1,
      "location_summary": "Charleston, South Carolina",
      "locations": [
        {
          "city": "Charleston",
          "state": "South Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01852188"
    },
    {
      "nct_id": "NCT00342667",
      "title": "Clinical, Biochemical, Histological and Biophysical Parameters in the Prediction of Cerebral Palsy in Patients With Preterm Labor and Premature Rupture of Membranes",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Preterm Birth",
        "Pregnancy"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)",
      "sponsor_class": "NIH",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": "45 Years",
        "sex": "ALL",
        "summary": "Up to 45 Years"
      },
      "enrollment_count": 4673,
      "start_date": "1997-12-08",
      "completion_date": "2014-09-15",
      "has_results": false,
      "last_update_posted_date": "2023-02-24",
      "last_synced_at": "2026-07-23T10:15:28.377Z",
      "location_count": 2,
      "location_summary": "Bethesda, Maryland • Detroit, Michigan",
      "locations": [
        {
          "city": "Bethesda",
          "state": "Maryland"
        },
        {
          "city": "Detroit",
          "state": "Michigan"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00342667"
    },
    {
      "nct_id": "NCT00326521",
      "title": "Evaluation of Fever Occurring in Labor in Patients Receiving Epidural Anesthesia",
      "overall_status": "UNKNOWN",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Fever"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "MemorialCare",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 50,
      "start_date": "2006-10",
      "completion_date": "2009-05",
      "has_results": false,
      "last_update_posted_date": "2008-06-06",
      "last_synced_at": "2026-07-23T10:15:28.377Z",
      "location_count": 2,
      "location_summary": "Long Beach, California • Orange, California",
      "locations": [
        {
          "city": "Long Beach",
          "state": "California"
        },
        {
          "city": "Orange",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00326521"
    },
    {
      "nct_id": "NCT05603624",
      "title": "Effect of Sterile Versus Clean Gloves Intrapartum and Postpartum Infections at Term",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Chorioamnionitis",
        "Intrauterine Infection",
        "Postpartum Endometritis",
        "Puerperal Infection"
      ],
      "interventions": [
        {
          "name": "Cervical examination to assess labor",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Eastern Virginia Medical School",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "50 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 50 Years · Female only"
      },
      "enrollment_count": 163,
      "start_date": "2021-09-02",
      "completion_date": "2022-09-01",
      "has_results": false,
      "last_update_posted_date": "2023-08-25",
      "last_synced_at": "2026-07-23T10:15:28.377Z",
      "location_count": 1,
      "location_summary": "Norfolk, Virginia",
      "locations": [
        {
          "city": "Norfolk",
          "state": "Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05603624"
    },
    {
      "nct_id": "NCT00814905",
      "title": "Treatment of Chorioamnionitis After Delivery",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Chorioamnionitis"
      ],
      "interventions": [
        {
          "name": "saline",
          "type": "DRUG"
        },
        {
          "name": "ampicillin gentamicin",
          "type": "DRUG"
        },
        {
          "name": "ampicillin gentamicin clindamycin",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "United States Naval Medical Center, Portsmouth",
      "sponsor_class": "FED",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "45 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 45 Years · Female only"
      },
      "enrollment_count": 0,
      "start_date": "2008-11-18",
      "completion_date": "2012-09",
      "has_results": false,
      "last_update_posted_date": "2025-08-03",
      "last_synced_at": "2026-07-23T10:15:28.377Z",
      "location_count": 1,
      "location_summary": "Portsmouth, Virginia",
      "locations": [
        {
          "city": "Portsmouth",
          "state": "Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00814905"
    },
    {
      "nct_id": "NCT07669207",
      "title": "Extended Azithromycin Treatment in Prelabor Rupture of Membranes",
      "overall_status": "NOT_YET_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Preterm Prelabor Rupture of Membranes",
        "PPROM"
      ],
      "interventions": [
        {
          "name": "Azithromycin (Azithro)",
          "type": "DRUG"
        },
        {
          "name": "Standard Azithromycin Dosing",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Alexa Henderson",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "Female only"
      },
      "enrollment_count": 30,
      "start_date": "2026-07-01",
      "completion_date": "2028-07",
      "has_results": false,
      "last_update_posted_date": "2026-06-25",
      "last_synced_at": "2026-07-23T10:15:28.377Z",
      "location_count": 1,
      "location_summary": "Pittsburgh, Pennsylvania",
      "locations": [
        {
          "city": "Pittsburgh",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07669207"
    },
    {
      "nct_id": "NCT02369601",
      "title": "PROMComplete for Determination of Rupture of Fetal Membranes",
      "overall_status": "UNKNOWN",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Fetal Membranes, Premature Rupture"
      ],
      "interventions": [
        {
          "name": "non- intervention study",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Pro-Lab Diagnostics",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "45 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 45 Years · Female only"
      },
      "enrollment_count": 600,
      "start_date": "2015-08",
      "completion_date": "2018-12",
      "has_results": false,
      "last_update_posted_date": "2018-04-25",
      "last_synced_at": "2026-07-23T10:15:28.377Z",
      "location_count": 6,
      "location_summary": "Birmingham, Alabama • Indianapolis, Indiana • Dallas, Texas + 2 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Indianapolis",
          "state": "Indiana"
        },
        {
          "city": "Dallas",
          "state": "Texas"
        },
        {
          "city": "San Antonio",
          "state": "Texas"
        },
        {
          "city": "San Antonio",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02369601"
    },
    {
      "nct_id": "NCT07119398",
      "title": "Oxytocin/Foley vs. Oxytocin for Induction in Patients With PPROM",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Preterm PROM (Pregnancy)"
      ],
      "interventions": [
        {
          "name": "Oxytocin plus Foley Catheter",
          "type": "COMBINATION_PRODUCT"
        },
        {
          "name": "Oxytocin",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "COMBINATION_PRODUCT",
        "DRUG"
      ],
      "sponsor": "Eastern Virginia Medical School",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "50 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 50 Years · Female only"
      },
      "enrollment_count": 80,
      "start_date": "2025-07-14",
      "completion_date": "2026-12-30",
      "has_results": false,
      "last_update_posted_date": "2025-08-13",
      "last_synced_at": "2026-07-23T10:15:28.377Z",
      "location_count": 1,
      "location_summary": "Norfolk, Virginia",
      "locations": [
        {
          "city": "Norfolk",
          "state": "Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07119398"
    },
    {
      "nct_id": "NCT04318470",
      "title": "Identification of Microbial DNA in Maternal Plasma After PPROM",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Preterm Rupture of Membranes"
      ],
      "interventions": [
        {
          "name": "mNGS",
          "type": "DIAGNOSTIC_TEST"
        }
      ],
      "intervention_types": [
        "DIAGNOSTIC_TEST"
      ],
      "sponsor": "University of California, San Francisco",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "55 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 55 Years · Female only"
      },
      "enrollment_count": 70,
      "start_date": "2020-02-12",
      "completion_date": "2022-12-31",
      "has_results": false,
      "last_update_posted_date": "2023-04-07",
      "last_synced_at": "2026-07-23T10:15:28.377Z",
      "location_count": 1,
      "location_summary": "San Francisco, California",
      "locations": [
        {
          "city": "San Francisco",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04318470"
    }
  ]
}