{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Preterm+Premature+Rupture+of+Membranes+%28PPROM%29&page=2",
    "query": {
      "condition": "Preterm Premature Rupture of Membranes (PPROM)",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Preterm+Premature+Rupture+of+Membranes+%28PPROM%29&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-06-10T10:39:14.561Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT00397735",
      "title": "N-acetylcysteine in Intra-amniotic Infection/Inflammation",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Labor, Premature",
        "Preterm Premature Rupture of the Membranes",
        "Infection",
        "Inflammation",
        "Chorioamnionitis"
      ],
      "interventions": [
        {
          "name": "amniocentesis",
          "type": "PROCEDURE"
        },
        {
          "name": "N-acetylcysteine or placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "PROCEDURE",
        "DRUG"
      ],
      "sponsor": "Ohio State University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 68,
      "start_date": "2006-10-01",
      "completion_date": "2018-08-01",
      "has_results": false,
      "last_update_posted_date": "2018-10-10",
      "last_synced_at": "2026-06-10T10:39:14.561Z",
      "location_count": 2,
      "location_summary": "New Haven, Connecticut • Columbus, Ohio",
      "locations": [
        {
          "city": "New Haven",
          "state": "Connecticut"
        },
        {
          "city": "Columbus",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00397735"
    },
    {
      "nct_id": "NCT02327637",
      "title": "A Comparison of Bed Rest Versus Moderate Activity in Preterm Premature Rupture of Membranes (PPROM)",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Preterm Premature Rupture of the Membranes",
        "Physical Activity"
      ],
      "interventions": [
        {
          "name": "Moderate Activity",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "University of California, San Diego",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 5,
      "start_date": "2014-12",
      "completion_date": "2016-12-12",
      "has_results": false,
      "last_update_posted_date": "2019-06-06",
      "last_synced_at": "2026-06-10T10:39:14.561Z",
      "location_count": 1,
      "location_summary": "San Diego, California",
      "locations": [
        {
          "city": "San Diego",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02327637"
    },
    {
      "nct_id": "NCT00466128",
      "title": "Indomethacin Versus Placebo in Women With Preterm Premature Rupture of Membranes (PPROM)",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Preterm Premature Rupture of Membranes"
      ],
      "interventions": [
        {
          "name": "indomethacin",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Thomas Jefferson University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "15 Years",
        "maximum_age": "50 Years",
        "sex": "FEMALE",
        "summary": "15 Years to 50 Years · Female only"
      },
      "enrollment_count": 116,
      "start_date": "2007-04",
      "completion_date": "2016-04",
      "has_results": false,
      "last_update_posted_date": "2015-03-18",
      "last_synced_at": "2026-06-10T10:39:14.561Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00466128"
    },
    {
      "nct_id": "NCT02997345",
      "title": "PPROM Registry (Preterm Premature Rupture of Membranes)",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Fetal Membranes, Premature Rupture",
        "Preterm Premature Rupture of the Membranes",
        "Oligohydramnios",
        "Premature Birth"
      ],
      "interventions": [
        {
          "name": "There is no intervention associated with this study.",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "American Alliance for pProm Support",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "14 Years",
        "maximum_age": "55 Years",
        "sex": "FEMALE",
        "summary": "14 Years to 55 Years · Female only"
      },
      "enrollment_count": 3000,
      "start_date": "2013-07",
      "completion_date": "2030-12",
      "has_results": false,
      "last_update_posted_date": "2026-03-16",
      "last_synced_at": "2026-06-10T10:39:14.561Z",
      "location_count": 1,
      "location_summary": "Denver, Colorado",
      "locations": [
        {
          "city": "Denver",
          "state": "Colorado"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02997345"
    },
    {
      "nct_id": "NCT04047849",
      "title": "Latency Antibiotics in Previable PPROM, 18 0/7- 22 6/7 WGA",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Rupture of Membranes; Delayed Delivery (Following Spontaneous Rupture)",
        "Rupture of Membranes; Premature",
        "Rupture of Membranes; Premature, Affecting Fetus",
        "Preterm Birth",
        "Preterm PROM (Pregnancy)",
        "Preterm Labor"
      ],
      "interventions": [
        {
          "name": "Antibiotics, oral Azithromycin and oral Amoxicillin",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Woman's",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 34,
      "start_date": "2019-08-28",
      "completion_date": "2021-07-01",
      "has_results": false,
      "last_update_posted_date": "2021-01-11",
      "last_synced_at": "2026-06-10T10:39:14.561Z",
      "location_count": 1,
      "location_summary": "Baton Rouge, Louisiana",
      "locations": [
        {
          "city": "Baton Rouge",
          "state": "Louisiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04047849"
    },
    {
      "nct_id": "NCT05893485",
      "title": "Physiological and Psychological Effects of Music Therapy in the Pregnant Woman and Fetus",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Music Therapy",
        "Preterm Premature Rupture of Membrane (PPROM)"
      ],
      "interventions": [
        {
          "name": "Music Therapy Intervention",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Christina Chianis Reed",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "64 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 64 Years · Female only"
      },
      "enrollment_count": 60,
      "start_date": "2023-05-15",
      "completion_date": "2026-03-01",
      "has_results": false,
      "last_update_posted_date": "2024-09-19",
      "last_synced_at": "2026-06-10T10:39:14.561Z",
      "location_count": 1,
      "location_summary": "Houston, Texas",
      "locations": [
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05893485"
    },
    {
      "nct_id": "NCT04516226",
      "title": "Vaginal Cleansing With Chlorhexidine Gluconate in Women With Preterm Pre-labor Rupture of Membranes",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Preterm Premature Rupture of Membrane"
      ],
      "interventions": [
        {
          "name": "Vaginal cleansing with chlorhexidine gluconate solution",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Albany Medical College",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "50 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 50 Years · Female only"
      },
      "enrollment_count": 40,
      "start_date": "2020-08-01",
      "completion_date": "2024-12-31",
      "has_results": false,
      "last_update_posted_date": "2023-04-18",
      "last_synced_at": "2026-06-10T10:39:14.561Z",
      "location_count": 1,
      "location_summary": "Albany, New York",
      "locations": [
        {
          "city": "Albany",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04516226"
    },
    {
      "nct_id": "NCT03715530",
      "title": "Use of Placental Alpha Microglobulin-1(PAMG-1) to Diagnose Premature Rupture of Membranes in Pregnant Women",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Preterm Labor",
        "Preterm Birth"
      ],
      "interventions": [
        {
          "name": "PAMG-1 immunoassay",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Mark Santillan",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "50 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 50 Years · Female only"
      },
      "enrollment_count": 162,
      "start_date": "2007-09",
      "completion_date": "2011-07",
      "has_results": true,
      "last_update_posted_date": "2019-10-03",
      "last_synced_at": "2026-06-10T10:39:14.561Z",
      "location_count": 1,
      "location_summary": "Iowa City, Iowa",
      "locations": [
        {
          "city": "Iowa City",
          "state": "Iowa"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03715530"
    },
    {
      "nct_id": "NCT01556334",
      "title": "Erythromycin Versus Azithromycin in Preterm Premature Rupture of Membranes",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Preterm Premature Ruptured Membranes"
      ],
      "interventions": [
        {
          "name": "Azithromycin",
          "type": "DRUG"
        },
        {
          "name": "Erythromycin",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Indiana University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 0,
      "start_date": "2010-04",
      "completion_date": "2012-10",
      "has_results": false,
      "last_update_posted_date": "2024-10-15",
      "last_synced_at": "2026-06-10T10:39:14.561Z",
      "location_count": 1,
      "location_summary": "Indianapolis, Indiana",
      "locations": [
        {
          "city": "Indianapolis",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01556334"
    },
    {
      "nct_id": "NCT06074601",
      "title": "MIRACLE of LIFE Study",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Preterm Labor",
        "Preterm Birth",
        "Preterm Birth Complication",
        "Preterm Premature Rupture of Membrane",
        "Preeclampsia",
        "HELLP",
        "Gestational Hypertension",
        "Gestational Diabetes Mellitus in Pregnancy",
        "Small for Gestational Age at Delivery",
        "Intrauterine Growth Restriction"
      ],
      "interventions": [
        {
          "name": "Mirvie Predictive Test for Adverse Pregnancy Outcomes",
          "type": "DIAGNOSTIC_TEST"
        }
      ],
      "intervention_types": [
        "DIAGNOSTIC_TEST"
      ],
      "sponsor": "Mirvie",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": null,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 10000,
      "start_date": "2021-08-01",
      "completion_date": "2025-12-31",
      "has_results": false,
      "last_update_posted_date": "2024-11-27",
      "last_synced_at": "2026-06-10T10:39:14.561Z",
      "location_count": 10,
      "location_summary": "San Diego, California • Orlando, Florida • New Orleans, Louisiana + 7 more",
      "locations": [
        {
          "city": "San Diego",
          "state": "California"
        },
        {
          "city": "Orlando",
          "state": "Florida"
        },
        {
          "city": "New Orleans",
          "state": "Louisiana"
        },
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "St Louis",
          "state": "Missouri"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06074601"
    }
  ]
}