{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Preterm+Premature+Ruptured+Membranes&page=2",
    "query": {
      "condition": "Preterm Premature Ruptured Membranes",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Preterm+Premature+Ruptured+Membranes&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-06-10T18:14:18.632Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT01975792",
      "title": "Fetal Thymus Involution as a Predictor of Adverse Neonatal Outcomes",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Women Admitted to Labor and Delivery for the Management of Preterm Labor and/or Preterm Premature Rupture of Membranes (PPROM)"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "University of Pennsylvania",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "50 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 50 Years · Female only"
      },
      "enrollment_count": 125,
      "start_date": "2013-03",
      "completion_date": "2014-04",
      "has_results": false,
      "last_update_posted_date": "2017-03-30",
      "last_synced_at": "2026-06-10T18:14:18.632Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01975792"
    },
    {
      "nct_id": "NCT00463736",
      "title": "Magnesium Sulfate Versus Placebo for Tocolysis in PPROM",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Preterm Premature Rupture of Membranes"
      ],
      "interventions": [
        {
          "name": "Magnesium sulfate",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Regional Obstetrical Consultants",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "45 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 45 Years · Female only"
      },
      "enrollment_count": 4,
      "start_date": "2007-04",
      "completion_date": "2010-03",
      "has_results": false,
      "last_update_posted_date": "2016-08-19",
      "last_synced_at": "2026-06-10T18:14:18.632Z",
      "location_count": 1,
      "location_summary": "Chattanooga, Tennessee",
      "locations": [
        {
          "city": "Chattanooga",
          "state": "Tennessee"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00463736"
    },
    {
      "nct_id": "NCT01973036",
      "title": "FOLCROM Trial: Foley Catheter in Rupture of Membranes",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Premature Rupture of Membranes"
      ],
      "interventions": [
        {
          "name": "Foley Catheter",
          "type": "DEVICE"
        },
        {
          "name": "Oxytocin",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "DRUG"
      ],
      "sponsor": "Geisinger Clinic",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "Female only"
      },
      "enrollment_count": 201,
      "start_date": "2014-03",
      "completion_date": "2016-08",
      "has_results": true,
      "last_update_posted_date": "2018-09-24",
      "last_synced_at": "2026-06-10T18:14:18.632Z",
      "location_count": 5,
      "location_summary": "Phoenix, Arizona • Newark, Delaware • Allentown, Pennsylvania + 2 more",
      "locations": [
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Newark",
          "state": "Delaware"
        },
        {
          "city": "Allentown",
          "state": "Pennsylvania"
        },
        {
          "city": "Danville",
          "state": "Pennsylvania"
        },
        {
          "city": "Wilkes-Barre",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01973036"
    },
    {
      "nct_id": "NCT04963465",
      "title": "The Accuracy of Amniotic Fluid Ferning in the Second Trimester in the Diagnosis of Preterm Prelabor Rupture of Membranes",
      "overall_status": "UNKNOWN",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Preterm Premature Rupture of Membrane",
        "Amniotic Fluid Leakage"
      ],
      "interventions": [
        {
          "name": "Ferning on microscopy",
          "type": "DIAGNOSTIC_TEST"
        }
      ],
      "intervention_types": [
        "DIAGNOSTIC_TEST"
      ],
      "sponsor": "Albany Medical College",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 100,
      "start_date": "2021-09-17",
      "completion_date": "2023-12-01",
      "has_results": false,
      "last_update_posted_date": "2023-04-18",
      "last_synced_at": "2026-06-10T18:14:18.632Z",
      "location_count": 1,
      "location_summary": "Albany, New York",
      "locations": [
        {
          "city": "Albany",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04963465"
    },
    {
      "nct_id": "NCT00290199",
      "title": "Foley Catheter for Labor Induction in Women With Term and Near Term Membrane Rupture",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Fetal Membranes, Premature Rupture",
        "Labor, Induced/IS"
      ],
      "interventions": [
        {
          "name": "Transcervical Foley catheter",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of Alabama at Birmingham",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "12 Years",
        "maximum_age": "55 Years",
        "sex": "FEMALE",
        "summary": "12 Years to 55 Years · Female only"
      },
      "enrollment_count": 169,
      "start_date": "2005-12",
      "completion_date": "2008-05",
      "has_results": true,
      "last_update_posted_date": "2017-05-23",
      "last_synced_at": "2026-06-10T18:14:18.632Z",
      "location_count": 3,
      "location_summary": "Birmingham, Alabama • Newark, Delaware • Greenville, South Carolina",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Newark",
          "state": "Delaware"
        },
        {
          "city": "Greenville",
          "state": "South Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00290199"
    },
    {
      "nct_id": "NCT04047849",
      "title": "Latency Antibiotics in Previable PPROM, 18 0/7- 22 6/7 WGA",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Rupture of Membranes; Delayed Delivery (Following Spontaneous Rupture)",
        "Rupture of Membranes; Premature",
        "Rupture of Membranes; Premature, Affecting Fetus",
        "Preterm Birth",
        "Preterm PROM (Pregnancy)",
        "Preterm Labor"
      ],
      "interventions": [
        {
          "name": "Antibiotics, oral Azithromycin and oral Amoxicillin",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Woman's",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 34,
      "start_date": "2019-08-28",
      "completion_date": "2021-07-01",
      "has_results": false,
      "last_update_posted_date": "2021-01-11",
      "last_synced_at": "2026-06-10T18:14:18.632Z",
      "location_count": 1,
      "location_summary": "Baton Rouge, Louisiana",
      "locations": [
        {
          "city": "Baton Rouge",
          "state": "Louisiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04047849"
    },
    {
      "nct_id": "NCT02997345",
      "title": "PPROM Registry (Preterm Premature Rupture of Membranes)",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Fetal Membranes, Premature Rupture",
        "Preterm Premature Rupture of the Membranes",
        "Oligohydramnios",
        "Premature Birth"
      ],
      "interventions": [
        {
          "name": "There is no intervention associated with this study.",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "American Alliance for pProm Support",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "14 Years",
        "maximum_age": "55 Years",
        "sex": "FEMALE",
        "summary": "14 Years to 55 Years · Female only"
      },
      "enrollment_count": 3000,
      "start_date": "2013-07",
      "completion_date": "2030-12",
      "has_results": false,
      "last_update_posted_date": "2026-03-16",
      "last_synced_at": "2026-06-10T18:14:18.632Z",
      "location_count": 1,
      "location_summary": "Denver, Colorado",
      "locations": [
        {
          "city": "Denver",
          "state": "Colorado"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02997345"
    },
    {
      "nct_id": "NCT00342277",
      "title": "Microarray Expression Profiling to Identify Stereotypic mRNA Profiles in Human Parturition",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Preterm Birth",
        "Premature Rupture of Membranes"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)",
      "sponsor_class": "NIH",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 6838,
      "start_date": "1999-12-21",
      "completion_date": "2016-05-05",
      "has_results": false,
      "last_update_posted_date": "2023-02-24",
      "last_synced_at": "2026-06-10T18:14:18.632Z",
      "location_count": 1,
      "location_summary": "Detroit, Michigan",
      "locations": [
        {
          "city": "Detroit",
          "state": "Michigan"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00342277"
    },
    {
      "nct_id": "NCT00201656",
      "title": "Removal Versus Retention of Cerclage in Preterm Premature Rupture of Membranes (PPROM)",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Fetal Membranes, Premature Rupture"
      ],
      "interventions": [
        {
          "name": "Retention of Cerclage",
          "type": "PROCEDURE"
        },
        {
          "name": "Removal of Cerclage",
          "type": "PROCEDURE"
        },
        {
          "name": "Removal vs. Retention of Cervical Cerclage",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Obstetrix Medical Group",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "60 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 60 Years · Female only"
      },
      "enrollment_count": 58,
      "start_date": "2004-11",
      "completion_date": "2014-04",
      "has_results": false,
      "last_update_posted_date": "2014-12-19",
      "last_synced_at": "2026-06-10T18:14:18.632Z",
      "location_count": 23,
      "location_summary": "Mesa, Arizona • Phoenix, Arizona • Tucson, Arizona + 18 more",
      "locations": [
        {
          "city": "Mesa",
          "state": "Arizona"
        },
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Tucson",
          "state": "Arizona"
        },
        {
          "city": "Laguna Hills",
          "state": "California"
        },
        {
          "city": "Long Beach",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00201656"
    },
    {
      "nct_id": "NCT00466128",
      "title": "Indomethacin Versus Placebo in Women With Preterm Premature Rupture of Membranes (PPROM)",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Preterm Premature Rupture of Membranes"
      ],
      "interventions": [
        {
          "name": "indomethacin",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Thomas Jefferson University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "15 Years",
        "maximum_age": "50 Years",
        "sex": "FEMALE",
        "summary": "15 Years to 50 Years · Female only"
      },
      "enrollment_count": 116,
      "start_date": "2007-04",
      "completion_date": "2016-04",
      "has_results": false,
      "last_update_posted_date": "2015-03-18",
      "last_synced_at": "2026-06-10T18:14:18.632Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00466128"
    }
  ]
}