{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Primary+Autonomic+Failure", "query": { "condition": "Primary Autonomic Failure" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 55, "total_pages": 6, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Primary+Autonomic+Failure&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-05-22T04:19:03.957Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT00775853", "title": "Biomarkers of Risk of Parkinson Disease", "overall_status": "COMPLETED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Parkinson Disease", "Autonomic Nervous System Diseases", "Pure Autonomic Failure" ], "interventions": [ { "name": "6-[18F]Fluorodopamine", "type": "DRUG" }, { "name": "6-[18F]Fluorodopa", "type": "DRUG" }, { "name": "13N-Ammonia", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "National Institute of Neurological Disorders and Stroke (NINDS)", "sponsor_class": "NIH", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "70 Years", "sex": "ALL", "summary": "18 Years to 70 Years" }, "enrollment_count": 89, "start_date": "2009-05-27", "completion_date": "2023-01-11", "has_results": false, "last_update_posted_date": "2025-09-19", "last_synced_at": "2026-05-22T04:19:03.957Z", "location_count": 1, "location_summary": "Bethesda, Maryland", "locations": [ { "city": "Bethesda", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT00775853" }, { "nct_id": "NCT06616363", "title": "Does a Periaqueductal Gray-vagus Nerve Interface Malfunction Explain the Nat hx With Its Numerous Co-morbidities?", "overall_status": "RECRUITING", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "POTS - Postural Orthostatic Tachycardia Syndrome" ], "interventions": [ { "name": "Questionnaires to be competed", "type": "BEHAVIORAL" }, { "name": "Provide list of medication and lifetime events", "type": "BEHAVIORAL" }, { "name": "Use phone App to record new life events", "type": "BEHAVIORAL" }, { "name": "Will wear an activity monitor", "type": "DEVICE" }, { "name": "Periodic 24-hour urine sodium check", "type": "OTHER" }, { "name": "A fMRI scan", "type": "DIAGNOSTIC_TEST" }, { "name": "A bedside tilt test will be performed", "type": "DIAGNOSTIC_TEST" }, { "name": "IV placed to collect blood samples", "type": "OTHER" }, { "name": "Stool Sample", "type": "OTHER" } ], "intervention_types": [ "BEHAVIORAL", "DEVICE", "OTHER", "DIAGNOSTIC_TEST" ], "sponsor": "Virginia Commonwealth University", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "12 Years", "maximum_age": "21 Years", "sex": "FEMALE", "summary": "12 Years to 21 Years · Female only" }, "enrollment_count": 120, "start_date": "2024-05-29", "completion_date": "2028-07", "has_results": false, "last_update_posted_date": "2025-09-26", "last_synced_at": "2026-05-22T04:19:03.957Z", "location_count": 1, "location_summary": "Richmond, Virginia", "locations": [ { "city": "Richmond", "state": "Virginia" } ], "official_url": "https://clinicaltrials.gov/study/NCT06616363" }, { "nct_id": "NCT04095793", "title": "Phase 3 Open-Label Extension Study of TD-9855 for Treating Symptomatic nOH in Subjects With Primary Autonomic Failure", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Symptomatic Neurogenic Orthostatic Hypotension" ], "interventions": [ { "name": "ampreloxetine", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Theravance Biopharma", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "30 Years", "maximum_age": null, "sex": "ALL", "summary": "30 Years and older" }, "enrollment_count": 110, "start_date": "2019-09-19", "completion_date": "2021-11-12", "has_results": true, "last_update_posted_date": "2022-11-30", "last_synced_at": "2026-05-22T04:19:03.957Z", "location_count": 13, "location_summary": "Colorado Springs, Colorado • Boca Raton, Florida • Port Charlotte, Florida + 10 more", "locations": [ { "city": "Colorado Springs", "state": "Colorado" }, { "city": "Boca Raton", "state": "Florida" }, { "city": "Port Charlotte", "state": "Florida" }, { "city": "Chicago", "state": "Illinois" }, { "city": "Glenview", "state": "Illinois" } ], "official_url": "https://clinicaltrials.gov/study/NCT04095793" }, { "nct_id": "NCT01522235", "title": "Evaluating the Effectiveness of Intravenous Immunoglobulin Therapy in Autoimmune Autonomic Ganglionopathy", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2", "PHASE3" ], "conditions": [ "Autoimmune Autonomic Ganglionopathy (AAG)" ], "interventions": [ { "name": "Double blinded IVIg", "type": "DRUG" }, { "name": "Double blinded Placebo", "type": "OTHER" }, { "name": "Single Blinded IVIg", "type": "OTHER" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "Beth Israel Deaconess Medical Center", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "85 Years", "sex": "ALL", "summary": "18 Years to 85 Years" }, "enrollment_count": 6, "start_date": "2012-02", "completion_date": "2015-09", "has_results": true, "last_update_posted_date": "2017-07-02", "last_synced_at": "2026-05-22T04:19:03.957Z", "location_count": 6, "location_summary": "Bethesda, Maryland • Boston, Massachusetts • Rochester, Minnesota + 3 more", "locations": [ { "city": "Bethesda", "state": "Maryland" }, { "city": "Boston", "state": "Massachusetts" }, { "city": "Rochester", "state": "Minnesota" }, { "city": "New York", "state": "New York" }, { "city": "Nashville", "state": "Tennessee" } ], "official_url": "https://clinicaltrials.gov/study/NCT01522235" }, { "nct_id": "NCT03312556", "title": "Treatment of Supine Hypertension in Autonomic Failure (CPAP)", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Supine Hypertension", "Autonomic Failure" ], "interventions": [ { "name": "continuous positive airway pressure (CPAP)", "type": "DEVICE" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DEVICE", "DRUG" ], "sponsor": "Vanderbilt University Medical Center", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "85 Years", "sex": "ALL", "summary": "18 Years to 85 Years" }, "enrollment_count": 12, "start_date": "2017-09-21", "completion_date": "2026-12-21", "has_results": false, "last_update_posted_date": "2025-11-06", "last_synced_at": "2026-05-22T04:19:03.957Z", "location_count": 1, "location_summary": "Nashville, Tennessee", "locations": [ { "city": "Nashville", "state": "Tennessee" } ], "official_url": "https://clinicaltrials.gov/study/NCT03312556" }, { "nct_id": "NCT04700722", "title": "Synuclein-One Study", "overall_status": "COMPLETED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Parkinson Disease", "Multiple System Atrophy", "Dementia With Lewy Bodies", "Pure Autonomic Failure" ], "interventions": [ { "name": "Skin Biopsy", "type": "DIAGNOSTIC_TEST" } ], "intervention_types": [ "DIAGNOSTIC_TEST" ], "sponsor": "CND Life Sciences", "sponsor_class": "OTHER", "healthy_volunteers": null, "eligibility": { "minimum_age": "40 Years", "maximum_age": "99 Years", "sex": "ALL", "summary": "40 Years to 99 Years" }, "enrollment_count": 428, "start_date": "2021-01-04", "completion_date": "2023-11-08", "has_results": false, "last_update_posted_date": "2024-01-03", "last_synced_at": "2026-05-22T04:19:03.957Z", "location_count": 23, "location_summary": "Chandler, Arizona • Phoenix, Arizona • Scottsdale, Arizona + 19 more", "locations": [ { "city": "Chandler", "state": "Arizona" }, { "city": "Phoenix", "state": "Arizona" }, { "city": "Scottsdale", "state": "Arizona" }, { "city": "Carlsbad", "state": "California" }, { "city": "Santa Monica", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT04700722" }, { "nct_id": "NCT00223717", "title": "Treatment of Supine Hypertension in Autonomic Failure", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Hypertension" ], "interventions": [ { "name": "Clonidine", "type": "DRUG" }, { "name": "Nitroglycerin transdermal", "type": "DRUG" }, { "name": "Dipyridamole/ Aspirin (Aggrenox)", "type": "DRUG" }, { "name": "Desmopressin (DDAVP)", "type": "DRUG" }, { "name": "Sildenafil", "type": "DRUG" }, { "name": "Nifedipine", "type": "DRUG" }, { "name": "Hydralazine", "type": "DRUG" }, { "name": "Hydrochlorothiazide", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" }, { "name": "Bosentan", "type": "DRUG" }, { "name": "Diltiazem", "type": "DRUG" }, { "name": "Eplerenone", "type": "DRUG" }, { "name": "guanfacine", "type": "DRUG" }, { "name": "L-arginine", "type": "DIETARY_SUPPLEMENT" }, { "name": "captopril", "type": "DRUG" }, { "name": "carbidopa", "type": "DRUG" }, { "name": "losartan", "type": "DRUG" }, { "name": "metoprolol tartrate", "type": "DRUG" }, { "name": "nebivolol hydrochloride", "type": "DRUG" }, { "name": "prazosin hydrochloride", "type": "DRUG" }, { "name": "tamsulosin hydrochloride", "type": "DRUG" }, { "name": "Head-up tilt.", "type": "OTHER" }, { "name": "aliskiren", "type": "DRUG" }, { "name": "Local heat stress", "type": "OTHER" } ], "intervention_types": [ "DRUG", "DIETARY_SUPPLEMENT", "OTHER" ], "sponsor": "Vanderbilt University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "18 Years to 80 Years" }, "enrollment_count": 152, "start_date": "2001-01", "completion_date": "2017-01", "has_results": false, "last_update_posted_date": "2017-10-13", "last_synced_at": "2026-05-22T04:19:03.957Z", "location_count": 1, "location_summary": "Nashville, Tennessee", "locations": [ { "city": "Nashville", "state": "Tennessee" } ], "official_url": "https://clinicaltrials.gov/study/NCT00223717" }, { "nct_id": "NCT00359346", "title": "Plasma Exchange for Autoimmune Autonomic Failure", "overall_status": "COMPLETED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Plasma Exchange", "Autonomic Failure" ], "interventions": [], "intervention_types": [], "sponsor": "National Institute of Neurological Disorders and Stroke (NINDS)", "sponsor_class": "NIH", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "99 Years", "sex": "ALL", "summary": "18 Years to 99 Years" }, "enrollment_count": 3, "start_date": "2006-07-14", "completion_date": "2009-04-16", "has_results": false, "last_update_posted_date": "2017-07-02", "last_synced_at": "2026-05-22T04:19:03.957Z", "location_count": 1, "location_summary": "Bethesda, Maryland", "locations": [ { "city": "Bethesda", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT00359346" }, { "nct_id": "NCT03829657", "title": "Phase 3 Clinical Effect Durability of TD-9855 for Treating Symptomatic nOH in Subjects With Primary Autonomic Failure", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Symptomatic Neurogenic Orthostatic Hypotension", "MSA", "Parkinson's Disease (PD)", "Pure Autonomic Failure (PAF)" ], "interventions": [ { "name": "ampreloxetine", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Theravance Biopharma", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "30 Years", "maximum_age": null, "sex": "ALL", "summary": "30 Years and older" }, "enrollment_count": 203, "start_date": "2019-02-22", "completion_date": "2021-11-10", "has_results": true, "last_update_posted_date": "2023-01-20", "last_synced_at": "2026-05-22T04:19:03.957Z", "location_count": 20, "location_summary": "Sun City, Arizona • La Jolla, California • Palo Alto, California + 16 more", "locations": [ { "city": "Sun City", "state": "Arizona" }, { "city": "La Jolla", "state": "California" }, { "city": "Palo Alto", "state": "California" }, { "city": "Colorado Springs", "state": "Colorado" }, { "city": "Boca Raton", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT03829657" }, { "nct_id": "NCT01316666", "title": "Norepinephrine Transporter Blockade as a Pathological Biomarker in Neurogenic Orthostatic Hypotension", "overall_status": "COMPLETED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Orthostatic Hypotension", "Pure Autonomic Failure", "Multiple System Atrophy", "Parkinson's Disease" ], "interventions": [], "intervention_types": [], "sponsor": "Vanderbilt University Medical Center", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "18 Years to 80 Years" }, "enrollment_count": 50, "start_date": "2011-03", "completion_date": "2016-12", "has_results": false, "last_update_posted_date": "2017-01-06", "last_synced_at": "2026-05-22T04:19:03.957Z", "location_count": 4, "location_summary": "Boston, Massachusetts • Rochester, Minnesota • New York, New York + 1 more", "locations": [ { "city": "Boston", "state": "Massachusetts" }, { "city": "Rochester", "state": "Minnesota" }, { "city": "New York", "state": "New York" }, { "city": "Nashville", "state": "Tennessee" } ], "official_url": "https://clinicaltrials.gov/study/NCT01316666" } ] }