{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Primary+Hypersomnia",
    "query": {
      "condition": "Primary Hypersomnia"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 30,
    "total_pages": 3,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Primary+Hypersomnia&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-05-22T04:18:58.631Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT05458128",
      "title": "A Long-Term Safety and Effectiveness Study to Evaluate Pitolisant in Adult Patients With Idiopathic Hypersomnia",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Idiopathic Hypersomnia",
        "Excessive Daytime Sleepiness"
      ],
      "interventions": [
        {
          "name": "Pitolisant",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Harmony Biosciences Management, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 119,
      "start_date": "2022-08-19",
      "completion_date": "2025-10-01",
      "has_results": false,
      "last_update_posted_date": "2025-12-12",
      "last_synced_at": "2026-05-22T04:18:58.631Z",
      "location_count": 32,
      "location_summary": "Los Angeles, California • San Ramon, California • Brandon, Florida + 29 more",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "San Ramon",
          "state": "California"
        },
        {
          "city": "Brandon",
          "state": "Florida"
        },
        {
          "city": "Clearwater",
          "state": "Florida"
        },
        {
          "city": "Winter Park",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05458128"
    },
    {
      "nct_id": "NCT05156047",
      "title": "A Phase 3 Study to Assess the Safety and Efficacy of Pitolisant in Adult Patients With Idiopathic Hypersomnia",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Idiopathic Hypersomnia"
      ],
      "interventions": [
        {
          "name": "Open-label pitolisant",
          "type": "DRUG"
        },
        {
          "name": "Double-blind placebo",
          "type": "DRUG"
        },
        {
          "name": "Double-blind pitolisant",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Harmony Biosciences Management, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 214,
      "start_date": "2022-05-25",
      "completion_date": "2023-09-08",
      "has_results": false,
      "last_update_posted_date": "2024-09-19",
      "last_synced_at": "2026-05-22T04:18:58.631Z",
      "location_count": 58,
      "location_summary": "Peoria, Arizona • Scottsdale, Arizona • Los Angeles, California + 53 more",
      "locations": [
        {
          "city": "Peoria",
          "state": "Arizona"
        },
        {
          "city": "Scottsdale",
          "state": "Arizona"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "San Ramon",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05156047"
    },
    {
      "nct_id": "NCT06843590",
      "title": "A Study to Evaluate the Safety and Effectiveness of ALKS 2680 in Subjects With Idiopathic Hypersomnia",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Idiopathic Hypersomnia"
      ],
      "interventions": [
        {
          "name": "ALKS 2680",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Alkermes, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "18 Years to 70 Years"
      },
      "enrollment_count": 96,
      "start_date": "2025-05-22",
      "completion_date": "2026-06",
      "has_results": false,
      "last_update_posted_date": "2026-02-12",
      "last_synced_at": "2026-05-22T04:18:58.631Z",
      "location_count": 32,
      "location_summary": "Cullman, Alabama • Phoenix, Arizona • Little Rock, Arkansas + 29 more",
      "locations": [
        {
          "city": "Cullman",
          "state": "Alabama"
        },
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Little Rock",
          "state": "Arkansas"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Redwood City",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06843590"
    },
    {
      "nct_id": "NCT04091438",
      "title": "A Study of a Single Intravenous Infusion Dose of TAK-925 in Participants With Idiopathic Hypersomnia",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Idiopathic Hypersomnia"
      ],
      "interventions": [
        {
          "name": "TAK-925",
          "type": "DRUG"
        },
        {
          "name": "TAK-925 Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Millennium Pharmaceuticals, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "18 Years to 75 Years"
      },
      "enrollment_count": 28,
      "start_date": "2020-01-26",
      "completion_date": "2020-11-23",
      "has_results": true,
      "last_update_posted_date": "2023-09-26",
      "last_synced_at": "2026-05-22T04:18:58.631Z",
      "location_count": 20,
      "location_summary": "Alabaster, Alabama • Glendale, Arizona • Little Rock, Arkansas + 17 more",
      "locations": [
        {
          "city": "Alabaster",
          "state": "Alabama"
        },
        {
          "city": "Glendale",
          "state": "Arizona"
        },
        {
          "city": "Little Rock",
          "state": "Arkansas"
        },
        {
          "city": "Redwood City",
          "state": "California"
        },
        {
          "city": "San Diego",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04091438"
    },
    {
      "nct_id": "NCT05668754",
      "title": "Placebo-Controlled, Double-Blind, Study to Determine the Safety and Efficacy of SDX in Patients With IH",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Idiopathic Hypersomnia"
      ],
      "interventions": [
        {
          "name": "Serdexmethylphenidate",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "Zevra Therapeutics",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 50,
      "start_date": "2022-12-28",
      "completion_date": "2024-03-21",
      "has_results": false,
      "last_update_posted_date": "2025-02-03",
      "last_synced_at": "2026-05-22T04:18:58.631Z",
      "location_count": 41,
      "location_summary": "Birmingham, Alabama • Daphne, Alabama • Guntersville, Alabama + 34 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Daphne",
          "state": "Alabama"
        },
        {
          "city": "Guntersville",
          "state": "Alabama"
        },
        {
          "city": "Huntington Beach",
          "state": "California"
        },
        {
          "city": "Redwood City",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05668754"
    },
    {
      "nct_id": "NCT06752668",
      "title": "A Study of ORX750 in Participants With Narcolepsy and Idiopathic Hypersomnia",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Narcolepsy Type 1",
        "Narcolepsy Type 2",
        "Idiopathic Hypersomnia"
      ],
      "interventions": [
        {
          "name": "ORX750",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Centessa Pharmaceuticals (UK) Limited",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 248,
      "start_date": "2024-12-23",
      "completion_date": "2026-12",
      "has_results": false,
      "last_update_posted_date": "2026-04-27",
      "last_synced_at": "2026-05-22T04:18:58.631Z",
      "location_count": 29,
      "location_summary": "Auburn, Alabama • Chandler, Arizona • Scottsdale, Arizona + 24 more",
      "locations": [
        {
          "city": "Auburn",
          "state": "Alabama"
        },
        {
          "city": "Chandler",
          "state": "Arizona"
        },
        {
          "city": "Scottsdale",
          "state": "Arizona"
        },
        {
          "city": "Long Beach",
          "state": "California"
        },
        {
          "city": "Santa Ana",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06752668"
    },
    {
      "nct_id": "NCT06767683",
      "title": "A Long-Term Study of ALKS 2680 in Subjects With Narcolepsy and Idiopathic Hypersomnia",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2",
        "PHASE3"
      ],
      "conditions": [
        "Narcolepsy Type 1",
        "Narcolepsy Type 2",
        "Idiopathic Hypersomnia"
      ],
      "interventions": [
        {
          "name": "ALKS 2680, 4mg",
          "type": "DRUG"
        },
        {
          "name": "ALKS 2680, 6mg",
          "type": "DRUG"
        },
        {
          "name": "ALKS 2680, 8mg",
          "type": "DRUG"
        },
        {
          "name": "ALKS 2680, 10mg",
          "type": "DRUG"
        },
        {
          "name": "ALKS 2680, 14mg",
          "type": "DRUG"
        },
        {
          "name": "ALKS 2680, 18mg",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Alkermes, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "18 Years to 70 Years"
      },
      "enrollment_count": 256,
      "start_date": "2025-01-27",
      "completion_date": "2028-06",
      "has_results": false,
      "last_update_posted_date": "2026-03-04",
      "last_synced_at": "2026-05-22T04:18:58.631Z",
      "location_count": 30,
      "location_summary": "Phoenix, Arizona • Little Rock, Arkansas • Los Angeles, California + 26 more",
      "locations": [
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Little Rock",
          "state": "Arkansas"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "Stanford",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06767683"
    },
    {
      "nct_id": "NCT05837091",
      "title": "Low Sodium Oxybate in Patients With Idiopathic Hypersomnia",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Idiopathic Hypersomnia"
      ],
      "interventions": [
        {
          "name": "Low Sodium Oxybate",
          "type": "DRUG"
        },
        {
          "name": "24-hour polysomnography",
          "type": "DIAGNOSTIC_TEST"
        },
        {
          "name": "Nextsense EEG earbuds",
          "type": "DEVICE"
        },
        {
          "name": "Axivity device",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DRUG",
        "DIAGNOSTIC_TEST",
        "DEVICE"
      ],
      "sponsor": "Mayo Clinic",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 30,
      "start_date": "2024-02-14",
      "completion_date": "2027-06",
      "has_results": false,
      "last_update_posted_date": "2026-05-12",
      "last_synced_at": "2026-05-22T04:18:58.631Z",
      "location_count": 4,
      "location_summary": "Phoenix, Arizona • Redwood City, California • Jacksonville, Florida + 1 more",
      "locations": [
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Redwood City",
          "state": "California"
        },
        {
          "city": "Jacksonville",
          "state": "Florida"
        },
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05837091"
    },
    {
      "nct_id": "NCT05371483",
      "title": "Cardiovascular and Cognitive Implications of Central Disorders of Hypersomnolence and Their Treatments",
      "overall_status": "ENROLLING_BY_INVITATION",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Narcolepsy",
        "Idiopathic Hypersomnia"
      ],
      "interventions": [
        {
          "name": "24-hour Ambulatory Blood Pressure Monitoring",
          "type": "DIAGNOSTIC_TEST"
        },
        {
          "name": "Oculo-Cognitive Addition Test (OCAT)",
          "type": "DIAGNOSTIC_TEST"
        }
      ],
      "intervention_types": [
        "DIAGNOSTIC_TEST"
      ],
      "sponsor": "Mayo Clinic",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "18 Years to 75 Years"
      },
      "enrollment_count": 100,
      "start_date": "2022-05-18",
      "completion_date": "2026-07",
      "has_results": false,
      "last_update_posted_date": "2025-06-29",
      "last_synced_at": "2026-05-22T04:18:58.631Z",
      "location_count": 1,
      "location_summary": "Scottsdale, Arizona",
      "locations": [
        {
          "city": "Scottsdale",
          "state": "Arizona"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05371483"
    },
    {
      "nct_id": "NCT01183312",
      "title": "Flumazenil for the Treatment of Primary Hypersomnia",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Hypersomnia",
        "Primary Hypersomnia",
        "Idiopathic Hypersomnia",
        "Narcolepsy Without Cataplexy"
      ],
      "interventions": [
        {
          "name": "Flumazenil",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Lynn Marie Trotti",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 10,
      "start_date": "2010-09",
      "completion_date": "2012-01",
      "has_results": true,
      "last_update_posted_date": "2017-12-12",
      "last_synced_at": "2026-05-22T04:18:58.631Z",
      "location_count": 1,
      "location_summary": "Atlanta, Georgia",
      "locations": [
        {
          "city": "Atlanta",
          "state": "Georgia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01183312"
    }
  ]
}