{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Primary+Immunodeficiency+Disorders", "query": { "condition": "Primary Immunodeficiency Disorders" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 390, "total_pages": 39, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Primary+Immunodeficiency+Disorders&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-06-25T21:26:42.888Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT00074581", "title": "Preventing Sexual Transmission of HIV With Anti-HIV Drugs", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "HIV Infections" ], "interventions": [ { "name": "Atazanavir", "type": "DRUG" }, { "name": "Didanosine", "type": "DRUG" }, { "name": "Efavirenz", "type": "DRUG" }, { "name": "Emtricitabine/Tenofovir disoproxil fumarate", "type": "DRUG" }, { "name": "Lamivudine", "type": "DRUG" }, { "name": "Lopinavir/Ritonavir", "type": "DRUG" }, { "name": "Nevirapine", "type": "DRUG" }, { "name": "Stavudine", "type": "DRUG" }, { "name": "Tenofovir disoproxil fumarate", "type": "DRUG" }, { "name": "Zidovudine/Lamivudine", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "National Institute of Allergy and Infectious Diseases (NIAID)", "sponsor_class": "NIH", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 3526, "start_date": "2005-02", "completion_date": "2015-05", "has_results": true, "last_update_posted_date": "2021-11-05", "last_synced_at": "2026-06-25T21:26:42.888Z", "location_count": 1, "location_summary": "Boston, Massachusetts", "locations": [ { "city": "Boston", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT00074581" }, { "nct_id": "NCT01912456", "title": "A Study to Evaluate the Clinical Efficacy and Safety of Subcutaneously Administered C1-esterase Inhibitor in the Prevention of Hereditary Angioedema", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Hereditary Angioedema Types I and II" ], "interventions": [ { "name": "Low-volume C1-esterase inhibitor", "type": "BIOLOGICAL" }, { "name": "Higher-volume C1-esterase inhibitor", "type": "BIOLOGICAL" }, { "name": "Low-volume placebo", "type": "BIOLOGICAL" }, { "name": "Higher-volume placebo", "type": "BIOLOGICAL" } ], "intervention_types": [ "BIOLOGICAL" ], "sponsor": "CSL Behring", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "12 Years", "maximum_age": null, "sex": "ALL", "summary": "12 Years and older" }, "enrollment_count": 90, "start_date": "2014-01", "completion_date": "2015-10", "has_results": true, "last_update_posted_date": "2021-01-29", "last_synced_at": "2026-06-25T21:26:42.888Z", "location_count": 19, "location_summary": "Birmingham, Alabama • Scottsdale, Arizona • Bell Gardens, California + 16 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Scottsdale", "state": "Arizona" }, { "city": "Bell Gardens", "state": "California" }, { "city": "La Jolla", "state": "California" }, { "city": "Orange", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT01912456" }, { "nct_id": "NCT03712228", "title": "A Study to Investigate CSL312 in Subjects With Hereditary Angioedema (HAE)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Hereditary Angioedema" ], "interventions": [ { "name": "Factor XIIa antagonist monoclonal antibody", "type": "BIOLOGICAL" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "BIOLOGICAL", "DRUG" ], "sponsor": "CSL Behring", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 44, "start_date": "2018-10-29", "completion_date": "2021-10-15", "has_results": true, "last_update_posted_date": "2022-11-08", "last_synced_at": "2026-06-25T21:26:42.888Z", "location_count": 7, "location_summary": "Orange, California • Walnut Creek, California • Centennial, Colorado + 4 more", "locations": [ { "city": "Orange", "state": "California" }, { "city": "Walnut Creek", "state": "California" }, { "city": "Centennial", "state": "Colorado" }, { "city": "Chevy Chase", "state": "Maryland" }, { "city": "New York", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT03712228" }, { "nct_id": "NCT05321407", "title": "COVID-19 Vaccine Responses in PIDD Subjects", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "X-linked Agammaglobulinemia", "XLA", "Primary Immune Deficiency", "CVID", "Common Variable Immunodeficiency", "Primary Antibody Deficiencies", "Secondary Hypogammaglobulinemia" ], "interventions": [], "intervention_types": [], "sponsor": "Duke University", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "6 Months", "maximum_age": null, "sex": "ALL", "summary": "6 Months and older" }, "enrollment_count": 100, "start_date": "2021-09-30", "completion_date": "2026-07-31", "has_results": false, "last_update_posted_date": "2025-06-03", "last_synced_at": "2026-06-25T21:26:42.888Z", "location_count": 3, "location_summary": "St. Petersburg, Florida • Chapel Hill, North Carolina • Durham, North Carolina", "locations": [ { "city": "St. Petersburg", "state": "Florida" }, { "city": "Chapel Hill", "state": "North Carolina" }, { "city": "Durham", "state": "North Carolina" } ], "official_url": "https://clinicaltrials.gov/study/NCT05321407" }, { "nct_id": "NCT00000801", "title": "Phase II Trial of Sequential Chemotherapy and Radiotherapy for AIDS-Related Primary Central Nervous System Lymphoma", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Lymphoma, Non-Hodgkin", "HIV Infections" ], "interventions": [ { "name": "Filgrastim", "type": "DRUG" }, { "name": "Vincristine sulfate", "type": "DRUG" }, { "name": "Doxorubicin hydrochloride", "type": "DRUG" }, { "name": "Cyclophosphamide", "type": "DRUG" }, { "name": "Cytarabine", "type": "DRUG" }, { "name": "Dexamethasone", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "National Institute of Allergy and Infectious Diseases (NIAID)", "sponsor_class": "NIH", "healthy_volunteers": false, "eligibility": { "minimum_age": "16 Years", "maximum_age": null, "sex": "ALL", "summary": "16 Years and older" }, "enrollment_count": 33, "start_date": null, "completion_date": "1998-04", "has_results": false, "last_update_posted_date": "2012-11-01", "last_synced_at": "2026-06-25T21:26:42.888Z", "location_count": 7, "location_summary": "San Francisco, California • Denver, Colorado • Boston, Massachusetts + 3 more", "locations": [ { "city": "San Francisco", "state": "California" }, { "city": "San Francisco", "state": "California" }, { "city": "Denver", "state": "Colorado" }, { "city": "Boston", "state": "Massachusetts" }, { "city": "Brookline", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT00000801" }, { "nct_id": "NCT06990529", "title": "Long-term Safety and Efficacy of Leniolisib in PIDs With Immune Dysregulation", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "PIDs Linked to PI3K" ], "interventions": [ { "name": "Leniolisib", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Pharming Technologies B.V.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "12 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "12 Years to 75 Years" }, "enrollment_count": 12, "start_date": "2025-04-29", "completion_date": "2029-04-13", "has_results": false, "last_update_posted_date": "2026-02-13", "last_synced_at": "2026-06-25T21:26:42.888Z", "location_count": 3, "location_summary": "Bethesda, Maryland • Burlington, Massachusetts • New York, New York", "locations": [ { "city": "Bethesda", "state": "Maryland" }, { "city": "Burlington", "state": "Massachusetts" }, { "city": "New York", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT06990529" }, { "nct_id": "NCT00695422", "title": "Detecting Anal and Genital Human Papillomavirus Infection and Squamous Intraepithelial Lesions in HIV-Positive Patients Enrolled in AIDS Cancer Clinical Trials", "overall_status": "COMPLETED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Aids-related Malignancies", "Lymphoma", "Precancerous Condition", "Sarcoma" ], "interventions": [ { "name": "polymerase chain reaction", "type": "GENETIC" }, { "name": "cytology specimen collection procedure", "type": "OTHER" }, { "name": "histological technique", "type": "OTHER" }, { "name": "colposcopic biopsy", "type": "PROCEDURE" } ], "intervention_types": [ "GENETIC", "OTHER", "PROCEDURE" ], "sponsor": "AIDS Malignancy Consortium", "sponsor_class": "NETWORK", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 47, "start_date": "2008-05-14", "completion_date": "2017-04-19", "has_results": false, "last_update_posted_date": "2020-08-10", "last_synced_at": "2026-06-25T21:26:42.888Z", "location_count": 10, "location_summary": "La Jolla, California • Los Angeles, California • San Francisco, California + 5 more", "locations": [ { "city": "La Jolla", "state": "California" }, { "city": "Los Angeles", "state": "California" }, { "city": "Los Angeles", "state": "California" }, { "city": "San Francisco", "state": "California" }, { "city": "Honolulu", "state": "Hawaii" } ], "official_url": "https://clinicaltrials.gov/study/NCT00695422" }, { "nct_id": "NCT03563053", "title": "Extension Treatment Using EryDex System in Patients With AT Who Participated in the ATTeST-IEDAT-02-2015 Study", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Ataxia Telangiectasia", "Genetic Syndrome" ], "interventions": [ { "name": "EryDex System", "type": "COMBINATION_PRODUCT" } ], "intervention_types": [ "COMBINATION_PRODUCT" ], "sponsor": "Quince Therapeutics S.p.A.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "6 Years", "maximum_age": null, "sex": "ALL", "summary": "6 Years and older" }, "enrollment_count": 104, "start_date": "2018-06-12", "completion_date": "2022-09-02", "has_results": true, "last_update_posted_date": "2024-10-08", "last_synced_at": "2026-06-25T21:26:42.888Z", "location_count": 4, "location_summary": "Los Angeles, California • Baltimore, Maryland • Cincinnati, Ohio + 1 more", "locations": [ { "city": "Los Angeles", "state": "California" }, { "city": "Baltimore", "state": "Maryland" }, { "city": "Cincinnati", "state": "Ohio" }, { "city": "Houston", "state": "Texas" } ], "official_url": "https://clinicaltrials.gov/study/NCT03563053" }, { "nct_id": "NCT00023010", "title": "Gene Therapy for Patients With Leukocyte Adherence Deficiency (Follow-Up of Phase 1 Trial)", "overall_status": "COMPLETED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Leukocyte Adhesion Deficiency Syndrome" ], "interventions": [], "intervention_types": [], "sponsor": "National Cancer Institute (NCI)", "sponsor_class": "NIH", "healthy_volunteers": false, "eligibility": { "minimum_age": null, "maximum_age": null, "sex": "ALL", "summary": "Not listed" }, "enrollment_count": 2, "start_date": "2001-08-15", "completion_date": "2010-12-13", "has_results": false, "last_update_posted_date": "2017-07-02", "last_synced_at": "2026-06-25T21:26:42.888Z", "location_count": 1, "location_summary": "Bethesda, Maryland", "locations": [ { "city": "Bethesda", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT00023010" }, { "nct_id": "NCT03485911", "title": "Efficacy and Safety Study of BCX7353 as an Oral Treatment for the Prevention of Attacks in HAE", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Hereditary Angioedema", "HAE" ], "interventions": [ { "name": "BCX7353 capsules", "type": "DRUG" }, { "name": "Placebo oral capsule", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "BioCryst Pharmaceuticals", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "12 Years", "maximum_age": null, "sex": "ALL", "summary": "12 Years and older" }, "enrollment_count": 121, "start_date": "2018-02-06", "completion_date": "2022-04-06", "has_results": true, "last_update_posted_date": "2023-06-26", "last_synced_at": "2026-06-25T21:26:42.888Z", "location_count": 27, "location_summary": "Birmingham, Alabama • Scottsdale, Arizona • Little Rock, Arkansas + 24 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Scottsdale", "state": "Arizona" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "San Diego", "state": "California" }, { "city": "Santa Monica", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT03485911" } ] }