{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Primary+Open+Angle+Glaucoma+or+Ocular+Hypertension", "query": { "condition": "Primary Open Angle Glaucoma or Ocular Hypertension" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 64, "total_pages": 7, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Primary+Open+Angle+Glaucoma+or+Ocular+Hypertension&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-05-22T08:15:43.567Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT00846989", "title": "Efficacy, Tolerability and Safety of RKI983 (0.05% & 0.10%) vs Xalatan in Patients With POAG or Ocular Hypertension", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1", "PHASE2" ], "conditions": [ "Glaucoma", "Ocular Hypertension" ], "interventions": [ { "name": "RKI983A", "type": "DRUG" }, { "name": "Latanoprost", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Novartis Pharmaceuticals", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "MALE", "summary": "18 Years and older · Male only" }, "enrollment_count": 276, "start_date": "2009-01", "completion_date": "2009-04", "has_results": false, "last_update_posted_date": "2020-12-19", "last_synced_at": "2026-05-22T08:15:43.567Z", "location_count": 29, "location_summary": "Artesia, California • Inglewood, California • La Jolla, California + 25 more", "locations": [ { "city": "Artesia", "state": "California" }, { "city": "Inglewood", "state": "California" }, { "city": "La Jolla", "state": "California" }, { "city": "Poway", "state": "California" }, { "city": "Stockton", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT00846989" }, { "nct_id": "NCT03216902", "title": "A Phase IIb Safety and Efficacy Study of DE-126 Ophthalmic Solution in Primary Open-Angle Glaucoma or Ocular Hypertension- Angel Study", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Open-angle Glaucoma, Ocular Hypertension" ], "interventions": [ { "name": "Vehicle of DE-126 Ophthalmic Solution, high dose of DE-126 Ophthalmic Solution", "type": "DRUG" }, { "name": "Topical ultra-low dose of DE-126 Ophthalmic Solution", "type": "DRUG" }, { "name": "Topical low dose of DE-126 Ophthalmic Solution", "type": "DRUG" }, { "name": "Topical medium dose of DE-126 Ophthalmic Solution", "type": "DRUG" }, { "name": "Topical high dose of DE-126 Ophthalmic Solution", "type": "DRUG" }, { "name": "0.005% Latanoprost Ophthalmic Solution", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Santen Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 241, "start_date": "2017-07-25", "completion_date": "2018-02-27", "has_results": true, "last_update_posted_date": "2020-10-23", "last_synced_at": "2026-05-22T08:15:43.567Z", "location_count": 12, "location_summary": "Artesia, California • Mission Hills, California • Newport Beach, California + 9 more", "locations": [ { "city": "Artesia", "state": "California" }, { "city": "Mission Hills", "state": "California" }, { "city": "Newport Beach", "state": "California" }, { "city": "Petaluma", "state": "California" }, { "city": "Largo", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT03216902" }, { "nct_id": "NCT01560975", "title": "IOP Fluctuations in Patients With Sleep Apnea With or Without Primary Open Angle Glaucoma Using Positive Airway Pressure", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Sleep Apnea, Obstructive", "Primary Open-angle Glaucoma" ], "interventions": [ { "name": "SENSIMED Triggerfish®", "type": "DEVICE" } ], "intervention_types": [ "DEVICE" ], "sponsor": "Sensimed AG", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "99 Years", "sex": "ALL", "summary": "18 Years to 99 Years" }, "enrollment_count": 10, "start_date": "2012-03", "completion_date": "2012-11", "has_results": true, "last_update_posted_date": "2016-01-27", "last_synced_at": "2026-05-22T08:15:43.567Z", "location_count": 1, "location_summary": "New York, New York", "locations": [ { "city": "New York", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT01560975" }, { "nct_id": "NCT03233308", "title": "Study of Netarsudil Ophthalmic Solution in Subjects With Primary Open Angle Glaucoma (POAG) or Ocular Hypertension (OHT)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Primary Open Angle Glaucoma or Ocular Hypertension" ], "interventions": [ { "name": "Netarsudil Ophthalmic Solution 0.02%", "type": "DRUG" }, { "name": "Placebo Comparator", "type": "OTHER" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "Aerie Pharmaceuticals", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 20, "start_date": "2017-10-20", "completion_date": "2018-04-19", "has_results": true, "last_update_posted_date": "2019-08-06", "last_synced_at": "2026-05-22T08:15:43.567Z", "location_count": 2, "location_summary": "Rochester, Minnesota • Durham, North Carolina", "locations": [ { "city": "Rochester", "state": "Minnesota" }, { "city": "Durham", "state": "North Carolina" } ], "official_url": "https://clinicaltrials.gov/study/NCT03233308" }, { "nct_id": "NCT05451329", "title": "A Phase 2 Double-masked Study of VVN539 in Subjects With Elevated Intraocular Pressure", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Glaucoma, Open-Angle" ], "interventions": [ { "name": "VVN539 Ophthalmic Solution 0.02%", "type": "DRUG" }, { "name": "VVN539 Ophthalmic Solution 0.04%", "type": "DRUG" }, { "name": "VVN539 Ophthalmic Solution Vehicle", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "VivaVision Biotech, Inc", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 68, "start_date": "2022-07-12", "completion_date": "2022-12-22", "has_results": true, "last_update_posted_date": "2024-01-17", "last_synced_at": "2026-05-22T08:15:43.567Z", "location_count": 1, "location_summary": "Durham, North Carolina", "locations": [ { "city": "Durham", "state": "North Carolina" } ], "official_url": "https://clinicaltrials.gov/study/NCT05451329" }, { "nct_id": "NCT04360174", "title": "CLN-0045: Safety, and Efficacy of OTX-TIC in Participants With Open Angle Glaucoma or Ocular Hypertension", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Ocular Hypertension", "Open Angle Glaucoma" ], "interventions": [ { "name": "OTX-TIC", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Ocular Therapeutix, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 19, "start_date": "2018-04-25", "completion_date": "2021-05-24", "has_results": true, "last_update_posted_date": "2024-10-01", "last_synced_at": "2026-05-22T08:15:43.567Z", "location_count": 5, "location_summary": "Petaluma, California • Torrance, California • Roswell, Georgia + 2 more", "locations": [ { "city": "Petaluma", "state": "California" }, { "city": "Torrance", "state": "California" }, { "city": "Roswell", "state": "Georgia" }, { "city": "Austin", "state": "Texas" }, { "city": "Racine", "state": "Wisconsin" } ], "official_url": "https://clinicaltrials.gov/study/NCT04360174" }, { "nct_id": "NCT01915940", "title": "Bimatoprost Ocular Insert Compared to Topical Timolol Solution in Patients With Glaucoma or Ocular Hypertension", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Primary Open-Angle Glaucoma", "Ocular Hypertension" ], "interventions": [ { "name": "Bimatoprost", "type": "DRUG" }, { "name": "Timolol 0.5%", "type": "DRUG" }, { "name": "Placebo Eye Drops", "type": "DRUG" }, { "name": "Placebo Ocular Insert", "type": "DEVICE" } ], "intervention_types": [ "DRUG", "DEVICE" ], "sponsor": "ForSight Vision5, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 169, "start_date": "2013-10-23", "completion_date": "2014-11-14", "has_results": true, "last_update_posted_date": "2018-04-20", "last_synced_at": "2026-05-22T08:15:43.567Z", "location_count": 10, "location_summary": "Artesia, California • La Jolla, California • Newport Beach, California + 7 more", "locations": [ { "city": "Artesia", "state": "California" }, { "city": "La Jolla", "state": "California" }, { "city": "Newport Beach", "state": "California" }, { "city": "Sacramento", "state": "California" }, { "city": "Atlanta", "state": "Georgia" } ], "official_url": "https://clinicaltrials.gov/study/NCT01915940" }, { "nct_id": "NCT01279083", "title": "Safety and Efficacy Trial to Treat Open-Angle Glaucoma or Ocular Hypertension", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1", "PHASE2" ], "conditions": [ "Open-angle Glaucoma", "Ocular Hypertension" ], "interventions": [ { "name": "DE-112", "type": "DRUG" }, { "name": "DE-112 Vehicle Solution", "type": "DRUG" }, { "name": "Timolol Maleate Solution", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Santen Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 147, "start_date": "2011-01", "completion_date": "2012-02", "has_results": false, "last_update_posted_date": "2012-12-17", "last_synced_at": "2026-05-22T08:15:43.567Z", "location_count": 2, "location_summary": "Austin, Texas • San Antonio, Texas", "locations": [ { "city": "Austin", "state": "Texas" }, { "city": "San Antonio", "state": "Texas" } ], "official_url": "https://clinicaltrials.gov/study/NCT01279083" }, { "nct_id": "NCT00650338", "title": "Safety and Efficacy Study of DE-104 Ophthalmic Solution to Treat Open-angle Glaucoma or Ocular Hypertension", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Open-Angle Glaucoma", "Ocular Hypertension" ], "interventions": [ { "name": "DE-104 ophthalmic solution, low concentration", "type": "DRUG" }, { "name": "DE-104 ophthalmic solution, medium concentration", "type": "DRUG" }, { "name": "DE-104 ophthalmic solution, high concentration", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" }, { "name": "0.005% latanoprost", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Santen Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 165, "start_date": "2008-03", "completion_date": "2008-10", "has_results": false, "last_update_posted_date": "2011-11-03", "last_synced_at": "2026-05-22T08:15:43.567Z", "location_count": 14, "location_summary": "Artesia, California • Los Angeles, California • Torrance, California + 9 more", "locations": [ { "city": "Artesia", "state": "California" }, { "city": "Los Angeles", "state": "California" }, { "city": "Torrance", "state": "California" }, { "city": "Stuart", "state": "Florida" }, { "city": "Bel Air", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT00650338" }, { "nct_id": "NCT03452033", "title": "H-1337 Ophthalmic Solution Phase 1/2", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1", "PHASE2" ], "conditions": [ "Glaucoma, Open-Angle" ], "interventions": [ { "name": "H-1337 Placebo", "type": "DRUG" }, { "name": "H-1337 [1]", "type": "DRUG" }, { "name": "H-1337 [2]", "type": "DRUG" }, { "name": "H-1337 [3]", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Allysta Pharmaceutical", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "99 Years", "sex": "ALL", "summary": "18 Years to 99 Years" }, "enrollment_count": 87, "start_date": "2018-03-15", "completion_date": "2018-08-15", "has_results": true, "last_update_posted_date": "2022-07-12", "last_synced_at": "2026-05-22T08:15:43.567Z", "location_count": 1, "location_summary": "Goose Creek, South Carolina", "locations": [ { "city": "Goose Creek", "state": "South Carolina" } ], "official_url": "https://clinicaltrials.gov/study/NCT03452033" } ] }