{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Primary+Ovarian+Insufficiency+%28Poi%29",
    "query": {
      "condition": "Primary Ovarian Insufficiency (Poi)"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 46,
    "total_pages": 5,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Primary+Ovarian+Insufficiency+%28Poi%29&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-06-11T09:14:47.290Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT01986777",
      "title": "LDX for the Treatment of Cognitive Functioning Issues in Women Post-Oophorectomy",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Cognitive Impairments",
        "RRSO"
      ],
      "interventions": [
        {
          "name": "lisdexamfetamine",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Pennsylvania",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "30 Years",
        "maximum_age": "60 Years",
        "sex": "FEMALE",
        "summary": "30 Years to 60 Years · Female only"
      },
      "enrollment_count": 0,
      "start_date": "2013-07",
      "completion_date": "2013-12",
      "has_results": false,
      "last_update_posted_date": "2017-09-18",
      "last_synced_at": "2026-06-11T09:14:47.290Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01986777"
    },
    {
      "nct_id": "NCT00140998",
      "title": "Estrogen Treatment (Oral vs. Patches) in Turner Syndrome",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Turner Syndrome",
        "Hypogonadism",
        "Premature Ovarian Failure"
      ],
      "interventions": [
        {
          "name": "17 beta estradiol",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Nemours Children's Clinic",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "10 Years",
        "maximum_age": "16 Years",
        "sex": "FEMALE",
        "summary": "10 Years to 16 Years · Female only"
      },
      "enrollment_count": 16,
      "start_date": "2001-01",
      "completion_date": "2004-06",
      "has_results": false,
      "last_update_posted_date": "2017-11-30",
      "last_synced_at": "2026-06-11T09:14:47.290Z",
      "location_count": 1,
      "location_summary": "Jacksonville, Florida",
      "locations": [
        {
          "city": "Jacksonville",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00140998"
    },
    {
      "nct_id": "NCT00650754",
      "title": "Study of Oral Dehydroepiandrosterone(DHEA) to Treat Previously Unexplained Infertility",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2",
        "PHASE3"
      ],
      "conditions": [
        "Primary Ovarian Insufficiency",
        "Unexplained Infertility"
      ],
      "interventions": [
        {
          "name": "Dehydroepiandrosterone",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Placebo",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT",
        "OTHER"
      ],
      "sponsor": "Center for Human Reproduction",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "37 Years",
        "sex": "FEMALE",
        "summary": "21 Years to 37 Years · Female only"
      },
      "enrollment_count": 35,
      "start_date": "2008-03",
      "completion_date": "2014-03",
      "has_results": false,
      "last_update_posted_date": "2015-09-30",
      "last_synced_at": "2026-06-11T09:14:47.290Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00650754"
    },
    {
      "nct_id": "NCT01702935",
      "title": "Ovarian Stem Cells From Women With Ovarian Insufficiency",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Infertility"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)",
      "sponsor_class": "NIH",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 11,
      "start_date": "2012-09-19",
      "completion_date": "2017-09-21",
      "has_results": false,
      "last_update_posted_date": "2019-12-17",
      "last_synced_at": "2026-06-11T09:14:47.290Z",
      "location_count": 1,
      "location_summary": "Bethesda, Maryland",
      "locations": [
        {
          "city": "Bethesda",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01702935"
    },
    {
      "nct_id": "NCT06673004",
      "title": "Ovarian Tissue Allo-transplantation",
      "overall_status": "NOT_YET_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Ovarian Failure",
        "Ovarian Insufficiency",
        "Menopause Ovarian Failure",
        "Menopause, Premature",
        "Infertility, Female",
        "Endocrine Female Infertility"
      ],
      "interventions": [
        {
          "name": "Ovarian tissue allo-transplantation",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Rebecca Flyckt",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "40 Years",
        "sex": "FEMALE",
        "summary": "21 Years to 40 Years · Female only"
      },
      "enrollment_count": 10,
      "start_date": "2026-05-01",
      "completion_date": "2030-05-30",
      "has_results": false,
      "last_update_posted_date": "2026-03-09",
      "last_synced_at": "2026-06-11T09:14:47.290Z",
      "location_count": 1,
      "location_summary": "Cleveland, Ohio",
      "locations": [
        {
          "city": "Cleveland",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06673004"
    },
    {
      "nct_id": "NCT00001951",
      "title": "Hormone Replacement in Young Women With Premature Ovarian Failure",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Healthy",
        "Osteoporosis",
        "Premature Ovarian Failure"
      ],
      "interventions": [
        {
          "name": "TMTDS",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)",
      "sponsor_class": "NIH",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "32 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 32 Years · Female only"
      },
      "enrollment_count": 250,
      "start_date": "1999-12",
      "completion_date": "2006-10",
      "has_results": false,
      "last_update_posted_date": "2007-02-27",
      "last_synced_at": "2026-06-11T09:14:47.290Z",
      "location_count": 1,
      "location_summary": "Bethesda, Maryland",
      "locations": [
        {
          "city": "Bethesda",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00001951"
    },
    {
      "nct_id": "NCT02467231",
      "title": "Ovarian Reserve After Cancer: Longitudinal Effects",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Effects of Chemotherapy",
        "Premature Ovarian Failure"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "University of Pennsylvania",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "11 Years",
        "maximum_age": "35 Years",
        "sex": "FEMALE",
        "summary": "11 Years to 35 Years · Female only"
      },
      "enrollment_count": 196,
      "start_date": "2009-02",
      "completion_date": "2028-12",
      "has_results": false,
      "last_update_posted_date": "2025-10-28",
      "last_synced_at": "2026-06-11T09:14:47.290Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02467231"
    },
    {
      "nct_id": "NCT07357701",
      "title": "Identifying Genome Variants in Non-Obstructive Azoospermia (NOA) or Primary Ovarian Insufficiency (POI)",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Primary Ovarian Insufficiency",
        "Azoospermia",
        "Oligospermia"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)",
      "sponsor_class": "NIH",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "100 Years",
        "sex": "ALL",
        "summary": "18 Years to 100 Years"
      },
      "enrollment_count": 500,
      "start_date": "2026-03-11",
      "completion_date": "2031-01-01",
      "has_results": false,
      "last_update_posted_date": "2026-03-16",
      "last_synced_at": "2026-06-11T09:14:47.290Z",
      "location_count": 2,
      "location_summary": "Bethesda, Maryland • Rockville, Maryland",
      "locations": [
        {
          "city": "Bethesda",
          "state": "Maryland"
        },
        {
          "city": "Rockville",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07357701"
    },
    {
      "nct_id": "NCT02922348",
      "title": "Hormone Replacement for Premature Ovarian Insufficiency",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Primary Ovarian Insufficiency"
      ],
      "interventions": [
        {
          "name": "Hormone Replacement Therapy",
          "type": "DRUG"
        },
        {
          "name": "Combined Oral Contraceptives",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Pennsylvania",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "14 Years",
        "maximum_age": "45 Years",
        "sex": "FEMALE",
        "summary": "14 Years to 45 Years · Female only"
      },
      "enrollment_count": 0,
      "start_date": "2016-03-01",
      "completion_date": "2018-12-01",
      "has_results": false,
      "last_update_posted_date": "2019-07-05",
      "last_synced_at": "2026-06-11T09:14:47.290Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02922348"
    },
    {
      "nct_id": "NCT03568708",
      "title": "Primary Ovarian Insufficiency: Phenotype and Optimal Treatment",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Primary Ovarian Insufficiency"
      ],
      "interventions": [
        {
          "name": "Transdermal Estrogen",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Children's Hospital Medical Center, Cincinnati",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "11 Years",
        "maximum_age": "18 Years",
        "sex": "FEMALE",
        "summary": "11 Years to 18 Years · Female only"
      },
      "enrollment_count": 19,
      "start_date": "2018-11-01",
      "completion_date": "2023-01-05",
      "has_results": true,
      "last_update_posted_date": "2024-06-25",
      "last_synced_at": "2026-06-11T09:14:47.290Z",
      "location_count": 1,
      "location_summary": "Cincinnati, Ohio",
      "locations": [
        {
          "city": "Cincinnati",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03568708"
    }
  ]
}