{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Primary+Progressive+Aphasia%28PPA%29&page=2",
    "query": {
      "condition": "Primary Progressive Aphasia(PPA)",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Primary+Progressive+Aphasia%28PPA%29&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-06-26T03:20:55.687Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT01738386",
      "title": "Living With Frontotemporal Dementia",
      "overall_status": "TERMINATED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Adaptation"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "National Human Genome Research Institute (NHGRI)",
      "sponsor_class": "NIH",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 16,
      "start_date": "2012-06-13",
      "completion_date": "2016-02-24",
      "has_results": false,
      "last_update_posted_date": "2018-07-26",
      "last_synced_at": "2026-06-26T03:20:55.687Z",
      "location_count": 3,
      "location_summary": "Baltimore, Maryland • New York, New York • Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Baltimore",
          "state": "Maryland"
        },
        {
          "city": "New York",
          "state": "New York"
        },
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01738386"
    },
    {
      "nct_id": "NCT06211374",
      "title": "Communication Bridge Pilot Study",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Primary Progressive Aphasia"
      ],
      "interventions": [
        {
          "name": "Communication Bridge",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "University of Chicago",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "100 Years",
        "sex": "ALL",
        "summary": "18 Years to 100 Years"
      },
      "enrollment_count": 12,
      "start_date": "2024-06-28",
      "completion_date": "2026-05-31",
      "has_results": false,
      "last_update_posted_date": "2025-08-07",
      "last_synced_at": "2026-06-26T03:20:55.687Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06211374"
    },
    {
      "nct_id": "NCT02736695",
      "title": "Assessment of Hyperphosphorylated Tau PET Binding in Primary Progressive Aphasia and Frontotemporal Dementia",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Primary Progressive Aphasia",
        "Behavioral Variant of Frontotemporal Dementia",
        "Frontotemporal Dementia, Behavioral Variant"
      ],
      "interventions": [
        {
          "name": "F-18 AV 1451",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Mayo Clinic",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 81,
      "start_date": "2016-07",
      "completion_date": "2024-08-01",
      "has_results": true,
      "last_update_posted_date": "2025-11-21",
      "last_synced_at": "2026-06-26T03:20:55.687Z",
      "location_count": 1,
      "location_summary": "Rochester, Minnesota",
      "locations": [
        {
          "city": "Rochester",
          "state": "Minnesota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02736695"
    },
    {
      "nct_id": "NCT02966145",
      "title": "4-Repeat Tauopathy Neuroimaging Initiative - Cycle 2",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Corticobasal Degeneration (CBD)",
        "Corticobasal Syndrome (CBS)",
        "Cortical-basal Ganglionic Degeneration (CBGD)",
        "Progressive Supranuclear Palsy (PSP)",
        "Nonfluent Variant Primary Progressive Aphasia (nfvPPA)",
        "Oligosymptomatic/Variant Progressive Supranuclear Palsy (o/vPSP)"
      ],
      "interventions": [
        {
          "name": "Observational Study",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of California, San Francisco",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "40 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "40 Years to 80 Years"
      },
      "enrollment_count": 293,
      "start_date": "2016-01",
      "completion_date": "2024-02-28",
      "has_results": false,
      "last_update_posted_date": "2025-04-13",
      "last_synced_at": "2026-06-26T03:20:55.687Z",
      "location_count": 7,
      "location_summary": "San Diego, California • San Francisco, California • Baltimore, Maryland + 4 more",
      "locations": [
        {
          "city": "San Diego",
          "state": "California"
        },
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "Baltimore",
          "state": "Maryland"
        },
        {
          "city": "Charlestown",
          "state": "Massachusetts"
        },
        {
          "city": "Rochester",
          "state": "Minnesota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02966145"
    },
    {
      "nct_id": "NCT03887481",
      "title": "Targeting Language-specific and Executive-control Networks With Transcranial Direct Current Stimulation in Logopenic Variant PPA",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Logopenic Progressive Aphasia",
        "Primary Progressive Aphasia"
      ],
      "interventions": [
        {
          "name": "High-definition active tDCS (HD-tDCS) + \"Repeat After Me\" (RAM) Treatment",
          "type": "DEVICE"
        },
        {
          "name": "Sham + \"Repeat After Me\" (RAM) Treatment",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Johns Hopkins University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "50 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "50 Years to 80 Years"
      },
      "enrollment_count": 60,
      "start_date": "2022-10-15",
      "completion_date": "2027-10-31",
      "has_results": false,
      "last_update_posted_date": "2025-09-15",
      "last_synced_at": "2026-06-26T03:20:55.687Z",
      "location_count": 1,
      "location_summary": "Baltimore, Maryland",
      "locations": [
        {
          "city": "Baltimore",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03887481"
    },
    {
      "nct_id": "NCT04104659",
      "title": "Study of Tau Imaging With the Use of [18F]MK-6240 Tracer",
      "overall_status": "ENROLLING_BY_INVITATION",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Alzheimer Disease"
      ],
      "interventions": [
        {
          "name": "MK 6240",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Tammie L. S. Benzinger, MD, PhD",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 200,
      "start_date": "2021-03-01",
      "completion_date": "2027-06-01",
      "has_results": false,
      "last_update_posted_date": "2026-06-08",
      "last_synced_at": "2026-06-26T03:20:55.687Z",
      "location_count": 1,
      "location_summary": "St Louis, Missouri",
      "locations": [
        {
          "city": "St Louis",
          "state": "Missouri"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04104659"
    },
    {
      "nct_id": "NCT01353430",
      "title": "Characterization of Inclusion Body Myopathy Associated With Paget's Disease of Bone and Frontotemporal Dementia (IBMPFD)",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Inclusion Body Myopathy With Early-onset Paget Disease and Frontotemporal Dementia",
        "Paget Disease of Bone",
        "Frontotemporal Dementia",
        "Myopathy"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "University of California, Irvine",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 50,
      "start_date": "2007-11-15",
      "completion_date": "2030-12",
      "has_results": false,
      "last_update_posted_date": "2025-06-18",
      "last_synced_at": "2026-06-26T03:20:55.687Z",
      "location_count": 1,
      "location_summary": "Irvine, California",
      "locations": [
        {
          "city": "Irvine",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01353430"
    },
    {
      "nct_id": "NCT03028324",
      "title": "Transcranial Magnetic Stimulation (TMS) for Primary Progressive Apraxia of Speech (PPAOS)",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Apraxia Speech"
      ],
      "interventions": [
        {
          "name": "Transcranial Magnetic Stimulation (TMS)",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of Miami",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 4,
      "start_date": "2017-08-09",
      "completion_date": "2018-11-13",
      "has_results": true,
      "last_update_posted_date": "2020-05-26",
      "last_synced_at": "2026-06-26T03:20:55.687Z",
      "location_count": 1,
      "location_summary": "Miami, Florida",
      "locations": [
        {
          "city": "Miami",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03028324"
    },
    {
      "nct_id": "NCT06768996",
      "title": "Music, Social Attention, and Dementia",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Frontotemporal Dementia",
        "Alzheimer Disease"
      ],
      "interventions": [
        {
          "name": "Synchronous Rhythm Production",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Solo Rhythm Production",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "University of California, San Francisco",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "55 Years",
        "maximum_age": "89 Years",
        "sex": "ALL",
        "summary": "55 Years to 89 Years"
      },
      "enrollment_count": 80,
      "start_date": "2025-01-10",
      "completion_date": "2026-12-01",
      "has_results": false,
      "last_update_posted_date": "2025-12-03",
      "last_synced_at": "2026-06-26T03:20:55.687Z",
      "location_count": 1,
      "location_summary": "San Francisco, California",
      "locations": [
        {
          "city": "San Francisco",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06768996"
    },
    {
      "nct_id": "NCT02141971",
      "title": "Down Syndrome Biomarker Initiative (DSBI)",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Down Syndrome",
        "Alzheimer's Disease"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Michael Rafii",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "30 Years",
        "maximum_age": "60 Years",
        "sex": "ALL",
        "summary": "30 Years to 60 Years"
      },
      "enrollment_count": 12,
      "start_date": "2013-06-01",
      "completion_date": "2017-04-15",
      "has_results": false,
      "last_update_posted_date": "2017-05-02",
      "last_synced_at": "2026-06-26T03:20:55.687Z",
      "location_count": 1,
      "location_summary": "La Jolla, California",
      "locations": [
        {
          "city": "La Jolla",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02141971"
    }
  ]
}