{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Prosthesis+Failure",
    "query": {
      "condition": "Prosthesis Failure"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-05-22T09:23:47.888Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT06713577",
      "title": "Clinical Study of a 3D Shaded Zirconia for Chairside CAD/CAM Restorations",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Dental Prosthesis Failure",
        "Dental Prosthesis Complication"
      ],
      "interventions": [
        {
          "name": "CEREC Cercon 4D",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Dentsply Sirona Implants and Consumables",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "18 Years to 75 Years"
      },
      "enrollment_count": 82,
      "start_date": "2024-12-03",
      "completion_date": "2031-11-22",
      "has_results": false,
      "last_update_posted_date": "2026-03-09",
      "last_synced_at": "2026-05-22T09:23:47.888Z",
      "location_count": 1,
      "location_summary": "Ann Arbor, Michigan",
      "locations": [
        {
          "city": "Ann Arbor",
          "state": "Michigan"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06713577"
    },
    {
      "nct_id": "NCT05459233",
      "title": "Valve Hemodynamic Optimization Based on Doppler-Echocardiography vs Catheterization Measurements Following ViV TAVR",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Aortic Valve Stenosis",
        "Aortic Valve Regurgitation",
        "Prosthesis Failure"
      ],
      "interventions": [
        {
          "name": "Doppler-echocardiography",
          "type": "PROCEDURE"
        },
        {
          "name": "Invasive hemodynamic measurements",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Institut universitaire de cardiologie et de pneumologie de Québec, University Laval",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 310,
      "start_date": "2023-01-11",
      "completion_date": "2029-09-01",
      "has_results": false,
      "last_update_posted_date": "2026-03-24",
      "last_synced_at": "2026-05-22T09:23:47.888Z",
      "location_count": 6,
      "location_summary": "San Francisco, California • Hollywood, Florida • Royal Oak, Michigan + 3 more",
      "locations": [
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "Hollywood",
          "state": "Florida"
        },
        {
          "city": "Royal Oak",
          "state": "Michigan"
        },
        {
          "city": "Rochester",
          "state": "Minnesota"
        },
        {
          "city": "Syracuse",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05459233"
    },
    {
      "nct_id": "NCT05619588",
      "title": "Exactech Vantage Total Ankle System Post Market Clinical Follow-Up - US Only",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Ankle Rheumatoid Arthritis",
        "Arthritis of Ankle",
        "Failure, Prosthesis"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Exactech",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 370,
      "start_date": "2017-04-04",
      "completion_date": "2031-09-30",
      "has_results": false,
      "last_update_posted_date": "2025-02-27",
      "last_synced_at": "2026-05-22T09:23:47.888Z",
      "location_count": 2,
      "location_summary": "Jacksonville, Florida • Durham, North Carolina",
      "locations": [
        {
          "city": "Jacksonville",
          "state": "Florida"
        },
        {
          "city": "Durham",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05619588"
    },
    {
      "nct_id": "NCT01840956",
      "title": "Safety and Efficacy of a Vascular Prosthesis for Hemodialysis Access in Patients With End-Stage Renal Disease",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "End-stage Renal Disease",
        "Kidney Failure, Chronic"
      ],
      "interventions": [
        {
          "name": "HAVG",
          "type": "BIOLOGICAL"
        }
      ],
      "intervention_types": [
        "BIOLOGICAL"
      ],
      "sponsor": "Humacyte, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 20,
      "start_date": "2013-05-23",
      "completion_date": "2016-04-28",
      "has_results": false,
      "last_update_posted_date": "2022-08-19",
      "last_synced_at": "2026-05-22T09:23:47.888Z",
      "location_count": 3,
      "location_summary": "Durham, North Carolina • Houston, Texas • Norfolk, Virginia",
      "locations": [
        {
          "city": "Durham",
          "state": "North Carolina"
        },
        {
          "city": "Houston",
          "state": "Texas"
        },
        {
          "city": "Norfolk",
          "state": "Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01840956"
    },
    {
      "nct_id": "NCT05752539",
      "title": "Clinical Evaluation of Implants Restored With Advanced Lithium Disilicate Screw-retained Crowns",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Dental Prosthesis Failure",
        "Dental Prosthesis Complication"
      ],
      "interventions": [
        {
          "name": "CEREC System by Dentsply Sirona",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Dentsply Sirona Implants and Consumables",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "18 Years to 75 Years"
      },
      "enrollment_count": 25,
      "start_date": "2023-10-10",
      "completion_date": "2028-02-20",
      "has_results": false,
      "last_update_posted_date": "2025-08-12",
      "last_synced_at": "2026-05-22T09:23:47.888Z",
      "location_count": 1,
      "location_summary": "Ann Arbor, Michigan",
      "locations": [
        {
          "city": "Ann Arbor",
          "state": "Michigan"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05752539"
    },
    {
      "nct_id": "NCT00677235",
      "title": "Post-Approval Study for the FLAIR Endovascular Stent Graft",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Stenosis of Vascular Prosthetic Devices, Implants and Grafts"
      ],
      "interventions": [
        {
          "name": "FLAIR Endovascular Stent Graft",
          "type": "DEVICE"
        },
        {
          "name": "PTA",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "PROCEDURE"
      ],
      "sponsor": "C. R. Bard",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 270,
      "start_date": "2008-12",
      "completion_date": "2013-03",
      "has_results": true,
      "last_update_posted_date": "2017-03-10",
      "last_synced_at": "2026-05-22T09:23:47.888Z",
      "location_count": 1,
      "location_summary": "Bamberg, South Carolina",
      "locations": [
        {
          "city": "Bamberg",
          "state": "South Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00677235"
    },
    {
      "nct_id": "NCT02316262",
      "title": "Targeted Reinnervation for Neuromas as a Means to Improve Prosthesis Control in Major Limb Amputation",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Neuroma",
        "Pain",
        "Prosthesis User",
        "Prosthesis Failure"
      ],
      "interventions": [
        {
          "name": "Targeted Muscle Reinnervation",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Northwestern University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "85 Years",
        "sex": "ALL",
        "summary": "18 Years to 85 Years"
      },
      "enrollment_count": 33,
      "start_date": "2014-10",
      "completion_date": "2018-01-01",
      "has_results": false,
      "last_update_posted_date": "2018-01-03",
      "last_synced_at": "2026-05-22T09:23:47.888Z",
      "location_count": 6,
      "location_summary": "Chicago, Illinois • Bethesda, Maryland • Columbus, Ohio + 3 more",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        },
        {
          "city": "Bethesda",
          "state": "Maryland"
        },
        {
          "city": "Columbus",
          "state": "Ohio"
        },
        {
          "city": "Oklahoma City",
          "state": "Oklahoma"
        },
        {
          "city": "Nashville",
          "state": "Tennessee"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02316262"
    },
    {
      "nct_id": "NCT01729858",
      "title": "Survival of Implant-Supported All-Ceramic Prostheses",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Partial Edentulism",
        "Disorder of Prostheses and Implants",
        "Dental Prosthesis Failure"
      ],
      "interventions": [
        {
          "name": "Ceramic-Ceramic",
          "type": "DEVICE"
        },
        {
          "name": "Metal-Ceramic",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of Florida",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "21 Years to 75 Years"
      },
      "enrollment_count": 106,
      "start_date": "2008-12",
      "completion_date": "2028-12",
      "has_results": false,
      "last_update_posted_date": "2025-06-15",
      "last_synced_at": "2026-05-22T09:23:47.888Z",
      "location_count": 1,
      "location_summary": "Gainesville, Florida",
      "locations": [
        {
          "city": "Gainesville",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01729858"
    },
    {
      "nct_id": "NCT05112679",
      "title": "Limb Health and Socket Pressure in Response to Powered Ankle Protheses",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Pressure Ulcer, Ankle",
        "Prosthesis User",
        "Prosthesis Durability",
        "Mobility Limitation",
        "Skin Wound",
        "Amputation; Traumatic, Foot",
        "Amputation",
        "Limb Deficiencies"
      ],
      "interventions": [
        {
          "name": "PROPRIO FOOT® by Ossur & Empower ankle by Ottobock",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Indiana University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 6,
      "start_date": "2021-11-15",
      "completion_date": "2023-07-19",
      "has_results": true,
      "last_update_posted_date": "2025-11-25",
      "last_synced_at": "2026-05-22T09:23:47.888Z",
      "location_count": 1,
      "location_summary": "Indianapolis, Indiana",
      "locations": [
        {
          "city": "Indianapolis",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05112679"
    },
    {
      "nct_id": "NCT05040165",
      "title": "Investigation on Failure Time Analysis of a New TPE Material in the Iceform Liner",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Prosthesis Failure"
      ],
      "interventions": [
        {
          "name": "Iceform liner and sleeve",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Össur Iceland ehf",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 64,
      "start_date": "2019-12-08",
      "completion_date": "2020-08-30",
      "has_results": false,
      "last_update_posted_date": "2021-09-10",
      "last_synced_at": "2026-05-22T09:23:47.888Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05040165"
    }
  ]
}