{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Pyelonephritis+Acute", "query": { "condition": "Pyelonephritis Acute" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 23, "total_pages": 3, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Pyelonephritis+Acute&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-07-22T07:37:13.799Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT03840148", "title": "Safety and Efficacy Study of Cefepime/VNRX-5133 in Patients With Complicated Urinary Tract Infections", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Urinary Tract Infections", "Acute Pyelonephritis" ], "interventions": [ { "name": "Cefepime/VNRX-5133 (taniborbactam)", "type": "DRUG" }, { "name": "Meropenem", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Venatorx Pharmaceuticals, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 661, "start_date": "2019-08-07", "completion_date": "2021-12-14", "has_results": true, "last_update_posted_date": "2025-06-06", "last_synced_at": "2026-07-22T07:37:13.799Z", "location_count": 4, "location_summary": "Buena Park, California • Chula Vista, California • La Mesa, California + 1 more", "locations": [ { "city": "Buena Park", "state": "California" }, { "city": "Chula Vista", "state": "California" }, { "city": "La Mesa", "state": "California" }, { "city": "Northridge", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT03840148" }, { "nct_id": "NCT02420366", "title": "Study of Cases of Serious Infections Due to Carbapenem-Resistant Enterobacteriaceae", "overall_status": "COMPLETED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Urinary Tract Infection, Complicated", "Acute Pyelonephritis", "Hospital Acquired Bacterial Pneumonia", "Ventilator-associated Bacterial Pneumonia", "Bacteremia" ], "interventions": [], "intervention_types": [], "sponsor": "Rempex (a wholly owned subsidiary of Melinta Therapeutics, Inc.)", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 257, "start_date": "2014-05", "completion_date": "2015-01", "has_results": false, "last_update_posted_date": "2018-05-02", "last_synced_at": "2026-07-22T07:37:13.799Z", "location_count": 12, "location_summary": "Chicago, Illinois • Evanston, Illinois • Detroit, Michigan + 8 more", "locations": [ { "city": "Chicago", "state": "Illinois" }, { "city": "Evanston", "state": "Illinois" }, { "city": "Detroit", "state": "Michigan" }, { "city": "New Brunswick", "state": "New Jersey" }, { "city": "Somers Point", "state": "New Jersey" } ], "official_url": "https://clinicaltrials.gov/study/NCT02420366" }, { "nct_id": "NCT01595438", "title": "Ceftazidime-Avibactam Compared With Doripenem Followed by Oral Therapy for Hospitalized Adults With Complicated UTIs (Urinary Tract Infections)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Complicated Urinary Tract Infection (cUTI) Including Acute Pyelonephritis" ], "interventions": [ { "name": "Ceftazidime - Avibactam ( CAZ-AVI)", "type": "DRUG" }, { "name": "Doripenem", "type": "DRUG" }, { "name": "Either switch to oral therapy: 500 mg of Ciprofloxacin (oral)", "type": "DRUG" }, { "name": "or switch to oral therapy: 800 mg/160 mg of sulfamethoxazole/trimethoprim (oral)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Pfizer", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "90 Years", "sex": "ALL", "summary": "18 Years to 90 Years" }, "enrollment_count": 598, "start_date": "2012-10", "completion_date": "2014-08", "has_results": true, "last_update_posted_date": "2017-09-06", "last_synced_at": "2026-07-22T07:37:13.799Z", "location_count": 3, "location_summary": "Sylmar, California • Royal Oak, Michigan • Lima, Ohio", "locations": [ { "city": "Sylmar", "state": "California" }, { "city": "Royal Oak", "state": "Michigan" }, { "city": "Lima", "state": "Ohio" } ], "official_url": "https://clinicaltrials.gov/study/NCT01595438" }, { "nct_id": "NCT07579312", "title": "Diagnosis of Abdominal Pain Using RNA Levels: The NATURAL Study", "overall_status": "RECRUITING", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Intra Abdominal Infections", "Appendicitis Acute", "Pyelonephritis", "Diverticulitis", "Epiploic Appendagitis" ], "interventions": [ { "name": "TruNAV, an RNA-based blood test for host immune activation by infections", "type": "DIAGNOSTIC_TEST" } ], "intervention_types": [ "DIAGNOSTIC_TEST" ], "sponsor": "True Bearing Diagnostics, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "7 Years", "maximum_age": null, "sex": "ALL", "summary": "7 Years and older" }, "enrollment_count": 1000, "start_date": "2026-04-17", "completion_date": "2027-09", "has_results": false, "last_update_posted_date": "2026-05-12", "last_synced_at": "2026-07-22T07:37:13.799Z", "location_count": 1, "location_summary": "Washington D.C., District of Columbia", "locations": [ { "city": "Washington D.C.", "state": "District of Columbia" } ], "official_url": "https://clinicaltrials.gov/study/NCT07579312" }, { "nct_id": "NCT04979806", "title": "Study of Cefepime-zidebactam (FEP-ZID) in Complicated Urinary Tract Infection (cUTI) or Acute Pyelonephritis (AP)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Complicated Urinary Tract Infection", "Acute Pyelonephritis" ], "interventions": [ { "name": "Cefepime-zidebactam (FEP-ZID)", "type": "DRUG" }, { "name": "Meropenem", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Wockhardt", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 530, "start_date": "2022-08-28", "completion_date": "2024-11-25", "has_results": true, "last_update_posted_date": "2026-05-22", "last_synced_at": "2026-07-22T07:37:13.799Z", "location_count": 2, "location_summary": "Fort Myers, Florida • Tampa, Florida", "locations": [ { "city": "Fort Myers", "state": "Florida" }, { "city": "Tampa", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT04979806" }, { "nct_id": "NCT06059846", "title": "A Study of Oral Tebipenem Pivoxil Hydrobromide (TBP-PI-HBr) Compared to Intravenous Imipenem-cilastatin in Participants With Complicated Urinary Tract Infection (cUTI) or Acute Pyelonephritis (AP)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Urinary Tract Infection", "Acute Pyelonephritis" ], "interventions": [ { "name": "TBP-PI-HBr", "type": "DRUG" }, { "name": "Imipenem-cilastatin", "type": "DRUG" }, { "name": "Dummy Infusion", "type": "DRUG" }, { "name": "Dummy Tablets", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Spero Therapeutics", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 1690, "start_date": "2023-12-21", "completion_date": "2025-02-06", "has_results": true, "last_update_posted_date": "2026-03-10", "last_synced_at": "2026-07-22T07:37:13.799Z", "location_count": 2, "location_summary": "Miami, Florida", "locations": [ { "city": "Miami", "state": "Florida" }, { "city": "Miami", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT06059846" }, { "nct_id": "NCT01281462", "title": "Comparative Study of Coadministered Ceftaroline Fosamil and NXL104 vs. Intravenous Doripenem in Adult Subjects With Complicated Urinary Tract Infections", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Urinary Tract Infections" ], "interventions": [ { "name": "Ceftaroline fosamil and NXL104 (q8h)", "type": "DRUG" }, { "name": "Ceftaroline fosamil and NXL104 (q12h)", "type": "DRUG" }, { "name": "Doripenem", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Forest Laboratories", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 217, "start_date": "2010-12", "completion_date": "2012-07", "has_results": false, "last_update_posted_date": "2014-02-03", "last_synced_at": "2026-07-22T07:37:13.799Z", "location_count": 5, "location_summary": "La Mesa, California • San Diego, California • Pensacola, Florida + 2 more", "locations": [ { "city": "La Mesa", "state": "California" }, { "city": "San Diego", "state": "California" }, { "city": "Pensacola", "state": "Florida" }, { "city": "Baltimore", "state": "Maryland" }, { "city": "Detroit", "state": "Michigan" } ], "official_url": "https://clinicaltrials.gov/study/NCT01281462" }, { "nct_id": "NCT01381549", "title": "GSK2251052 in Complicated Urinary Tract Infection", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Infections, Urinary Tract" ], "interventions": [ { "name": "GSK2251052", "type": "DRUG" }, { "name": "imipenem-cilastatin", "type": "DRUG" }, { "name": "Placebo", "type": "OTHER" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "GlaxoSmithKline", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 20, "start_date": "2011-06-28", "completion_date": "2012-03-06", "has_results": true, "last_update_posted_date": "2017-09-08", "last_synced_at": "2026-07-22T07:37:13.799Z", "location_count": 4, "location_summary": "Los Angeles, California • Council Bluffs, Iowa • Topeka, Kansas + 1 more", "locations": [ { "city": "Los Angeles", "state": "California" }, { "city": "Council Bluffs", "state": "Iowa" }, { "city": "Topeka", "state": "Kansas" }, { "city": "Corsicana", "state": "Texas" } ], "official_url": "https://clinicaltrials.gov/study/NCT01381549" }, { "nct_id": "NCT03788967", "title": "Study to Assess the Efficacy, Safety and Pharmacokinetics of Orally Administered Tebipenem Pivoxil Hydrobromide (SPR994) Compared to Intravenous Ertapenem in Participants With Complicated Urinary Tract Infection (cUTI) or Acute Pyelonephritis (AP)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Complicated Urinary Tract Infection", "Acute Pyelonephritis" ], "interventions": [ { "name": "TBPM-PI-HBr", "type": "DRUG" }, { "name": "Ertapenem", "type": "DRUG" }, { "name": "Dummy Infusion", "type": "DRUG" }, { "name": "Dummy tablets", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Spero Therapeutics", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 1372, "start_date": "2019-06-03", "completion_date": "2020-05-27", "has_results": true, "last_update_posted_date": "2022-07-25", "last_synced_at": "2026-07-22T07:37:13.799Z", "location_count": 2, "location_summary": "La Mesa, California • Miami, Florida", "locations": [ { "city": "La Mesa", "state": "California" }, { "city": "Miami", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT03788967" }, { "nct_id": "NCT04700787", "title": "Safety, Tolerability, and Pharmacokinetics of Sulopenem in Adolescents", "overall_status": "WITHDRAWN", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Urinary Tract Infections", "Pyelonephritis Acute", "Intraabdominal Infections" ], "interventions": [ { "name": "Sulopenem", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Iterum Therapeutics, International Limited", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "12 Years", "maximum_age": "18 Years", "sex": "ALL", "summary": "12 Years to 18 Years" }, "enrollment_count": 0, "start_date": "2021-04-30", "completion_date": "2022-04-04", "has_results": false, "last_update_posted_date": "2022-06-13", "last_synced_at": "2026-07-22T07:37:13.799Z", "location_count": 1, "location_summary": "St Louis, Missouri", "locations": [ { "city": "St Louis", "state": "Missouri" } ], "official_url": "https://clinicaltrials.gov/study/NCT04700787" } ] }