{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Radiation-Induced+Parotid+Gland+Hypofunction",
    "query": {
      "condition": "Radiation-Induced Parotid Gland Hypofunction"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 4,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-05-22T03:10:55.874Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT04043104",
      "title": "A Phase 1 Open-Label, Dose Escalation Study to Determine the Optimal Dose, Safety, and Activity of AAV2hAQP1 in Subjects With Radiation-Induced Parotid Gland Hypofunction and Xerostomia",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Radiation-Induced Parotid Gland Hypofunction",
        "Xerostomia Due to Radiotherapy",
        "Head and Neck Cancer"
      ],
      "interventions": [
        {
          "name": "AAV2hAQP1: 1 x 10^11 vg/gland (single gland)",
          "type": "DRUG"
        },
        {
          "name": "AAV2hAQP1: 3 x 10^10 vg/gland (both glands)",
          "type": "DRUG"
        },
        {
          "name": "AAV2hAQP1: 3 x 10^11 vg/gland (single gland)",
          "type": "DRUG"
        },
        {
          "name": "AAV2hAQP1: 1 x 10^11 vg/gland (both glands)",
          "type": "DRUG"
        },
        {
          "name": "AAV2hAQP1: 1 x 10^12 vg/gland (single gland)",
          "type": "DRUG"
        },
        {
          "name": "AAV2hAQP1: 3 x 10^11 vg/gland (both glands)",
          "type": "DRUG"
        },
        {
          "name": "AAV2hAQP1: 3 x 10^12 vg/gland (single gland)",
          "type": "DRUG"
        },
        {
          "name": "AAV2hAQP1: 1 x 10^12 vg/gland (both glands)",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "MeiraGTx UK II Ltd",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 24,
      "start_date": "2019-06-30",
      "completion_date": "2023-03-28",
      "has_results": false,
      "last_update_posted_date": "2023-04-24",
      "last_synced_at": "2026-05-22T03:10:55.874Z",
      "location_count": 5,
      "location_summary": "Stanford, California • Louisville, Kentucky • Boston, Massachusetts + 2 more",
      "locations": [
        {
          "city": "Stanford",
          "state": "California"
        },
        {
          "city": "Louisville",
          "state": "Kentucky"
        },
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "New York",
          "state": "New York"
        },
        {
          "city": "Charlotte",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04043104"
    },
    {
      "nct_id": "NCT05060341",
      "title": "Long-Term Follow-Up Study of AAV2hAQP1 for Radiation Induced Xerostomia",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Radiation-induced Xerostomia"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "MeiraGTx, LLC",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": null,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "81 Years",
        "sex": "ALL",
        "summary": "18 Years to 81 Years"
      },
      "enrollment_count": 22,
      "start_date": "2020-11-12",
      "completion_date": "2027-03",
      "has_results": false,
      "last_update_posted_date": "2025-05-22",
      "last_synced_at": "2026-05-22T03:10:55.874Z",
      "location_count": 3,
      "location_summary": "Stanford, California • Boston, Massachusetts • Charlotte, North Carolina",
      "locations": [
        {
          "city": "Stanford",
          "state": "California"
        },
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "Charlotte",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05060341"
    },
    {
      "nct_id": "NCT02446249",
      "title": "Safety of a Single Administration of AAV2hAQP1, an Adeno-Associated Viral Vector Encoding Human Aquaporin-1 to One Parotid Salivary Gland in People With Irradiation-Induced Parotid Salivary Hypofunction",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Squamous Cell Head and Neck Cancer",
        "Radiation Induced Xerostomia",
        "Salivary Hypofunction"
      ],
      "interventions": [
        {
          "name": "AAV2hAQP1",
          "type": "BIOLOGICAL"
        }
      ],
      "intervention_types": [
        "BIOLOGICAL"
      ],
      "sponsor": "MeiraGTx, LLC",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 17,
      "start_date": "2015-05-04",
      "completion_date": "2026-07",
      "has_results": false,
      "last_update_posted_date": "2025-09-25",
      "last_synced_at": "2026-05-22T03:10:55.874Z",
      "location_count": 1,
      "location_summary": "Bethesda, Maryland",
      "locations": [
        {
          "city": "Bethesda",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02446249"
    },
    {
      "nct_id": "NCT00372320",
      "title": "Effect of AdhAQP1 on Salivary Flow in Patients Treated With Radiation for Head and Neck Cancer",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Parotid Salivary Dysfunction"
      ],
      "interventions": [
        {
          "name": "Gene Transfer",
          "type": "GENETIC"
        },
        {
          "name": "AdhAQP1",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "GENETIC",
        "DRUG"
      ],
      "sponsor": "National Institute of Dental and Craniofacial Research (NIDCR)",
      "sponsor_class": "NIH",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 17,
      "start_date": "2006-09-01",
      "completion_date": "2018-09-05",
      "has_results": false,
      "last_update_posted_date": "2018-09-11",
      "last_synced_at": "2026-05-22T03:10:55.874Z",
      "location_count": 1,
      "location_summary": "Bethesda, Maryland",
      "locations": [
        {
          "city": "Bethesda",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00372320"
    }
  ]
}