{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Refractory+Ischemia",
    "query": {
      "condition": "Refractory Ischemia"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 17,
    "total_pages": 2,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Refractory+Ischemia&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-07-22T15:09:59.421Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT03455725",
      "title": "CardiAMP Cell Therapy Chronic Myocardial Ischemia Trial",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Refractory Angina",
        "Chronic Myocardial Ischemia"
      ],
      "interventions": [
        {
          "name": "CardiAMP Cell Therapy System",
          "type": "DEVICE"
        },
        {
          "name": "Sham Treatment",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "OTHER"
      ],
      "sponsor": "BioCardia, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "21 Years to 80 Years"
      },
      "enrollment_count": 343,
      "start_date": "2021-06-30",
      "completion_date": "2027-12",
      "has_results": false,
      "last_update_posted_date": "2026-01-06",
      "last_synced_at": "2026-07-22T15:09:59.421Z",
      "location_count": 2,
      "location_summary": "Gainesville, Florida • Madison, Wisconsin",
      "locations": [
        {
          "city": "Gainesville",
          "state": "Florida"
        },
        {
          "city": "Madison",
          "state": "Wisconsin"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03455725"
    },
    {
      "nct_id": "NCT05102019",
      "title": "Efficacy of the COronary SInus Reducer in Patients With Refractory Angina II",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Refractory Angina"
      ],
      "interventions": [
        {
          "name": "Arm 1: treatment with Shockwave Reducer",
          "type": "DEVICE"
        },
        {
          "name": "Arm 2 (control): Implantation procedure with no device implanted",
          "type": "OTHER"
        },
        {
          "name": "Arm 3 (unblinded, non-randomized): Single arm registry",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "OTHER"
      ],
      "sponsor": "Shockwave Medical, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 380,
      "start_date": "2022-01-04",
      "completion_date": "2032-01",
      "has_results": false,
      "last_update_posted_date": "2026-04-22",
      "last_synced_at": "2026-07-22T15:09:59.421Z",
      "location_count": 70,
      "location_summary": "Phoenix, Arizona • Scottsdale, Arizona • Tucson, Arizona + 56 more",
      "locations": [
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Scottsdale",
          "state": "Arizona"
        },
        {
          "city": "Tucson",
          "state": "Arizona"
        },
        {
          "city": "Long Beach",
          "state": "California"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05102019"
    },
    {
      "nct_id": "NCT00300053",
      "title": "ACT34-CMI -- Adult Autologous CD34+ Cells",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Myocardial Ischemia"
      ],
      "interventions": [
        {
          "name": "CLBS14 (low-dose)",
          "type": "BIOLOGICAL"
        },
        {
          "name": "CLBS14 (high-dose)",
          "type": "BIOLOGICAL"
        },
        {
          "name": "placebo injection",
          "type": "BIOLOGICAL"
        }
      ],
      "intervention_types": [
        "BIOLOGICAL"
      ],
      "sponsor": "Lisata Therapeutics, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "21 Years to 80 Years"
      },
      "enrollment_count": 321,
      "start_date": "2006-04",
      "completion_date": "2009-03",
      "has_results": true,
      "last_update_posted_date": "2021-01-26",
      "last_synced_at": "2026-07-22T15:09:59.421Z",
      "location_count": 26,
      "location_summary": "Birmingham, Alabama • Phoenix, Arizona • La Jolla, California + 18 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "La Jolla",
          "state": "California"
        },
        {
          "city": "Stanford",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00300053"
    },
    {
      "nct_id": "NCT01508910",
      "title": "Efficacy and Safety of Targeted Intramyocardial Delivery of Auto CD34+ Stem Cells for Improving Exercise Capacity in Subjects With Refractory Angina",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Chronic Myocardial Ischemia",
        "Refractory Angina Pectoris",
        "Advanced Coronary Heart Disease"
      ],
      "interventions": [
        {
          "name": "Auto-CD34+ cells",
          "type": "BIOLOGICAL"
        },
        {
          "name": "Placebo: Diluent used to suspend Auto-CD34+ cells",
          "type": "BIOLOGICAL"
        },
        {
          "name": "Standard of care",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "BIOLOGICAL",
        "OTHER"
      ],
      "sponsor": "Lisata Therapeutics, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "21 Years to 80 Years"
      },
      "enrollment_count": 291,
      "start_date": "2012-04",
      "completion_date": "2015-11",
      "has_results": true,
      "last_update_posted_date": "2018-12-19",
      "last_synced_at": "2026-07-22T15:09:59.421Z",
      "location_count": 41,
      "location_summary": "Birmingham, Alabama • Gilbert, Arizona • Phoenix, Arizona + 38 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Gilbert",
          "state": "Arizona"
        },
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "La Jolla",
          "state": "California"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01508910"
    },
    {
      "nct_id": "NCT06081283",
      "title": "Antiseizure Medication in Seizure Networks at Early Acute Brain Injury",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Brain Injuries, Acute",
        "Brain Injuries, Traumatic",
        "Brain Ischemia",
        "Brain Hypoxia",
        "Hypoxia-Ischemia, Brain",
        "Heart Arrest",
        "Stroke",
        "Intracranial Hemorrhages",
        "Coma",
        "Persistent Vegetative State"
      ],
      "interventions": [
        {
          "name": "Phenobarbital Sodium Injection",
          "type": "DRUG"
        },
        {
          "name": "Levetiracetam",
          "type": "DRUG"
        },
        {
          "name": "Lacosamide Injectable Product",
          "type": "DRUG"
        },
        {
          "name": "Valproate Sodium",
          "type": "DRUG"
        },
        {
          "name": "Fosphenytoin",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of North Carolina, Chapel Hill",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Months",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "18 Months to 70 Years"
      },
      "enrollment_count": 5,
      "start_date": "2023-11-20",
      "completion_date": "2025-01-22",
      "has_results": true,
      "last_update_posted_date": "2025-11-14",
      "last_synced_at": "2026-07-22T15:09:59.421Z",
      "location_count": 1,
      "location_summary": "Chapel Hill, North Carolina",
      "locations": [
        {
          "city": "Chapel Hill",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06081283"
    },
    {
      "nct_id": "NCT05851391",
      "title": "buRst-supprESsion TO Stop Refractory Status Epilepticus Post-cardiac Arrest",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Hypoxia-Ischemia, Brain",
        "Heart Arrest",
        "Status Epilepticus",
        "Refractory Status Epilepticus",
        "Seizures",
        "Anoxic-Ischemic Encephalopathy",
        "Anoxia-Ischemia, Cerebral"
      ],
      "interventions": [
        {
          "name": "Burst Suppression EEG Target Intravenous Anesthesia",
          "type": "DRUG"
        },
        {
          "name": "Seizure Suppression EEG Target Intravenous Anesthesia",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of California, San Francisco",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 30,
      "start_date": "2023-08-07",
      "completion_date": "2027-04-30",
      "has_results": false,
      "last_update_posted_date": "2025-05-15",
      "last_synced_at": "2026-07-22T15:09:59.421Z",
      "location_count": 1,
      "location_summary": "San Francisco, California",
      "locations": [
        {
          "city": "San Francisco",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05851391"
    },
    {
      "nct_id": "NCT00200070",
      "title": "Neurostimulation to Treat Refractory Angina Pectoris Pain",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Angina Pectoris"
      ],
      "interventions": [
        {
          "name": "Spinal Cord Stimulation",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "MedtronicNeuro",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 228,
      "start_date": "2002-12",
      "completion_date": "2007-04",
      "has_results": false,
      "last_update_posted_date": "2010-08-30",
      "last_synced_at": "2026-07-22T15:09:59.421Z",
      "location_count": 6,
      "location_summary": "Gainesville, Florida • Indianapolis, Indiana • Boston, Massachusetts + 3 more",
      "locations": [
        {
          "city": "Gainesville",
          "state": "Florida"
        },
        {
          "city": "Indianapolis",
          "state": "Indiana"
        },
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "Minneapolis",
          "state": "Minnesota"
        },
        {
          "city": "Rochester",
          "state": "Minnesota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00200070"
    },
    {
      "nct_id": "NCT07048808",
      "title": "Investigational Trial to Evaluate XC001 Delivered Via an Cardiac Catheter in Subjects With Chronic Angina.",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Refractory Angina",
        "Coronary Artery Disease"
      ],
      "interventions": [
        {
          "name": "XC001",
          "type": "COMBINATION_PRODUCT"
        },
        {
          "name": "Sham (No Treatment)",
          "type": "COMBINATION_PRODUCT"
        }
      ],
      "intervention_types": [
        "COMBINATION_PRODUCT"
      ],
      "sponsor": "XyloCor Therapeutics, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "85 Years",
        "sex": "ALL",
        "summary": "18 Years to 85 Years"
      },
      "enrollment_count": 106,
      "start_date": "2025-06-24",
      "completion_date": "2027-06-30",
      "has_results": false,
      "last_update_posted_date": "2025-08-03",
      "last_synced_at": "2026-07-22T15:09:59.421Z",
      "location_count": 1,
      "location_summary": "Cincinnati, Ohio",
      "locations": [
        {
          "city": "Cincinnati",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07048808"
    },
    {
      "nct_id": "NCT04125732",
      "title": "Epicardial Delivery of XC001 Gene Therapy for Refractory Angina Coronary Treatment (The EXACT Trial)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Coronary Artery Disease",
        "Ischemia",
        "Angina Refractory",
        "Cardiovascular Diseases",
        "Heart Diseases"
      ],
      "interventions": [
        {
          "name": "AdVEGFXC1",
          "type": "BIOLOGICAL"
        }
      ],
      "intervention_types": [
        "BIOLOGICAL"
      ],
      "sponsor": "XyloCor Therapeutics, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 41,
      "start_date": "2020-01-24",
      "completion_date": "2023-05-30",
      "has_results": false,
      "last_update_posted_date": "2024-01-30",
      "last_synced_at": "2026-07-22T15:09:59.421Z",
      "location_count": 16,
      "location_summary": "Stanford, California • Washington D.C., District of Columbia • Daytona Beach, Florida + 11 more",
      "locations": [
        {
          "city": "Stanford",
          "state": "California"
        },
        {
          "city": "Washington D.C.",
          "state": "District of Columbia"
        },
        {
          "city": "Daytona Beach",
          "state": "Florida"
        },
        {
          "city": "Gainesville",
          "state": "Florida"
        },
        {
          "city": "Tampa",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04125732"
    },
    {
      "nct_id": "NCT06593418",
      "title": "Cardiac Radioablation for VT",
      "overall_status": "NOT_YET_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Ventricular Tachycardia",
        "Myocardial Infarction"
      ],
      "interventions": [
        {
          "name": "Stereotactic Body Radiation Therapy (SBRT)",
          "type": "RADIATION"
        }
      ],
      "intervention_types": [
        "RADIATION"
      ],
      "sponsor": "Corewell Health East",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 24,
      "start_date": "2026-07",
      "completion_date": "2028-01",
      "has_results": false,
      "last_update_posted_date": "2026-04-20",
      "last_synced_at": "2026-07-22T15:09:59.421Z",
      "location_count": 1,
      "location_summary": "Royal Oak, Michigan",
      "locations": [
        {
          "city": "Royal Oak",
          "state": "Michigan"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06593418"
    }
  ]
}