{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Retinal+Detachment+Rhegmatogenous",
    "query": {
      "condition": "Retinal Detachment Rhegmatogenous"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 16,
    "total_pages": 2,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Retinal+Detachment+Rhegmatogenous&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-06-10T19:07:24.872Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT06541574",
      "title": "Prevention of ProliFerative Vitreoretinopathy with Intravitreal MethotreXate in Primary Retinal DEtachment Repair (FIXER) Trial",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Proliferative Vitreoretinopathy",
        "Rhegmatogenous Retinal Detachment"
      ],
      "interventions": [
        {
          "name": "Methotrexate Injection",
          "type": "DRUG"
        },
        {
          "name": "Methotrexate Infusion",
          "type": "DRUG"
        },
        {
          "name": "Sham Injection",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Cincinnati Eye Institute, Southwest Ohio",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 860,
      "start_date": "2024-03-01",
      "completion_date": "2026-06",
      "has_results": false,
      "last_update_posted_date": "2024-09-19",
      "last_synced_at": "2026-06-10T19:07:24.872Z",
      "location_count": 1,
      "location_summary": "Cincinnati, Ohio",
      "locations": [
        {
          "city": "Cincinnati",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06541574"
    },
    {
      "nct_id": "NCT02574624",
      "title": "Vitreous Surgery With Intraocular Assistance",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Traction Retinal Detachments",
        "Rhegmatogenous Retinal Detachments",
        "Dislocated Intraocular Lens"
      ],
      "interventions": [
        {
          "name": "Intraocular assistance",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Johns Hopkins University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "100 Years",
        "sex": "ALL",
        "summary": "18 Years to 100 Years"
      },
      "enrollment_count": 5,
      "start_date": "2015-11",
      "completion_date": "2017-09",
      "has_results": false,
      "last_update_posted_date": "2017-09-26",
      "last_synced_at": "2026-06-10T19:07:24.872Z",
      "location_count": 1,
      "location_summary": "Baltimore, Maryland",
      "locations": [
        {
          "city": "Baltimore",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02574624"
    },
    {
      "nct_id": "NCT06056596",
      "title": "Lamivudine and Plasma Markers of Inflammation in Retinal Detachment",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "EARLY_PHASE1"
      ],
      "conditions": [
        "Retinal Detachment",
        "Rhegmatogenous Retinal Detachment"
      ],
      "interventions": [
        {
          "name": "Lamivudine 300 MG",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Wisconsin, Madison",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "18 Years to 75 Years"
      },
      "enrollment_count": 2,
      "start_date": "2024-01-30",
      "completion_date": "2024-09-06",
      "has_results": false,
      "last_update_posted_date": "2024-09-19",
      "last_synced_at": "2026-06-10T19:07:24.872Z",
      "location_count": 1,
      "location_summary": "Madison, Wisconsin",
      "locations": [
        {
          "city": "Madison",
          "state": "Wisconsin"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06056596"
    },
    {
      "nct_id": "NCT03332758",
      "title": "Inflammasomes in Cell Death in FTMH, ERM, and RRD",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Retinal Detachment",
        "Full Thickness Macular Hole",
        "Epiretinal Membrane"
      ],
      "interventions": [
        {
          "name": "Pars plana vitrectomy",
          "type": "PROCEDURE"
        },
        {
          "name": "External drainage",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Allen C. Ho, MD",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 41,
      "start_date": "2017-09-08",
      "completion_date": "2018-05-01",
      "has_results": false,
      "last_update_posted_date": "2018-08-17",
      "last_synced_at": "2026-06-10T19:07:24.872Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03332758"
    },
    {
      "nct_id": "NCT05730218",
      "title": "A Phase 2 Study to Assess the Safety and Efficacy of Intravitreal ONL1204 Ophthalmic Solution in Subjects With Mac-off Retinal Detachment",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Rhegmatogenous Retinal Detachment - Macula Off"
      ],
      "interventions": [
        {
          "name": "ONL1204 Ophthalmic Solution",
          "type": "DRUG"
        },
        {
          "name": "Sham treatment",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "ONL Therapeutics",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 136,
      "start_date": "2023-04-04",
      "completion_date": "2024-02-21",
      "has_results": false,
      "last_update_posted_date": "2024-02-29",
      "last_synced_at": "2026-06-10T19:07:24.872Z",
      "location_count": 36,
      "location_summary": "Phoenix, Arizona • Tucson, Arizona • Arcadia, California + 32 more",
      "locations": [
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Tucson",
          "state": "Arizona"
        },
        {
          "city": "Arcadia",
          "state": "California"
        },
        {
          "city": "Glendale",
          "state": "California"
        },
        {
          "city": "Huntington Beach",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05730218"
    },
    {
      "nct_id": "NCT04830878",
      "title": "Methotrexate For The Prevention and Treatment of Proliferative Vitreoretinopathy in Pediatric Patients",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Proliferative Vitreoretinopathy"
      ],
      "interventions": [
        {
          "name": "Methotrexate",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Stanford University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": "18 Years",
        "sex": "ALL",
        "summary": "Up to 18 Years"
      },
      "enrollment_count": 0,
      "start_date": "2021-04",
      "completion_date": "2024-04",
      "has_results": false,
      "last_update_posted_date": "2023-04-20",
      "last_synced_at": "2026-06-10T19:07:24.872Z",
      "location_count": 1,
      "location_summary": "Palo Alto, California",
      "locations": [
        {
          "city": "Palo Alto",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04830878"
    },
    {
      "nct_id": "NCT04580147",
      "title": "Intravitreal Aflibercept for the Prevention of Proliferative Vitreoretinopathy Following Retinal Detachment Repair",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Retinal Detachment With Multiple Breaks, Unspecified Eye",
        "Proliferative Vitreoretinopathy"
      ],
      "interventions": [
        {
          "name": "Intravitreal aflibercept injection",
          "type": "DRUG"
        },
        {
          "name": "Sham control",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "M. Ali Khan, MD",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 150,
      "start_date": "2020-10-15",
      "completion_date": "2023-12-15",
      "has_results": false,
      "last_update_posted_date": "2022-05-03",
      "last_synced_at": "2026-06-10T19:07:24.872Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04580147"
    },
    {
      "nct_id": "NCT07054281",
      "title": "UNITY VCS Vitreoretinal Surgery",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Epiretinal Membrane",
        "Macular Hole",
        "Visually Significant Vitreous Floater",
        "Vitreomacular Traction",
        "Vitreous Hemorrhage",
        "Proliferative Diabetic Retinopathy",
        "Rhegmatogenous Retinal Detachment",
        "Retained Lens Material in the Posterior Segment"
      ],
      "interventions": [
        {
          "name": "UNITY Vitreoretinal Cataract System (VCS)",
          "type": "DEVICE"
        },
        {
          "name": "CONSTELLATION Vision System",
          "type": "DEVICE"
        },
        {
          "name": "Vitreoretinal ophthalmic surgery",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "PROCEDURE"
      ],
      "sponsor": "Alcon Research",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 0,
      "start_date": "2026-01",
      "completion_date": "2027-02",
      "has_results": false,
      "last_update_posted_date": "2025-12-12",
      "last_synced_at": "2026-06-10T19:07:24.872Z",
      "location_count": 8,
      "location_summary": "Scottsdale, Arizona • Laguna Hills, California • West Des Moines, Iowa + 5 more",
      "locations": [
        {
          "city": "Scottsdale",
          "state": "Arizona"
        },
        {
          "city": "Laguna Hills",
          "state": "California"
        },
        {
          "city": "West Des Moines",
          "state": "Iowa"
        },
        {
          "city": "Albuquerque",
          "state": "New Mexico"
        },
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07054281"
    },
    {
      "nct_id": "NCT01716507",
      "title": "23 Gauge and 20 Gauge Vitrectomy for Rhegmatogenous Retinal Detachments",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Retinal Detachment"
      ],
      "interventions": [
        {
          "name": "Retinal Detachment repair",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Wills Eye",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 46,
      "start_date": "2008-04",
      "completion_date": "2011-07",
      "has_results": false,
      "last_update_posted_date": "2016-12-12",
      "last_synced_at": "2026-06-10T19:07:24.872Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01716507"
    },
    {
      "nct_id": "NCT05620901",
      "title": "DEXTENZA in Pediatric Patients Following Retinal Surgery or Laser Treatment Under Anesthesia",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "EARLY_PHASE1"
      ],
      "conditions": [
        "Vitreoretinopathy",
        "Coats' Disease",
        "Exudative Retinopathy",
        "Lattice Degeneration",
        "Retinal Hole",
        "Sickler's Syndrome",
        "Retinal Detachment Rhegmatogenous",
        "Retinal Detachment Exudative",
        "Retinal Detachment Traction"
      ],
      "interventions": [
        {
          "name": "Dextenza 0.4Mg Ophthalmic Insert",
          "type": "DRUG"
        },
        {
          "name": "Pred Forte",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Lejla Vajzovic, MD, FASRS",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "3 Years",
        "maximum_age": "17 Years",
        "sex": "ALL",
        "summary": "3 Years to 17 Years"
      },
      "enrollment_count": 15,
      "start_date": "2023-02-01",
      "completion_date": "2025-02-24",
      "has_results": true,
      "last_update_posted_date": "2026-04-23",
      "last_synced_at": "2026-06-10T19:07:24.872Z",
      "location_count": 1,
      "location_summary": "Durham, North Carolina",
      "locations": [
        {
          "city": "Durham",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05620901"
    }
  ]
}