{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Rett+Syndrome",
    "query": {
      "condition": "Rett Syndrome"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 57,
    "total_pages": 6,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Rett+Syndrome&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-06-07T15:01:57.633Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT04988867",
      "title": "An Open-Label Study of Trofinetide for the Treatment of Girls Two to Five Years of Age Who Have Rett Syndrome",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2",
        "PHASE3"
      ],
      "conditions": [
        "Rett Syndrome"
      ],
      "interventions": [
        {
          "name": "Trofinetide",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "ACADIA Pharmaceuticals Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "2 Years",
        "maximum_age": "5 Years",
        "sex": "FEMALE",
        "summary": "2 Years to 5 Years · Female only"
      },
      "enrollment_count": 15,
      "start_date": "2021-09-22",
      "completion_date": "2023-05-31",
      "has_results": true,
      "last_update_posted_date": "2024-09-24",
      "last_synced_at": "2026-06-07T15:01:57.633Z",
      "location_count": 7,
      "location_summary": "Birmingham, Alabama • Aurora, Colorado • Chicago, Illinois + 4 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Aurora",
          "state": "Colorado"
        },
        {
          "city": "Chicago",
          "state": "Illinois"
        },
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "Saint Paul",
          "state": "Minnesota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04988867"
    },
    {
      "nct_id": "NCT02715115",
      "title": "A Safety Study of NNZ-2566 in Pediatric Rett Syndrome",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Rett Syndrome"
      ],
      "interventions": [
        {
          "name": "NNZ-2566",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Neuren Pharmaceuticals Limited",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "5 Years",
        "maximum_age": "15 Years",
        "sex": "FEMALE",
        "summary": "5 Years to 15 Years · Female only"
      },
      "enrollment_count": 82,
      "start_date": "2016-03",
      "completion_date": "2017-01-05",
      "has_results": false,
      "last_update_posted_date": "2020-08-14",
      "last_synced_at": "2026-06-07T15:01:57.633Z",
      "location_count": 12,
      "location_summary": "Birmingham, Alabama • Oakland, California • San Diego, California + 9 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Oakland",
          "state": "California"
        },
        {
          "city": "San Diego",
          "state": "California"
        },
        {
          "city": "Aurora",
          "state": "Colorado"
        },
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02715115"
    },
    {
      "nct_id": "NCT00299312",
      "title": "Genetic and Physical Characteristics of Rett Syndrome",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Rett Syndrome",
        "MECP2 Duplication Disorder",
        "Rett-related Disorder"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "University of Alabama at Birmingham",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 10,
      "start_date": "2006-03",
      "completion_date": "2015-10",
      "has_results": false,
      "last_update_posted_date": "2017-03-16",
      "last_synced_at": "2026-06-07T15:01:57.633Z",
      "location_count": 11,
      "location_summary": "Birmingham, Alabama • Oakland, California • San Diego, California + 8 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Oakland",
          "state": "California"
        },
        {
          "city": "San Diego",
          "state": "California"
        },
        {
          "city": "Denver",
          "state": "Colorado"
        },
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00299312"
    },
    {
      "nct_id": "NCT05898620",
      "title": "A Novel, Regulated Gene Therapy (NGN-401) Study for Females With Rett Syndrome",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Rett Syndrome"
      ],
      "interventions": [
        {
          "name": "NGN-401",
          "type": "GENETIC"
        }
      ],
      "intervention_types": [
        "GENETIC"
      ],
      "sponsor": "Neurogene Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "3 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "3 Years and older · Female only"
      },
      "enrollment_count": 33,
      "start_date": "2023-06-13",
      "completion_date": "2029-12",
      "has_results": false,
      "last_update_posted_date": "2026-03-13",
      "last_synced_at": "2026-06-07T15:01:57.633Z",
      "location_count": 13,
      "location_summary": "Birmingham, Alabama • Oakland, California • Aurora, Colorado + 10 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Oakland",
          "state": "California"
        },
        {
          "city": "Aurora",
          "state": "Colorado"
        },
        {
          "city": "Miami",
          "state": "Florida"
        },
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05898620"
    },
    {
      "nct_id": "NCT02738281",
      "title": "Natural History of Rett Syndrome & Related Disorders",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Rett Syndrome",
        "MECP2 Duplication dIsorder",
        "CDKL5 Disorder",
        "FOXG1 Syndrome"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "University of Alabama at Birmingham",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 1044,
      "start_date": "2015-11",
      "completion_date": "2021-07-31",
      "has_results": false,
      "last_update_posted_date": "2021-08-05",
      "last_synced_at": "2026-06-07T15:01:57.633Z",
      "location_count": 14,
      "location_summary": "Birmingham, Alabama • Oakland, California • San Diego, California + 11 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Oakland",
          "state": "California"
        },
        {
          "city": "San Diego",
          "state": "California"
        },
        {
          "city": "Denver",
          "state": "Colorado"
        },
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02738281"
    },
    {
      "nct_id": "NCT02428673",
      "title": "Effects of Standing on Non-Ambulatory Children With Neuromuscular Conditions",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Osteopenia",
        "Spinal Muscular Atrophy",
        "Cerebral Palsy",
        "Muscular Dystrophy",
        "Spina Bifida",
        "Rett Syndrome"
      ],
      "interventions": [
        {
          "name": "Assisted Standing Treatment Program",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Gillette Children's Specialty Healthcare",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "3 Years",
        "maximum_age": "14 Years",
        "sex": "ALL",
        "summary": "3 Years to 14 Years"
      },
      "enrollment_count": 6,
      "start_date": "2015-12-09",
      "completion_date": "2018-03-23",
      "has_results": false,
      "last_update_posted_date": "2021-02-21",
      "last_synced_at": "2026-06-07T15:01:57.633Z",
      "location_count": 1,
      "location_summary": "Saint Paul, Minnesota",
      "locations": [
        {
          "city": "Saint Paul",
          "state": "Minnesota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02428673"
    },
    {
      "nct_id": "NCT00496210",
      "title": "Predictors of Caregiver Adaptation to Pervasive Developmental Disorders",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Autism",
        "Asperger's Syndrome",
        "Rett's Disorder"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "National Human Genome Research Institute (NHGRI)",
      "sponsor_class": "NIH",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 324,
      "start_date": "2007-06-27",
      "completion_date": "2015-12-07",
      "has_results": false,
      "last_update_posted_date": "2019-11-15",
      "last_synced_at": "2026-06-07T15:01:57.633Z",
      "location_count": 1,
      "location_summary": "Bethesda, Maryland",
      "locations": [
        {
          "city": "Bethesda",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00496210"
    },
    {
      "nct_id": "NCT03836300",
      "title": "Parent and Infant Inter(X)Action Intervention (PIXI)",
      "overall_status": "ENROLLING_BY_INVITATION",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Fragile X Syndrome",
        "Angelman Syndrome",
        "Prader-Willi Syndrome",
        "Dup15Q Syndrome",
        "Duchenne Muscular Dystrophy",
        "Phelan-McDermid Syndrome",
        "Rett Syndrome",
        "Smith Magenis Syndrome",
        "Williams Syndrome",
        "Turner Syndrome",
        "Klinefelter Syndrome",
        "Chromosome 22q11.2 Deletion Syndrome",
        "Tuberous Sclerosis",
        "Down Syndrome"
      ],
      "interventions": [
        {
          "name": "Parent-Infant Inter(X)action Intervention (PIXI)",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "RTI International",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": "99 Years",
        "sex": "ALL",
        "summary": "Up to 99 Years"
      },
      "enrollment_count": 120,
      "start_date": "2018-11-30",
      "completion_date": "2026-12-31",
      "has_results": false,
      "last_update_posted_date": "2025-07-31",
      "last_synced_at": "2026-06-07T15:01:57.633Z",
      "location_count": 1,
      "location_summary": "Research Triangle Park, North Carolina",
      "locations": [
        {
          "city": "Research Triangle Park",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03836300"
    },
    {
      "nct_id": "NCT03196323",
      "title": "Development of a Behavioral Outcome Measure for Rett Syndrome (RettBe)",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Rett Syndrome"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "University of South Florida",
      "sponsor_class": "OTHER",
      "healthy_volunteers": null,
      "eligibility": {
        "minimum_age": "3 Years",
        "maximum_age": "18 Years",
        "sex": "FEMALE",
        "summary": "3 Years to 18 Years · Female only"
      },
      "enrollment_count": 146,
      "start_date": "2017-06-01",
      "completion_date": "2020-09-24",
      "has_results": false,
      "last_update_posted_date": "2020-12-09",
      "last_synced_at": "2026-06-07T15:01:57.633Z",
      "location_count": 1,
      "location_summary": "Tampa, Florida",
      "locations": [
        {
          "city": "Tampa",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03196323"
    },
    {
      "nct_id": "NCT02563860",
      "title": "Pharmacological Treatment of Rett Syndrome With Statins",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Rett Syndrome"
      ],
      "interventions": [
        {
          "name": "Lovastatin",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Montefiore Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "3 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "3 Years and older · Female only"
      },
      "enrollment_count": 20,
      "start_date": "2015-07",
      "completion_date": "2016-07",
      "has_results": true,
      "last_update_posted_date": "2019-07-12",
      "last_synced_at": "2026-06-07T15:01:57.633Z",
      "location_count": 1,
      "location_summary": "The Bronx, New York",
      "locations": [
        {
          "city": "The Bronx",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02563860"
    }
  ]
}