{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Rhytides",
    "query": {
      "condition": "Rhytides"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 271,
    "total_pages": 28,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Rhytides&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-05-22T09:14:56.647Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT05091788",
      "title": "Robotic Mechanical Coring for the Treatment of Moderate to Severe Facial Wrinkles",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Wrinkle"
      ],
      "interventions": [
        {
          "name": "Venus Aime",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Venus Concept",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "22 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "22 Years to 75 Years"
      },
      "enrollment_count": 70,
      "start_date": "2022-03-22",
      "completion_date": "2025-08-15",
      "has_results": false,
      "last_update_posted_date": "2024-01-26",
      "last_synced_at": "2026-05-22T09:14:56.647Z",
      "location_count": 2,
      "location_summary": "Chicago, Illinois • Charlotte, North Carolina",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        },
        {
          "city": "Charlotte",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05091788"
    },
    {
      "nct_id": "NCT05779280",
      "title": "Prospective Study of Topical Vitamin C (THDA) Versus Topical Vitamin C (THDA) With Acetyl Zingerone",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Wrinkle",
        "Skin Pigmentation"
      ],
      "interventions": [
        {
          "name": "THDA + Acetyl Zingerone Topical Product",
          "type": "OTHER"
        },
        {
          "name": "THDA",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Integrative Skin Science and Research",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "30 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "30 Years to 65 Years"
      },
      "enrollment_count": 44,
      "start_date": "2023-04-06",
      "completion_date": "2023-12-20",
      "has_results": false,
      "last_update_posted_date": "2023-07-25",
      "last_synced_at": "2026-05-22T09:14:56.647Z",
      "location_count": 1,
      "location_summary": "Sacramento, California",
      "locations": [
        {
          "city": "Sacramento",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05779280"
    },
    {
      "nct_id": "NCT05167864",
      "title": "Evaluation of Four Injectable Neuromodulators in the Glabella Area Glabella Area",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Cosmetic Techniques"
      ],
      "interventions": [
        {
          "name": "Onabotulinumtoxina for Injection",
          "type": "DRUG"
        },
        {
          "name": "Abobotulinumtoxina for Injection",
          "type": "DRUG"
        },
        {
          "name": "IncobotulinumtoxinA for Injection",
          "type": "DRUG"
        },
        {
          "name": "PrabotulinumtoxinA for Injection",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Pennsylvania",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "30 Years",
        "maximum_age": "65 Years",
        "sex": "FEMALE",
        "summary": "30 Years to 65 Years · Female only"
      },
      "enrollment_count": 143,
      "start_date": "2022-03-04",
      "completion_date": "2023-06-30",
      "has_results": true,
      "last_update_posted_date": "2025-01-17",
      "last_synced_at": "2026-05-22T09:14:56.647Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05167864"
    },
    {
      "nct_id": "NCT04162496",
      "title": "Restylane Refyne for Correction of Horizontal Neck Rhytides",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Aging",
        "Wrinkle",
        "Rhytides"
      ],
      "interventions": [
        {
          "name": "Restylane Refyne",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Siperstein Dermatology",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 24,
      "start_date": "2020-08-11",
      "completion_date": "2021-09-30",
      "has_results": false,
      "last_update_posted_date": "2021-06-08",
      "last_synced_at": "2026-05-22T09:14:56.647Z",
      "location_count": 1,
      "location_summary": "Boynton Beach, Florida",
      "locations": [
        {
          "city": "Boynton Beach",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04162496"
    },
    {
      "nct_id": "NCT05182502",
      "title": "Evaluating the Safety and Effectiveness of the Tixel Fractional System in the Treatment of Photodamage at Low Settings",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Wrinkle"
      ],
      "interventions": [
        {
          "name": "Tixel",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Eric Bernstein, MD",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "25 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "25 Years to 70 Years"
      },
      "enrollment_count": 25,
      "start_date": "2022-01-07",
      "completion_date": "2023-12",
      "has_results": false,
      "last_update_posted_date": "2022-04-06",
      "last_synced_at": "2026-05-22T09:14:56.647Z",
      "location_count": 1,
      "location_summary": "Ardmore, Pennsylvania",
      "locations": [
        {
          "city": "Ardmore",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05182502"
    },
    {
      "nct_id": "NCT04128046",
      "title": "The Effect of Platelet-rich Fibrin Matrix on Skin Rejuvenation",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Skin Rejuvenation",
        "Skin Quality",
        "Wrinkle",
        "Nasolabial Fold"
      ],
      "interventions": [
        {
          "name": "PRFM injection",
          "type": "PROCEDURE"
        },
        {
          "name": "Saline injection",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "New York Medical College",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 30,
      "start_date": "2018-09-03",
      "completion_date": "2019-06-01",
      "has_results": false,
      "last_update_posted_date": "2019-10-22",
      "last_synced_at": "2026-05-22T09:14:56.647Z",
      "location_count": 1,
      "location_summary": "Valhalla, New York",
      "locations": [
        {
          "city": "Valhalla",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04128046"
    },
    {
      "nct_id": "NCT01012661",
      "title": "Evaluation of Pain With Lidocaine-Mixed Radiesse® Injectable Dermal Filler",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Nasolabial Folds"
      ],
      "interventions": [
        {
          "name": "Radiesse® Injectable Dermal Filler Mixed with Lidocaine",
          "type": "DEVICE"
        },
        {
          "name": "Radiesse® Injectable Dermal Filler without Lidocaine",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Merz North America, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 50,
      "start_date": "2008-09",
      "completion_date": "2009-01",
      "has_results": true,
      "last_update_posted_date": "2013-04-26",
      "last_synced_at": "2026-05-22T09:14:56.647Z",
      "location_count": 2,
      "location_summary": "Rockville, Maryland • New York, New York",
      "locations": [
        {
          "city": "Rockville",
          "state": "Maryland"
        },
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01012661"
    },
    {
      "nct_id": "NCT00797459",
      "title": "Safety & Tolerability Study That Compares Restylane to Restylane With Lidocaine While Correcting Wrinkles in the Nasolabial Folds",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Nasolabial Folds"
      ],
      "interventions": [
        {
          "name": "Restylane and Restylane-L",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Medicis Global Service Corporation",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 60,
      "start_date": "2008-11",
      "completion_date": "2009-03",
      "has_results": true,
      "last_update_posted_date": "2013-09-06",
      "last_synced_at": "2026-05-22T09:14:56.647Z",
      "location_count": 3,
      "location_summary": "Coral Gables, Florida • Hunt Valley, Maryland • Mount Kisco, New York",
      "locations": [
        {
          "city": "Coral Gables",
          "state": "Florida"
        },
        {
          "city": "Hunt Valley",
          "state": "Maryland"
        },
        {
          "city": "Mount Kisco",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00797459"
    },
    {
      "nct_id": "NCT03774849",
      "title": "PicoWay™ 730 Resolve Fusion for Benign Pigmented Lesions and Wrinkles",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Benign Pigmented Lesions",
        "Facial Wrinkles"
      ],
      "interventions": [
        {
          "name": "PicoWay™ 532nm fractional handpiece",
          "type": "DEVICE"
        },
        {
          "name": "PicoWay™ 730nm wavelength",
          "type": "DEVICE"
        },
        {
          "name": "PicoWay™ 1064nm fractional handpiece",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Candela Corporation",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "21 Years to 80 Years"
      },
      "enrollment_count": 115,
      "start_date": "2018-12-05",
      "completion_date": "2020-11-12",
      "has_results": true,
      "last_update_posted_date": "2023-12-01",
      "last_synced_at": "2026-05-22T09:14:56.647Z",
      "location_count": 1,
      "location_summary": "Wayland, Massachusetts",
      "locations": [
        {
          "city": "Wayland",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03774849"
    },
    {
      "nct_id": "NCT00113100",
      "title": "Mechanisms of Skin Repair by Topical Estrogen",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Skin Wrinkling"
      ],
      "interventions": [
        {
          "name": "Topical 17-beta estradiol in ethanol/propylene glycol (ETOH/PG)",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Michigan",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "50 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "50 Years and older"
      },
      "enrollment_count": 152,
      "start_date": "2004-08",
      "completion_date": "2007-06",
      "has_results": false,
      "last_update_posted_date": "2015-05-21",
      "last_synced_at": "2026-05-22T09:14:56.647Z",
      "location_count": 1,
      "location_summary": "Ann Arbor, Michigan",
      "locations": [
        {
          "city": "Ann Arbor",
          "state": "Michigan"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00113100"
    }
  ]
}