{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Rhytides&page=2",
    "query": {
      "condition": "Rhytides",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Rhytides&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-06-10T23:39:53.400Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT01813760",
      "title": "Treatment of Periorbital and Perioral Wrinkles With the Applications of the Iluminage Diode Laser",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Peri-orbital Wrinkles",
        "Peri-oral Wrinkles"
      ],
      "interventions": [
        {
          "name": "Illuiminage ® Diode Laser",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Cynosure, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "35 Years",
        "maximum_age": "60 Years",
        "sex": "FEMALE",
        "summary": "35 Years to 60 Years · Female only"
      },
      "enrollment_count": 60,
      "start_date": "2012-11",
      "completion_date": "2013-08",
      "has_results": false,
      "last_update_posted_date": "2014-03-26",
      "last_synced_at": "2026-06-10T23:39:53.400Z",
      "location_count": 1,
      "location_summary": "Westford, Massachusetts",
      "locations": [
        {
          "city": "Westford",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01813760"
    },
    {
      "nct_id": "NCT06074276",
      "title": "The Effects of Almond on Facial Skin Collagen and Wrinkles",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Collagen Degeneration",
        "Wrinkle",
        "Pigmentation",
        "Elastic Skin"
      ],
      "interventions": [
        {
          "name": "Food: whole almonds",
          "type": "OTHER"
        },
        {
          "name": "Food: non-nut snack",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Integrative Skin Science and Research",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "35 Years",
        "maximum_age": "70 Years",
        "sex": "FEMALE",
        "summary": "35 Years to 70 Years · Female only"
      },
      "enrollment_count": 60,
      "start_date": "2023-10-04",
      "completion_date": "2024-12-31",
      "has_results": false,
      "last_update_posted_date": "2024-06-18",
      "last_synced_at": "2026-06-10T23:39:53.400Z",
      "location_count": 1,
      "location_summary": "Sacramento, California",
      "locations": [
        {
          "city": "Sacramento",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06074276"
    },
    {
      "nct_id": "NCT05388604",
      "title": "Clinical Study To Evaluate Paired Treatment With An Alexandrite Laser And Radiofrequency Microneedling For Facial Aging",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Wrinkle",
        "Photoaging",
        "Dyschromia"
      ],
      "interventions": [
        {
          "name": "RF device",
          "type": "DEVICE"
        },
        {
          "name": "Microneedling device",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Cynosure, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "40 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "40 Years to 65 Years"
      },
      "enrollment_count": 42,
      "start_date": "2022-06-15",
      "completion_date": "2023-08-29",
      "has_results": false,
      "last_update_posted_date": "2023-10-18",
      "last_synced_at": "2026-06-10T23:39:53.400Z",
      "location_count": 3,
      "location_summary": "Sacramento, California • Montclair, New Jersey • New York, New York",
      "locations": [
        {
          "city": "Sacramento",
          "state": "California"
        },
        {
          "city": "Montclair",
          "state": "New Jersey"
        },
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05388604"
    },
    {
      "nct_id": "NCT06868615",
      "title": "AVAVA MIRIA General Use",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Acne",
        "Acne Scars - Mixed Atrophic and Hypertrophic",
        "Scars",
        "Wrinkle",
        "Pigment; Lesion",
        "Skin Texture Disorder"
      ],
      "interventions": [
        {
          "name": "AVAVA",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "AVAVA, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "18 Years to 70 Years"
      },
      "enrollment_count": 200,
      "start_date": "2024-09-11",
      "completion_date": "2027-12-30",
      "has_results": false,
      "last_update_posted_date": "2025-03-11",
      "last_synced_at": "2026-06-10T23:39:53.400Z",
      "location_count": 1,
      "location_summary": "Waltham, Massachusetts",
      "locations": [
        {
          "city": "Waltham",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06868615"
    },
    {
      "nct_id": "NCT05231681",
      "title": "Study to Identify if Saie Beauty's Under Eye Concealer Works to Improve Under-Eye Skin Appearance and Reduce Imperfections",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Wrinkle"
      ],
      "interventions": [
        {
          "name": "Saie Beauty's Hydrabeam Sheer Brightening Under Eye Concealer",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "Saie Beauty",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "45 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 45 Years · Female only"
      },
      "enrollment_count": 35,
      "start_date": "2022-02-15",
      "completion_date": "2022-05-01",
      "has_results": false,
      "last_update_posted_date": "2022-05-06",
      "last_synced_at": "2026-06-10T23:39:53.400Z",
      "location_count": 1,
      "location_summary": "Santa Monica, California",
      "locations": [
        {
          "city": "Santa Monica",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05231681"
    },
    {
      "nct_id": "NCT01113606",
      "title": "A Trial of Skin Care Protocols for Facial Resurfacing",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Facial Photo Damage",
        "Periocular Fine Wrinkles",
        "Perioral Fine Wrinkles"
      ],
      "interventions": [
        {
          "name": "Obagi New-Derm System",
          "type": "OTHER"
        },
        {
          "name": "Standard of Care",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "The Plastic Surgery Foundation",
      "sponsor_class": "OTHER",
      "healthy_volunteers": null,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 65 Years · Female only"
      },
      "enrollment_count": null,
      "start_date": null,
      "completion_date": null,
      "has_results": false,
      "last_update_posted_date": "2010-04-30",
      "last_synced_at": "2026-06-10T23:39:53.400Z",
      "location_count": 9,
      "location_summary": "Oxnard, California • Rancho Santa Margarita, California • Greeley, Colorado + 6 more",
      "locations": [
        {
          "city": "Oxnard",
          "state": "California"
        },
        {
          "city": "Rancho Santa Margarita",
          "state": "California"
        },
        {
          "city": "Greeley",
          "state": "Colorado"
        },
        {
          "city": "Melbourne",
          "state": "Florida"
        },
        {
          "city": "Louisville",
          "state": "Kentucky"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01113606"
    },
    {
      "nct_id": "NCT05524662",
      "title": "Clinical and Histological Evaluation of BTL-785F Device for Non-invasive Treatment of Face",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Wrinkle"
      ],
      "interventions": [
        {
          "name": "BTL-785-7",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "BTL Industries Ltd.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "21 Years to 70 Years"
      },
      "enrollment_count": 7,
      "start_date": "2022-06-15",
      "completion_date": "2023-03-31",
      "has_results": false,
      "last_update_posted_date": "2023-04-12",
      "last_synced_at": "2026-06-10T23:39:53.400Z",
      "location_count": 1,
      "location_summary": "Hackensack, New Jersey",
      "locations": [
        {
          "city": "Hackensack",
          "state": "New Jersey"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05524662"
    },
    {
      "nct_id": "NCT03477825",
      "title": "Pilot Study of Triphala and Rubia Cordifolia on Gut Microbiome and Skin",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Sebum Production",
        "Stool Microbiome",
        "Transepidermal Water Loss",
        "Facial Brrightness",
        "Erythema",
        "Wrinkles",
        "Facial Shine"
      ],
      "interventions": [
        {
          "name": "Placebo Oral Tablet",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Rubia Cordifolia",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Triphala",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "University of California, Davis",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "60 Years",
        "sex": "ALL",
        "summary": "18 Years to 60 Years"
      },
      "enrollment_count": 35,
      "start_date": "2018-03-12",
      "completion_date": "2019-01-25",
      "has_results": false,
      "last_update_posted_date": "2019-05-15",
      "last_synced_at": "2026-06-10T23:39:53.400Z",
      "location_count": 1,
      "location_summary": "Sacramento, California",
      "locations": [
        {
          "city": "Sacramento",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03477825"
    },
    {
      "nct_id": "NCT03426098",
      "title": "Secret Micro-Needle Fractional RF System® for the Treatment of Facial Wrinkles",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Aging",
        "Wrinkle"
      ],
      "interventions": [
        {
          "name": "Secret RF",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Goldman, Butterwick, Fitzpatrick and Groff",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "22 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "22 Years and older"
      },
      "enrollment_count": 40,
      "start_date": "2018-02-10",
      "completion_date": "2019-06-30",
      "has_results": false,
      "last_update_posted_date": "2019-05-10",
      "last_synced_at": "2026-06-10T23:39:53.400Z",
      "location_count": 1,
      "location_summary": "San Diego, California",
      "locations": [
        {
          "city": "San Diego",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03426098"
    },
    {
      "nct_id": "NCT07222397",
      "title": "2910 nm Erbium-Doped Fluoride Fiber Glass Laser for the Treatment of Advanced Perioral Lines and Wrinkles",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Photodamaged Skin",
        "Rhytids",
        "Lines Skin",
        "Wrinkles and Rhytides"
      ],
      "interventions": [
        {
          "name": "Laser Resurfacing",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "FA Corporation",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "50 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "50 Years to 80 Years"
      },
      "enrollment_count": 20,
      "start_date": "2025-03-01",
      "completion_date": "2026-02",
      "has_results": false,
      "last_update_posted_date": "2025-10-29",
      "last_synced_at": "2026-06-10T23:39:53.400Z",
      "location_count": 1,
      "location_summary": "Houston, Texas",
      "locations": [
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07222397"
    }
  ]
}