{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Rhytids",
    "query": {
      "condition": "Rhytids"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 21,
    "total_pages": 3,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Rhytids&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-05-22T05:17:28.656Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT02466178",
      "title": "Efficacy Trial for the Reduction of Glabellar Lines",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Rhytids in the Glabellar Region"
      ],
      "interventions": [
        {
          "name": "Serene RF System",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Serene Medical Inc",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "18 Years to 70 Years"
      },
      "enrollment_count": 78,
      "start_date": "2015-02",
      "completion_date": "2016-12",
      "has_results": false,
      "last_update_posted_date": "2017-03-22",
      "last_synced_at": "2026-05-22T05:17:28.656Z",
      "location_count": 5,
      "location_summary": "Palo Alto, California • San Mateo, California • New York, New York + 2 more",
      "locations": [
        {
          "city": "Palo Alto",
          "state": "California"
        },
        {
          "city": "San Mateo",
          "state": "California"
        },
        {
          "city": "New York",
          "state": "New York"
        },
        {
          "city": "Clackamas",
          "state": "Oregon"
        },
        {
          "city": "Kirkland",
          "state": "Washington"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02466178"
    },
    {
      "nct_id": "NCT00765583",
      "title": "A Study to Determine How Long Restylane® Will Last After Initial Treatment With 2 Different Re-treatment Schedules.",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Rhytids"
      ],
      "interventions": [
        {
          "name": "Restylane",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Medicis Aesthetics, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 75,
      "start_date": "2005-11",
      "completion_date": "2009-02",
      "has_results": false,
      "last_update_posted_date": "2011-09-22",
      "last_synced_at": "2026-05-22T05:17:28.656Z",
      "location_count": 3,
      "location_summary": "Coral Gables, Florida • Chicago, Illinois • White Plains, New York",
      "locations": [
        {
          "city": "Coral Gables",
          "state": "Florida"
        },
        {
          "city": "Chicago",
          "state": "Illinois"
        },
        {
          "city": "White Plains",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00765583"
    },
    {
      "nct_id": "NCT00662389",
      "title": "Application of the Apsara Thermal Wand System",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "EARLY_PHASE1"
      ],
      "conditions": [
        "Tightening of Skin Laxity"
      ],
      "interventions": [
        {
          "name": "Apsara Thermal Wand System",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Apsara Medical Corporation",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "40 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "40 Years to 65 Years"
      },
      "enrollment_count": 4,
      "start_date": "2008-04",
      "completion_date": "2009-03",
      "has_results": true,
      "last_update_posted_date": "2009-08-28",
      "last_synced_at": "2026-05-22T05:17:28.656Z",
      "location_count": 1,
      "location_summary": "San Francisco, California",
      "locations": [
        {
          "city": "San Francisco",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00662389"
    },
    {
      "nct_id": "NCT00818311",
      "title": "Skin Safety Profile of Different Exposure to the Light Emitting Diode (LED) in Healthy Subjects",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Radiation Tolerance",
        "Skin Aging",
        "Rhytids"
      ],
      "interventions": [
        {
          "name": "LED GentleWaves®",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "L'Oreal",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 100,
      "start_date": "2008-06",
      "completion_date": "2008-12",
      "has_results": false,
      "last_update_posted_date": "2009-01-07",
      "last_synced_at": "2026-05-22T05:17:28.656Z",
      "location_count": 1,
      "location_summary": "Carrollton, Texas",
      "locations": [
        {
          "city": "Carrollton",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00818311"
    },
    {
      "nct_id": "NCT01713907",
      "title": "Evaluation of the Ulthera® System for Treatment of the Face and Neck",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Wrinkles",
        "Rhytids",
        "Skin Laxity"
      ],
      "interventions": [
        {
          "name": "Ulthera® Treatment",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Ulthera, Inc",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "30 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "30 Years to 65 Years"
      },
      "enrollment_count": 15,
      "start_date": "2011-06",
      "completion_date": "2012-01",
      "has_results": false,
      "last_update_posted_date": "2017-11-24",
      "last_synced_at": "2026-05-22T05:17:28.656Z",
      "location_count": 1,
      "location_summary": "Rockville, Maryland",
      "locations": [
        {
          "city": "Rockville",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01713907"
    },
    {
      "nct_id": "NCT01986634",
      "title": "Laser Spot Treatment of Perioral Rhytids",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Facial Aging"
      ],
      "interventions": [
        {
          "name": "Laser Treatment",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "University Hospitals Cleveland Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 30,
      "start_date": "2013-09",
      "completion_date": "2015-12-31",
      "has_results": false,
      "last_update_posted_date": "2023-07-05",
      "last_synced_at": "2026-05-22T05:17:28.656Z",
      "location_count": 1,
      "location_summary": "Lyndhurst, Ohio",
      "locations": [
        {
          "city": "Lyndhurst",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01986634"
    },
    {
      "nct_id": "NCT07222397",
      "title": "2910 nm Erbium-Doped Fluoride Fiber Glass Laser for the Treatment of Advanced Perioral Lines and Wrinkles",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Photodamaged Skin",
        "Rhytids",
        "Lines Skin",
        "Wrinkles and Rhytides"
      ],
      "interventions": [
        {
          "name": "Laser Resurfacing",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "FA Corporation",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "50 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "50 Years to 80 Years"
      },
      "enrollment_count": 20,
      "start_date": "2025-03-01",
      "completion_date": "2026-02",
      "has_results": false,
      "last_update_posted_date": "2025-10-29",
      "last_synced_at": "2026-05-22T05:17:28.656Z",
      "location_count": 1,
      "location_summary": "Houston, Texas",
      "locations": [
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07222397"
    },
    {
      "nct_id": "NCT03092219",
      "title": "RHA Redensity - Perioral Rhytids",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Perioral Rhytids",
        "Aging",
        "Wrinkle"
      ],
      "interventions": [
        {
          "name": "TEOSYAL RHA Redensity",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Teoxane SA",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "22 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "22 Years and older"
      },
      "enrollment_count": 202,
      "start_date": "2016-12-20",
      "completion_date": "2019-01-08",
      "has_results": true,
      "last_update_posted_date": "2023-06-22",
      "last_synced_at": "2026-05-22T05:17:28.656Z",
      "location_count": 6,
      "location_summary": "Beverly Hills, California • Santa Monica, California • Coral Gables, Florida + 3 more",
      "locations": [
        {
          "city": "Beverly Hills",
          "state": "California"
        },
        {
          "city": "Santa Monica",
          "state": "California"
        },
        {
          "city": "Coral Gables",
          "state": "Florida"
        },
        {
          "city": "Omaha",
          "state": "Nebraska"
        },
        {
          "city": "High Point",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03092219"
    },
    {
      "nct_id": "NCT01212809",
      "title": "Comparative Study of Reconstituted JUVÉDERM® Ultra vs COSMODERM® 1 for Lip and Cheek Lines, Folds or Wrinkles",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Intrinsic Aging of Skin"
      ],
      "interventions": [
        {
          "name": "Juvéderm Ultra",
          "type": "DEVICE"
        },
        {
          "name": "Cosmoderm 1",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Steven Fagien",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "25 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "25 Years to 70 Years"
      },
      "enrollment_count": 30,
      "start_date": "2010-09",
      "completion_date": "2011-06",
      "has_results": false,
      "last_update_posted_date": "2011-09-12",
      "last_synced_at": "2026-05-22T05:17:28.656Z",
      "location_count": 1,
      "location_summary": "Boca Raton, Florida",
      "locations": [
        {
          "city": "Boca Raton",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01212809"
    },
    {
      "nct_id": "NCT04057768",
      "title": "Fractional Radiofrequency for the Treatment and Reduction of Acne Scars and Wrinkles",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Acne Scars - Mixed Atrophic and Hypertrophic",
        "Wrinkle"
      ],
      "interventions": [
        {
          "name": "Venus Viva",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Venus Concept",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "22 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "22 Years and older"
      },
      "enrollment_count": 10,
      "start_date": "2019-08-19",
      "completion_date": "2020-03-03",
      "has_results": true,
      "last_update_posted_date": "2021-06-29",
      "last_synced_at": "2026-05-22T05:17:28.656Z",
      "location_count": 1,
      "location_summary": "Sacramento, California",
      "locations": [
        {
          "city": "Sacramento",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04057768"
    }
  ]
}