{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Root+Canal+Infection", "query": { "condition": "Root Canal Infection" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 14, "total_pages": 2, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Root+Canal+Infection&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-05-22T04:50:07.742Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT04028479", "title": "The Registry of Oncology Outcomes Associated With Testing and Treatment", "overall_status": "COMPLETED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Adenocarcinoma", "Adenocystic Carcinoma", "Anal Cancer", "Appendix Cancer", "Brain Tumor", "Glioblastoma", "Astrocytoma", "Bile Duct Cancer", "Cholangiocarcinoma", "Bladder Cancer", "Bone Cancer", "Synovial Sarcoma", "Chondrosarcoma", "Liposarcoma", "Sarcoma, Kaposi", "Sarcoma,Soft Tissue", "Sarcoma", "Osteosarcoma", "CNS Cancer", "Brain Stem Neoplasms", "Breast Cancer", "Cervical Cancer", "Colorectal Cancer", "Rectal Cancer", "Colon Cancer", "Esophageal Cancer", "Esophagus Cancer", "Cancer of Colon", "Pancreatic Cancer", "Cancer of Pancreas", "Testis Cancer", "Testicular Cancer", "Ureter Cancer", "Renal Cell Carcinoma", "Kidney Cancer", "Gestational Trophoblastic Tumor", "Head and Neck Neoplasms", "Parotid Tumor", "Larynx Cancer", "Tongue Cancer", "Pharynx Cancer", "Salivary Gland Cancer", "Acute Myeloid Leukemia", "Chronic Myeloid Leukemia", "Acute Lymphoblastic Leukemia", "Multiple Myeloma", "Non Hodgkin Lymphoma", "Carcinoid Tumor", "Lung Cancer", "Neuroendocrine Tumors", "Mesothelioma", "Thyroid Cancer", "Parathyroid Neoplasms", "Adrenal Cancer", "Small Bowel Cancer", "Stomach Cancer", "Liver Cancer", "Hepatic Cancer", "Melanoma", "Skin Cancer", "Unknown Primary Tumors", "Uterine Cancer", "Fallopian Tube Cancer", "Ovarian Cancer", "Prostate Cancer", "Vaginal Cancer", "Penile Cancer", "Vulvar Cancer", "Waldenstrom Macroglobulinemia", "Cancer, Advanced", "Thymus Cancer", "Nasopharyngeal Carcinoma", "Multiple Endocrine Neoplasia", "Pheochromocytoma", "Small Cell Carcinoma", "Pulmonary Carcinoma" ], "interventions": [ { "name": "Biomarker Testing (L)", "type": "DIAGNOSTIC_TEST" }, { "name": "Systemic Treatment (T)", "type": "DRUG" }, { "name": "Patient Reported Outcomes (P)", "type": "OTHER" } ], "intervention_types": [ "DIAGNOSTIC_TEST", "DRUG", "OTHER" ], "sponsor": "Taproot Health", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 167, "start_date": "2021-05-05", "completion_date": "2024-10-31", "has_results": false, "last_update_posted_date": "2024-12-18", "last_synced_at": "2026-05-22T04:50:07.742Z", "location_count": 2, "location_summary": "Idaho Falls, Idaho • Laredo, Texas", "locations": [ { "city": "Idaho Falls", "state": "Idaho" }, { "city": "Laredo", "state": "Texas" } ], "official_url": "https://clinicaltrials.gov/study/NCT04028479" }, { "nct_id": "NCT01870973", "title": "Effect of Root Canal Treatment (Versus no Treatment) for Patients With Tooth Infections and Toothaches", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Postoperative Pain" ], "interventions": [ { "name": "root canal treatment, anesthesia, pain medications, and antibiotic", "type": "PROCEDURE" }, { "name": "no root canal treatment, anesthesia, pain medications, and antibiotic", "type": "PROCEDURE" } ], "intervention_types": [ "PROCEDURE" ], "sponsor": "Ohio State University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 108, "start_date": "2013-03", "completion_date": "2014-06", "has_results": true, "last_update_posted_date": "2015-06-18", "last_synced_at": "2026-05-22T04:50:07.742Z", "location_count": 1, "location_summary": "Columbus, Ohio", "locations": [ { "city": "Columbus", "state": "Ohio" } ], "official_url": "https://clinicaltrials.gov/study/NCT01870973" }, { "nct_id": "NCT07518901", "title": "Nanozymes in Endodontics", "overall_status": "NOT_YET_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Apical Periodontitis", "Endodontic Disease", "Root Canal Infection" ], "interventions": [ { "name": "Nanozyme treatment", "type": "DRUG" }, { "name": "Control (Standard treatment)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of Pennsylvania", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 72, "start_date": "2026-06", "completion_date": "2028-06", "has_results": false, "last_update_posted_date": "2026-04-09", "last_synced_at": "2026-05-22T04:50:07.742Z", "location_count": 1, "location_summary": "Philadelphia, Pennsylvania", "locations": [ { "city": "Philadelphia", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT07518901" }, { "nct_id": "NCT02418494", "title": "Health-Related Symptom Questionnaires in Measuring Quality of Life in HIV-Infected Participants Treated or Monitored for Anal Lesions", "overall_status": "COMPLETED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "High Grade Anal Canal Squamous Intraepithelial Neoplasia", "HIV Infection" ], "interventions": [ { "name": "Concept Elicitation", "type": "OTHER" }, { "name": "Comprehension Assessment", "type": "OTHER" } ], "intervention_types": [ "OTHER" ], "sponsor": "AIDS Malignancy Consortium", "sponsor_class": "NETWORK", "healthy_volunteers": false, "eligibility": { "minimum_age": "35 Years", "maximum_age": null, "sex": "ALL", "summary": "35 Years and older" }, "enrollment_count": 85, "start_date": "2015-04", "completion_date": "2016-05", "has_results": false, "last_update_posted_date": "2016-06-09", "last_synced_at": "2026-05-22T04:50:07.742Z", "location_count": 6, "location_summary": "San Francisco, California • Chicago, Illinois • New York, New York + 1 more", "locations": [ { "city": "San Francisco", "state": "California" }, { "city": "Chicago", "state": "Illinois" }, { "city": "New York", "state": "New York" }, { "city": "New York", "state": "New York" }, { "city": "New York", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT02418494" }, { "nct_id": "NCT05555043", "title": "Comparison of Clinical Outcomes Between GentleWave® and Biolase®", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Endodontic Disease", "Periapical Diseases", "Periapical Periodontitis", "Root Canal Infection" ], "interventions": [ { "name": "Irrisafe ip", "type": "DEVICE" }, { "name": "GentleWave System", "type": "DEVICE" }, { "name": "Waterlase iPlus", "type": "DEVICE" } ], "intervention_types": [ "DEVICE" ], "sponsor": "University of North Carolina, Chapel Hill", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "14 Years", "maximum_age": "99 Years", "sex": "ALL", "summary": "14 Years to 99 Years" }, "enrollment_count": 120, "start_date": "2022-11-08", "completion_date": "2025-07-25", "has_results": false, "last_update_posted_date": "2025-08-12", "last_synced_at": "2026-05-22T04:50:07.742Z", "location_count": 1, "location_summary": "Chapel Hill, North Carolina", "locations": [ { "city": "Chapel Hill", "state": "North Carolina" } ], "official_url": "https://clinicaltrials.gov/study/NCT05555043" }, { "nct_id": "NCT05959629", "title": "Erbium, Chromium: Yttrium, Scandium, Gallium, Garnet (Er,Cr:YSGG) Laser in Root Canal Disinfection", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Endodontic Disease", "Root Canal Infection" ], "interventions": [ { "name": "Waterlase Express™, BIOLASE®", "type": "DEVICE" }, { "name": "Sodium Hypochlorite", "type": "OTHER" } ], "intervention_types": [ "DEVICE", "OTHER" ], "sponsor": "University of Pennsylvania", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 56, "start_date": "2023-10-11", "completion_date": "2024-05-02", "has_results": true, "last_update_posted_date": "2025-10-09", "last_synced_at": "2026-05-22T04:50:07.742Z", "location_count": 1, "location_summary": "Philadelphia, Pennsylvania", "locations": [ { "city": "Philadelphia", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT05959629" }, { "nct_id": "NCT03384004", "title": "Effect of Apical Negative Pressure Irrigation System at Cleaning Lateral Canals and Reduction of Periapical Lesions After Endodontic Therapy", "overall_status": "UNKNOWN", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Root Canal Infection" ], "interventions": [ { "name": "Irrigation Technique 1", "type": "DEVICE" }, { "name": "Irrigation Technique 2", "type": "DEVICE" } ], "intervention_types": [ "DEVICE" ], "sponsor": "KaVo Kerr", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 60, "start_date": "2017-11-20", "completion_date": "2019-01", "has_results": false, "last_update_posted_date": "2017-12-27", "last_synced_at": "2026-05-22T04:50:07.742Z", "location_count": 1, "location_summary": "Niles, Illinois", "locations": [ { "city": "Niles", "state": "Illinois" } ], "official_url": "https://clinicaltrials.gov/study/NCT03384004" }, { "nct_id": "NCT04276935", "title": "Development of a Health-Related Symptom Index for Participants With and Either Treated or Monitored for Anal High-Grade Squamous Intraepithelial Lesions", "overall_status": "COMPLETED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "High Grade Anal Canal Squamous Intraepithelial Neoplasia", "Human Immunodeficiency Virus" ], "interventions": [ { "name": "Interview", "type": "OTHER" }, { "name": "Quality-of-Life Assessment", "type": "OTHER" }, { "name": "Questionnaire Administration", "type": "OTHER" } ], "intervention_types": [ "OTHER" ], "sponsor": "AIDS Malignancy Consortium", "sponsor_class": "NETWORK", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 20, "start_date": "2018-11-06", "completion_date": "2020-03-01", "has_results": true, "last_update_posted_date": "2025-03-07", "last_synced_at": "2026-05-22T04:50:07.742Z", "location_count": 4, "location_summary": "San Francisco, California • Miami, Florida • Chicago, Illinois + 1 more", "locations": [ { "city": "San Francisco", "state": "California" }, { "city": "Miami", "state": "Florida" }, { "city": "Chicago", "state": "Illinois" }, { "city": "Seattle", "state": "Washington" } ], "official_url": "https://clinicaltrials.gov/study/NCT04276935" }, { "nct_id": "NCT03302858", "title": "A Safety and Efficacy Trial of Circumferential Anal Canal Radiofrequency Ablation for High-Grade Anal Intraepithelial Neoplasia Using the BARRX™ Anorectal Wand", "overall_status": "UNKNOWN", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "HSIL, High Grade Squamous Intraepithelial Lesions", "Anal Cancer", "HPV-Related Squamous Cell Carcinoma", "Human Papilloma Virus", "Human Papillomavirus Infection", "Ain III" ], "interventions": [ { "name": "BARRX™ Anorectal Wand", "type": "DEVICE" } ], "intervention_types": [ "DEVICE" ], "sponsor": "Stephen E. Goldstone", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "18 Years to 75 Years" }, "enrollment_count": 70, "start_date": "2017-10", "completion_date": "2020-10", "has_results": false, "last_update_posted_date": "2017-10-05", "last_synced_at": "2026-05-22T04:50:07.742Z", "location_count": 1, "location_summary": "New York, New York", "locations": [ { "city": "New York", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT03302858" }, { "nct_id": "NCT04432376", "title": "Efficacy and Safety Study of Miconazole Oil Versus Vehicle on Fungal Infection of the Ear Canal (Otomycosis)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2", "PHASE3" ], "conditions": [ "Otomycosis" ], "interventions": [ { "name": "miconazole 2% oil", "type": "DRUG" }, { "name": "vehicle oil", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Hill Dermaceuticals, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "7 Years", "maximum_age": null, "sex": "ALL", "summary": "7 Years and older" }, "enrollment_count": 382, "start_date": "2020-07-08", "completion_date": "2021-11-01", "has_results": true, "last_update_posted_date": "2024-01-19", "last_synced_at": "2026-05-22T04:50:07.742Z", "location_count": 12, "location_summary": "Chula Vista, California • La Jolla, California • Roseville, California + 9 more", "locations": [ { "city": "Chula Vista", "state": "California" }, { "city": "La Jolla", "state": "California" }, { "city": "Roseville", "state": "California" }, { "city": "Sacramento", "state": "California" }, { "city": "Leesburg", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT04432376" } ] }