{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Rupture+of+Membranes%3B+Premature&page=3",
    "query": {
      "condition": "Rupture of Membranes; Premature",
      "page": 3
    },
    "page_size": 10
  },
  "pagination": {
    "page": 3,
    "page_size": 10,
    "total_count": 60,
    "total_pages": 6,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Rupture+of+Membranes%3B+Premature&page=4&page_size=10",
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Rupture+of+Membranes%3B+Premature&page=2&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-10-12T10:12:28.568Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT00326521",
      "title": "Evaluation of Fever Occurring in Labor in Patients Receiving Epidural Anesthesia",
      "overall_status": "UNKNOWN",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Fever"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "MemorialCare",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 50,
      "start_date": "2006-10",
      "completion_date": "2009-05",
      "has_results": false,
      "last_update_posted_date": "2008-06-06",
      "last_synced_at": "2026-10-12T10:12:28.568Z",
      "location_count": 2,
      "location_summary": "Long Beach, California • Orange, California",
      "locations": [
        {
          "city": "Long Beach",
          "state": "California"
        },
        {
          "city": "Orange",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00326521"
    },
    {
      "nct_id": "NCT02939742",
      "title": "Does a Rescue Course of Betamethasone in Pregnant Women With PPROM Decrease Neonatal Morbidity?",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2",
        "PHASE3"
      ],
      "conditions": [
        "PPROM",
        "Respiratory Distress Syndrome in Premature Infants"
      ],
      "interventions": [
        {
          "name": "Betamethasone",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "The University of Texas Medical Branch, Galveston",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "50 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 50 Years · Female only"
      },
      "enrollment_count": 33,
      "start_date": "2016-11",
      "completion_date": "2023-12-20",
      "has_results": true,
      "last_update_posted_date": "2026-06-30",
      "last_synced_at": "2026-10-12T10:12:28.568Z",
      "location_count": 1,
      "location_summary": "Galveston, Texas",
      "locations": [
        {
          "city": "Galveston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02939742"
    },
    {
      "nct_id": "NCT06396078",
      "title": "Improvement of PPROM Management With Prophylactic Antimicrobial Therapy (iPROMPT)",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Preterm Premature Rupture of Membrane",
        "Pregnancy, High Risk",
        "Preterm Birth"
      ],
      "interventions": [
        {
          "name": "Ceftriaxone 1000 MG",
          "type": "DRUG"
        },
        {
          "name": "Clarithromycin 500mg",
          "type": "DRUG"
        },
        {
          "name": "Metronidazole 500 mg",
          "type": "DRUG"
        },
        {
          "name": "Ampicillin 2 GM Injection",
          "type": "DRUG"
        },
        {
          "name": "Amoxicillin 250 MG",
          "type": "DRUG"
        },
        {
          "name": "Azithromycin",
          "type": "DRUG"
        },
        {
          "name": "Erythromycin",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Ohio State University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 56,
      "start_date": "2024-07-18",
      "completion_date": "2026-12",
      "has_results": false,
      "last_update_posted_date": "2026-01-27",
      "last_synced_at": "2026-10-12T10:12:28.568Z",
      "location_count": 2,
      "location_summary": "Columbus, Ohio • Galveston, Texas",
      "locations": [
        {
          "city": "Columbus",
          "state": "Ohio"
        },
        {
          "city": "Galveston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06396078"
    },
    {
      "nct_id": "NCT04047849",
      "title": "Latency Antibiotics in Previable PPROM, 18 0/7- 22 6/7 WGA",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Rupture of Membranes; Delayed Delivery (Following Spontaneous Rupture)",
        "Rupture of Membranes; Premature",
        "Rupture of Membranes; Premature, Affecting Fetus",
        "Preterm Birth",
        "Preterm PROM (Pregnancy)",
        "Preterm Labor"
      ],
      "interventions": [
        {
          "name": "Antibiotics, oral Azithromycin and oral Amoxicillin",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Woman's",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 34,
      "start_date": "2019-08-28",
      "completion_date": "2021-07-01",
      "has_results": false,
      "last_update_posted_date": "2021-01-11",
      "last_synced_at": "2026-10-12T10:12:28.568Z",
      "location_count": 1,
      "location_summary": "Baton Rouge, Louisiana",
      "locations": [
        {
          "city": "Baton Rouge",
          "state": "Louisiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04047849"
    },
    {
      "nct_id": "NCT04318470",
      "title": "Identification of Microbial DNA in Maternal Plasma After PPROM",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Preterm Rupture of Membranes"
      ],
      "interventions": [
        {
          "name": "mNGS",
          "type": "DIAGNOSTIC_TEST"
        }
      ],
      "intervention_types": [
        "DIAGNOSTIC_TEST"
      ],
      "sponsor": "University of California, San Francisco",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "55 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 55 Years · Female only"
      },
      "enrollment_count": 70,
      "start_date": "2020-02-12",
      "completion_date": "2022-12-31",
      "has_results": false,
      "last_update_posted_date": "2023-04-07",
      "last_synced_at": "2026-10-12T10:12:28.568Z",
      "location_count": 1,
      "location_summary": "San Francisco, California",
      "locations": [
        {
          "city": "San Francisco",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04318470"
    },
    {
      "nct_id": "NCT03060473",
      "title": "Treatment of ppROM With Erythromycin vs. Azithromycin Trial",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Preterm Premature Rupture of Membranes (PPROM)"
      ],
      "interventions": [
        {
          "name": "Azithromycin",
          "type": "DRUG"
        },
        {
          "name": "Erythromycin",
          "type": "DRUG"
        },
        {
          "name": "Ampicillin",
          "type": "DRUG"
        },
        {
          "name": "Amoxicillin",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "The University of Texas Medical Branch, Galveston",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 21,
      "start_date": "2017-02-23",
      "completion_date": "2023-12-08",
      "has_results": true,
      "last_update_posted_date": "2024-06-25",
      "last_synced_at": "2026-10-12T10:12:28.568Z",
      "location_count": 3,
      "location_summary": "Austin, Texas • Galveston, Texas • Salt Lake City, Utah",
      "locations": [
        {
          "city": "Austin",
          "state": "Texas"
        },
        {
          "city": "Galveston",
          "state": "Texas"
        },
        {
          "city": "Salt Lake City",
          "state": "Utah"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03060473"
    },
    {
      "nct_id": "NCT00294242",
      "title": "Safety Study of Membrane Sweeping in Pregnancy",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Pregnancy",
        "Prelabor Rupture of Membranes"
      ],
      "interventions": [
        {
          "name": "Membrane Sweep",
          "type": "PROCEDURE"
        },
        {
          "name": "No Membrane Sweep",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Tripler Army Medical Center",
      "sponsor_class": "FED",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "50 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 50 Years · Female only"
      },
      "enrollment_count": 300,
      "start_date": "2006-02",
      "completion_date": "2007-05",
      "has_results": false,
      "last_update_posted_date": "2025-02-11",
      "last_synced_at": "2026-10-12T10:12:28.568Z",
      "location_count": 1,
      "location_summary": "Tripler AMC, Hawaii",
      "locations": [
        {
          "city": "Tripler AMC",
          "state": "Hawaii"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00294242"
    },
    {
      "nct_id": "NCT00342277",
      "title": "Microarray Expression Profiling to Identify Stereotypic mRNA Profiles in Human Parturition",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Preterm Birth",
        "Premature Rupture of Membranes"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)",
      "sponsor_class": "NIH",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 6838,
      "start_date": "1999-12-21",
      "completion_date": "2016-05-05",
      "has_results": false,
      "last_update_posted_date": "2023-02-24",
      "last_synced_at": "2026-10-12T10:12:28.568Z",
      "location_count": 1,
      "location_summary": "Detroit, Michigan",
      "locations": [
        {
          "city": "Detroit",
          "state": "Michigan"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00342277"
    },
    {
      "nct_id": "NCT02314728",
      "title": "Cervical Ripening in Premature Rupture of Membranes",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Pregnancy",
        "Premature Rupture of Membranes",
        "Preterm Premature Rupture of Membranes",
        "Unfavorable Cervix"
      ],
      "interventions": [
        {
          "name": "Misoprostol",
          "type": "DRUG"
        },
        {
          "name": "Oxytocin",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Montefiore Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "15 Years",
        "maximum_age": "50 Years",
        "sex": "FEMALE",
        "summary": "15 Years to 50 Years · Female only"
      },
      "enrollment_count": 230,
      "start_date": "2014-10-01",
      "completion_date": "2016-05-30",
      "has_results": true,
      "last_update_posted_date": "2021-08-10",
      "last_synced_at": "2026-10-12T10:12:28.568Z",
      "location_count": 1,
      "location_summary": "The Bronx, New York",
      "locations": [
        {
          "city": "The Bronx",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02314728"
    },
    {
      "nct_id": "NCT04451109",
      "title": "Dilapan-S®: A Multicenter US E-registry",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Post Term Pregnancy",
        "Premature Rupture of Membrane",
        "Fetal Growth Retardation",
        "Oligohydramnios",
        "Gestational Diabetes",
        "High Blood Pressure in Pregnancy"
      ],
      "interventions": [
        {
          "name": "Dilapan-S",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Medicem Technology s.r.o.",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 1200,
      "start_date": "2020-12-01",
      "completion_date": "2025-06-30",
      "has_results": false,
      "last_update_posted_date": "2024-11-22",
      "last_synced_at": "2026-10-12T10:12:28.568Z",
      "location_count": 1,
      "location_summary": "Galveston, Texas",
      "locations": [
        {
          "city": "Galveston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04451109"
    }
  ]
}