{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=SCN2A+Encephalopathy", "query": { "condition": "SCN2A Encephalopathy" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 5, "total_pages": 1, "next_page_url": null, "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-05-22T04:49:43.721Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT05737784", "title": "A Clinical Trial of PRAX-222 in Pediatric Participants With Early Onset SCN2A Developmental and Epileptic Encephalopathy", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1", "PHASE2" ], "conditions": [ "SCN2A-DEE", "Epilepsy" ], "interventions": [ { "name": "PRAX-222 - Initial Dose", "type": "DRUG" }, { "name": "PRAX-222 - Initial Ascending Doses", "type": "DRUG" }, { "name": "PRAX-222 - Optional Ascending Doses", "type": "DRUG" }, { "name": "PRAX-222 - Fixed Doses", "type": "DRUG" }, { "name": "Placebo", "type": "PROCEDURE" } ], "intervention_types": [ "DRUG", "PROCEDURE" ], "sponsor": "Praxis Precision Medicines", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "2 Years", "maximum_age": "18 Years", "sex": "ALL", "summary": "2 Years to 18 Years" }, "enrollment_count": 60, "start_date": "2023-04-13", "completion_date": "2027-09", "has_results": false, "last_update_posted_date": "2025-08-21", "last_synced_at": "2026-05-22T04:49:43.721Z", "location_count": 1, "location_summary": "Memphis, Tennessee", "locations": [ { "city": "Memphis", "state": "Tennessee" } ], "official_url": "https://clinicaltrials.gov/study/NCT05737784" }, { "nct_id": "NCT07019922", "title": "A Clinical Trial of Elsunersen in Pediatric SCN2A-DEE to Assess Efficacy and Safety", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Epileptic Encephalopathy", "SCN2A Encephalopathy" ], "interventions": [ { "name": "1mg elsunersen", "type": "DRUG" }, { "name": "sham procedure", "type": "PROCEDURE" }, { "name": "0.5mg elsunersen", "type": "DRUG" } ], "intervention_types": [ "DRUG", "PROCEDURE" ], "sponsor": "Praxis Precision Medicines", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "1 Day", "maximum_age": "18 Years", "sex": "ALL", "summary": "1 Day to 18 Years" }, "enrollment_count": 50, "start_date": "2025-08-13", "completion_date": "2028-12", "has_results": false, "last_update_posted_date": "2026-05-13", "last_synced_at": "2026-05-22T04:49:43.721Z", "location_count": 2, "location_summary": "San Diego, California • Chicago, Illinois", "locations": [ { "city": "San Diego", "state": "California" }, { "city": "Chicago", "state": "Illinois" } ], "official_url": "https://clinicaltrials.gov/study/NCT07019922" }, { "nct_id": "NCT05818553", "title": "A Clinical Trial of PRAX-562 in Subjects With Developmental and Epileptic Encephalopathies (DEE)", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2", "PHASE3" ], "conditions": [ "SCN2A Encephalopathy", "SCN8A Encephalopathy" ], "interventions": [ { "name": "PRAX-562", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Praxis Precision Medicines", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "1 Year", "maximum_age": "18 Years", "sex": "ALL", "summary": "1 Year to 18 Years" }, "enrollment_count": 77, "start_date": "2023-08-02", "completion_date": "2027-03-01", "has_results": false, "last_update_posted_date": "2026-01-29", "last_synced_at": "2026-05-22T04:49:43.721Z", "location_count": 4, "location_summary": "Atlanta, Georgia • Chicago, Illinois • Minneapolis, Minnesota + 1 more", "locations": [ { "city": "Atlanta", "state": "Georgia" }, { "city": "Chicago", "state": "Illinois" }, { "city": "Minneapolis", "state": "Minnesota" }, { "city": "Hackensack", "state": "New Jersey" } ], "official_url": "https://clinicaltrials.gov/study/NCT05818553" }, { "nct_id": "NCT05407727", "title": "A Prospective, Remote Observational Study in Pediatric Participants With Early-Onset SCN2A-Developmental and Epileptic Encephalopathy", "overall_status": "COMPLETED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "SCN2A-DEE", "Epilepsy" ], "interventions": [], "intervention_types": [], "sponsor": "Praxis Precision Medicines", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "1 Year", "maximum_age": "16 Years", "sex": "ALL", "summary": "1 Year to 16 Years" }, "enrollment_count": 5, "start_date": "2022-04-15", "completion_date": "2023-03-31", "has_results": false, "last_update_posted_date": "2024-01-10", "last_synced_at": "2026-05-22T04:49:43.721Z", "location_count": 1, "location_summary": "Atlanta, Georgia", "locations": [ { "city": "Atlanta", "state": "Georgia" } ], "official_url": "https://clinicaltrials.gov/study/NCT05407727" }, { "nct_id": "NCT01238250", "title": "Online Study of People Who Have Genetic Changes and Features of Autism: Simons Searchlight", "overall_status": "RECRUITING", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "16P11.2 Deletion Syndrome", "16p11.2 Duplications", "1Q21.1 Deletion", "1Q21.1 Microduplication Syndrome (Disorder)", "ACTL6B", "ADNP", "AHDC1", "ANK2", "ANKRD11", "ARID1B", "ASH1L", "BCL11A", "CHAMP1", "CHD2", "CHD8", "CSNK2A1", "CTBP1", "CTNNB1 Gene Mutation", "CUL3", "DDX3X", "DNMT3A", "DSCAM", "DYRK1A", "FOXP1", "GRIN2A", "GRIN2B", "HIVEP2-Related Intellectual Disability", "HNRNPH2", "KATNAL2", "KDM5B", "KDM6B", "KMT2C Gene Mutation", "KMT2E", "KMT5B", "MBD5", "MED13L", "PACS1", "PPP2R5D-Related Intellectual Disability", "PTCHD1", "REST", "SCN2A Encephalopathy", "SETBP1 Gene Mutation", "SETD5", "SMARCA4 Gene Mutation", "SMARCC2", "STXBP1 Encephalopathy With Epilepsy", "SYNGAP1-Related Intellectual Disability", "TBR1", "ARHGEF9", "HNRNPU", "PPP3CA", "PPP2R1A", "SLC6A1", "2p16.3 Deletions", "5q35 Deletions", "5q35 Duplications", "7q11.23 Duplications", "15Q13.3 Deletion Syndrome", "16p11.2 Triplications", "16P12.2 Microdeletion", "16P13.11 Microdeletion Syndrome (Disorder)", "17Q12 Microdeletion Syndrome (Disorder)", "17Q12 Duplication Syndrome", "17Q21.31 Deletion Syndrome", "17q21.3 Duplications", "ACTB", "ADSL", "AFF2", "ALDH5A1", "ANK3", "ARX", "ATRX Gene Mutation", "AUTS2 Syndrome", "BCKDK", "BRSK2", "CACNA1C", "CAPRIN1", "CASK", "CASZ1", "CHD3", "CIC", "CNOT3", "CREBBP Gene Mutation", "CSDE1", "CTCF", "DEAF1", "DHCR7", "DLG4", "EBF3", "EHMT1", "EP300 Gene Mutation", "GIGYF1", "GRIN1", "GRIN2D", "IQSEC2-Related Syndromic Intellectual Disability", "IRF2BPL", "KANSL1", "KCNB1", "KDM3B", "NEXMIF", "KMT2A", "MBOAT7", "MEIS2", "MYT1L", "NAA15", "NBEA", "NCKAP1", "NIPBL", "NLGN2", "NLGN3", "NLGN4X", "NR4A2", "NRXN1", "NRXN2", "NSD1 Gene Mutation", "PHF21A", "PHF3", "PHIP", "POMGNT1", "PSMD12", "RELN", "RERE", "RFX3", "RIMS1", "RORB", "SCN1A", "SETD2 Gene Mutation", "SHANK2", "SIN3A", "SLC9A6", "SON", "SOX5", "SPAST", "SRCAP", "TAOK1", "TANC2", "TCF20", "TLK2", "TRIO", "TRIP12", "UPF3B", "USP9X", "VPS13B", "WAC", "WDFY3", "ZBTB20", "ZNF292", "ZNF462", "2Q37 Deletion Syndrome", "9q34 Duplications", "15q15 Deletions", "15Q24 Deletion", "NR3C2", "SYNCRIP", "2q34 Duplication", "2q37.3 Deletion", "6q16 Deletion", "15q11.2 BP1-BP2 Deletion", "16p13.3 Deletion", "17Q11.2 Microduplication Syndrome (Disorder)", "17p13.3", "Xq28 Duplication", "CLCN4", "CSNK2B", "DYNC1H1", "EIF3F", "GNB1", "MED13", "MEF2C", "RALGAPB", "SCN1B", "YY1", "Xp11.22 Duplication", "PACS2", "MAOA", "MAOB", "HNRNPC", "HNRNPD", "HNRNPK", "HNRNPR", "HNRNPUL2", "5P Deletion Syndrome", "TCF7L2 Gene Mutation", "HECW2" ], "interventions": [], "intervention_types": [], "sponsor": "Simons Searchlight", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": null, "maximum_age": null, "sex": "ALL", "summary": "Not listed" }, "enrollment_count": 100000, "start_date": "2010-10", "completion_date": "2050-10", "has_results": false, "last_update_posted_date": "2025-06-06", "last_synced_at": "2026-05-22T04:49:43.721Z", "location_count": 2, "location_summary": "Boston, Massachusetts • Lewisburg, Pennsylvania", "locations": [ { "city": "Boston", "state": "Massachusetts" }, { "city": "Lewisburg", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT01238250" } ] }