{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Safety+and+Performance",
    "query": {
      "condition": "Safety and Performance"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 273,
    "total_pages": 28,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Safety+and+Performance&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-11T17:31:43.704Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT04689854",
      "title": "Cervical Interbody Implant Study",
      "overall_status": "ENROLLING_BY_INVITATION",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Degenerative Disc Disease",
        "Cervical Spinal Instability"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "NuVasive",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 150,
      "start_date": "2020-07-07",
      "completion_date": "2025-12-31",
      "has_results": false,
      "last_update_posted_date": "2025-12-22",
      "last_synced_at": "2026-09-11T17:31:43.704Z",
      "location_count": 7,
      "location_summary": "Orange, California • Hartford, Connecticut • Somerville, Massachusetts + 4 more",
      "locations": [
        {
          "city": "Orange",
          "state": "California"
        },
        {
          "city": "Hartford",
          "state": "Connecticut"
        },
        {
          "city": "Somerville",
          "state": "Massachusetts"
        },
        {
          "city": "Columbia",
          "state": "Missouri"
        },
        {
          "city": "Durham",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04689854"
    },
    {
      "nct_id": "NCT05877833",
      "title": "Evaluating the Safety and Performance Characteristics of Ephemeral® Tattoo Ink in Healthy Subjects",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Tattoo; Pigmentation"
      ],
      "interventions": [
        {
          "name": "Vibrancy Assessment",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Ephemeral Solutions Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "60 Years",
        "sex": "ALL",
        "summary": "18 Years to 60 Years"
      },
      "enrollment_count": 45,
      "start_date": "2020-08-10",
      "completion_date": "2023-02-01",
      "has_results": false,
      "last_update_posted_date": "2023-05-30",
      "last_synced_at": "2026-09-11T17:31:43.704Z",
      "location_count": 1,
      "location_summary": "Milford, Connecticut",
      "locations": [
        {
          "city": "Milford",
          "state": "Connecticut"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05877833"
    },
    {
      "nct_id": "NCT03885531",
      "title": "Safety and Performance of JOURNEY™ II Cruciate Retaining (CR) Total Knee System (TKS)",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Journey II CR Total Knee System"
      ],
      "interventions": [
        {
          "name": "Total knee arthroplasty with Journey II CR Total Knee System",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Smith & Nephew, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": null,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 586,
      "start_date": "2019-03-27",
      "completion_date": "2020-06-30",
      "has_results": false,
      "last_update_posted_date": "2024-01-03",
      "last_synced_at": "2026-09-11T17:31:43.704Z",
      "location_count": 6,
      "location_summary": "Scottsdale, Arizona • Pikeville, Kentucky • Reno, Nevada + 3 more",
      "locations": [
        {
          "city": "Scottsdale",
          "state": "Arizona"
        },
        {
          "city": "Pikeville",
          "state": "Kentucky"
        },
        {
          "city": "Reno",
          "state": "Nevada"
        },
        {
          "city": "New York",
          "state": "New York"
        },
        {
          "city": "New Albany",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03885531"
    },
    {
      "nct_id": "NCT06400732",
      "title": "Post Market Evaluation of Clinical Safety and Performance of the Fitbone Transport and Lengthening System",
      "overall_status": "TERMINATED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Fractures, Bone",
        "Fractures, Closed",
        "Fractures, Open",
        "Fracture of Femur",
        "Fracture Nonunion",
        "Fracture of Tibia",
        "Limb Deformity",
        "Limb Fracture",
        "Limb Defect",
        "Limb Asymmetry"
      ],
      "interventions": [
        {
          "name": "Fitbone Transport and Lengthening System",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Orthofix Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 1,
      "start_date": "2024-11-19",
      "completion_date": "2026-02-28",
      "has_results": false,
      "last_update_posted_date": "2026-04-02",
      "last_synced_at": "2026-09-11T17:31:43.704Z",
      "location_count": 9,
      "location_summary": "Los Angeles, California • Orange, California • Atlanta, Georgia + 6 more",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Orange",
          "state": "California"
        },
        {
          "city": "Atlanta",
          "state": "Georgia"
        },
        {
          "city": "Indianapolis",
          "state": "Indiana"
        },
        {
          "city": "Baltimore",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06400732"
    },
    {
      "nct_id": "NCT04552119",
      "title": "Safety of Treatment of Shoulder Repair",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Rotator Cuff"
      ],
      "interventions": [
        {
          "name": "HEALICOIL Knotless PEEK",
          "type": "DEVICE"
        },
        {
          "name": "HEALICOIL Knotless REGENESORB",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Smith & Nephew, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 138,
      "start_date": "2021-01-26",
      "completion_date": "2024-05-24",
      "has_results": true,
      "last_update_posted_date": "2026-04-16",
      "last_synced_at": "2026-09-11T17:31:43.704Z",
      "location_count": 5,
      "location_summary": "Redwood City, California • Colorado Springs, Colorado • Denver, Colorado + 2 more",
      "locations": [
        {
          "city": "Redwood City",
          "state": "California"
        },
        {
          "city": "Colorado Springs",
          "state": "Colorado"
        },
        {
          "city": "Denver",
          "state": "Colorado"
        },
        {
          "city": "Rockford",
          "state": "Illinois"
        },
        {
          "city": "Altoona",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04552119"
    },
    {
      "nct_id": "NCT05066711",
      "title": "NuVasive® ACP System Study",
      "overall_status": "ENROLLING_BY_INVITATION",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Cervical Spondylosis",
        "Cervical Radiculopathy",
        "Cervical Myelopathy",
        "Cervical Disc Disease",
        "Cervical Stenosis",
        "Cervical Disc Herniation",
        "Cervical Spine Disease"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "NuVasive",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": null,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 75,
      "start_date": "2022-05-22",
      "completion_date": "2027-06-30",
      "has_results": false,
      "last_update_posted_date": "2025-12-22",
      "last_synced_at": "2026-09-11T17:31:43.704Z",
      "location_count": 3,
      "location_summary": "Naperville, Illinois • Columbia, Missouri • Wilmington, North Carolina",
      "locations": [
        {
          "city": "Naperville",
          "state": "Illinois"
        },
        {
          "city": "Columbia",
          "state": "Missouri"
        },
        {
          "city": "Wilmington",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05066711"
    },
    {
      "nct_id": "NCT05019664",
      "title": "Affixus Natural Nail System Humeral Nail PMCF",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Humeral Fractures, Proximal",
        "Humeral Fractures"
      ],
      "interventions": [
        {
          "name": "humeral fracture",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Zimmer Biomet",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 100,
      "start_date": "2022-08-29",
      "completion_date": "2027-08",
      "has_results": false,
      "last_update_posted_date": "2026-05-20",
      "last_synced_at": "2026-09-11T17:31:43.704Z",
      "location_count": 1,
      "location_summary": "San Antonio, Texas",
      "locations": [
        {
          "city": "San Antonio",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05019664"
    },
    {
      "nct_id": "NCT05796453",
      "title": "Post Market Clinical Follow-up (PMCF) Study of Clareon Vivity & Clareon PanOptix",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Aphakia",
        "Astigmatism",
        "Presbyopia"
      ],
      "interventions": [
        {
          "name": "Clareon Vivity IOL - Non Toric",
          "type": "DEVICE"
        },
        {
          "name": "Clareon Vivity IOL - Toric",
          "type": "DEVICE"
        },
        {
          "name": "Clareon PanOptix Trifocal IOL - Non Toric",
          "type": "DEVICE"
        },
        {
          "name": "Clareon PanOptix Trifocal IOL - Toric",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Alcon Research",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 470,
      "start_date": "2023-09-19",
      "completion_date": "2026-08-21",
      "has_results": false,
      "last_update_posted_date": "2026-09-02",
      "last_synced_at": "2026-09-11T17:31:43.704Z",
      "location_count": 6,
      "location_summary": "Torrance, California • Jacksonville, Florida • Liverpool, New York + 3 more",
      "locations": [
        {
          "city": "Torrance",
          "state": "California"
        },
        {
          "city": "Jacksonville",
          "state": "Florida"
        },
        {
          "city": "Liverpool",
          "state": "New York"
        },
        {
          "city": "Tulsa",
          "state": "Oklahoma"
        },
        {
          "city": "Fort Worth",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05796453"
    },
    {
      "nct_id": "NCT03245320",
      "title": "Clinical Evaluation of the TITAN™ Total Shoulder System",
      "overall_status": "TERMINATED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Arthritis",
        "Arthritis, Degenerative",
        "Rheumatoid Arthritis",
        "Post-traumatic Arthrosis of Other Joints, Shoulder Region",
        "Rotator Cuff Syndrome of Shoulder and Allied Disorders",
        "Fracture",
        "Avascular Necrosis",
        "Joint Instability",
        "Joint Trauma",
        "Dislocation, Shoulder",
        "Pain, Shoulder"
      ],
      "interventions": [
        {
          "name": "Integra TITAN™ Total Shoulder Generation 1.0",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Smith & Nephew, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 50,
      "start_date": "2017-03-20",
      "completion_date": "2022-06-23",
      "has_results": false,
      "last_update_posted_date": "2023-12-21",
      "last_synced_at": "2026-09-11T17:31:43.704Z",
      "location_count": 2,
      "location_summary": "Indianapolis, Indiana • Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Indianapolis",
          "state": "Indiana"
        },
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03245320"
    },
    {
      "nct_id": "NCT01990950",
      "title": "Fenestrated AAA Endovascular Graft Post-Approval Study",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Abdominal Aortic Aneurysm (AAA)",
        "Aorto-iliac Aneurysm",
        "Juxtarenal Aneurysm"
      ],
      "interventions": [
        {
          "name": "Zenith® Fenestrated AAA Endovascular Graft",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Cook Research Incorporated",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 21,
      "start_date": "2014-03",
      "completion_date": "2020-10-12",
      "has_results": true,
      "last_update_posted_date": "2021-10-05",
      "last_synced_at": "2026-09-11T17:31:43.704Z",
      "location_count": 6,
      "location_summary": "Sacramento, California • Aurora, Colorado • Kalamazoo, Michigan + 3 more",
      "locations": [
        {
          "city": "Sacramento",
          "state": "California"
        },
        {
          "city": "Aurora",
          "state": "Colorado"
        },
        {
          "city": "Kalamazoo",
          "state": "Michigan"
        },
        {
          "city": "Newark",
          "state": "New Jersey"
        },
        {
          "city": "Winston-Salem",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01990950"
    }
  ]
}