{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Sanfilippo+Syndrome+Type+A+%28MPS+IIIA%29",
    "query": {
      "condition": "Sanfilippo Syndrome Type A (MPS IIIA)"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 28,
    "total_pages": 3,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Sanfilippo+Syndrome+Type+A+%28MPS+IIIA%29&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-07-23T22:29:26.415Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT01047306",
      "title": "A Study of Patients With Sanfilippo Syndrome Type A (MPS IIIA)",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Sanfilippo Syndrome Type A"
      ],
      "interventions": [
        {
          "name": "assessment",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Shire",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "1 Year",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "1 Year and older"
      },
      "enrollment_count": 25,
      "start_date": "2010-02-15",
      "completion_date": "2013-07-10",
      "has_results": true,
      "last_update_posted_date": "2021-06-11",
      "last_synced_at": "2026-07-23T22:29:26.415Z",
      "location_count": 1,
      "location_summary": "Minneapolis, Minnesota",
      "locations": [
        {
          "city": "Minneapolis",
          "state": "Minnesota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01047306"
    },
    {
      "nct_id": "NCT06614894",
      "title": "An Open Label Dose Escalation Study to Assess the Safety, Tolerability, and Pharmacologic Properties of High Dose Ambroxol Hydrochloride in Adult (≥ 18 Years of Age) Subjects With MPS III",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2",
        "PHASE3"
      ],
      "conditions": [
        "Sanfilippo Syndrome",
        "MPS3"
      ],
      "interventions": [
        {
          "name": "Ambroxol Hydrochloride 30 mg tablet - 9 mg/kg/day",
          "type": "DRUG"
        },
        {
          "name": "Ambroxol Hydrochloride 30 mg tablet - 18 mg/kg/day",
          "type": "DRUG"
        },
        {
          "name": "Ambroxol Hydrochloride 30 mg tablet - 27 mg/kg/day",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Ozlem Goker-Alpan",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "99 Years",
        "sex": "ALL",
        "summary": "18 Years to 99 Years"
      },
      "enrollment_count": 10,
      "start_date": "2024-12-01",
      "completion_date": "2026-06-30",
      "has_results": false,
      "last_update_posted_date": "2025-08-20",
      "last_synced_at": "2026-07-23T22:29:26.415Z",
      "location_count": 1,
      "location_summary": "Fairfax, Virginia",
      "locations": [
        {
          "city": "Fairfax",
          "state": "Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06614894"
    },
    {
      "nct_id": "NCT03784287",
      "title": "A Treatment Extension Study of Mucopolysaccharidosis Type IIIB",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Mucopolysaccharidosis Type IIIB",
        "MPS III B"
      ],
      "interventions": [
        {
          "name": "AX 250",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Allievex Corporation",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "0 Years",
        "maximum_age": "18 Years",
        "sex": "ALL",
        "summary": "0 Years to 18 Years"
      },
      "enrollment_count": 20,
      "start_date": "2018-02-19",
      "completion_date": "2025-02",
      "has_results": false,
      "last_update_posted_date": "2023-01-18",
      "last_synced_at": "2026-07-23T22:29:26.415Z",
      "location_count": 2,
      "location_summary": "Oakland, California • Pittsburgh, Pennsylvania",
      "locations": [
        {
          "city": "Oakland",
          "state": "California"
        },
        {
          "city": "Pittsburgh",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03784287"
    },
    {
      "nct_id": "NCT05492799",
      "title": "Safety, Tolerability and Efficacy of ICV AX 250 Treatment in MPS IIIB -OLE",
      "overall_status": "ENROLLING_BY_INVITATION",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "MPS III B"
      ],
      "interventions": [
        {
          "name": "AX 250",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Allievex Corporation",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 15,
      "start_date": "2022-12-02",
      "completion_date": "2027-12",
      "has_results": false,
      "last_update_posted_date": "2023-08-09",
      "last_synced_at": "2026-07-23T22:29:26.415Z",
      "location_count": 2,
      "location_summary": "Oakland, California • Pittsburgh, Pennsylvania",
      "locations": [
        {
          "city": "Oakland",
          "state": "California"
        },
        {
          "city": "Pittsburgh",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05492799"
    },
    {
      "nct_id": "NCT02716246",
      "title": "Phase I/II/III Gene Transfer Clinical Trial of scAAV9.U1a.hSGSH",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2",
        "PHASE3"
      ],
      "conditions": [
        "MPS IIIA",
        "Sanfilippo Syndrome",
        "Sanfilippo A",
        "Mucopolysaccharidosis III"
      ],
      "interventions": [
        {
          "name": "UX111",
          "type": "BIOLOGICAL"
        },
        {
          "name": "Prophylactic Immunomodulatory (IM) Therapy",
          "type": "DRUG"
        },
        {
          "name": "Optimized Prophylactic IM Therapy",
          "type": "DRUG"
        },
        {
          "name": "Adjuvant IM Therapy",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "BIOLOGICAL",
        "DRUG"
      ],
      "sponsor": "Ultragenyx Pharmaceutical Inc",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 36,
      "start_date": "2016-04-25",
      "completion_date": "2029-03",
      "has_results": false,
      "last_update_posted_date": "2026-07-17",
      "last_synced_at": "2026-07-23T22:29:26.415Z",
      "location_count": 2,
      "location_summary": "Columbus, Ohio • Pittsburgh, Pennsylvania",
      "locations": [
        {
          "city": "Columbus",
          "state": "Ohio"
        },
        {
          "city": "Pittsburgh",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02716246"
    },
    {
      "nct_id": "NCT02493998",
      "title": "A Study of Mucopolysaccharidosis Type IIIB (MPS IIIB)",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Mucopolysaccharidosis Type IIIB",
        "Mucopolysaccharidosis Type 3 B",
        "MPS III B",
        "MPS 3 B"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Allievex Corporation",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "1 Year",
        "maximum_age": "10 Years",
        "sex": "ALL",
        "summary": "1 Year to 10 Years"
      },
      "enrollment_count": 22,
      "start_date": "2015-11",
      "completion_date": "2019-04",
      "has_results": false,
      "last_update_posted_date": "2020-03-06",
      "last_synced_at": "2026-07-23T22:29:26.415Z",
      "location_count": 1,
      "location_summary": "Oakland, California",
      "locations": [
        {
          "city": "Oakland",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02493998"
    },
    {
      "nct_id": "NCT05523206",
      "title": "A Natural History Study of Biomarkers and Clinical Outcomes in Mucopolysaccharidosis Type IIIA (MPS IIIA; Sanfilippo Syndrome)",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Mucopolysaccharidosis III-A"
      ],
      "interventions": [
        {
          "name": "No intervention",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Sanguine Biosciences",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "4 Months",
        "maximum_age": "13 Years",
        "sex": "ALL",
        "summary": "4 Months to 13 Years"
      },
      "enrollment_count": 15,
      "start_date": "2022-09-27",
      "completion_date": "2025-01-28",
      "has_results": false,
      "last_update_posted_date": "2025-01-30",
      "last_synced_at": "2026-07-23T22:29:26.415Z",
      "location_count": 1,
      "location_summary": "Woburn, Massachusetts",
      "locations": [
        {
          "city": "Woburn",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05523206"
    },
    {
      "nct_id": "NCT07712003",
      "title": "Natural History to Assess Disease in Patients With MPS IIIC",
      "overall_status": "NOT_YET_RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Sanfilippo Syndrome Type C",
        "Mucopolysaccharidosis (MPS) IIIC"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Phoenix Nest",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "1 Year",
        "maximum_age": "25 Years",
        "sex": "ALL",
        "summary": "1 Year to 25 Years"
      },
      "enrollment_count": 35,
      "start_date": "2026-11-01",
      "completion_date": "2029-02-01",
      "has_results": false,
      "last_update_posted_date": "2026-07-17",
      "last_synced_at": "2026-07-23T22:29:26.415Z",
      "location_count": 1,
      "location_summary": "Dallas, Texas",
      "locations": [
        {
          "city": "Dallas",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07712003"
    },
    {
      "nct_id": "NCT04018755",
      "title": "Open-label Study of Anakinra in MPS III",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Mucopolysaccharidosis III"
      ],
      "interventions": [
        {
          "name": "anakinra",
          "type": "BIOLOGICAL"
        }
      ],
      "intervention_types": [
        "BIOLOGICAL"
      ],
      "sponsor": "Lynda E Polgreen",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "4 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "4 Years and older"
      },
      "enrollment_count": 24,
      "start_date": "2020-01-30",
      "completion_date": "2023-03-08",
      "has_results": false,
      "last_update_posted_date": "2024-10-22",
      "last_synced_at": "2026-07-23T22:29:26.415Z",
      "location_count": 1,
      "location_summary": "Torrance, California",
      "locations": [
        {
          "city": "Torrance",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04018755"
    },
    {
      "nct_id": "NCT03423186",
      "title": "A Study to Assess the Safety and Tolerability of SOBI003 in Pediatric MPS IIIA Patients",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Sanfilippo Syndrome Type A (MPS IIIA)"
      ],
      "interventions": [
        {
          "name": "SOBI003",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Swedish Orphan Biovitrum",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "12 Months",
        "maximum_age": "72 Months",
        "sex": "ALL",
        "summary": "12 Months to 72 Months"
      },
      "enrollment_count": 6,
      "start_date": "2018-06-19",
      "completion_date": "2019-10-25",
      "has_results": true,
      "last_update_posted_date": "2021-11-19",
      "last_synced_at": "2026-07-23T22:29:26.415Z",
      "location_count": 2,
      "location_summary": "Oakland, California • Chapel Hill, North Carolina",
      "locations": [
        {
          "city": "Oakland",
          "state": "California"
        },
        {
          "city": "Chapel Hill",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03423186"
    }
  ]
}