{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Sepsis+Severe",
    "query": {
      "condition": "Sepsis Severe"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 117,
    "total_pages": 12,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Sepsis+Severe&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-07-23T01:03:09.958Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT00793442",
      "title": "Endothelium in Severe Sepsis",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Sepsis",
        "Severe Sepsis",
        "Septic Shock"
      ],
      "interventions": [
        {
          "name": "Blood Collection and Assays",
          "type": "DIAGNOSTIC_TEST"
        }
      ],
      "intervention_types": [
        "DIAGNOSTIC_TEST"
      ],
      "sponsor": "Beth Israel Deaconess Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 910,
      "start_date": "2008-03",
      "completion_date": "2013-05",
      "has_results": false,
      "last_update_posted_date": "2024-10-29",
      "last_synced_at": "2026-07-23T01:03:09.958Z",
      "location_count": 7,
      "location_summary": "Birmingham, Alabama • Boston, Massachusetts • Manhasset, New York + 3 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "Manhasset",
          "state": "New York"
        },
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00793442"
    },
    {
      "nct_id": "NCT00386425",
      "title": "Evaluate Protein C Levels in Severe Sepsis Patients on Drotrecogin Alfa (Activated)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Severe Sepsis"
      ],
      "interventions": [
        {
          "name": "Drotrecogin alfa (activated)",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Eli Lilly and Company",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 486,
      "start_date": "2006-11",
      "completion_date": "2009-08",
      "has_results": true,
      "last_update_posted_date": "2010-12-16",
      "last_synced_at": "2026-07-23T01:03:09.958Z",
      "location_count": 17,
      "location_summary": "Phoenix, Arizona • Scottsdale, Arizona • Fresno, California + 14 more",
      "locations": [
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Scottsdale",
          "state": "Arizona"
        },
        {
          "city": "Fresno",
          "state": "California"
        },
        {
          "city": "Loma Linda",
          "state": "California"
        },
        {
          "city": "Stanford",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00386425"
    },
    {
      "nct_id": "NCT05665153",
      "title": "Symphony IL-6 Study in Patients at Risk of Severe Sepsis",
      "overall_status": "UNKNOWN",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Severe Sepsis"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Bluejay Diagnostics, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": null,
      "eligibility": {
        "minimum_age": "22 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "22 Years and older"
      },
      "enrollment_count": 200,
      "start_date": "2022-11-22",
      "completion_date": "2024-11-21",
      "has_results": false,
      "last_update_posted_date": "2023-09-07",
      "last_synced_at": "2026-07-23T01:03:09.958Z",
      "location_count": 1,
      "location_summary": "Ann Arbor, Michigan",
      "locations": [
        {
          "city": "Ann Arbor",
          "state": "Michigan"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05665153"
    },
    {
      "nct_id": "NCT02969343",
      "title": "Patient Safety Learning Laboratory: Making Acute Care More Patient-Centered",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Central Line-Associated Bloodstream Infection (CLABSI)",
        "Venous Thromboembolism",
        "Patient Fall",
        "Catheter-Associated Infection",
        "Severe Hypoglycemia",
        "Opioid-Related Severe Adverse Drug Event",
        "Hospital Acquired Pressure Ulcer",
        "Adverse Drug Event",
        "Severe Hospital Acquired Delerium",
        "Rapid Response Related to Arrhythmia"
      ],
      "interventions": [
        {
          "name": "Patient Safety health information technology",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Brigham and Women's Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "99 Years",
        "sex": "ALL",
        "summary": "18 Years to 99 Years"
      },
      "enrollment_count": 21000,
      "start_date": "2015-04",
      "completion_date": "2018-12",
      "has_results": false,
      "last_update_posted_date": "2019-07-10",
      "last_synced_at": "2026-07-23T01:03:09.958Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02969343"
    },
    {
      "nct_id": "NCT01739933",
      "title": "The MENDS2 Study, Maximizing the Efficacy of Sedation and Reducing Neurological Dysfunction and Mortality in Septic Patients With Acute Respiratory Failure",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Sepsis",
        "Delirium",
        "Impaired Cognition"
      ],
      "interventions": [
        {
          "name": "Dexmedetomidine",
          "type": "DRUG"
        },
        {
          "name": "Propofol",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Vanderbilt University Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 438,
      "start_date": "2013-05-15",
      "completion_date": "2019-07",
      "has_results": true,
      "last_update_posted_date": "2021-06-07",
      "last_synced_at": "2026-07-23T01:03:09.958Z",
      "location_count": 11,
      "location_summary": "San Francisco, California • Baton Rouge, Louisiana • Boston, Massachusetts + 7 more",
      "locations": [
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "Baton Rouge",
          "state": "Louisiana"
        },
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "Springfield",
          "state": "Massachusetts"
        },
        {
          "city": "Asheville",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01739933"
    },
    {
      "nct_id": "NCT00448968",
      "title": "The Utility of Ischemia Modified Albumin (IMA) in Sepsis",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Sepsis",
        "Severe Sepsis",
        "Systemic Inflammatory Response Syndrome",
        "Sepsis Syndrome"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Inverness Medical Innovations",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 150,
      "start_date": "2007-03",
      "completion_date": "2007-09",
      "has_results": false,
      "last_update_posted_date": "2007-09-27",
      "last_synced_at": "2026-07-23T01:03:09.958Z",
      "location_count": 3,
      "location_summary": "Boston, Massachusetts • Cleveland, Ohio • Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "Cleveland",
          "state": "Ohio"
        },
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00448968"
    },
    {
      "nct_id": "NCT00034476",
      "title": "A Phase IIb Study to Determine the Efficacy and Safety of the Study Drug in Patients With Severe Sepsis",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Sepsis"
      ],
      "interventions": [
        {
          "name": "sPLA2 Inhibitor",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Eli Lilly and Company",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 466,
      "start_date": "2001-10",
      "completion_date": "2002-10",
      "has_results": false,
      "last_update_posted_date": "2006-07-19",
      "last_synced_at": "2026-07-23T01:03:09.958Z",
      "location_count": 60,
      "location_summary": "Birmingham, Alabama • Phoenix, Arizona • Berkeley, California + 57 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Berkeley",
          "state": "California"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Orange",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00034476"
    },
    {
      "nct_id": "NCT02532959",
      "title": "Diagnostic Breath Analysis Study to Detect Sepsis",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Puerperal: [Major Infection] or [Sepsis]"
      ],
      "interventions": [
        {
          "name": "Diagnostic Breath Analysis",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Landon Pediatric Foundation",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 10,
      "start_date": "2015-06",
      "completion_date": "2015-09",
      "has_results": false,
      "last_update_posted_date": "2016-09-08",
      "last_synced_at": "2026-07-23T01:03:09.958Z",
      "location_count": 1,
      "location_summary": "Ventura, California",
      "locations": [
        {
          "city": "Ventura",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02532959"
    },
    {
      "nct_id": "NCT03497182",
      "title": "Sepsis, Severe Sepsis and Septic Shock Detection by Breath Analysis",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Sepsis"
      ],
      "interventions": [
        {
          "name": "Breath sample collection",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Landon Pediatric Foundation",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 45,
      "start_date": "2017-05-02",
      "completion_date": "2018-10-31",
      "has_results": false,
      "last_update_posted_date": "2019-05-07",
      "last_synced_at": "2026-07-23T01:03:09.958Z",
      "location_count": 1,
      "location_summary": "Ventura, California",
      "locations": [
        {
          "city": "Ventura",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03497182"
    },
    {
      "nct_id": "NCT04986943",
      "title": "ABTHERA ADVANCE™ Use Without Wittman Patch",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Necrotizing Pancreatitis"
      ],
      "interventions": [
        {
          "name": "Using ABTHERA Advance without a Wittmann Patch",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Wake Forest University Health Sciences",
      "sponsor_class": "OTHER",
      "healthy_volunteers": null,
      "eligibility": {
        "minimum_age": "22 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "22 Years and older"
      },
      "enrollment_count": 3,
      "start_date": "2020-10-12",
      "completion_date": "2023-03-14",
      "has_results": false,
      "last_update_posted_date": "2023-08-31",
      "last_synced_at": "2026-07-23T01:03:09.958Z",
      "location_count": 1,
      "location_summary": "Charlotte, North Carolina",
      "locations": [
        {
          "city": "Charlotte",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04986943"
    }
  ]
}