{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Severe+Aortic+Stenosis&page=2",
    "query": {
      "condition": "Severe Aortic Stenosis",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Severe+Aortic+Stenosis&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-05-22T09:06:20.705Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT07116551",
      "title": "Early Feasibility Study (EFS) of Abbott's Balloon-expandable (BE) TAVI System for the Treatment of Severe, Symptomatic Aortic Stenosis",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Symptomatic Severe Aortic Stenosis"
      ],
      "interventions": [
        {
          "name": "Abbott BE TAVI System",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Abbott Medical Devices",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 11,
      "start_date": "2025-10-30",
      "completion_date": "2031-06",
      "has_results": false,
      "last_update_posted_date": "2026-02-06",
      "last_synced_at": "2026-05-22T09:06:20.705Z",
      "location_count": 4,
      "location_summary": "Wichita, Kansas • Minneapolis, Minnesota • New York, New York + 1 more",
      "locations": [
        {
          "city": "Wichita",
          "state": "Kansas"
        },
        {
          "city": "Minneapolis",
          "state": "Minnesota"
        },
        {
          "city": "New York",
          "state": "New York"
        },
        {
          "city": "The Bronx",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07116551"
    },
    {
      "nct_id": "NCT02214277",
      "title": "Cerebral Protection in Transcatheter Aortic Valve Replacement",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Severe Symptomatic Calcified Native Aortic Valve Stenosis"
      ],
      "interventions": [
        {
          "name": "Cerebral Protection System-The SENTINEL System with TAVR",
          "type": "DEVICE"
        },
        {
          "name": "TAVR",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Claret Medical",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 363,
      "start_date": "2014-09",
      "completion_date": "2016-06",
      "has_results": true,
      "last_update_posted_date": "2018-05-11",
      "last_synced_at": "2026-05-22T09:06:20.705Z",
      "location_count": 14,
      "location_summary": "Los Angeles, California • Washington D.C., District of Columbia • Clearwater, Florida + 9 more",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Washington D.C.",
          "state": "District of Columbia"
        },
        {
          "city": "Clearwater",
          "state": "Florida"
        },
        {
          "city": "Atlanta",
          "state": "Georgia"
        },
        {
          "city": "Detroit",
          "state": "Michigan"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02214277"
    },
    {
      "nct_id": "NCT03222141",
      "title": "PARTNER II Trial: Placement of AoRTic TraNscathetER Valves II - High Risk and Nested Registry 7",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Symptomatic Severe Aortic Stenosis"
      ],
      "interventions": [
        {
          "name": "TAVR Implantation of the THV Prosthesis",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Edwards Lifesciences",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "19 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "19 Years and older"
      },
      "enrollment_count": 583,
      "start_date": "2013-10",
      "completion_date": "2020-08",
      "has_results": true,
      "last_update_posted_date": "2021-05-12",
      "last_synced_at": "2026-05-22T09:06:20.705Z",
      "location_count": 39,
      "location_summary": "Los Angeles, California • Sacramento, California • Stanford, California + 34 more",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Sacramento",
          "state": "California"
        },
        {
          "city": "Stanford",
          "state": "California"
        },
        {
          "city": "Denver",
          "state": "Colorado"
        },
        {
          "city": "Washington D.C.",
          "state": "District of Columbia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03222141"
    },
    {
      "nct_id": "NCT01060020",
      "title": "Acute Hemodynamic Effects of Sildenafil in Patients With Severe Aortic Stenosis",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Aortic Stenosis"
      ],
      "interventions": [
        {
          "name": "Sildenafil",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Washington University School of Medicine",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 20,
      "start_date": "2010-01",
      "completion_date": "2011-10",
      "has_results": true,
      "last_update_posted_date": "2018-04-25",
      "last_synced_at": "2026-05-22T09:06:20.705Z",
      "location_count": 1,
      "location_summary": "St Louis, Missouri",
      "locations": [
        {
          "city": "St Louis",
          "state": "Missouri"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01060020"
    },
    {
      "nct_id": "NCT03635424",
      "title": "Medtronic Transcatheter Aortic Valve Replacement (TAVR) Low Risk Bicuspid Study",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Bicuspid Aortic Valve"
      ],
      "interventions": [
        {
          "name": "Medtronic TAVR Systems",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Medtronic Cardiovascular",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "60 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "60 Years and older"
      },
      "enrollment_count": 150,
      "start_date": "2018-10-30",
      "completion_date": "2030-12",
      "has_results": true,
      "last_update_posted_date": "2026-05-05",
      "last_synced_at": "2026-05-22T09:06:20.705Z",
      "location_count": 25,
      "location_summary": "Phoenix, Arizona • La Jolla, California • Thousand Oaks, California + 21 more",
      "locations": [
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "La Jolla",
          "state": "California"
        },
        {
          "city": "Thousand Oaks",
          "state": "California"
        },
        {
          "city": "New Haven",
          "state": "Connecticut"
        },
        {
          "city": "Clearwater",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03635424"
    },
    {
      "nct_id": "NCT04066634",
      "title": "Vivio AS (Aortic Stenosis) Detection Study",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Aortic Stenosis"
      ],
      "interventions": [
        {
          "name": "Vivio System",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Avicena LLC",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 200,
      "start_date": "2019-04-02",
      "completion_date": "2019-10-29",
      "has_results": false,
      "last_update_posted_date": "2021-08-02",
      "last_synced_at": "2026-05-22T09:06:20.705Z",
      "location_count": 3,
      "location_summary": "Morristown, New Jersey • Roslyn, New York • Providence, Rhode Island",
      "locations": [
        {
          "city": "Morristown",
          "state": "New Jersey"
        },
        {
          "city": "Roslyn",
          "state": "New York"
        },
        {
          "city": "Providence",
          "state": "Rhode Island"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04066634"
    },
    {
      "nct_id": "NCT07278310",
      "title": "STAR Trial (Siegel Transcatheter Aortic Valve Replacement in Patients With Symptomatic Severe Aortic Stenosis)",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Symptomatic Severe Native Aortic Stenosis",
        "Aortic Stenosis"
      ],
      "interventions": [
        {
          "name": "TAVR Device",
          "type": "DEVICE"
        },
        {
          "name": "Siegel TAVR Device",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "MiRus",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 1025,
      "start_date": "2026-04",
      "completion_date": "2028-04",
      "has_results": false,
      "last_update_posted_date": "2026-04-09",
      "last_synced_at": "2026-05-22T09:06:20.705Z",
      "location_count": 1,
      "location_summary": "Atlanta, Georgia",
      "locations": [
        {
          "city": "Atlanta",
          "state": "Georgia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07278310"
    },
    {
      "nct_id": "NCT04011722",
      "title": "Portico Next Generation Approval Study",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Symptomatic Severe Aortic Stenosis"
      ],
      "interventions": [
        {
          "name": "Portico™ NG (Navitor) Valve and FlexNav™ Delivery System",
          "type": "DEVICE"
        },
        {
          "name": "Navitor Titan Valve (35mm) Valve and Large FlexNav™ Delivery System",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Abbott Medical Devices",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "100 Years",
        "sex": "ALL",
        "summary": "18 Years to 100 Years"
      },
      "enrollment_count": 333,
      "start_date": "2019-09-17",
      "completion_date": "2027-12",
      "has_results": true,
      "last_update_posted_date": "2025-07-31",
      "last_synced_at": "2026-05-22T09:06:20.705Z",
      "location_count": 21,
      "location_summary": "Los Angeles, California • Thousand Oaks, California • Washington D.C., District of Columbia + 17 more",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Thousand Oaks",
          "state": "California"
        },
        {
          "city": "Washington D.C.",
          "state": "District of Columbia"
        },
        {
          "city": "Oak Lawn",
          "state": "Illinois"
        },
        {
          "city": "Indianapolis",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04011722"
    },
    {
      "nct_id": "NCT03483051",
      "title": "Targeting Pulsatile Load to Increase Exercise Capacity and Quality of Life After Aortic Valve Replacement for Severe Aortic Stenosis (PULSE AS)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Aortic Valve Stenosis"
      ],
      "interventions": [
        {
          "name": "Potassium Nitrate",
          "type": "DRUG"
        },
        {
          "name": "Potassium Chloride",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Pennsylvania",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "50 Years",
        "maximum_age": "90 Years",
        "sex": "ALL",
        "summary": "50 Years to 90 Years"
      },
      "enrollment_count": 5,
      "start_date": "2018-05-01",
      "completion_date": "2019-05-23",
      "has_results": true,
      "last_update_posted_date": "2020-06-17",
      "last_synced_at": "2026-05-22T09:06:20.705Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03483051"
    },
    {
      "nct_id": "NCT00530894",
      "title": "THE PARTNER TRIAL: Placement of AoRTic TraNscathetER Valve Trial",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Critical Aortic Stenosis"
      ],
      "interventions": [
        {
          "name": "Edwards SAPIEN Transcatheter Heart Valve",
          "type": "DEVICE"
        },
        {
          "name": "Surgical Valve Replacement",
          "type": "DEVICE"
        },
        {
          "name": "medical management and/or balloon aortic valvuloplasty",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "OTHER"
      ],
      "sponsor": "Edwards Lifesciences",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 1057,
      "start_date": "2007-04",
      "completion_date": "2017-07",
      "has_results": true,
      "last_update_posted_date": "2017-09-13",
      "last_synced_at": "2026-05-22T09:06:20.705Z",
      "location_count": 22,
      "location_summary": "La Jolla, California • Los Angeles, California • Stanford, California + 17 more",
      "locations": [
        {
          "city": "La Jolla",
          "state": "California"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Stanford",
          "state": "California"
        },
        {
          "city": "Washington D.C.",
          "state": "District of Columbia"
        },
        {
          "city": "Miami",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00530894"
    }
  ]
}