{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Severe+Brain+Injury&page=2",
    "query": {
      "condition": "Severe Brain Injury",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Severe+Brain+Injury&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-06-26T09:06:49.924Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT02957461",
      "title": "Validation of Brain Function Assessment Algorithm for mTBI/Concussion in College Athletes",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Brain Injuries, Traumatic",
        "Concussion, Mild",
        "Concussion, Brain",
        "Concussion, Severe",
        "Concussion, Intermediate"
      ],
      "interventions": [
        {
          "name": "BrainScope Ahead 200iD",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "BrainScope Company, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "25 Years",
        "sex": "ALL",
        "summary": "18 Years to 25 Years"
      },
      "enrollment_count": 420,
      "start_date": "2017-02-03",
      "completion_date": "2018-03-02",
      "has_results": false,
      "last_update_posted_date": "2019-05-23",
      "last_synced_at": "2026-06-26T09:06:49.924Z",
      "location_count": 8,
      "location_summary": "Fayetteville, Arkansas • Storrs, Connecticut • Tampa, Florida + 5 more",
      "locations": [
        {
          "city": "Fayetteville",
          "state": "Arkansas"
        },
        {
          "city": "Storrs",
          "state": "Connecticut"
        },
        {
          "city": "Tampa",
          "state": "Florida"
        },
        {
          "city": "East Lansing",
          "state": "Michigan"
        },
        {
          "city": "Rochester",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02957461"
    },
    {
      "nct_id": "NCT04515212",
      "title": "In-Field Detection of Intracranial Pressure",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Traumatic Brain Injury"
      ],
      "interventions": [
        {
          "name": "Optic Nerve Ultrasounds",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Duke University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "99 Years",
        "sex": "ALL",
        "summary": "18 Years to 99 Years"
      },
      "enrollment_count": 53,
      "start_date": "2021-02-03",
      "completion_date": "2024-02-10",
      "has_results": false,
      "last_update_posted_date": "2024-07-22",
      "last_synced_at": "2026-06-26T09:06:49.924Z",
      "location_count": 1,
      "location_summary": "Durham, North Carolina",
      "locations": [
        {
          "city": "Durham",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04515212"
    },
    {
      "nct_id": "NCT02680704",
      "title": "Mechanical Ventilation in Severe Brain Injury: The Effect of Positive End Expiratory Pressure on Intracranial Pressure",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Intracranial Hypertension",
        "Critical Illness",
        "Brain Injuries",
        "Lung Injury",
        "Respiratory Failure",
        "Positive-Pressure Respiration, Intrinsic"
      ],
      "interventions": [
        {
          "name": "PEEP titrated mechanical ventilation",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Beth Israel Deaconess Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 4,
      "start_date": "2016-02",
      "completion_date": "2018-08-02",
      "has_results": false,
      "last_update_posted_date": "2019-02-22",
      "last_synced_at": "2026-06-26T09:06:49.924Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02680704"
    },
    {
      "nct_id": "NCT00761228",
      "title": "Efficacy Study of NH001 in Vegetative State & Minimally Conscious State Following a Traumatic Brain Injury",
      "overall_status": "SUSPENDED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Brain Injury"
      ],
      "interventions": [
        {
          "name": "Apomorphine",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "NeuroHealing Pharmaceuticals Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "50 Years",
        "sex": "ALL",
        "summary": "18 Years to 50 Years"
      },
      "enrollment_count": 76,
      "start_date": "2010-07",
      "completion_date": "2018-12",
      "has_results": false,
      "last_update_posted_date": "2017-03-31",
      "last_synced_at": "2026-06-26T09:06:49.924Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00761228"
    },
    {
      "nct_id": "NCT06028334",
      "title": "GetUp&Go: A Randomized Controlled Trial of an Intervention to Enhance Physical Activity After TBI",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Traumatic Brain Injury"
      ],
      "interventions": [
        {
          "name": "GetUp&Go",
          "type": "BEHAVIORAL"
        },
        {
          "name": "GetUp&Go with 10-Week Delay",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Albert Einstein Healthcare Network",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 70,
      "start_date": "2023-12-19",
      "completion_date": "2027-08-31",
      "has_results": false,
      "last_update_posted_date": "2025-03-20",
      "last_synced_at": "2026-06-26T09:06:49.924Z",
      "location_count": 1,
      "location_summary": "Elkins Park, Pennsylvania",
      "locations": [
        {
          "city": "Elkins Park",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06028334"
    },
    {
      "nct_id": "NCT06938542",
      "title": "Palliative Care Needs of Children With Rare Diseases and Their Families",
      "overall_status": "ENROLLING_BY_INVITATION",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Trisomy 13 Syndrome",
        "Arthrogryposis Congenita Multiplex With Intestinal Atresia",
        "Asparagine Synthetase Deficiency",
        "CHARGE Syndrome",
        "Early Infantile Epileptic Encephalopathy",
        "FOXG1 Syndrome",
        "KBG Syndrome",
        "Noonan Syndrome",
        "Severe Hemophilia A",
        "Short Bowel Syndrome",
        "Beta-Propeller Protein-Associated Neurodegeneration",
        "Brain Injury of Prematurity With Periventricular Leukomalacia",
        "Chromosome 17p13.3 Microdeletion Syndrome",
        "Chromosome 1q43-1q44 Deletion",
        "Cockayne Syndrome",
        "Congenital Diaphragmatic Hernia",
        "End-Stage Renal Disease With Cloacal Anomaly",
        "Mitochondrial Depletion Disorder",
        "Severe Factor VII Deficiency"
      ],
      "interventions": [
        {
          "name": "Family Centered pediatric palliative care for family caregivers of children with rare diseases.",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Children's National Research Institute",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "12 Months",
        "maximum_age": "99 Years",
        "sex": "ALL",
        "summary": "12 Months to 99 Years"
      },
      "enrollment_count": 480,
      "start_date": "2025-10-02",
      "completion_date": "2029-08-02",
      "has_results": false,
      "last_update_posted_date": "2026-01-28",
      "last_synced_at": "2026-06-26T09:06:49.924Z",
      "location_count": 1,
      "location_summary": "Washington D.C., District of Columbia",
      "locations": [
        {
          "city": "Washington D.C.",
          "state": "District of Columbia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06938542"
    },
    {
      "nct_id": "NCT06169696",
      "title": "EMPOWER Early Feasibility Study: Non-invasive BCI to Control a Wheelchair for People With Paralysis",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Neurologic Disorder",
        "Paralysis",
        "Paralysis; Stroke",
        "Amyotrophic Lateral Sclerosis",
        "Spinal Cord Injuries",
        "Cervical Spinal Cord Injury",
        "Tetraplegic; Paralysis",
        "Quadriplegia/Tetraplegia"
      ],
      "interventions": [
        {
          "name": "Intervention/Treatment",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Synaptrix Labs Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "21 Years to 75 Years"
      },
      "enrollment_count": 6,
      "start_date": "2024-11",
      "completion_date": "2025-01",
      "has_results": false,
      "last_update_posted_date": "2024-01-18",
      "last_synced_at": "2026-06-26T09:06:49.924Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06169696"
    },
    {
      "nct_id": "NCT00498498",
      "title": "Observational Endothelin and Markers of Cellular Apoptosis In CSF Head Injury",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Cerebrovascular Trauma",
        "Neurohormones",
        "Cellular Apoptosis",
        "Endothelin System"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Virginia Commonwealth University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "18 Years to 70 Years"
      },
      "enrollment_count": 51,
      "start_date": "2007-07",
      "completion_date": "2009-12",
      "has_results": false,
      "last_update_posted_date": "2011-11-16",
      "last_synced_at": "2026-06-26T09:06:49.924Z",
      "location_count": 8,
      "location_summary": "Sacramento, California • Torrance, California • Miami, Florida + 5 more",
      "locations": [
        {
          "city": "Sacramento",
          "state": "California"
        },
        {
          "city": "Torrance",
          "state": "California"
        },
        {
          "city": "Miami",
          "state": "Florida"
        },
        {
          "city": "Iowa City",
          "state": "Iowa"
        },
        {
          "city": "Lexington",
          "state": "Kentucky"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00498498"
    },
    {
      "nct_id": "NCT04530032",
      "title": "Ketogenic Diet & Functional Recovery in Moderate to Severe Traumatic Brain Injury",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Traumatic Brain Injury"
      ],
      "interventions": [
        {
          "name": "ketogenic/modified Atkins diet",
          "type": "OTHER"
        },
        {
          "name": "Standard diet",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Loma Linda University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "16 Years",
        "maximum_age": "90 Years",
        "sex": "ALL",
        "summary": "16 Years to 90 Years"
      },
      "enrollment_count": 21,
      "start_date": "2020-12-07",
      "completion_date": "2025-08-14",
      "has_results": false,
      "last_update_posted_date": "2026-02-04",
      "last_synced_at": "2026-06-26T09:06:49.924Z",
      "location_count": 1,
      "location_summary": "Loma Linda, California",
      "locations": [
        {
          "city": "Loma Linda",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04530032"
    },
    {
      "nct_id": "NCT03169647",
      "title": "Evaluating the Effectiveness of Treatment for Metacognition in Moderate and Severe Traumatic Brain Injury",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Brain Injuries, Traumatic"
      ],
      "interventions": [
        {
          "name": "Listening-based intervention",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Kessler Foundation",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "59 Years",
        "sex": "ALL",
        "summary": "18 Years to 59 Years"
      },
      "enrollment_count": 18,
      "start_date": "2017-08-17",
      "completion_date": "2019-06-30",
      "has_results": false,
      "last_update_posted_date": "2019-10-23",
      "last_synced_at": "2026-06-26T09:06:49.924Z",
      "location_count": 1,
      "location_summary": "East Hanover, New Jersey",
      "locations": [
        {
          "city": "East Hanover",
          "state": "New Jersey"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03169647"
    }
  ]
}