{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Severe+Mental+Illness&page=25", "query": { "condition": "Severe Mental Illness", "page": 25 }, "page_size": 10 }, "pagination": { "page": 25, "page_size": 10, "total_count": 1852, "total_pages": 186, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Severe+Mental+Illness&page=26&page_size=10", "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Severe+Mental+Illness&page=24&page_size=10" }, "source": "remote", "last_synced_at": "2026-10-15T20:57:45.405Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT04806620", "title": "Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation Research", "overall_status": "RECRUITING", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Post-Acute COVID-19 Syndrome", "ME/CFS", "Rheumatic Arthritis", "Juvenile Rheumatoid Arthritis (JRA)", "Psoriatic Arthritis (PsA)", "Ankylosing Spondylitis (AS)", "Autoimmune Encephalitis", "Celiac Disease", "Celiac Disease in Children", "Chronic Lyme Disease", "Post-treatment Lyme Disease Syndrome", "Crohn's Disease", "Dysautonomia", "Anorexia Nervosa", "Bulimia Nervosa", "ARFID", "Avoidant / Restrictive Food Intake Disorder", "Ehlers Danlos Syndrome", "Endometriosis", "Fibromyalgia (FM)", "Long COVID", "Lupus", "Migraines", "Mast Cell Activation Syndrome", "Multiple Sclerosis", "Myalgic Encephalomyelitis (ME)", "Myasthenia Gravis, Generalized", "Myasthenia Gravis in Children", "Narcolepsy", "Obsessive Compulsive Disorder (OCD)", "PANDAS", "Pediatric Acute-onset Neuropsychiatric Syndrome (PANS)", "POTS - Postural Orthostatic Tachycardia Syndrome", "General Anxiety Disorder, Social Anxiety Disorder", "PTSD - Post Traumatic Stress Disorder", "Psoriasis", "Traumatic Brain Injury", "Tourette's Syndrome", "Inflammatory Bowel Disease (IBD)", "Autoimmune Diseases", "Neurological Diseases or Conditions", "Psychiatric Disorder", "Sjogren's Syndrome", "Ulcerative Colitis and Crohn's Disease" ], "interventions": [], "intervention_types": [], "sponsor": "Brain Inflammation Collaborative", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "2 Years", "maximum_age": null, "sex": "ALL", "summary": "2 Years and older" }, "enrollment_count": 10000, "start_date": "2023-07-05", "completion_date": "2030-12-31", "has_results": false, "last_update_posted_date": "2026-01-22", "last_synced_at": "2026-10-15T20:57:45.405Z", "location_count": 1, "location_summary": "Delafield, Wisconsin", "locations": [ { "city": "Delafield", "state": "Wisconsin" } ], "official_url": "https://clinicaltrials.gov/study/NCT04806620" }, { "nct_id": "NCT02176291", "title": "Incomplete Response in Late-Life Depression: Getting to Remission With Buprenorphine", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Depression", "Major Depressive Disorder" ], "interventions": [ { "name": "Buprenorphine", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Jordan F. Karp", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "50 Years", "maximum_age": null, "sex": "ALL", "summary": "50 Years and older" }, "enrollment_count": 31, "start_date": "2014-08", "completion_date": "2018-02", "has_results": true, "last_update_posted_date": "2018-08-29", "last_synced_at": "2026-10-15T20:57:45.405Z", "location_count": 1, "location_summary": "Pittsburgh, Pennsylvania", "locations": [ { "city": "Pittsburgh", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT02176291" }, { "nct_id": "NCT07127913", "title": "Closed-Loop Deep Brain Stimulation for Treatment-Resistant Bipolar Depression", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Bipolar II Disorder", "Bipolar II Disorder, Most Recent Episode Major Depressive" ], "interventions": [ { "name": "Device: Stimulation-ON", "type": "DEVICE" }, { "name": "Device: Stimulation-OFF", "type": "DEVICE" }, { "name": "Device: Stimulation -ON Active Control", "type": "DEVICE" } ], "intervention_types": [ "DEVICE" ], "sponsor": "Andrew Krystal", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "22 Years", "maximum_age": "70 Years", "sex": "ALL", "summary": "22 Years to 70 Years" }, "enrollment_count": 10, "start_date": "2025-07-16", "completion_date": "2035-06-28", "has_results": false, "last_update_posted_date": "2025-08-17", "last_synced_at": "2026-10-15T20:57:45.405Z", "location_count": 1, "location_summary": "San Francisco, California", "locations": [ { "city": "San Francisco", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT07127913" }, { "nct_id": "NCT02752724", "title": "Ketamine Anesthesia for Improvement of Depression in ECT", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Major Depressive Disorder" ], "interventions": [ { "name": "Ketamine", "type": "DRUG" }, { "name": "Methohexital", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "VA Puget Sound Health Care System", "sponsor_class": "FED", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "100 Years", "sex": "ALL", "summary": "18 Years to 100 Years" }, "enrollment_count": 52, "start_date": "2016-03", "completion_date": "2018-04-30", "has_results": false, "last_update_posted_date": "2018-06-06", "last_synced_at": "2026-10-15T20:57:45.405Z", "location_count": 1, "location_summary": "Seattle, Washington", "locations": [ { "city": "Seattle", "state": "Washington" } ], "official_url": "https://clinicaltrials.gov/study/NCT02752724" }, { "nct_id": "NCT01625546", "title": "Whole Body Hyperthermia and Major Depression (MDD)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Depressive Disorder, Major" ], "interventions": [ { "name": "Whole Body Hyperthermia system", "type": "DEVICE" } ], "intervention_types": [ "DEVICE" ], "sponsor": "University of Arizona", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 34, "start_date": "2012-07", "completion_date": "2015-05", "has_results": false, "last_update_posted_date": "2015-08-10", "last_synced_at": "2026-10-15T20:57:45.405Z", "location_count": 1, "location_summary": "Tucson, Arizona", "locations": [ { "city": "Tucson", "state": "Arizona" } ], "official_url": "https://clinicaltrials.gov/study/NCT01625546" }, { "nct_id": "NCT06976697", "title": "Home-Based tDCS Treatment Of Major Depressive Disorder", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Major Depressive Disorder (MDD)" ], "interventions": [ { "name": "Transcranial direct current stimulation", "type": "DEVICE" }, { "name": "Sham transcranial direct current stimulation", "type": "DEVICE" } ], "intervention_types": [ "DEVICE" ], "sponsor": "Sooma Medical Inc", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "22 Years", "maximum_age": "70 Years", "sex": "ALL", "summary": "22 Years to 70 Years" }, "enrollment_count": 200, "start_date": "2025-06-27", "completion_date": "2026-12-23", "has_results": false, "last_update_posted_date": "2026-08-14", "last_synced_at": "2026-10-15T20:57:45.405Z", "location_count": 1, "location_summary": "Boston, Massachusetts", "locations": [ { "city": "Boston", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT06976697" }, { "nct_id": "NCT00697268", "title": "p11 Protein Levels in Patients With Major Depressive Disorder Treated With Citalopram", "overall_status": "COMPLETED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Depression" ], "interventions": [], "intervention_types": [], "sponsor": "National Institute of Mental Health (NIMH)", "sponsor_class": "NIH", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 38, "start_date": "2008-06-03", "completion_date": "2016-07-28", "has_results": false, "last_update_posted_date": "2019-12-17", "last_synced_at": "2026-10-15T20:57:45.405Z", "location_count": 1, "location_summary": "Bethesda, Maryland", "locations": [ { "city": "Bethesda", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT00697268" }, { "nct_id": "NCT03926520", "title": "Electroconvulsive Therapy (ECT) for Agitation in Dementia (AD)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Alzheimer Dementia", "Agitation,Psychomotor" ], "interventions": [ { "name": "Electroconvulsive Therapy (ECT)", "type": "DEVICE" } ], "intervention_types": [ "DEVICE" ], "sponsor": "Brent Forester", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "40 Years", "maximum_age": null, "sex": "ALL", "summary": "40 Years and older" }, "enrollment_count": 41, "start_date": "2021-01-28", "completion_date": "2026-05-31", "has_results": false, "last_update_posted_date": "2026-07-30", "last_synced_at": "2026-10-15T20:57:45.405Z", "location_count": 5, "location_summary": "Atlanta, Georgia • Belmont, Massachusetts • Grand Rapids, Michigan + 2 more", "locations": [ { "city": "Atlanta", "state": "Georgia" }, { "city": "Belmont", "state": "Massachusetts" }, { "city": "Grand Rapids", "state": "Michigan" }, { "city": "Rochester", "state": "Minnesota" }, { "city": "Glen Oaks", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT03926520" }, { "nct_id": "NCT07479550", "title": "Study of Psilocybin Under Anesthesia Controlled by EEG", "overall_status": "NOT_YET_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Major Depression" ], "interventions": [ { "name": "Psilocybin (Usona Institute)", "type": "DRUG" }, { "name": "Propofol", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Stanford University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "25 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "25 Years to 65 Years" }, "enrollment_count": 10, "start_date": "2026-07", "completion_date": "2027-08", "has_results": false, "last_update_posted_date": "2026-05-06", "last_synced_at": "2026-10-15T20:57:45.405Z", "location_count": 1, "location_summary": "Stanford, California", "locations": [ { "city": "Stanford", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT07479550" }, { "nct_id": "NCT07467473", "title": "Causal Role of Rostromedial Prefrontal Cortex for Positive Savoring in Depression", "overall_status": "ENROLLING_BY_INVITATION", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Left Rostromedial Prefrontal Cortex - Accelerated Intermittent Theta Burst", "Left Dorsolateral Prefrontal Cortex - Accelerated Intermittent Theta Burst", "Left Primary Somatosensory Cortex - Accelerated Intermittent Theta Burst" ], "interventions": [ { "name": "Accelerated Intermittent Theta Burst Transcranial Magnetic Stimulation", "type": "DEVICE" } ], "intervention_types": [ "DEVICE" ], "sponsor": "Florida State University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 48, "start_date": "2026-03-23", "completion_date": "2028-12-31", "has_results": false, "last_update_posted_date": "2026-05-20", "last_synced_at": "2026-10-15T20:57:45.405Z", "location_count": 1, "location_summary": "Tallahassee, Florida", "locations": [ { "city": "Tallahassee", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT07467473" } ] }