{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Severe+Sepsis+With+Septic+Shock",
    "query": {
      "condition": "Severe Sepsis With Septic Shock"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 27,
    "total_pages": 3,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Severe+Sepsis+With+Septic+Shock&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-07-23T09:21:18.369Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT02668432",
      "title": "Use of Amiodarone in Atrial Fibrillation Associated With Severe Sepsis or Septic Shock",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "New Onset Atrial Fibrillation",
        "Severe Sepsis",
        "Septic Shock"
      ],
      "interventions": [
        {
          "name": "Amiodarone",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "The University of Texas Health Science Center at San Antonio",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 9,
      "start_date": "2016-05",
      "completion_date": "2018-09-20",
      "has_results": true,
      "last_update_posted_date": "2019-04-02",
      "last_synced_at": "2026-07-23T09:21:18.369Z",
      "location_count": 1,
      "location_summary": "San Antonio, Texas",
      "locations": [
        {
          "city": "San Antonio",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02668432"
    },
    {
      "nct_id": "NCT03592277",
      "title": "Vitamin C & Thiamine to Treat Sepsis and Septic Shock",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Sepsis",
        "Septic Shock"
      ],
      "interventions": [
        {
          "name": "Vitamin C",
          "type": "DRUG"
        },
        {
          "name": "Vitamin B1",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Trinity Health Of New England",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "90 Years",
        "sex": "ALL",
        "summary": "18 Years to 90 Years"
      },
      "enrollment_count": 120,
      "start_date": "2018-09-14",
      "completion_date": "2021-02-22",
      "has_results": true,
      "last_update_posted_date": "2022-09-28",
      "last_synced_at": "2026-07-23T09:21:18.369Z",
      "location_count": 1,
      "location_summary": "Hartford, Connecticut",
      "locations": [
        {
          "city": "Hartford",
          "state": "Connecticut"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03592277"
    },
    {
      "nct_id": "NCT00046072",
      "title": "A Safety and Efficacy Study of Intravenous E5564 in Patients With Severe Sepsis",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Sepsis",
        "Shock, Septic",
        "Sepsis Syndrome",
        "Septicemia",
        "Infection"
      ],
      "interventions": [
        {
          "name": "E5564",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Eisai Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "85 Years",
        "sex": "ALL",
        "summary": "18 Years to 85 Years"
      },
      "enrollment_count": 300,
      "start_date": "2001-10",
      "completion_date": "2005-04",
      "has_results": false,
      "last_update_posted_date": "2005-12-12",
      "last_synced_at": "2026-07-23T09:21:18.369Z",
      "location_count": 17,
      "location_summary": "Mobile, Alabama • San Diego, California • Santa Barbara, California + 14 more",
      "locations": [
        {
          "city": "Mobile",
          "state": "Alabama"
        },
        {
          "city": "San Diego",
          "state": "California"
        },
        {
          "city": "Santa Barbara",
          "state": "California"
        },
        {
          "city": "Jacksonville",
          "state": "Florida"
        },
        {
          "city": "Miami",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00046072"
    },
    {
      "nct_id": "NCT01689441",
      "title": "Randomized Controlled Trial of Calcitriol vs. Placebo Among Critically-ill Patients With Sepsis",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Severe Sepsis or Septic Shock"
      ],
      "interventions": [
        {
          "name": "Calcitriol",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Brigham and Women's Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 67,
      "start_date": "2013-02",
      "completion_date": "2014-02",
      "has_results": true,
      "last_update_posted_date": "2020-11-10",
      "last_synced_at": "2026-07-23T09:21:18.369Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01689441"
    },
    {
      "nct_id": "NCT02640807",
      "title": "A Study of IL-7 to Restore Absolute Lymphocyte Counts in Sepsis Patients",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Severe Sepsis With Septic Shock"
      ],
      "interventions": [
        {
          "name": "Interleukin-7",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Revimmune",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 27,
      "start_date": "2016-01",
      "completion_date": "2018-08-27",
      "has_results": true,
      "last_update_posted_date": "2020-07-09",
      "last_synced_at": "2026-07-23T09:21:18.369Z",
      "location_count": 1,
      "location_summary": "Nashville, Tennessee",
      "locations": [
        {
          "city": "Nashville",
          "state": "Tennessee"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02640807"
    },
    {
      "nct_id": "NCT00335907",
      "title": "Protocol-driven Hemodynamic Support for Patients With Septic Shock",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Shock, Septic",
        "Severe Sepsis",
        "Sepsis"
      ],
      "interventions": [
        {
          "name": "Fluid and Vasopressor Protocol",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "National Institute of General Medical Sciences (NIGMS)",
      "sponsor_class": "NIH",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 70,
      "start_date": "2006-09",
      "completion_date": "2011-01",
      "has_results": false,
      "last_update_posted_date": "2010-08-25",
      "last_synced_at": "2026-07-23T09:21:18.369Z",
      "location_count": 1,
      "location_summary": "Baltimore, Maryland",
      "locations": [
        {
          "city": "Baltimore",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00335907"
    },
    {
      "nct_id": "NCT03913468",
      "title": "Outcomes of Septic Shock Patients Treated With a Metabolic Resuscitation Bundle Consisting of Intravenous Hydrocortisone, Ascorbic Acid and Thiamine.",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Septic Shock",
        "Ascorbic Acid Deficiency"
      ],
      "interventions": [
        {
          "name": "Intravenous Ascorbic Acid",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Wisconsin, Madison",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "90 Years",
        "sex": "ALL",
        "summary": "18 Years to 90 Years"
      },
      "enrollment_count": 206,
      "start_date": "2019-01-01",
      "completion_date": "2019-12-01",
      "has_results": false,
      "last_update_posted_date": "2021-09-14",
      "last_synced_at": "2026-07-23T09:21:18.369Z",
      "location_count": 1,
      "location_summary": "Madison, Wisconsin",
      "locations": [
        {
          "city": "Madison",
          "state": "Wisconsin"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03913468"
    },
    {
      "nct_id": "NCT00334828",
      "title": "ACCESS: A Controlled Comparison of Eritoran Tetrasodium and Placebo in Patients With Severe Sepsis",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Severe Sepsis"
      ],
      "interventions": [
        {
          "name": "eritoran tetrasodium",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Eisai Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 2000,
      "start_date": "2006-06",
      "completion_date": null,
      "has_results": false,
      "last_update_posted_date": "2017-07-25",
      "last_synced_at": "2026-07-23T09:21:18.369Z",
      "location_count": 69,
      "location_summary": "Birmingham, Alabama • Mobile, Alabama • Mesa, Arizona + 66 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Mobile",
          "state": "Alabama"
        },
        {
          "city": "Mesa",
          "state": "Arizona"
        },
        {
          "city": "Loma Linda",
          "state": "California"
        },
        {
          "city": "Marysville",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00334828"
    },
    {
      "nct_id": "NCT02576457",
      "title": "Safety, Pharmacokinetics and Pharmacodynamics of BMS-936559 in Severe Sepsis",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Severe Sepsis",
        "Septic Shock"
      ],
      "interventions": [
        {
          "name": "BMS-936559",
          "type": "BIOLOGICAL"
        },
        {
          "name": "Placebo",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "BIOLOGICAL",
        "OTHER"
      ],
      "sponsor": "Bristol-Myers Squibb",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 35,
      "start_date": "2015-12-02",
      "completion_date": "2017-03-15",
      "has_results": false,
      "last_update_posted_date": "2017-09-15",
      "last_synced_at": "2026-07-23T09:21:18.369Z",
      "location_count": 13,
      "location_summary": "Sacramento, California • Denver, Colorado • Gainesville, Florida + 10 more",
      "locations": [
        {
          "city": "Sacramento",
          "state": "California"
        },
        {
          "city": "Denver",
          "state": "Colorado"
        },
        {
          "city": "Gainesville",
          "state": "Florida"
        },
        {
          "city": "Atlanta",
          "state": "Georgia"
        },
        {
          "city": "Peoria",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02576457"
    },
    {
      "nct_id": "NCT06809868",
      "title": "Role of Transposable Elements in Septic Immune Aging",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Sepsis",
        "Sepsis and Septic Shock",
        "Sepsis With Multiple Organ Dysfunction (MOD)",
        "Sepsis With Acute Organ Dysfunction",
        "Sepsis, Severe",
        "Sepsis at Intensive Care Unit",
        "Sepsis, Severe Sepsis and Septic Shock",
        "Sepsis, Septic Shock"
      ],
      "interventions": [
        {
          "name": "RNA and DNA Sequencing",
          "type": "GENETIC"
        }
      ],
      "intervention_types": [
        "GENETIC"
      ],
      "sponsor": "University of California, San Francisco",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 116,
      "start_date": "2025-02-14",
      "completion_date": "2028-08-14",
      "has_results": false,
      "last_update_posted_date": "2026-01-30",
      "last_synced_at": "2026-07-23T09:21:18.369Z",
      "location_count": 1,
      "location_summary": "San Francisco, California",
      "locations": [
        {
          "city": "San Francisco",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06809868"
    }
  ]
}