{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Severe+Symptomatic+Aortic+Stenosis", "query": { "condition": "Severe Symptomatic Aortic Stenosis" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 21, "total_pages": 3, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Severe+Symptomatic+Aortic+Stenosis&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-07-24T02:11:57.139Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT00530894", "title": "THE PARTNER TRIAL: Placement of AoRTic TraNscathetER Valve Trial", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Critical Aortic Stenosis" ], "interventions": [ { "name": "Edwards SAPIEN Transcatheter Heart Valve", "type": "DEVICE" }, { "name": "Surgical Valve Replacement", "type": "DEVICE" }, { "name": "medical management and/or balloon aortic valvuloplasty", "type": "OTHER" } ], "intervention_types": [ "DEVICE", "OTHER" ], "sponsor": "Edwards Lifesciences", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": null, "maximum_age": null, "sex": "ALL", "summary": "Not listed" }, "enrollment_count": 1057, "start_date": "2007-04", "completion_date": "2017-07", "has_results": true, "last_update_posted_date": "2017-09-13", "last_synced_at": "2026-07-24T02:11:57.139Z", "location_count": 22, "location_summary": "La Jolla, California • Los Angeles, California • Stanford, California + 17 more", "locations": [ { "city": "La Jolla", "state": "California" }, { "city": "Los Angeles", "state": "California" }, { "city": "Stanford", "state": "California" }, { "city": "Washington D.C.", "state": "District of Columbia" }, { "city": "Miami", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT00530894" }, { "nct_id": "NCT02628899", "title": "Feasibility of Transcatheter Aortic Valve Replacement in Low-Risk Patients With Symptomatic, Severe Aortic Stenosis", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Aortic Stenosis" ], "interventions": [ { "name": "Transfemoral TAVR", "type": "DEVICE" }, { "name": "SAVR", "type": "DEVICE" } ], "intervention_types": [ "DEVICE" ], "sponsor": "Medstar Health Research Institute", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": null, "maximum_age": null, "sex": "ALL", "summary": "Not listed" }, "enrollment_count": 277, "start_date": "2016-01", "completion_date": "2023-01", "has_results": false, "last_update_posted_date": "2024-05-16", "last_synced_at": "2026-07-24T02:11:57.139Z", "location_count": 11, "location_summary": "Sacramento, California • San Diego, California • Washington D.C., District of Columbia + 7 more", "locations": [ { "city": "Sacramento", "state": "California" }, { "city": "San Diego", "state": "California" }, { "city": "Washington D.C.", "state": "District of Columbia" }, { "city": "Marietta", "state": "Georgia" }, { "city": "Portland", "state": "Maine" } ], "official_url": "https://clinicaltrials.gov/study/NCT02628899" }, { "nct_id": "NCT03222128", "title": "PARTNER II Trial: Placement of AoRTic TraNscathetER Valves II - S3 Intermediate", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Symptomatic Severe Aortic Stenosis" ], "interventions": [ { "name": "TAVR", "type": "DEVICE" } ], "intervention_types": [ "DEVICE" ], "sponsor": "Edwards Lifesciences", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "19 Years", "maximum_age": null, "sex": "ALL", "summary": "19 Years and older" }, "enrollment_count": 1074, "start_date": "2014-02-17", "completion_date": "2024-10-09", "has_results": true, "last_update_posted_date": "2025-01-03", "last_synced_at": "2026-07-24T02:11:57.139Z", "location_count": 51, "location_summary": "La Jolla, California • Los Angeles, California • Sacramento, California + 44 more", "locations": [ { "city": "La Jolla", "state": "California" }, { "city": "Los Angeles", "state": "California" }, { "city": "Sacramento", "state": "California" }, { "city": "Stanford", "state": "California" }, { "city": "Denver", "state": "Colorado" } ], "official_url": "https://clinicaltrials.gov/study/NCT03222128" }, { "nct_id": "NCT05932615", "title": "ENVISION IDE Trial: Safety and Effectiveness of NAVITOR in Transcatheter Aortic Valve Implantation", "overall_status": "ENROLLING_BY_INVITATION", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Aortic Valve Stenosis", "Heart Valve Diseases", "Aortic Valve Disease", "Heart Disease Structural Disorder" ], "interventions": [ { "name": "Navitor Transcatheter Aortic Valve Implantation (TAVI) System", "type": "DEVICE" }, { "name": "Any Commercially Available Transcatheter Aortic Valve (CAV) System", "type": "DEVICE" } ], "intervention_types": [ "DEVICE" ], "sponsor": "Abbott Medical Devices", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 1500, "start_date": "2024-03-15", "completion_date": "2036-04", "has_results": false, "last_update_posted_date": "2026-05-08", "last_synced_at": "2026-07-24T02:11:57.139Z", "location_count": 67, "location_summary": "Birmingham, Alabama • Phoenix, Arizona • Tucson, Arizona + 58 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Phoenix", "state": "Arizona" }, { "city": "Tucson", "state": "Arizona" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "Fontana", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT05932615" }, { "nct_id": "NCT02184442", "title": "The PARTNER II Trial: Placement of AoRTic TraNscathetER Valves - PII B", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Severe", "Symptomatic", "Calcific Aortic Stenosis" ], "interventions": [ { "name": "TAVR Implantation with SAPIEN XT", "type": "DEVICE" }, { "name": "TAVR Implantation with SAPIEN", "type": "DEVICE" } ], "intervention_types": [ "DEVICE" ], "sponsor": "Edwards Lifesciences", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "19 Years", "maximum_age": null, "sex": "ALL", "summary": "19 Years and older" }, "enrollment_count": 560, "start_date": "2011-03-09", "completion_date": "2017-05-30", "has_results": true, "last_update_posted_date": "2018-09-25", "last_synced_at": "2026-07-24T02:11:57.139Z", "location_count": 53, "location_summary": "Little Rock, Arkansas • La Jolla, California • Los Angeles, California + 45 more", "locations": [ { "city": "Little Rock", "state": "Arkansas" }, { "city": "La Jolla", "state": "California" }, { "city": "La Jolla", "state": "California" }, { "city": "Los Angeles", "state": "California" }, { "city": "Sacramento", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT02184442" }, { "nct_id": "NCT03222141", "title": "PARTNER II Trial: Placement of AoRTic TraNscathetER Valves II - High Risk and Nested Registry 7", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Symptomatic Severe Aortic Stenosis" ], "interventions": [ { "name": "TAVR Implantation of the THV Prosthesis", "type": "DEVICE" } ], "intervention_types": [ "DEVICE" ], "sponsor": "Edwards Lifesciences", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "19 Years", "maximum_age": null, "sex": "ALL", "summary": "19 Years and older" }, "enrollment_count": 583, "start_date": "2013-10", "completion_date": "2020-08", "has_results": true, "last_update_posted_date": "2021-05-12", "last_synced_at": "2026-07-24T02:11:57.139Z", "location_count": 39, "location_summary": "Los Angeles, California • Sacramento, California • Stanford, California + 34 more", "locations": [ { "city": "Los Angeles", "state": "California" }, { "city": "Sacramento", "state": "California" }, { "city": "Stanford", "state": "California" }, { "city": "Denver", "state": "Colorado" }, { "city": "Washington D.C.", "state": "District of Columbia" } ], "official_url": "https://clinicaltrials.gov/study/NCT03222141" }, { "nct_id": "NCT01314313", "title": "PARTNER II Trial: Placement of AoRTic TraNscathetER Valves II - XT Intermediate and High Risk", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Symptomatic Severe Aortic Stenosis" ], "interventions": [ { "name": "TAVR Implantation with SAPIEN XT", "type": "DEVICE" }, { "name": "SAVR Implantation", "type": "DEVICE" } ], "intervention_types": [ "DEVICE" ], "sponsor": "Edwards Lifesciences", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": null, "maximum_age": null, "sex": "ALL", "summary": "Not listed" }, "enrollment_count": 2032, "start_date": "2011-03", "completion_date": "2024-01-17", "has_results": true, "last_update_posted_date": "2024-03-07", "last_synced_at": "2026-07-24T02:11:57.139Z", "location_count": 55, "location_summary": "Little Rock, Arkansas • La Jolla, California • Los Angeles, California + 46 more", "locations": [ { "city": "Little Rock", "state": "Arkansas" }, { "city": "La Jolla", "state": "California" }, { "city": "La Jolla", "state": "California" }, { "city": "Los Angeles", "state": "California" }, { "city": "Sacramento", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT01314313" }, { "nct_id": "NCT05712161", "title": "Use of DurAVR™ THV System in Subjects With Severe Aortic Stenosis: Early Feasibility Study", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Aortic Stenosis", "Symptomatic Aortic Stenosis", "Severe Aortic Valve Stenosis", "Aortic Valve Calcification" ], "interventions": [ { "name": "DurAVRTM THV System", "type": "DEVICE" } ], "intervention_types": [ "DEVICE" ], "sponsor": "Anteris Technologies Ltd.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "65 Years", "maximum_age": null, "sex": "ALL", "summary": "65 Years and older" }, "enrollment_count": 15, "start_date": "2023-08-07", "completion_date": "2033-12", "has_results": false, "last_update_posted_date": "2026-06-26", "last_synced_at": "2026-07-24T02:11:57.139Z", "location_count": 5, "location_summary": "Tucson, Arizona • Ann Arbor, Michigan • New York, New York + 2 more", "locations": [ { "city": "Tucson", "state": "Arizona" }, { "city": "Ann Arbor", "state": "Michigan" }, { "city": "New York", "state": "New York" }, { "city": "The Bronx", "state": "New York" }, { "city": "Cleveland", "state": "Ohio" } ], "official_url": "https://clinicaltrials.gov/study/NCT05712161" }, { "nct_id": "NCT01531374", "title": "Safety and Efficacy Continued Access Study of the Medtronic CoreValve® System in the Treatment of Symptomatic Severe Aortic Stenosis in Very High Risk Subjects and High Risk Subjects Who Need Aortic Valve Replacement", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Severe Aortic Stenosis" ], "interventions": [ { "name": "Medtronic CoreValve® System Transcatheter Aortic Valve Implantation (TAVI)", "type": "DEVICE" } ], "intervention_types": [ "DEVICE" ], "sponsor": "Medtronic Cardiovascular", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": null, "maximum_age": null, "sex": "ALL", "summary": "Not listed" }, "enrollment_count": 2777, "start_date": "2012-02-21", "completion_date": "2019-11-18", "has_results": true, "last_update_posted_date": "2022-10-25", "last_synced_at": "2026-07-24T02:11:57.139Z", "location_count": 45, "location_summary": "Phoenix, Arizona • Los Angeles, California • Mountain View, California + 35 more", "locations": [ { "city": "Phoenix", "state": "Arizona" }, { "city": "Los Angeles", "state": "California" }, { "city": "Los Angeles", "state": "California" }, { "city": "Mountain View", "state": "California" }, { "city": "Palo Alto", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT01531374" }, { "nct_id": "NCT03517436", "title": "ExCEED: CENTERA THV System in Intermediate Risk Patients Who Have Symptomatic, Severe, Calcific, Aortic Stenosis", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Aortic Valve Stenosis" ], "interventions": [ { "name": "TAVR with CENTERA THV", "type": "DEVICE" } ], "intervention_types": [ "DEVICE" ], "sponsor": "Edwards Lifesciences", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": null, "maximum_age": null, "sex": "ALL", "summary": "Not listed" }, "enrollment_count": 101, "start_date": "2018-09-18", "completion_date": "2030-07", "has_results": true, "last_update_posted_date": "2025-11-13", "last_synced_at": "2026-07-24T02:11:57.139Z", "location_count": 23, "location_summary": "Los Angeles, California • Stanford, California • Loveland, Colorado + 19 more", "locations": [ { "city": "Los Angeles", "state": "California" }, { "city": "Stanford", "state": "California" }, { "city": "Loveland", "state": "Colorado" }, { "city": "Washington D.C.", "state": "District of Columbia" }, { "city": "Sarasota", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT03517436" } ] }