{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Severe+Uncontrolled+Asthma&page=2", "query": { "condition": "Severe Uncontrolled Asthma", "page": 2 }, "page_size": 10 }, "pagination": { "page": 2, "page_size": 10, "total_count": 10, "total_pages": 1, "next_page_url": null, "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Severe+Uncontrolled+Asthma&page=1&page_size=10" }, "source": "remote", "last_synced_at": "2026-07-24T08:09:09.877Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT01854047", "title": "An Evaluation of Dupilumab in Patients With Moderate to Severe Uncontrolled Asthma", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Asthma" ], "interventions": [ { "name": "Dupilumab", "type": "DRUG" }, { "name": "placebo", "type": "DRUG" }, { "name": "ICS/LABA therapy", "type": "DRUG" }, { "name": "Salbutamol/albuterol", "type": "DRUG" }, { "name": "Levosalbutamol/levalbuterol", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Sanofi", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 776, "start_date": "2013-06", "completion_date": "2015-04", "has_results": true, "last_update_posted_date": "2017-06-26", "last_synced_at": "2026-07-24T08:09:09.877Z", "location_count": 50, "location_summary": "Fullerton, California • Huntington Beach, California • Los Angeles, California + 38 more", "locations": [ { "city": "Fullerton", "state": "California" }, { "city": "Huntington Beach", "state": "California" }, { "city": "Los Angeles", "state": "California" }, { "city": "Los Angeles", "state": "California" }, { "city": "Los Angeles", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT01854047" }, { "nct_id": "NCT03968978", "title": "Tezepelumab Home Use Study", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Asthma" ], "interventions": [ { "name": "Tezepelumab (APFS)", "type": "BIOLOGICAL" }, { "name": "Tezepelumab (AI)", "type": "BIOLOGICAL" } ], "intervention_types": [ "BIOLOGICAL" ], "sponsor": "AstraZeneca", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "12 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "12 Years to 80 Years" }, "enrollment_count": 216, "start_date": "2019-05-21", "completion_date": "2020-06-05", "has_results": true, "last_update_posted_date": "2021-07-29", "last_synced_at": "2026-07-24T08:09:09.877Z", "location_count": 16, "location_summary": "Hoover, Alabama • Gilbert, Arizona • Northridge, California + 12 more", "locations": [ { "city": "Hoover", "state": "Alabama" }, { "city": "Gilbert", "state": "Arizona" }, { "city": "Northridge", "state": "California" }, { "city": "Palm Desert", "state": "California" }, { "city": "Westminster", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT03968978" }, { "nct_id": "NCT04545385", "title": "A Study to Test if TEV-48574 is Effective in Relieving Asthma", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Asthma" ], "interventions": [ { "name": "TEV-48574", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Teva Branded Pharmaceutical Products R&D, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 65, "start_date": "2020-10-07", "completion_date": "2022-01-17", "has_results": true, "last_update_posted_date": "2023-03-13", "last_synced_at": "2026-07-24T08:09:09.877Z", "location_count": 55, "location_summary": "Birmingham, Alabama • Little Rock, Arkansas • Bakersfield, California + 47 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "Bakersfield", "state": "California" }, { "city": "Huntington Beach", "state": "California" }, { "city": "Los Angeles", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT04545385" }, { "nct_id": "NCT02869438", "title": "A Study to Evaluate the Onset of Effect and Time Course of Change in Lung Function With Benralizumab in Severe, Uncontrolled Asthma Patients With Eosinophilic Inflammation", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Asthma" ], "interventions": [ { "name": "Benralizumab", "type": "DRUG" }, { "name": "Placebo", "type": "OTHER" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "AstraZeneca", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "18 Years to 75 Years" }, "enrollment_count": 233, "start_date": "2016-11-09", "completion_date": "2018-08-01", "has_results": true, "last_update_posted_date": "2019-10-29", "last_synced_at": "2026-07-24T08:09:09.877Z", "location_count": 16, "location_summary": "Scottsboro, Alabama • Gilbert, Arizona • Denver, Colorado + 13 more", "locations": [ { "city": "Scottsboro", "state": "Alabama" }, { "city": "Gilbert", "state": "Arizona" }, { "city": "Denver", "state": "Colorado" }, { "city": "Miami", "state": "Florida" }, { "city": "Tampa", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT02869438" }, { "nct_id": "NCT04718103", "title": "A Study of GSK3511294 (Depemokimab) in Participants With Severe Asthma With an Eosinophilic Phenotype", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Asthma" ], "interventions": [ { "name": "GSK3511294", "type": "BIOLOGICAL" }, { "name": "Placebo", "type": "BIOLOGICAL" } ], "intervention_types": [ "BIOLOGICAL" ], "sponsor": "GlaxoSmithKline", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "12 Years", "maximum_age": null, "sex": "ALL", "summary": "12 Years and older" }, "enrollment_count": 397, "start_date": "2021-02-04", "completion_date": "2024-04-11", "has_results": true, "last_update_posted_date": "2024-11-29", "last_synced_at": "2026-07-24T08:09:09.877Z", "location_count": 41, "location_summary": "Alabaster, Alabama • Mobile, Alabama • Phoenix, Arizona + 34 more", "locations": [ { "city": "Alabaster", "state": "Alabama" }, { "city": "Mobile", "state": "Alabama" }, { "city": "Phoenix", "state": "Arizona" }, { "city": "Beverly Hills", "state": "California" }, { "city": "Lancaster", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT04718103" }, { "nct_id": "NCT06196879", "title": "A Study to Investigate the Efficacy and Safety of Verekitug (UPB-101) in Adult Participants With Severe Asthma (VALIANT)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Severe Asthma" ], "interventions": [ { "name": "Verekitug (UPB-101)", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Upstream Bio Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "18 Years to 80 Years" }, "enrollment_count": 479, "start_date": "2024-02-27", "completion_date": "2026-03-19", "has_results": false, "last_update_posted_date": "2026-05-01", "last_synced_at": "2026-07-24T08:09:09.877Z", "location_count": 55, "location_summary": "Birmingham, Alabama • Bakersfield, California • Los Angeles, California + 47 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Bakersfield", "state": "California" }, { "city": "Los Angeles", "state": "California" }, { "city": "Newport Beach", "state": "California" }, { "city": "Northridge", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT06196879" }, { "nct_id": "NCT04305405", "title": "PK/PD and Long Term Safety Study of Benralizumab in Children With Severe Eosinophilic Asthma", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Severe Uncontrolled Asthma" ], "interventions": [ { "name": "Benralizumab", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "AstraZeneca", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "6 Years", "maximum_age": "14 Years", "sex": "ALL", "summary": "6 Years to 14 Years" }, "enrollment_count": 30, "start_date": "2019-11-21", "completion_date": "2022-09-12", "has_results": true, "last_update_posted_date": "2023-05-18", "last_synced_at": "2026-07-24T08:09:09.877Z", "location_count": 7, "location_summary": "Los Angeles, California • Orlando, Florida • Lincoln, Nebraska + 4 more", "locations": [ { "city": "Los Angeles", "state": "California" }, { "city": "Orlando", "state": "Florida" }, { "city": "Lincoln", "state": "Nebraska" }, { "city": "Cincinnati", "state": "Ohio" }, { "city": "Pittsburgh", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT04305405" }, { "nct_id": "NCT06020014", "title": "Phase 2a Study to Assess the Efficacy and Safety of AZD4604 in Adult Patients With Moderate-to-Severe Asthma Uncontrolled on Medium-High Dose ICS-LABA", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Asthma" ], "interventions": [ { "name": "AZD4604", "type": "DRUG" }, { "name": "Placebo", "type": "OTHER" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "AstraZeneca", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "18 Years to 80 Years" }, "enrollment_count": 339, "start_date": "2023-11-16", "completion_date": "2025-10-28", "has_results": false, "last_update_posted_date": "2025-11-13", "last_synced_at": "2026-07-24T08:09:09.877Z", "location_count": 22, "location_summary": "Birmingham, Alabama • Chandler, Arizona • Newport Beach, California + 19 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Chandler", "state": "Arizona" }, { "city": "Newport Beach", "state": "California" }, { "city": "Sacramento", "state": "California" }, { "city": "Lakeland", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT06020014" }, { "nct_id": "NCT01000506", "title": "Dose Ranging Efficacy And Safety With Mepolizumab in Severe Asthma", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Asthma" ], "interventions": [ { "name": "Mepolizumab 750", "type": "BIOLOGICAL" }, { "name": "Mepolizumab 250", "type": "BIOLOGICAL" }, { "name": "Mepolizumab 75", "type": "BIOLOGICAL" }, { "name": "Placebo saline", "type": "DRUG" } ], "intervention_types": [ "BIOLOGICAL", "DRUG" ], "sponsor": "GlaxoSmithKline", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "12 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "12 Years to 65 Years" }, "enrollment_count": 621, "start_date": "2009-11-01", "completion_date": "2012-03-23", "has_results": true, "last_update_posted_date": "2018-01-24", "last_synced_at": "2026-07-24T08:09:09.877Z", "location_count": 21, "location_summary": "Long Beach, California • Los Angeles, California • Riverside, California + 18 more", "locations": [ { "city": "Long Beach", "state": "California" }, { "city": "Los Angeles", "state": "California" }, { "city": "Riverside", "state": "California" }, { "city": "San Diego", "state": "California" }, { "city": "Denver", "state": "Colorado" } ], "official_url": "https://clinicaltrials.gov/study/NCT01000506" }, { "nct_id": "NCT05763121", "title": "A Study to Assess the Effect of Dexpramipexole in Adolescents and Adults With Severe Eosinophilic Asthma.", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Eosinophilic Asthma", "Asthma; Eosinophilic", "Asthma" ], "interventions": [ { "name": "Dexpramipexole Dihydrochloride", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Areteia Therapeutics", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "12 Years", "maximum_age": "99 Years", "sex": "ALL", "summary": "12 Years to 99 Years" }, "enrollment_count": 1061, "start_date": "2023-01-30", "completion_date": "2025-12-08", "has_results": false, "last_update_posted_date": "2025-12-15", "last_synced_at": "2026-07-24T08:09:09.877Z", "location_count": 89, "location_summary": "Bakersfield, California • La Palma, California • Newport Beach, California + 73 more", "locations": [ { "city": "Bakersfield", "state": "California" }, { "city": "La Palma", "state": "California" }, { "city": "Newport Beach", "state": "California" }, { "city": "Newport Beach", "state": "California" }, { "city": "Redding", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT05763121" } ] }